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01Part-I Friedel Craft TheoryandExercise
01Part-I Friedel Craft TheoryandExercise
||
NH – C – CH3
CH3
13. Rank the following reactions A, B and C in order of increasing rate,
1.
Me Me Me Me
A
C SO3H
B SO3/H2SO4
SO3/H2SO4
Identify the position where electrophilic aromatic substitution (EAS) is most favourable.
(A) (B)
(a) A (b) B SO3H
(c) C (d) A and C
NO2 Cl CH3 NO2 NO2
SO3/H2SO4
2. (C)
(a) (b) (c) (d) SO3H
Correct order of rate of EAS (electrophilic aromatic substitution) is : (a) B > A > C (b) B > C > A (c) A > B > C (d) A > C > B
(a) c > b > a > d (b) c > d > a > b
(c) a > b > c > d (d) c > d > b > a 14. Rank in order of increasing rate of reaction towards EAS
FeBr 3 .
CO
+ 1.SOCl 2
6. O ¾1.
¾¾¾
AlCl 3 Zn— Hg, HCl, heat
® A ¾ ¾¾¾¾¾¾® B ¾ ¾¾¾® C. with bromine in the presence of
2. H 3O + 2. AlCl 3
CO
3. H 3O +
(A) (B) (C)
The end product (C) is :
O
(a) B < A < C (b) B < C < A
(a) (b) (c) A < B < C (d) A < C < B
O O
O O 15.
C — C6H5 C
(c) (d) Identify the position where E.A.S. can take place.
C — C6H5 COOH (a) 1 (b) 2 (c) 3 (d) 4
O
1
7. How many benzylic hydrogens are present in the hydrocarbon shown below ?
2 O
Sulphonation is most favourable at the carbon number... .
3 NH
17. 4
NO2
(a) (b) (c)
NO2
(a) a > b > c (b) c > b > a (c) a > c > b (d) c > a > b
(a) (b) (c) (d)
NO2
NO2
9. The major product formed in the reaction is :
O
Conc. HNO /conc. H SO
3 2 4
C–O ¾ ¾¾¾¾¾¾¾¾ ¾ ® 19.
(mononitration)
(a) (c) (d)
(b)
Decreasing order of rate of electrophilic aromatic substitution is :
O
O a>b>c>d a>c>b>d
(a) C–O (b) O2N C–O
O2 N (c) b > a > c > d (d) b > c > a > d
O O
25. In which of the following compound electrophilic aromatic substitution take place in phenyl
(c) C–O (d) C–O NO2 ring present in left hand side ?
O O
NO2
(a) C—O (b) C — NH
2 4 H SO
26. + A ¾ ¾¾ ¾ ® ; Reactant (A) is :
(i) (ii) (iii)
O
| CO2H
(a) iii < ii< i (b) ii < iii < i (c) i < iii < ii (d) i < ii < iii (a) O (b) O (c) O (d)
| CO2H
O
11. Increasing order of rate of reaction with Br 2 AlCl 3 is : 27. Which of the following compounds is the slowest to react with nitrosonium ion (NO + ) ?
OH OH O OH O CH3 OMe
(c) (d)
CO2H
30. What combination of acid chloride or anhydride and arene would you choose to prepare O–H
given compound ?
HNO3/H2SO4
52. (A) + ( B)
(more volatile) (less volatile)
Product (A) of the above reaction is :
C — CH2 — CH2 — CO2H
OH OH OH NO2
O NO2
O O O
AlCl3 AlCl3
(a) (b) (c) (d)
+ Cl — C — CH2 — CH — C — Cl + O
(a) (c) NO2
CH3
O NH2 NO2
O O
2ICl
AlCl3 AlCl3 53. x + 2HCl; Major product ( x) in this reaction is :
+ O +
(b) (d) (56 – 63%)
O O
NO2
31. In the given conversion best yield will obtained with : NH2 NH2 NH2 NH2
O I I I I
C (a) (b) (c) (d)
(A)
CH3 I I I I
(B) NO2 NO2 NO2 NO2
NO2
O
O HNO3
|| 54. H2SO4 , van’t-Hoff factor (i) for this reaction is :
(a) A = CH 3 — C — Cl, AlCl 3 , B = Zn(Hg), HCl
O
|| (a) 2 (b) 3 (c) 4 (d) 5
(b) A = Zn(Hg),HCl, B = CH 3 — C — Cl, AlCl 3
(c) A = CH 3 — CH 2 — Cl, AlCl 3 , B = Zn(Hg), HCl 3 AlCl
(d) A = NH 2 — NH 2 HO - ,D , B = CH 3 — CH 2 — Cl, AlCl 3 64. Ph - NO 2 + Et - Cl ¾ ¾¾ ® ( A), Product (A) of the given reaction is :
NO2 NO2
+
34. Which position will be attacked most rapidly by the nitronium ion ( – NO 2 ) when the
compound undergoes nitration with HNO 3 H 2 SO 4 :
O A B C D (a) Ph – NH – Et (b) no–reaction (c) (d)
OCH3
Et
Et
(a) A (b) B (c) C (d) D 65. In nitration of benzene by mixed acid the rate of reaction will be :
(a) C 6 H 6 = C 6 D 6 = C 6 T6 (b) C 6 H 6 > C 6 D 6 > C 6 T6
36. All the hydrocarbons shown are very weak acids. One, however, is far more acidic than the
others. Which one is the strongest acid ?
