S.NO.

OBSERVATION CORRECTION MADE AS

1 ON PAGE 5, LINE 12: MIXED WITH in active …" SHOULD READ " …MIXED WITH AN inactive corrected as inactive
ON PAGE 6, IT IS STATED THAT THE BASIC PRINCIPLE OF SPECTROPHOTOMETER IS ABSORBANCE
2 OF LIGHT; WELL, THIS IS NOT ALL WHAT IT IS AND THERE IS MUCH MORE TO IT.
ONE PAGE 48 (LAST LINE) - 49 (FIRST AND SECOND LINES), IT HAS BEEN STATED THAT
" A PECULIAR BEHAVIOUR WAS OBSERVED THAT ABSENT OF ANODIC PEAK IN REVERSE SCAN
3 AND … DUE TO THE REDUCTION OF AZOMETHINE GROUP TO SATURATED AMINE DERIVATION …"
IS THER PRECEDENCE FOR THIS IN THE LITERATURE"

4 CONTRARY TO WHAT HAS BEEN MENTOIONED ON AGE 50 (CHAPTER 5)

"D.P.P. TECHNIQUES HAVE BEEN APPLIED FOR THE QUANTITATIVE ESTIMATION OF THE DRUG…"
5 BUT NO QUANTIFICATION HAS BEEN MADE
ALTHOUGH IR SPECTRA HAVE BEEN GIVEN, THERE IS NO MENTION OF THE MEDIUM IN WHICH THE
6 SPECTRA HAVE BEEN RECORDED; ALSO, NONE OF THE PEAKS HAVE BEEN ASSIGNED
WHAT ARE THE ERROR BARS IN THE POLAROGRAPHIC (TABLES 5.1, 5.4, 5.7) SHOULD BE GIVE ONLY
7 UP TO TWO SIGNIFICANT DIGITS AND NOT THREE
IDENTIFICATION OF THE REDUCED PRODUCT (PAGE 60) IS BASED SOLELY ON IR SPECTRAL DATA - THISIS
8 NOT CONVINCING
SCHEME GIVEN IN FIG.5.20 (PAGE 71) IS NOT CLEAR, IT SHOULD BE REDRAWN. WHAT IS THE
9 SPECIESFORMED IN THE FIRST STEP? HOW WAS THE RATE DETERMIN ING STEP IN THIS SCHEME
ESTABLISHED?

THE TEXTULA MATERIAL ON PAGE 72 ARE ALL VERTATIM REPRODUCTIONS OF TEXTUAL MATERIAL
10 FROM PREVIOUS SECTIONS. THIS SHOULD NOT BE DONE

IT IS NOT CLEAR AS TO HOW THE DIFFUSION COEFFICIENT, TRANSFER COEFFICIENT. RATE CONSTANT
11 VALUED (PAGE 73) WERE OBTAINED
ALL THE FIGURES (IR SPECTRA, CVs AND POLAROGRAPHS) SEEN TO HAVE BEEN REPRODUCED FROM
12 AUTHOR'S PUBLISHED PAPERS. QUALITY OF REPRODUCED FIGURES IS VERY POOR
13 IN CHAPTER 6, RESULTS OF SPECTROPHOTOMETRIC STUDIES HAVE BEEN DESCRIBED
FROM ALL THE SPECTRAL DATA, INSTEAD OF wt/vol. A BETTER WAY TO EXPRESS THE CONCENTRATION IS
14 MOLARITY
WITH REGARD TO THE ACCURACY OF THE PROPOSED METHOD (TABLE 6.3, PAGE 86). IT IS NOT CLEAR AS
15 TO HOW THE VALUE OF AMOUNT FOUND, DETERMINED.
AND WITH REGARD TO ROBUSTNESS OF THE PROPOSED METHODS (TABLE 6.10 (PAGE 86)), HAS THE
16 REPRODUCIBILITY CHECK DONE? IS THE METHOD REPRODUCIBLE
IN TABLE 6.10 (PAGE 100), % ABSORBANCE IS GIVEN. ABSORBANCE IS JUST A NUMBER, IT IS NOT A
17 PERCENTAGE
IN TABLE 6.11 (PAGE 100) A RECOVERY OF 101% (5th COLUMN, 1st ROW) HAS BEEN MENTIONED. HOW
18 IS IT POSSIBLE TO RECOVER MORE THAN WHAT HAS BEEN STARTED WITH? THIS IS A SERIOUS FLAW!
 IT HAS BEEN MENTIONED (PAGE 102) THAT THE METHODS USED IN THIS STUDY WOULD PROVIDE
BIO-AVAILABILITY AND PHARMACOKINETICS PROFILE OF ANY DRUG IN BLOOD, URINE, AND OTHER
19 BIOLOGICAL FLUIDS. CONTRARY TOT HIS STATEMENT. THE PRESENT STUDY DID NOT INCLUDE ASPECTS
PERTAINING TO BIO-AVAILABILITY SO IT CANNOT BE CLAIMED THAT THIS STUDY WILL PROVIDE
INFORMATION ABOUT BIO-AVAILABILITY
ON PAGE 104 (2nd PARAGRAPH), NO COMPARISONS HAVE ACTUALLY BEEN MADE WITH OTHER
20 TECHNIQUES.
INCORRECT USAGE OF ARTICLES "A" AND "AN" : SEVERAL INSTANCES ARTICLE "AN" HAS BEEN
21 USED FOR CONSONANTS AND ARTICLE "A" HAS BEEN USED FOR VOWELS. THIS MUST BE CORRECTED
EVERYWHERE IN THE THESIS (THERE ARE SEVERAL OF THEM).

