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PC-651/MJ
F-3/2051

MEDICINAL CHEMISTRY–III
Paper – BP-601T
(Semester–VI)

Time : Three Hours] [Maximum Marks : 75

Note : Attempt any two questions from section A, seven questions

from Section B and all the questions from Section C.

SECTION – A

(Attempt any two question)

I. Write notes on the following :

(a) Difference between the Free Wilson model and Hansch
model for QSAR.
(b) Advantages and limitations of pro-drug design. (5,5)

II. Write notes on the following :

(a) Etiology of malaria.
(b) Carrier linked prodrugs. (10)

651-MJ/PDF/HHH/899 [P.T.O.
III. Give synthetic procedures for the following drugs :
(a) Diethylcarbamazine.
(b) Mebendazole.
(c) Sulphamethoxazole.
(d) Acyclovir. (10)

SECTION – B
(Attempt any seven question)

IV. Write a note on  -lactamase inhibitors. (5)

V. Write note on Hemmet's electronic parameter. (5)

VI. Discuss synthesis, mechanism of action and uses of

Chloramphenicol. (5)

VII. Write a note on various forces involved in drug receptor

interactions. (5)

VIII. Write a note on chemical degradation of Cephalosporins.

(5)

IX. Discuss the advantages and limitations of QSAR approach

of drug design. (5)

X. Discuss the SAR of Tetracyclines. (5)

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XI. Give structure, IUPAC name, mechanism of action and uses
of Tinidazole. (5)

XII. Discuss applications and limitations of combinatorial

chemistry. (5)

SECTION – C
(Attempt all question)

XIII. (a) Give difference between structure-based drug design

and ligand-based drug design.
(b) Give MOA and uses of Ofloxacin.
(c) Give the synthesis of Isoniazid.
(d) Draw structure, IUPAC name and uses of Ketoconazole.
(e) Give MOA and uses of Furazolidine.
(f) Limitations of CADD.
(g) Draw structure, IUPAC name and uses of
Pyrimethamine.
(h) Name the drugs used as first line therapy against
Tuberculosis.
(i) Name two anthelmintic drugs obtained from natural
origin.
(j) Give structure and IUPAC name of any one folate
reductase inhibitor. (2×10=20)

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