(c) C 6 H 6 = C 6 D 6 > C 6 T6 (d) C 6 H 6 < C 6 D 6 < C 6 T6
(a) (b) (c) (d) 67. Which of the following ring compounds obeys Huckel's rule ?
(a) C 4 H -41 (b) C 4 H +41 (c) C 4 H -2
4 (d) C 4 H 4
68. Nitration of which of the following reactant gives maximum % of meta product (using
HNO 3 H 2 SO 4 ) ?
39. What is the correct order of o p ratio when E + attacks the following system ?
(a) Toluene (b) Aniline
PhF PhCl PhBr PhI (c) Benzene (d) Isopropyl benzene
A B C D
(a) A < B < C < D (b) A = B = C = D (c) D < C < B < A (d) D < B < A < C Br
Ph Ph
40. How many products are capable of beings formed from toluene in each of following reaction ?
2AgBF
Mono-nitration 69. 4
¾ ¾¾¾ ® ( x) 2BF4- ; compound (x) will be :
CH3 O3 (A)
HN Ph Ph
SO 4 Br
H 2 °)
(40
Ph Ph Ph Ph Ph Ph Ph Ph
HNO
3 (a) +2 (b) –2 (c) +1 (d) –1
H2 S Di-nitration
O
HNO3 (80°) 4 (B) Ph Ph Ph Ph
Ph Ph Ph Ph
H2SO4
(110°)
3 3
Tri-nitration Br
(C)
73. For the reaction ; ? ¾¾® ; the best combination of reactants is :
(a) A = 3 , B = 6 , C = 8 (b) A = 3 , B = 6 , C = 6 NO2
(c) A = 3 , B = 6 , C = 10 (d) A = 3 , B = 4 , C = 6 (a) C 6 H 5 Br + HNO 3 , H 2 SO 4 (b) C 6 H 5 Br + H 2 SO 4 , heat
41. Nitration takes place at the which position of the given compound ? (c) C 6 H 5 NO 2 + Br 2 , FeBr 3 (d) C 6 H 5 NO 2 + HBr
CMe3 74. The action of AlCl 3 in Friedel Craft’s reaction is:
(a) to absorb HCl (b) to release HCl
D A (c) to produce electrophile (d) to produce nucleophile
C
B
CHMe2
(a) A (b) B 88. Which of the following molecules is expected to have the greatest resonance stabilization ?
(c) C (d) D
O
(a) (b) (c) (d)
43. Cl – C Cl (A) ; Unknown (A) is :
AlCl3
CH2CH3
(a) (b) (c) (d) O
CH2CH3
CH3 — C — Cl NH2 — NH2, NaOH
(A) (B)
112. AlCl3 (80%) triethylene glycol. heat (73%)
CH2CH3
R R R
Product ( B ) is :
NO2
HNO3
114. H2SO4
+
(ortho)
(a) (b) (c) (d)
NO2
In the above reaction o/p ratio will be highest when :
(a) R = - CH 3 (b) R = - CH 2 - CH 3
(c) R = - CHMe 2 (d) R = - CMe 3
THE FRIEDEL CRAFTS
ALKYLATION
CONTENTS
Exercise-I : 22
Exercise-II :23-24
Exercise-III : 25-27
Exercise-IV : 28-29
Exercise-V : 30-31
Exercise-VI : 32 -37
Exercise-VII : 38-44
Answer Key : 45-61
FRIEDEL-CRAFTS REACTION
• For example, aluminum chloride catalyzes the alkylation of benzene by tert-butyl chloride. HCl gas is evolved.
