ye “xavauai) ore AIND. qyoINHodL ayuox TAKORADI TECHNICAL UNIVERSITY FACULTY OF APPLIED SCIENC ES INDUSTRIAL & HEALTH SCIENCES DEPARTMENT MESTER Il EXAMINATION, 2020/2021 END OFS BIOLOGICAL CHEMISTRY II B-TECH (MEDICAL LABTECH: LEVEL 100) ‘Course Code: BML 316 ‘Time Allowed: 2 HOURS ‘Answer ALL Questions in Section A and ANY TWO Questions in Section B SECTION A [Answer ALL Questions in this Section] . Which statement below best defines the “quaternary structure’* of a protein? a. The arrangement of two or more poly peptide subunits in a single functional complex b. The folding of a polypeptide backbone is three dimensional space c. The interaction of amino acid chains d. The sequence of amino acids ina polypeptide chain Disulphide bonds are formed between a. Cystine residues that are close together b. Cysteine residues that close together ¢. Proline residues that are close together d. Histidine residues that are close together . Which of the following statements are true regarding primary structure of proteins? 8. Primary structure denotes the number of amino acids in a protein b. Primary structure determines the biological activity of a proteinrARQRADI TECHNICAL UNIT) LIBRARY x ity of protein ¢, Primary structure determines the biological a d. All ofthe above 4. The amyloid protein deposition with Alzheimer’s disease is composed of a. Alpha helix b, Beta pleated sheets ¢ Beta bonds d. Tertiary structure ptide chain is he first amino acid is a polype a. Serine b.Valine ¢ Alanine 4 Methionine H would be provided by a protein rich in whit 6 The greatest buffering capacity’ at physiological p of the following amino acids? a. Serine b, Cysteine © Alanine d. Histidine h of the following concepts is most plavsible? a. Proteins evolved before nucleic acids b, Nucleic acids evolved before proteins ¢. Proteins and nucleic acids evolved from carbohydrate condensation d. Proteins and nuclei acids must have evolved in parallel 8. When a boundary or membrane is formed around catabolically active molecules, such a struc is termed a. Protocell b.Prototype ©. Protobiont d. Protozoa 9, SieSi bond are rare because they are a, Unstable b. Too big Too weak di. Tetravalent 10. Several factors enable proteins to participate in wide range of functions except i Proteins are linear polymers: built of monomer units ii. Proteins contain only one function group ii, Proteins do not occur as complexes with other biomoleculespbular forms jy, Proteins could exist as rigid and a. Land tV) belfonly ef and tit dst, 11, MM and 1V es plyeine? 11. Which of the following eh acteristics best des 4. Optically innetive bs Hydrophobic, basic and ch cllydrophobied. __d Hydrophilic, acte sino acid already presents by modification of an proteins additional amino acids thal arise in a peptide. Example ‘of such modified amino acids include dd. All ofthe above J-hydroxprofine b, Bealunine ¢. Y-aming buiie id, Which statement bes! 13, A mutation has changed an Isoleucine residue of a protein sribes its location in a hydrophilic exterior? On the surface since it is hydrophilic in exterior? b, Inside the core of the protein since itis hydrophobic in natu ‘Anywhere inside or outside dL. Inside the core of the protein since it has a polar but charged side chain 4. ‘The highest concentration of eysteine ean be found in a. Melanin b.Kerain ¢. Myosin d, Collagen ids may be considered hydrophobic at physiolog 15. Which of the following ami a. Isoleucine b, Arginine ¢. Asparticacid d. Threonine 16. All the following are metalloproteins exeept a, Carbonic anhydrase b. Xanthine oxidase e. Lactate dehydrogenase d, Superoxide dismutase 17. Biotin is involved in the transfer of a. One Cunits b. Acyl groups ¢, Phenyl groups d. Single