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1. What are biological databases? Write notes on protein and DNA databases. [12]
2. Describe the RNA secondary structure and add a note on RNA structure prediction
methods. [12]
sequence alignment.
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3. What is sequence alignment? Discuss in detail pair wise alignment and multiple
[12]
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4. Write short notes on any TWO of the following.
a) Shotgun sequencing
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b) Functional Genomics tools
c) ORF analysis. [12]
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5. Define protein tertiary structure. Discuss the concept of homology modeling in
protein structure prediction.
6. Explain the Process of drug discover cycle and add a note on MOE.
[12]
[12]
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7. Write short notes on any TWO of the following.
a) Kyte and Doolittle scale
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b) Dynamic Programming
c) Insilico Primer Design. [12]
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