Educational Reference

Hb Variant coeluted before Hb A, on the HbF window

Usually constitutes more than 50% of total hemoglobin in simple heterozygotes

The presence of this variant may interfere with the measurement of glycated
hemoglobin and or with Hb F by HPLC

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Hb J Iran

Variation data: β 77 (His → Asp) heterozygote

Case commentary:
Chromatography: Y can be referred as an adduct of the variant hemoglobin J,
eluted slightly before the F1 peak.

X hemoglobin J Iran coeluted on HbF

Other methods:
Hematology and Clinical Presentation:
Normal oxygen affinity and stability.

No Known clinical significance

CBC data:

Other studies:

External links:
http://onlinelibrary.wiley.com/doi/10.1002/9781444328318.index/summary

Case and Comments from: “Bain, B. J., Wild, B. J., Stephens, A. D. and Phelan, L.
A. (2010) Variant Haemoglobins: A Guide to Identification, Wiley-Blackwell, Oxford,
UK.”

References: “Bain, B. J., Wild, B. J., Stephens, A. D. and Phelan, L. A. (2010) Variant
Haemoglobins: A Guide to Identification, Wiley-Blackwell, Oxford, UK.”
Disclaimer: The chromatogram and data in this case report are actual laboratory
findings. Bio-Rad Laboratories, Inc. does not validate or confirm the sample data
included in this database. All information contained herein is for informational use only
and is not meant as a definitive identification of the hemoglobin genotype nor for
diagnostic purposes. We welcome your comments at hemoglobins@bio-rad.com