22 ETCETRA IS ETC AND NOT ECT: THIS NEEDS TO BE CORRECTED IN SEVERAL PLACES IN THE THESIS.
PAGE 1. LINE 5 FROM BOTTOM: " BUT WHEREAS" - INCORRECT USAGE (TWO NEGATIVES); EITHER
23 "BUT" OR "WHEREAS" BUT NOT BOTH TOGETHER.

24 PAGE 2. TABLE 1.1: "PARACETAMOL" AND "SALBUTAMOL" MIS-SPELT.

25 PAGE 3. LINE 3 FROM BOTTOM: "EXCRETED" MIS-SPELT.
26 PAGE 5: p11-INCORRECT; CORRECT WAY:Ph.
27 PAGEC 8. LAST PARA LINE: BEER-LAMBERS LAW SHOULD READ " BEER L AMBERT'S LAW
CORRECT USAGE OF BETWEEN: BETWEEN 'X' AND 'Y' AND NOT BETWEEN 'X' AND 'Y' ; THIS MUST BE
28 CORRECTED THROUGHTOUT THE THESIS

29 PAGE 16, 2nd PARA: POOR SENTENCE FRAMING; SHOULD BE REFRAMED TO READ BETTER.
30 PAGE 16, LINE 8 FROM BOTTOM; STOICHIOMETRIC MIS-SPELT
31 PAGE 19, LAST PARA: POOR SENTENCE FRAMING; SHOULD BE REFRAMED TO READ BETTER.
32 PAGE 25, 3rd PARA:POOR CHOICE OF WORDS, REFRAME TO READ BETTER.
33 PAGE 32 , LINE 11 FROM BOTTOM: FARADIC SHOULD READ " FARADAIC"
34 PAGE 38. LINE 6: PLATEAU MIS-SPELT
35 PAGE 40" "… WHERE AND AND THE EXPOSED …" PROBLEM WITH SENTENCE FRAMING.
36 PAGE 43, LINE 1: "BEER LAW" SHOULD READ "BEER LAMBERTS LAW".
37 PAGE 47, LINE 2: POLAR GRAPHIC SHOULD READ POLAROGRAPHIC
38 PAGE 65, FIGURE 5.16: LABEL FOR Y-AXIS MISSING.
39 PAGE 68, SUB-HEADING OF SECTION 5.3: CHEMICAL MIS-SPELT
40 PAGE 69, LINE 8: ORTHOSHOSPHATE MIS-SPELT
41 CAREFUL MIS-SPELT THROUGHTOUT THE THESIS; IT MUST BE CORRECTED
PAGE 82, LINE 9 FROM BOTTOM: "ABSORBENCIES" - INCORRECT USAGE; CORRECT USAGE
42 "ABSORBANCE"
43 PAGE 82 LAST BUT ONE LINE: REPLACE "ABSORPTIVE" WITH "ABSORPTIVITY"
44 PAGE 87, LINE 14: HPCL SHOULD READ HPLC.
45 PAGE 87, LAST BUT ONE LINE: CEFDITORINE MIS-SPELT
46 PAGE 88, 89 , 90, 91: CEFDITORINE MIS-SPELT IN MANY PLACES ON THESE PAGES.
47 POWERFUL MIS-SPELT THROUGHOUT THE THESIS: IT MUST BE CORRECTED
 PAGE 104, 2nd PARA: "THIS WORK PROVIDES … WITHIN THE BODY" - VERY POOR SENTENCE
48 FRAMING; REFRAME TO READ BETTER
49 PAGE 105, LINE 11 FROM BOTTOM AND PAGE 106, LINE 7: REPLACE "PLANKED" WITH "FLANKED"
50 PAGE 112, LINE 1: RECOMMENDATIONS MIS-SPELT
THE FOLLOWING REFERENCES HAVE BEEN CITED MULTIPLE TIMES:
51 REF 10 - REPEATED AS REF 70, 81; REF 83-REPEATED AS REF 88; REF 111- REPEATED AS REF 117,122.
ALL THE FIGURES ARE OF POOR QUALITY, IN SEVERAL INSTANCES, THEY ARE HARDLY READABLE;
52 THIS MUST BE TAKEN CARE OF.