MMR vaccine and autism: an update of the scientific evidence - PubMed https://pubmed.ncbi.nlm.nih.

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Review Expert Rev Vaccines. 2004 Feb;3(1):19-22. doi: 10.1586/14760584.3.1.19.

MMR vaccine and autism: an update of the scientific

evidence
Frank DeStefano 1 , William W Thompson

Affiliations
PMID: 14761240 DOI: 10.1586/14760584.3.1.19

Abstract
An hypothesis published in 1998 suggested that measles-mumps-rubella vaccine may cause
autism as a result of persistent measles virus infection of the gastrointestinal tract. Results of early
studies were not supportive and in 2001 a review by the Institute of Medicine concluded that the
evidence favors the rejection of a causal relationship at the population level between measles-
mumps-rubella vaccine and autistic spectrum disorder. Studies published since the Institute of
Medicine report have continued not to find an increased risk of autistic spectrum disorder
associated with measles-mumps-rubella. The vaccine also has not been found to be associated
with a unique syndrome of developmental regression and gastrointestinal disorders. The evidence
now is convincing that the measles-mumps-rubella vaccine does not cause autism or any
particular subtypes of autistic spectrum disorder.

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