• This alkylation is a typical electrophilic aromatic substitution, with the tert-butyl cation acting as the electrophile.
Mechanism :
• Friedel–Crafts alkylation is an electrophilic aromatic substitution in which an alkyl cation acts as the
electrophile.
Step 1: Formation of a carbocation
3 3
+
3 3
3 3
Example : When benzene reacts with 1-chlorobutane, 60%–80% of the product (the actual percentage depends on
the reaction conditions) has the rearranged alkyl substituent. (See the box on “Incipient Primary
Carbocations”).
Example : When benzene reacts with 1-chloro-2,2-dimethylpropane, the initially formed primary carbocation
rearranges to a tertiary carbocation; in this case, 100% of the product (under all reaction conditions) has
the rearranged alkyl substituent.
PRACTICE – 1
2. For each reaction, show the generation of the electrophile and predict the products.
(A) benzene + cyclohexene + HF
(B) tert-butyl alcohol + benzene + BF3
(C) tert-butylbenzene + 2-methylpropene + HF
(D) propan-2-ol + toluene + BF3
IMPORTANT POINTS :
® Friedel–Crafts alkylations are used with a wide variety of primary, secondary, and tertiary alkyl halides. With
secondary and tertiary halides, the reacting electrophile is probably the carbocation.
® With primary alkyl halides, the free primary carbocation is too unstable. The actual electrophile is likely a
complex of aluminum chloride with the alkyl halide. In this complex, the carbon–halogen bond is weakened
(as indicated by dashed lines) and there is considerable positive charge on the carbon atom. The mechanism
for the aluminum chloride-catalyzed reaction of ethyl chloride with benzene is as follows:
d+ d-
¾¾
CH3–CH2–Cl + AlCl3 ¬¾® CH - CH L ClL AlCl
¾ 3 2 3
® Alkenes are protonated by HF to give carbocations. Fluoride ion is a weak nucleophile and does not immediately
attack the carbocation. If benzene (or an activated benzene derivative) is present, electrophilic substitution
occurs. The protonation step follows Markovnikov’s rule, forming the more stable carbocation, which alkylates
the aromatic ring.
® Alcohols are another source of carbocations for Friedel–Crafts alkylations. Alcohols commonly form
carbocations when treated with Lewis acids such as boron trifluoride (BF3). If benzene (or an activated
benzene derivative) is present, substitution may occur.
Formation of the cation :
Electrophilic substitution on benzene :
The BF3 used in this reaction is consumed and not regenerated. A full equivalent of the Lewis acid is needed,
so we say that the reaction is promoted by BF3 rather than catalyzed by BF3.
+
where Y = – NR3 , –NO2, –CN, –SO3H, –CHO, –COCH3, –COOH, – COOCH3 (–NH2, –NHR, –NR2)
Example :
PRACTICE – 2
A. Identify the product formed during the reaction :
1. 2.
3. 4.
PRACTICE – 3
1. What would be the major product of a Friedel–Crafts alkylation using the following alkyl chlorides?
a. CH3CH2Cl
b. CH3CH2CH2Cl
c. CH3CH2CH(Cl)CH3
d. (CH3)3CCl
e. (CH3)2CHCH2Cl
f. CH2 CHCH2Cl
Limitation–2 :
Like other carbocation reactions, the Friedel–Crafts alkylation is susceptible to carbocation rearrangements.
As a result, only certain alkylbenzenes can be made using the Friedel–Crafts alkylation. tert-Butylbenzene,
isopropylbenzene, and ethylbenzene can be synthesized using the Friedel–Crafts alkylation because the
corresponding cations are not prone to rearrangement. Consider what happens, however, when we try to
make n-propylbenzene by the Friedel–Crafts alkylation.
Ionization with rearrangement gives isopropyl cation
¾¾
CH3–CH2–CH2–Cl + AlCl3 ¬¾®
¾
PRACTICE – 4
1.
2.
3.
Limitation – 3 :
® Because alkyl groups are activating substituents, the product of the Friedel–Crafts alkylation is more reactive
than the starting material. Multiple alkylations are hard to avoid. As some ethylbenzene is formed,
however, it is activated, reacting even faster than benzene itself. The product is a mixture of some (ortho and
para) diethylbenzenes, some triethylbenzenes, a small amount of ethylbenzene, and some leftover benzene.
