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  • Ho - Efficacy and Safety of Tramadolacetaminophen in The Treatment of Breakthrough Pain in

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    Syifa Fadlillah
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    Tramadol/acetaminophen was evaluated for treating breakthrough cancer pain in 59 patients. Patients had moderate or greater breakthrough pain. Pain scores significantly improved from a mean of 77.8 at onset to lower scores at 10, 30, and 60 minutes after treatment. The mean time to pain relief was 10 minutes and mean pain score at relief was 43.4. The treatment was effective in reducing pain scores by 30% or more in 75-95% of patients. Only two cases of drowsiness were reported, indicating tramadol/acetaminophen is an efficacious and safe option for treating breakthrough cancer pain.

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    Ho - Efficacy and Safety of Tramadolacetaminophen in the Treatment of Breakthrough Pain in

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    Tramadol/acetaminophen was evaluated for treating breakthrough cancer pain in 59 patients. Patients had moderate or greater breakthrough pain. Pain scores significantly improved from a mean of 77.8 at onset to lower scores at 10, 30, and 60 minutes after treatment. The mean time to pain relief was 10 minutes and mean pain score at relief was 43.4. The treatment was effective in reducing pain scores by 30% or more in 75-95% of patients. Only two cases of drowsiness were reported, indicating tramadol/acetaminophen is an efficacious and safe option for treating breakthrough cancer pain.

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    2 views1 page

    Ho - Efficacy and Safety of Tramadolacetaminophen in The Treatment of Breakthrough Pain in

    Uploaded by

    Syifa Fadlillah
    Tramadol/acetaminophen was evaluated for treating breakthrough cancer pain in 59 patients. Patients had moderate or greater breakthrough pain. Pain scores significantly improved from a mean of 77.8 at onset to lower scores at 10, 30, and 60 minutes after treatment. The mean time to pain relief was 10 minutes and mean pain score at relief was 43.4. The treatment was effective in reducing pain scores by 30% or more in 75-95% of patients. Only two cases of drowsiness were reported, indicating tramadol/acetaminophen is an efficacious and safe option for treating breakthrough cancer pain.

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    1/28/22, 1:36 PM Efficacy and safety of tramadol/acetaminophen in the treatment of breakthrough pain in cancer patients - PubMed

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    Español

    Saudi Med J. 2010 Dec;31(12):1315-9.

    Efficacy and safety of tramadol/acetaminophen in


    the treatment of breakthrough pain in cancer
    patients
    Ming-Lin Ho  1 , Chih-Yuan Chung, Chuan-Cheng Wang, Hsuan-Yu Lin, Nicholas C Hsu, 
    Cheng-Shyong Chang

    Affiliations
    PMID:
    21135993

    Abstract
    Objective:
    We evaluated the analgesic efficacy and safety of tramadol 37.5 mg/acetaminophen 325
    mg combination tablet, for the treatment of breakthrough pain in cancer patients.

    Methods:
    This study was conducted at Changhua Christian Hospital, Changhua, Taiwan from January
    2006 to February 2007. The single-center and open-label study enrolled 59 opioid-treated cancer
    patients with at least moderate breakthrough pain (visual analog scale [VAS] score ≥40mm on a 100-
    mm scale). The efficacy measures included VAS scores and adverse effect assessment 10, 30, and 60
    minutes after the administration of tramadol/acetaminophen. Visual analog scale score at time of pain
    relief was reported.

    Results:
    The mean VAS score when the breakthrough pain episode began (0 minute) was 77.8.
    Analysis showed significant better mean pain VAS scores at 10, 30, and 60 minutes after the
    administration of tramadol/acetaminophen (p≤0.001 versus 0 min for all 3 time points). The mean
    time to pain relief was 597.2 seconds and the mean VAS score at time of relief was 43.4. The effective
    rates, defined by more than 30% reduction of the VAS score, after 10 minutes of administration was
    74.6%, 30 minutes 86.4%, and one hour 94.9% (p≤0.001 versus 0 minute for all 3 time points). Two
    cases of drowsiness were reported.

    Conclusion:
    Tramadol/acetaminophen might be efficacious and safe in the treatment of
    breakthrough pain in cancer.

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    Medical
    MedlinePlus Health Information

    https://pubmed.ncbi.nlm.nih.gov/21135993/ 1/1

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