New Protocol Lit Review

Citations:
Antoniou, A., Spanoudes, K., & Damianou, C. (2023). Treatment of mammary
cancer with focused ultrasound: A pilot study in canine and feline patients.
Ultrasonics, 132, 106974. https://doi.org/10.1016/j.ultras.2023.106974

Ashar, H., & Ranjan, A. (2023). Immunomodulation and targeted drug delivery with
high intensity focused ultrasound (HIFU): Principles and Mechanisms.
Pharmacology & Therapeutics, 244, 108393.
https://doi.org/10.1016/j.pharmthera.2023.108393

Carriero, S., Lanza, C., & Carrafiello, G. (2023, March 14). Ablative therapies for
breast cancer: State of art - sage journals. Sage Journals.
https://journals.sagepub.com/doi/full/10.1177/15330338231157193

di Biase, L., Falato, E., Caminiti, M. L., Pecoraro, P. M., Narducci, F., & Di Lazzaro,
V. (2021). Focused Ultrasound (FUS) for chronic pain management: Approved
and potential applications. Neurology Research International, 2021, 1–16.
https://doi.org/10.1155/2021/8438498

Domínguez-Oliva, A., Hernández-Ávalos, I., Martínez-Burnes, J., Olmos-Hernández, A.,

Verduzco-Mendoza, A., & Mota-Rojas, D. (2023a). The importance of
animal models in biomedical research: Current insights and applications.
Animals, 13(7), 1223. https://doi.org/10.3390/ani13071223

Fite, B. Z., Wang, J., Kare, A. J., Ilovitsh, A., Chavez, M., Ilovitsh, T., Zhang, N., Chen,
W., Robinson, E., Zhang, H., Kheirolomoom, A., Silvestrini, M. T., Ingham, E. S.,
Mahakian, L. M., Tam, S. M., Davis, R. R., Tepper, C. G., Borowsky, A. D.,
& Ferrara, K. W. (2021). Immune modulation resulting from MR-guided high
intensity focused ultrasound in a model of murine breast cancer. Scientific
Reports, 11(1). https://doi.org/10.1038/s41598-020-80135-1

Frutos Díaz-Alejo, J., Gonzalez Gomez, I., & Earl, J. (2022). Ultrasounds in cancer
therapy: A summary of their use and unexplored potential. Oncology Reviews,
16(1). https://doi.org/10.4081/oncol.2022.531

Han, X., Huang, R., Meng, T., Yin, H., & Song, D. (2021). The roles of Magnetic
Resonance-guided focused ultrasound in pain relief in patients with bone
 metastases: A systemic review and meta-analysis. Frontiers in Oncology, 11.
https://doi.org/10.3389/fonc.2021.617295

Joiner, J. B., Pylayeva-Gupta, Y., & Dayton, P. A. (2020). Focused ultrasound for
immunomodulation of the tumor microenvironment. The Journal of Immunology,
205(9), 2327–2341. https://doi.org/10.4049/jimmunol.1901430

Kumari, M., Singla, M., & Sobti, R. C. (2022). Animal models and their substitutes
in biomedical research. Advances in Animal Experimentation and Modeling, 87–
101. https://doi.org/10.1016/b978-0-323-90583-1.00014-3

Lee, F., He, Q., Gao, J., Pan, A., Sun, S., Liang, X., & Luo, J. (2019). Evaluating
hifu‐mediated local drug release using thermal strain imaging: Phantom and
preliminary            in ‐vivo   
        studies. Medical Physics, 46(9), 3864–3876.
https://doi.org/10.1002/mp.13719

Sun, S., Tang, Q., Sun, L., Zhang, J., Zhang, L., Xu, M., Chen, J., Gong, M., &
Liang, X. (2022). Ultrasound-mediated immune regulation in tumor
immunotherapy. Materials Today Advances, 14, 100248.
https://doi.org/10.1016/j.mtadv.2022.100248

Yan, B., Liu, C., Wang, S., Li, H., Jiao, J., Lee, W. S., Zhang, S., Hou, Y., Hou, Y., Ma,
X., Fan, H., Lv, Y., & Liu, X. (2022). Magnetic hyperthermia induces
effective and genuine immunogenic tumor cell death with respect to exogenous
heating. Journal of Materials Chemistry B, 10(28), 5364–5374.
https://doi.org/10.1039/d2tb01004f