® The problem of overalkylation can be minimized by using a large excess of benzene. For example, if 1 mole
of ethyl chloride is used with 50 moles of benzene, the concentration of ethylbenzene is always low, and the
electrophile is more likely to react with benzene than with ethylbenzene. Distillation separates the product
from excess benzene. This is a common industrial approach, since a continuous distillation can recycle the
unreacted benzene.
Note : Lewis acid catalyst can also effect dealkylation i.e. reaction is reversible. Thus ethylbenzene with BF 3 &
HF is found to be disproportionate.
Limitations – 4 :
Only alkyl halides can be used. Alkyl fluorides, chlorides, bromides and iodides all react well, but aryl
halides and vinylic halides do not react. Aryl and vinylic carbocations are too high in energy to form under
Friedel-Crafts conditions.
EXAMPLE : Draw a mechanism for the following reaction, which involves two consecutive Friedel-Crafts alkylations.
When drawing the mechanism, do not try to draw the two alkylations as occurring simultaneously (such
a mechanism would have too many curved arrows and too many simultaneous charges). First draw the
steps that install one alkyl group and then draw the steps that install the second alkyl group.
MECHANISM : An interaction between a lone pair (on one of the chlorine atoms) and the Lewis acid generates a
complex that can lose a leaving group (AlCl4¯) to give a tertiary carbocation. This carbocation then functions
as an electrophile in an electrophilic aromatic substitution reaction. That is, benzene attacks the carbocation
to give an intermediate sigma complex, which then loses a proton to restore aromaticity. All of the steps
above are then repeated once again to close the ring, except this time, the electrophilic aromatic substitution
reaction occurs in an intramolecular fashion. A lone pair on the chlorine atom interacts with the Lewis acid to
generate a complex that can lose a leaving group (AlCl4¯) to give a tertiary carbocation. This carbocation
then functions as an electrophile in an intramolecular electrophilic aromatic substitution reaction. That is, the
aromatic ring attacks the carbocation to give an intermediate sigma complex, which then loses a proton to
restore aromaticity:
EXAMPLE : A Friedel-Crafts alkylation is an electrophilic aromatic substitution in which the electrophile (E +) is a
carbocation. In previous chapters, we have seen other methods of forming carbocations, such as
protonation of an alkene using a strong acid. The resulting carbocation can also be attacked by a
benzene ring, resulting in alkylation of the aromatic ring. With this in mind, draw a mechanism for the
following transformation:
MECHANISM : Sulfuric acid is used as an aqueous solution, so we must indicate H3O+ as the proton source in
our mechanism, rather than H2SO4 (because H2SO4 is a stronger acid than H3O+, so mixing H2SO4 and water
causes the protons to be transferred from H2SO4 to H2O, giving H3O+). In these acidic conditions, the alkene
is protonated to give a carbocation. This carbocation then serves as an electrophile in an electrophilic
aromatic substitution reaction. The aromatic ring attacks the electrophile to give an intermediate sigma
complex, which is then deprotonated to restore aromaticity, thereby giving the product. Water is the likely
base for the final deprotonation step, since water is present in a solution of sulfuric acid (and there are no
strong bases present in strongly acidic conditions).
PRACTICE – 5
Predict the expected product(s) when benzene is treated with each of the following alkyl halides in the
presence of AlCl3. In each case, assume conditions have been controlled to favor monoalkylation.
WORKSHEET-1
Þ Identify product :
1. C6H6 + C6H5CH2Cl
AlCl3
¾¾¾D
®
3. ¾¾¾
AlCl3
D
®
4. + ClCH2CH2Cl + ¾¾¾
AlCl3
D
®
5.
6.
D
7.
8. ¾¾¾
AlCl3
D
®
9.
THE FRIEDEL–CRAFTS ACYLATION
Ø An acyl group is a carbonyl group with an alkyl group attached. Acyl groups are named systematically by
dropping the final -e from the alkane name and adding the -oyl suffix. Historical names are often used for the
formyl group, the acetyl group, and the propionyl group, however.
Ø An acyl chloride is an acyl group bonded to a chlorine atom. Acyl chlorides are made by reaction of the
corresponding carboxylic acids with thionyl chloride. Therefore, acyl chlorides are also called acid chlorides.
Ø In the presence of aluminum chloride, an acyl chloride reacts with benzene (or an activated benzene derivative)
to give a phenyl ketone: an acylbenzene. The Friedel–Crafts acylation is analogous to the Friedel–Crafts
alkylation, except that the reagent is an acyl chloride instead of an alkyl halide and the product is an
acylbenzene (a “phenone”) instead of an alkylbenzene.
