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Code No: D0307


R09
JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
M.Tech II - Semester Examinations October / November 2011
BIOINFORMATICS
(BIOTECHNOLOGY)
Time: 3hours Max.Marks:60
Answer any five questions
All questions carry equal marks
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1. What are biological databases? Write notes on protein and DNA databases. [12]

2. Describe the RNA secondary structure and add a note on RNA structure prediction
methods. [12]

sequence alignment.

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3. What is sequence alignment? Discuss in detail pair wise alignment and multiple
[12]

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4. Write short notes on any TWO of the following.
a) Shotgun sequencing

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b) Functional Genomics tools
c) ORF analysis. [12]

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5. Define protein tertiary structure. Discuss the concept of homology modeling in
protein structure prediction.

6. Explain the Process of drug discover cycle and add a note on MOE.
[12]

[12]

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7. Write short notes on any TWO of the following.
a) Kyte and Doolittle scale

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b) Dynamic Programming
c) Insilico Primer Design. [12]

8. Write short notes on any TWO of the following.


a) Micro arrays
b) Protein post translational modification
c) Scoring Matrices. [12]

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