Hepa 13 virus

MYCOLOGY & VIROLOGY • Diagnosis:

-
LEC / LAB o Serology ¢
R eference: Ma’am Cherries’ presentation o Viral antigen
Other Viruses and Prions detection

÷
o PCR
• Oncogenic: liver cancer
Outline
• Treatment:
• Viral hepatitis o Antivirals
• Arboviruses o 0 Liver transplant for fulminant disease
• Roboviruses • Prevention:
-

• Oncoviruses o HBV vaccine ✗

• Prions o Hepatitis B immune globulin ←
Viral Hepatitis Serological Markers for HBV
• Hepatitis A • HBsAg HBS kg

]
• Hepatitis B • HBcAg
H Be
Ag
• Hepatitis C
G ID * em
• HBeAg Anti ABS

• Hepatitis D • Anti-HBc
Anti Hbo
" " "
"
• Hepatitis E Antibodies
"

• Anti-HBe
Hepatitis A Virus (HAV) - • Anti-HBs
• Infectious hepatitis
o Enterovirus 72
• Picornavirus
• MOT: fecal-oral
• Most common cause of
hepatitis
• Disease
o Hepatitis with _ short incubation
o Abrupt onset
o Low mortality
o No carrier state
o No chronic infection
• Detection: serology
o Lab criteria: IgM Ab to hepatitis A virus (anti-
HAV positive)
• Treatment: supportive
• Prevention

¥
o Vaccine
o Prevent clinical illness with serum
immunoglobulin
Hepatitis B virus (HBV)
• Serum hepatitis
• Hepadnavirus
• Second most common cause of acute hepatitis
cellular

1¥
• Partly dsDNA genome carcinoma
o Icosahedral capsid with envelope Hepatitis C virus (HCV) Blood Borne
• MOT: blood, sexual contact, perinatal • Non-A, Non-B hepatitis
C. Transfusion
• Site of latency: liver
• Disease
• Blood borne hepatitis
o Post-transfusion hepatitis Hepatitis

E-
o Acute hepatitis • Flaviviridae

=
o Fulminant hepatitis
 Most co-infected with delta virus
o Chronic hepatitis
• MOT: Parenteral or sexual
• Disease
o Acute and chronic hepatitis
o Asymptomatic carrier state .
o Strong correlation between HCV infection and
o Chronic persisten -
hepatocellular carcinoma
o Chronic active disease ,
• Detection:
 Progressive liver damage / o Serology
o RT-PCR =
1 | AACA. 2023.
MYCOVIRO – Other Viruses and Prions | NOT FOR SALE
 ⊖
o Viral genotyping
-
• O’nyong nyong virus
• Treatment: o Fever & Arthritis (Anopheles) Mosquito
o Supportive
⊖
It
o Interferon Reoviridae
• Prevention • Orbivirus Culicoides spp
.

o Avoid contact with the virus o Culicoides spp.

o Blood supply screened for Ab to Hepa C virus Roboviruses Areuaviridae
g Of Bunya
-
.

Hepatitis D µ ,,
y • ROdent-BOrne Virus
• Delta hepatitis
satellite vines
I
€-087m
Arenaviridae
• Delta agent • New-world viruses – HEMORRHAGIC fever
o Satellite virus o Junin virus – Argentinian HF lllemorrhaqhic
• Enveloped with no distinct nucleocapsid

¥ Fever)
- o Machupo virus – Bolivian HF
o (-) ss RNA virus
o Guanarito virus – Venezuelan HF
• Defective hepatotropic virus that requires helper functions
Sabia virus – Brazilian HF
②
from HBV in order to ensure its replication and infectivity
•
o
Old-world viruses
• →
Cannot occur in the absence of Hepa B virus (helper virus)
→
o Lassa fever virus – Lassa HF

0¥ #
-

Hepatitis E o Lymphocytic choriomeningitis virus – LCM

• Water-borne Non-A, Non-B hepatitis
Bunyaviridae
• Hepeviridae
⊖
o Previously classified in the family of caliciviruses
• Naked Icosahedral
• Hantavirus
Oncoviruses
o (+) ss RNA Catroi viruses • Causes tumor
• MOT: Fecal-oral • Human Papilloma Virus
• Disease:
-

• Epstein Barr Virus

o Hepatitis similar to that caused by Hepa A virus • Human Herpes virus 8
except for extraordinary high case fatality rate • Hepatitis B virus
among pregnant women • Hepatitis C virus =
• Diagnosis: serology • Human T Lymphotropic virus 1 _
• Treatment: supportive
• Prevention: avoid contact with virus Human Papilloma Virus (HPV)

0-psr.it#--=ppN
• Cervical cancer

÷ÉÉ÷
Arboviruses • Oropharyngeal cancer
• ARthropod-BOrne Virus • Anogenital cancer
Bunyaviridae • Testicular cancer
• Bunyavirus (Ochlerotatus triseriatus / Aede triseriatus)
o LaCrosse virus (LACV)
o California encephalitis virus
o Encephalitis
• Phlebovirus
o Phlebotomine sandflies
• Nairovirus
o Rhipicephalus appendiculatus
Flaviviridae
• Dengue virus (Aedes aegypti)

÷
• Yellow fever virus (Aedes aegypti)
• West Nile Encephalitis (Culex, Aedes, Anopheles)
• St. Louis Encephalitis Virus (Culex)
• Japanese B Encephalitis (Culex) Epstein Barr Virus (EBV / HHV 4) Infectious Mononucleosis
• Zika Virus (Aedes aegypti) • Burkitt’s Lymphoma
• Nasopharyngeal carcinoma
Togaviridae
• Hodgkin’s disease
• Alphaviruses – Encephalitis (Aedes, Culex)
o Eastern equine encephalitis virus (EEE) Human Herpes Virus 8
o Western equine encephalitis virus (WEE)
=
• Kaposi’s Sarcoma
o Venezuelan equine encephalitis virus (VEE) .
• Chikungunya Virus @
Hepatitis B Virus Aepa
.
o Fever & Arthritis (Aedes aegypti) • Hepatocellular Carcinoma
2 | AACA. 2023.
MYCOVIRO – Other Viruses and Prions | NOT FOR SALE
Hepatitis C Virus

⑤ • Hepatocellular Carcinoma
Human T Lymphotropic Virus 1 (HTLV-1)
• Adult T cell Leukemia adult T cell leukemia
Prions

Human Prion Diseases CU G FK

• Cruetzfeldt-Jakob Disease -
• Variant Cruetzfeldt-Jakod Disease ,
• Gerstmann-Straussler-Scheinker Syndrome ✓
• Fatal Familial Insomnia -
• Kuru -

3 | AACA. 2023.
MYCOVIRO – Other Viruses and Prions | NOT FOR SALE