Friedel–Crafts acylation
Example :
Mechanism of Acylation
• The mechanism of Friedel–Crafts acylation (shown next) resembles that for alkylation, except that the
electrophile is a resonance-stabilized acylium ion. The acylium ion reacts with benzene or an activated
benzene derivative via an electrophilic aromatic substitution to form an acylbenzene.
• Friedel–Crafts acylation is an electrophilic aromatic substitution with an acylium ion acting as the electrophile.
Steps 2 and 3: Electrophilic attack forms a sigma complex, and loss of a proton regenerates the aromatic
system.
Step 4: Complexation of the product. The product complex must be hydrolyzed (by water) to release the free
acylbenzene.
• The product of acylation (the acylbenzene) is a ketone. The ketone’s carbonyl group has nonbonding
electrons that complex with the Lewis acid (AlCl3), requiring a full equivalent of AlCl3 in the acylation. The
initial product is the aluminum chloride complex of the acylbenzene. Addition of water hydrolyzes this
complex, giving the free acylbenzene.
EXAMPLES :
1.
MECHANISM : The anhydride interacts with the Lewis acid to give a complex which loses a leaving group to
produce an acylium ion. This acylium ion then serves as an electrophile in an electrophilic aromatic substitution
reaction. The aromatic ring attacks the electrophile to give an intermediate sigma complex, which is then
deprotonated to restore aromaticity, thereby giving the product. An acetate ion is the likely base for the final
deprotonation step, since acetate is a by-product of the reaction. Acetate is formed when the leaving group
(of the second step of mechanism) breaks apart into AICI3 and acetate (as shown).
2.
3.
4.
5.
WORKSHEET–2
Na -Hg
1. ¾¾¾
AlCl3
® A ¾¾¾®
HCl
B
AlCl
2. C6H6 + RCOCl ¾¾¾¾3
PhNO
® 2
CH3COCl
4. ¾¾¾¾
AlCl3
®
5. ¾¾¾
AlCl3
®
6.
7.
2. One of the most attractive features of the Friedel–Crafts acylation is the deactivation of the product toward
further substitution. The acylbenzene has a carbonyl group (a deactivating group) bonded to the aromatic
ring. Since Friedel–Crafts reactions do not occur on strongly deactivated rings, the acylation stops after one
substitution.
SUMMARY
COMPARISON OF FRIEDEL–CRAFTS ALKYLATION AND ACYLATION
Alkylation Acylation
The alkylation cannot be used with strongly Also true: Only benzene, halobenzenes,
deactivated and activated derivatives are suitable.
The carbocations involved in the alkylation may Resonance-stabilized acylium ions are not
rearrange. prone to rearrangement.
Polyalkylation is commonly a problem. The acylation forms a deactivated acylbenzene,
which does not react further.
Summary of Directing and Activating or Deactivating Effects of Some Common Functional Groups
(Groups are listed in decreasing order of activation)
® Carboxylic acid anhydrides, compounds of the type , can also serve as sources of acyl cations
and, in the presence of aluminum chloride, acylate benzene. One acyl unit of an acid anhydride becomes
attached to the benzene ring, while the other becomes part of a carboxylic acid.
® Succinic anhydride, the structure of which is shown, is a cyclic anhydride often used in Friedel-Crafts
acylations. Give the structure of the product obtained when benzene is acylated with succinic anhydride in
the presence of aluminum chloride.
® An important difference between Friedel-Crafts alkylations and acylations is that acyl cations do not rearrange.
The acyl group of the acyl chloride or acid anhydride is transferred to the benzene ring unchanged. The
reason for this is that an acyl cation is so strongly stabilized by resonance that it is more stable than any ion
that could conceivably arise from it by a hydride or alkyl group shift.
® Polyacylation is not observed, because introduction of an acyl group deactivates the ring toward further
acylation. This will be explained in more detail in the upcoming sections.
PROBLEM : The following compound cannot be made with either a Friedel-Crafts alkylation or acylation. Explain.
PROBLEM : Identify whether each of the following compounds can be made using a direct Friedel-Crafts alkylation or
whether it is necessary to perform an acylation followed by a Clemmensen reduction to avoid carbocation
rearrangements:
(A) (B)
(C) (D)
EXERCISE–1
Prepare the following by friedal craft reaction :
Reactant
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
EXERCISE–2
1. What product is formed when benzene is treated with each organic halide in the presence of AlCl3?
2. What acid chloride would be needed to prepare each of the following ketones from benzene using a Friedel-
Crafts acylation ?