carbon unit as CO?PAROLADT TAG Nee we LIBRARY | reducing agents were exhausted, the photosynthetic machinery utilized 18, When the weInstend, a.120 b.H2S c. O2 d CO: 19. Oxygen was a minor component of the atmosphere until ‘a. Photosynthetic organisms began to produce oxygen from the oxidation of water b. Multiple photosynthetic cells were produced from parent cells c. HsS was completely consumed 4. Photochemical splitting of water by the sun. released Oz from sea water 20. The glucosidie linkage present in sucrose is a Gl>B2 db. dl +fl c. @2— fl a. atl 4) 21. Of all the disaccharides, is a non-reducing sugar. a, Maltose b, Jactose ¢, Sucrose 4. Allose 22. The principal storage carbohydrate in plants is ..... | whereas its equivalent in animals a. Cellulose, glycogen b, Sucrose, glucose ¢. Starch, glycogen d. Starch, glucose 23, Anomers are isomers which differin the a Spal anangement of toms round a eee carbon.FARORADI TECHNICAL UNIV. LIBRARY c. Protects the anomeric carbon d. Is more stable 6, Biological evolution refers to the a. Biological processes by which life evolved b. Theory that unicellular organisms were the first forms of life and evolved over complex ‘evolutionary trends to form multiple species c. Formation of living matter from chemical agents d. Formation of living cells from complex organic molecules sen Reaction 27. Prebiotic monosaccharides could have been formed by the .... a, Pentose b, Formose c. Aldose-ketose d. Strecker 28. Nucleotide bases in the prebiotie atmosphere were synthesized by the polymerization of a. CHO b. HPQ? CN d HCN 29. The primitive atmosphere was said to be reducing because a. There was little or no oxygen present b. Meteorites contained iron either as Fe or Fe" ¢. Carbon was present as clemental carbon od. “The mater from whieh the earth was formed was mostly hydrogen cy gyeeras are mostly Found inthe Liver at cidneys d. Adipose tissues , by plants through the process of sis C. Photosynthesis d. EvolutionYAKORADI TECHNICAL Overy LIBRARY rates usually referred 10 as -..-- 33. Starch and cellulase belong to a class of carbohydi carbohydrates a. Complex b, Digestible © Ingestible in intensive manual work may prefer complex d. Glycosidie 34. A labourer who indulges carbohydrates for breakfast because they ‘a. Contain more energy b. Are cheaper ¢. ‘Areheavier d. Are digested over a longer period and thus supply a sustained flow ofenergy ees Unit 35. Monosaccharides contain a single ... a. Carbohydrate b, Sugar ec, Glucose d. Hexose 36. Base stacking is possible in nucleic acids because the constituent nucleotides are a. Heterocyclic b. Aliphatic c. Planar d. Aromatic 37, DNA is usually associated with basic proteins such as a. Nucleosomes and octameres b. Chromatids and centromeres ‘ ¢.Histones and protamines d. Prealbumin and haemoglobin age, nutritional state and other 38.‘The hasie composition of a given organtsm is dependent in itsTAKO?ADI TECHNICAL UNIFi LIBRARY SECTION B Question 1 Define the following: (1), Polymer (il). Monomer (Ill). A peptide (IV). An enzyme (V). Zwi Question 1b ‘What is the difference between an addition polymes Question le Deseribe the following: (). Primary structure of a protein (1D, Secondary structure of a pretcin (IL), Tertiary structure of a prot Ima mark Imark Imark imark iad the condensation polymer? 2 marks Imark Imark mark‘Question 2a. State the two types of nucleic acids. Question 2b. Define: (1), Nucleotides and (Il). Polynucleotides Question 2c ‘Define the following terms: (1). Nucleic acids, (II). Complementary bases: (111). Deoxyribonucleic acid (DNA) (IN). Ribonucleic acid (RNA) Question 3 a. Define the following: FAKORADI TECHNICAL ONT LIBRARY Qmarks 2marks each Imark Imark mark. Imark