PE&SCIENCE PT

Alexander Disease
Maki Miyamoto

Type of genetic mutation and how it

occured
Alexander disease cases are caused by
mutations in a gene called GFAP. It
provides instructions for making a protein
called glial fibrillary acidic protein. Several
molecules of this protein bind together to
form intermediate filaments, which provide
support and strength to cells.

Symptoms
enlarged brain and head size
stiffness in the arms and/or legs
intellectual disability
developmental delay
seizures

Alexander disease is a rare disorder of the nervous system. It is one

of a group of disorders, called leukodystrophies, that involve the
destruction of myelin. Myelin is the fatty covering that insulates
nerve fibers and promotes the rapid transmission of nerve impulses.

Treatment or Ways to promote healthy

Medication and active lifestyle
There is no treatment or Eat at least five fruits and
medication for Alexander vegetables a day.
disease, nor is there a standard Get enough sleep
course of treatment. The Drink more water
treatment of Alexander disease Exercise daily
is symptomatic and supportive. Purge negative people from

your life.

“Health is a state of complete harmony of the body, mind and spirit"