H SO
(A) + H2SO 4
¾¾ ¾¾® (B) ¾¾2 ¾¾
4®
H SO
(C) (D) ¾¾2 ¾¾
4®
5. Draw the products formed when each compound is treated with HNO3 and H2SO4.
HNO
(A) (B) ¾¾ ¾
¾3®
H2SO 4
CH3CH2Cl
(C) ¾¾ ¾ ¾¾® (D)
AlCl3
(E) (F)
(G) (H)
HNO3 Br2
(A) ¾¾ ¾
¾® (B) ¾¾¾®
H2SO 4 hv
Br2
(C) HNO3 (D) ¾¾¾®
¾¾ ¾
¾® FeBr3
H2SO 4
HNO
(E) ¾¾ ¾
¾3
® (F)
Br2
¾¾¾®
H2SO 4 FeBr3
EXERCISE–3
1. Which of the following alkyl halides would you expect to undergo Friedel–Crafts reaction without rearrangement?
Explain.
(A) CH3CH2Cl (B) CH3CH2CH(Cl)CH3
(C) CH3CH2CH2Cl (D) (CH3)3CCH2Cl
(E) Chlorocyclohexane
2. What is the major monosubstitution product from the Friedel–Crafts reaction of benzene with 1-chloro-2-
methylpropane in the presence of AlCl3?
3. Identify the carboxylic acid chloride that might be used in a Friedel-Crafts acylation reaction to prepare each
of the following acylbenzenes :
(A) (B)
4. Propose products (if any) and mechanisms for the following reactions:
(A) chlorocyclohexane with benzene
(B) methyl chloride with anisole
(C) 3-chloro-2,2-dimethylbutane with isopropylbenzene
(i)
(ii)
(iii)
(iv)
(v)
(vi)
(vii)
(viii) What is the relationship between the products (A) & (B) :
8. Rank the following aromatic compounds in the expected order of their reactivity toward Friedel-Crafts alkylation.
Which compound are unreactive ?
(A) Bromobenzene (B) Toluene
(C) Phenol (D) Aniline
(E) Nitrobenzene (F) p-Bromotoluene
9. The carbocation electrophile in a Friedel-Crafts reaction can be generated in ways other than by reaction of
an alkyl chloride with AlCl3. For example, reaction of benzene with 2-methylpropene in the presence of H3PO4
yields tert-butylbenzene. Propose a mechanism for this reaction.
10. Which reactions will produce the desired product in good yield? You may assume that aluminum chloride is
added as a catalyst in each case. For the reactions that will not give a good yield of the desired product,
predict the major products.
Reagents Desired Product
(A) benzene + n-butyl bromide n-butylbenzene
(B) ethylbenzene + tert-butyl chloride p-ethyl-tert-butylbenzene
(C) bromobenzene + ethyl chloride p-bromoethylbenzene
(D) benzamide (PhCONH2) + CH3CH2Cl p-ethylbenzamide
(E) toluene + HNO3, H2SO4, heat 2,4,6-trinitrotoluene (TNT)
11. Show how you would synthesize the following aromatic derivatives from benzene.
(A) p-tert-butylnitrobenzene (B) p-toluenesulfonic acid (C) p-chlorotoluene
EXERCISE–4
A. Identify the product formed during the reaction.
Reactant Reactant
1. 2.
3. 4.
5. 6.
3
7. 8.
9. 10.
11. 12.
13. 14.
15.
D. Identify reactant
24. AlCl3
A + B ¾¾ 25. AlCl3
A + B ¾¾
¾¾® ¾¾®
(A) AlCl3
+ R–Cl ¾¾ (P) Friedel craft alkylation
¾¾®
1.
2.
3.
4.
3
5.
6.
3
7.
8.
9.
EXERCISE–6
1.
2.
3.
4.
5.
7.
8.
9.
(A) (B)
(C) (D)
11.
(A) (B)
(C) (D)
12.
(A) (B)
(C) (D)
13.
(A) (B)
(C) (D)
14.
(A) (B)
(C) (D)
15.
(A) (B)
(C) (D)
16.
(A) (B)
(C) (D)
17.
(A) (B)
(C) (D)
18.
(A) (B)
(C) (D)
19.
(A) (B)
(C) (D)
20.
22.
1.
2.
3.
4.
6.
7.
9.
10.
12.
13.
14.
16.
17.
18.
(A) (B)
(C) (D)
20.
(A) (B)
(C) (D)
21.
(A) (B)
(C) (D)
22.
(A) (B)
(C) (D)