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Insulin Preparations > increase uptake of glucose, Type 1 & type2 DM HypoglycemiaReaction :Insulin shock
amino acids & free fatty acids HA, lightheadedness
for storage nervousness, tremors, tachycardia
> synthesize glycogen, fats & sweating, slurred speech
Proteins memory lapse, seizure
excessive hunger
blood sugar= < 60 mg/dl
A. Short acting/ rapid acting onset peak duration
1. Lispro (Insulin analog) 5 min O.5 – 1 h 2–4h
• Humalog
Hyperglycemic Reaction:DiabeticKetoacidosis
2. Crystalline Zinc Insulin (Regular) 0.5 – 1 h 2–4h 6–8h polyuria , extreme thirst
• Humulin R, Novolin R dry mucous membranes, poor turgor
fruity breath, kussmaul
rapid, thready pulse
3. Semilente 1 – 1.5 h 1–4h 12 – 16 h blood sugar = > 250 mg/dl
C. Long-acting
1. Ultralente insulin 5–8h 14 – 20 h > 36 h
a. Humulin U
D. Combination
1. NPH + Regular insulin
• Humulin 70/30 0.5 h 4–8h 22 – 24 h
• Humulin 50/ 50 0.5 h 4–8h 24 h
• Humulin 75/25 15 min 0.5 – 6 h 20 – 24 h
2. 2nd generation
• Glypizide
• Glyburide
• Glimepiride