Abstracts / Journal of the Neurological Sciences 429 (2021) 118056
Results
Between-groups analysis revealed a statistically significant
increase of radial diffusivity of the main fasciculi of WM in ICD+
compared to ICD- patients. In details, these differences were
detectable bilaterally in thalamic radiations, cortico-spinal tracts,
inferior longitudinal, superior longitudinal and uncinate fasciculi and
in the splenium of corpus callosum.
Conclusions
We demonstrated, in PD patients who will eventually develop ICD,
the presence of WM changes at baseline, in several areas strongly
involved in cognitive and behavioural functions, with a central role
played in the reward system and motor inhibition. The evidence of early
axonal damage may represent a potential biomarker and an additional
risk factor for the emergence of ICD in PD patients.
doi:10.1016/j.jns.2021.119516
119517
Impacts of classical music and dancing on cognitive functions in
Parkinson's disease
Shokhijakhon Shokhimardonov, Kuzieva Shakhnoza, Tashkent
Medical Academy, Neurology, Tashkent, Uzbekistan
Background and aims
In the modern world, Parkinson's disease is the second most
common neurodegenerative disease. And variety of non-
pharmacological methods and technologies occupy an important
place rehabilitation. To study changes in the cognitive plan among
patients with Parkinson's disease after conducting dance classes and
listening to classical music based on rehabilitation therapy under the
TMA program, evaluate the dynamics of changes in such cognitive
functions, memory, speech, attention, etc. according to MMSE and
MoCa rating scales.
Methods
Patients were divided into two groups. The first group (n = 27)
underwent therapy with rehabilitation therapy with TMA and the
control group (n = 26) who received standardized treatment
without this program. The lesson was held once a week for 1 h for
12 weeks at the base of rehabilitation of neurological patients at the
TMA clinic. Patients had an early stage of PD without cognitive
impairment (Addenbrook score: DG = 92.3 ± 2.7, CG = 90.8 ± 3.9).
Both groups took cognitive function tests on the first day of
admission, as well as on days 21 and 48.
Results
Comparison of the results showed that the cognitive functions of
patients such as verbal training (= 28%), delay (= 28%), recall delay
(= 20%), memory capacity for verbal material (= 12%) improved in
relation to the control group. (p b 0.05).
Conclusions
Rehabilitation with the help of dance lessons and classical music
have a clear benefit from psychological symptoms, preservation and
optimization of cognitive function. Long-term studies are necessary
to confirm the persistence of these effects.
doi:10.1016/j.jns.2021.119517
311
119518
Comparative evaluation of the effectiveness of group cognitive
rehabilitation and relaxation therapy in patients with Parkinson's
disease
Shokhijakhon Shokhimardonov, Kuzieva Shakhnoza, Tashkent
Medical Academy, Neurology, Tashkent, Uzbekistan
Background and aims
Compare the effectiveness of group cognitive rehabilitation and
relaxation therapy in patients with Parkinson's disease (PD).
Methods
We examined 20 patients with PD and conducted a prospective,
single-blind, randomized clinical trial. Participants passed tests to
evaluate cognitive function to assess the presence of mild cognitive
impairment or dementia in PD. All patients were divided into two
groups by the group of cognitive rehabilitation and relaxation
therapy group in random order. CRG participants (n = 12) trained
cognitive functions in the perspective of household life. This group
focused on strategies for restoring, compensating, and optimizing
cognitive brain function. Patients of the second group (n = 8) also
performed home training. They underwent music therapy and art
therapy. All trainings were 2 times a week for 10 weeks.
Results
The results showed a significant improvement in CRG
demonstrated in verbal learning (by = 28%), retention (by = 28%),
delayed recall (by = 20%), memory capacity for verbal material (by
= 12%). There were significant improvements in the WG that were
demonstrated in verbal learning (by = 36%) deferred recall (by =
40%), the amount of memory for verbal material (by = 12%) and the
total amount of recall in non-verbal memory (by = 36%).
Conclusions
Based on the results obtained, it can be concluded that CR does
not have a specific effect on short-term memory performance in
patients with PD. These requests require further research in the long
term because other types of interventions may also be effective in
relation to the cognitive functions of patients with PD.
doi:10.1016/j.jns.2021.119518
119519
Influencing factors on cognitive function in Parkinson's disease
Bekzod Muminov, Rustambek Matmurodov, Eldor Abdukodirov,
Khanifa Khalimova, Tashkent medical academy, Neurology, Tashkent,
Uzbekistan
Background and aims
The cognitive impairment in Parkinson's disease is influenced by
many factors, including sleep disturbance. To clarify clinical features
of sleep disorders in patients with Parkinson's disease (PD) and their
effect on cognitive function.
Methods
The study involved 106 patients with PD (55 men and 51
women) mean age 56,04 + 10,9 years. The control group consisted
of 20 patients without Parkinsonism matching by age and sex. The