Author Year Source Terms Searched Relevant Sections

Adriana Domínguez- 2023 PubMed pain, distress, “Many animal

Oliva, Ismael alternative, research studies
Hernández-Ávalos, anesthesia, show the vital role
Julio Martínez- analgesia, non- of animal models
Burnes,Adriana animal model, in advancing
Olmos- mouse, HIFU, biomedical
Hernández,Antonio immune cell research”
Verduzco-Mendoza, death
and Daniel Mota-
Rojas
Lazzaro di Biase, 2021 Hindawi pain, analgesia, “FUS is a
Emma Falato, Maria (Google scholar) murine, mrgfus noninvasive
Letizia Caminiti, technique for
Pasquale Maria neuromodulation
Pecoraro, Flavia and for tissue
Narducci, and ablation that can
Vincenzo Di Lazzaro be applied to
several tissues”

Xiaying Han, Runzhi 2021 Frontiers pain, analgesia, Meta-analysis on

Huang, Tong Meng, (Google scholar) murine, mrgfus studies reporting
Huabin Yin, Dianwen MRgFUS for
Song patients with
bone metastases.

Jesús Frutos Díaz- 2022 PubMed Distress, Different

Alejo, Itziar González anesthesia, biological effects
Gómez, and Julie Earl mouse, hifu, are induced in
immune cell tissues and cells
death by ultrasound
actuation
depending on
acoustic
parameters, such
as the wave
intensity,
frequency and
treatment dose.

Serena Carriero, MD 2023 Sage Journals Pain, anesthesia, Minimally

Carolina Lanza, MD, (Google Scholars) murine, mrgfus, invasive
[…], and Gianpaolo immune cell treatments are
Carrafiello, MD death convenient
alternatives with
promising
effectiveness,
lower morbidity,
less cost, less
scarring and pain,
and more
satisfying
cosmetic results.

Mamtesh Kumari, 2022 Science Direct Pain, analgesia, These alternatives

Mandakini Singla, non-animal to animal testing
Ranbir Chander Sobti model, immune include
cell death, sophisticated in
mammory vitro methods like
 neoplasm human cells and
tissues, in silico
modes like
advanced
computer
modeling
techniques, use of
stem cells, in vivo
imaging
techniques,
metaanalysis, use
of lower
vertebrates/invert
ebrates, Organ-
on-a-chip, system
biology tools, and
studies with
human volunteers
and human
patient
simulators.

Harshini Ashar, 2023 Journal Article Heat Shock - The role of HIFU
Ashish Ranjan (ScienceDirect) Proteins (HSPs), in enhancing drug
mice, focused delivery and
ultrasound immunomodulatio
n in soft and
calcified tissues

Fu-Feng Lee, 2019 Journal Article Mouse, mammary - An effective

Qiong He, Jing (PubMed) neoplasm, HIFU method based on
Gao, Anni Pan, thermal strain
Suhui Sun, imaging (TSI) for
Xiaolong Liang, the evaluation of
Jianwen Luo HIFU-mediated
drug release.

S. Sun, Q. Tang, L. 2022 Journal Article HIFU, mouse, - High intensity

Sun, J. Zhang, L. (ScienceDirect) tumor focused
Zhang, M. Xu, J. ultrasound can
Chen, M. Gong, X. destroy tumor
Liang tissue and lead to
the in situ
 production of
tumor fragments
at the same time,
which can be used
as antigens of the
immune system to
form in situ
vaccines to induce
a systemic
immune response.

Anastasia 2023 Journal Article mice, MRI - During

Antoniou, (ScienceDirect) thermometry,ma anesthesia, no
Kyriakos mmary neoplasm animal showed
Spanoudes, signs of suffering
Christakis - Thermal FUS in
Damianou treating Canines
and Felines

Brett Z. Fite, 2021 Journal Article mouse, breast - Assess the

James Wang, et. (PubMed) neoplasm, HIFU, immunomodulato
al. pain ry effects of MR-
guided HIFU

Jordan B. Joiner, 2020 Review Article Heat Shock - Summarized

Yuliya Pylayeva- (The Journal of Proteins (HSPs), four mechanisms
Gupta, Paul A. Immunology) mice, focused of action,
Dayton ultrasound including thermal
ablation,
hyperthermia/the
rmal stress,
mechanical
perturbation, and
histotripsy

Bin Yan, Chen Liu, 2022 Journal Article Heat Shock - MH induced
et. al. (Journal of Proteins (HSPs), genuine ICD with
Materials mice, focused high efficiency
Chemistry B) ultrasound,
Damage-
associated
molecular
patterns