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BREAST IMPLANT ASSOCIATED SQUAMOUS CELL CARCINOMA

Goldberg, M., Llaneras, J., Willson, T., Boyd, J., Venegas, R., Dauphine, C., & Kalantari, B. (2020, August
15). Squamous Cell Carcinoma Arising in Breast Implant Capsules. Annals of Plastic Surgery.

- Case report/lit review


- 2 cases from this institution
o Implants over ten years ago
o Unilateral breast erythema, swelling
o First patient died during chemo
o Second received chemo but declined further surgery
o

Olsen, D.L., Keeney, G.L., Chen, B., Visscher, D.W., & Carter, J.M. (2017, September). Breast implant
capsule-associated squamous cell carcinoma: A report of 2 cases. Human pathology, 67, 94-100.

- Case report
- 56F, acute left breast enlargement
o Implants in 1984; diagnosis in 2012
o Left breast tumor invaded into chest wall
o Treated with chemorads
o Developed treatment refractory mets within a year; eventually palliated
- 81F, acute left breast enlargement
o Implants in 1970s; diagnosis in 2012
o Ultrasound detected 3cm mass, with subsequent growth to 5cm
o L mastectomy and SLNB; then treated with chemorads
o Developed treatment refractory mets within 5 months, and expired

Paletta C., Paletta F.X., Paletta F.X.: Squamous cell carcinoma following breast augmentation. Ann Plast
Surg 1992; 29: pp. 425-429. [discussion 429-432]

- Case report; isolated case of squamous cell carcinoma, similar presentation with poor outcome

Kitchen S.B., Paletta C.E., Shehadi S.I., Bauer W.C.: Epithelialization of the lining of a breast implant
capsule. Possible origins of squamous cell carcinoma associated with a breast implant capsule. Cancer
1994; 73: pp. 1449-1452.

Zomerlei T.A., Samarghandi A., Terando A.M.: Primary squamous cell carcinoma arising from a breast
implant capsule. Plast Reconstr Surg Glob Open 2016; 3: pp. e586.

Liu Z, Liu, C, Chengglong, Z, Yu, Q, Zhang G, Wang X, Yu Z. Breast prosthetic implant-associated


Squamous Cell Carcinoma: A case report and Literature Review. Research Square. 2021 Jan.
doi.org/10.21203/rs.3.rs-141167/v1
Satgunaseelan L, Cheung D, Reddy, J. Breast Implant-Associated Squamous Cell Carcinoma – A Rare Long
Term Complication. Pathology. Volume 47, Supplement 1, S72-S73, JANUARY 01, 2015.

Alikhan MB, Nassar A, Mansoor I. Squamous metaplasia on the breast implant capsule. Int J Surg Pathol.
2010 Dec;18(6):570-4. doi: 10.1177/1066896908329587. Epub 2009 Jan 14. PMID: 19147510.

Soni SE, Laun JC, Beard AS, Kuykendall LV. "Breast Implant Capsule-Associated Squamous Cell Carcinoma
During Pregnancy: A Mimicker of Breast Implant-Associated Anaplastic Large Cell Lymphoma". Plast
Reconstr Surg. 2022 Aug 12. doi: 10.1097/PRS.0000000000009506. Epub ahead of print. PMID:
35960919.

Whaley RD, Aldrees R, Dougherty RE, Prieto Granada C, Badve SS, Al Diffalha S. Breast Implant Capsule-
Associated Squamous Cell Carcinoma: Report of 2 Patients. Int J Surg Pathol. 2022 Mar
18:10668969221086940. doi: 10.1177/10668969221086940. Epub ahead of print. PMID: 35300538.

Zhou YM, Chaudhry HE, Shah A, Andrews J. Breast Squamous Cell Carcinoma Following Breast
Augmentation. Cureus. 2018 Oct 3;10(10):e3405. doi: 10.7759/cureus.3405. PMID: 30533339; PMCID:
PMC6278994.

Zomerlei TA, Samarghandi A, Terando AM. Primary Squamous Cell Carcinoma Arising from a Breast
Implant Capsule. Plast Reconstr Surg Glob Open. 2016 Jan 7;3(12):e586. doi:
10.1097/GOX.0000000000000567. PMID: 26894011; PMCID: PMC4727695.
BREAST SCC

Hennessy B.T., Krishnamurthy S., Giordano S., et. al.: Squamous cell carcinoma of the breast. J Clin Oncol
2005; 23: pp. 7827-7835.

Nayak A., Wu Y., Gilcrease M.Z.: Primary squamous cell carcinoma of the breast: predictors of
locoregional recurrence and overall survival. Am J Surg Pathol 2013; 37: pp. 867-873.

Behranwala K.A., Nasiri N., Abdullah N., Trott P.A., Gui G.P.: Squamous cell carcinoma of the breast:
clinico-pathologic implications and outcome. Eur J Surg Oncol 2003; 29: pp. 386-389.

Liu J., Yu Y., Sun J.Y., et. al.: Clinicopathologic characteristics and prognosis of primary squamous cell
carcinoma of the breast. Breast Cancer Res Treat 2015; 149: pp. 133-140.

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