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1.2. Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses of the substance or mixture
Industry sector : Plastic processing industry.
Type of use : Flame retardants
3.2 Mixtures
Components
Chemical name CAS-No. Classification Concentration
EC-No. (% w/w)
Index-No.
Registration number
Melamine 108-78-1 Carc. 2; H351 >= 0.1 - < 1
203-615-4 Repr. 2; H361f
613-345-00-2 Repr. 2; H361f
01-2119485947-16 STOT RE 2; H373
01-2119485947-16- (Urinary tract)
0000
01-2119485947-16-
0025
01-2119485947-16-
0050
In case of skin contact : In case of contact, immediately flush skin with soap and plenty
of water.
In case of eye contact : In the case of contact with eyes, rinse immediately with plenty
of water and seek medical advice.
4.2 Most important symptoms and effects, both acute and delayed
Symptoms : No symptoms known currently.
4.3 Indication of any immediate medical attention and special treatment needed
Treatment : Treat symptomatically.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Hygiene measures : Wash hands before breaks and at the end of workday. Use
protective skin cream before handling the product. Take off
immediately all contaminated clothing and wash it before
reuse.
Remarks:DNEL
Predicted No Effect Concentration (PNEC) according to Regulation (EC) No. 1907/2006:
Substance name Environmental Compartment Value
organic phosphorous salt Fresh water 1 mg/l
Water (intermittent release) 0.1 mg/l
Marine water 0.1 mg/l
Sewage treatment plant 48.3 mg/l
Melamine Fresh water 0.51 mg/l
CAS-No.: 108-78-1
Water (intermittent release) 2 mg/l
Marine water 0.051 mg/l
Sewage treatment plant 200 mg/l
Fresh water sediment 2.524 mg/kg dry
weight (d.w.)
Marine sediment 0.252 mg/kg dry
weight (d.w.)
Soil 0.206 mg/kg dry
weight (d.w.)
8.2 Exposure controls
Personal protective equipment
Eye/face protection : Goggles
Hand protection
Remarks : Antistatic gloves Nitrile rubber gloves. Minimum breakthrough
time (glove): not determined Minimum thickness (glove): not
determined Take note of the information given by the
producer concerning permeability and break through times,
and of special workplace conditions (mechanical strain,
duration of contact).
Colour : white
Odour : odourless
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Viscosity
Viscosity, dynamic : Not applicable
Solubility(ies)
Water solubility : 12 g/l soluble
Particle characteristics
Particle size : 12.151 µm
Method: Laser diffraction with dispersion in dry air.
Median value
Oxidizing properties :
Method: Expert judgement
not oxidizing The product does not contain organic peroxide-
groups which result from either the manufacturing process or
from added ingredients.
Flammable solids
Burning number : 1
Does not catch fire
200 °C
Method: VDI 2263 (Grewer)
10.1 Reactivity
See section 10.3. "Possibility of hazardous reactions"
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Components:
Melamine:
Acute oral toxicity : LD50 (Rat, male and female): 3,161 - 3,828 mg/kg
Method: Other
GLP: No information available.
Acute inhalation toxicity : LC50 (Rat, male and female): > 5.19 mg/l
Exposure time: 4 h
Test atmosphere: dust/mist
Method: OECD Test Guideline 403
GLP: yes
Assessment: The substance or mixture has no acute
inhalation toxicity
Skin corrosion/irritation
Product:
Species : Rabbit
Result : slight irritant effect - does not require labelling
Remarks : The product has not been tested. The information is derived
from the properties of the individual components.
Components:
Melamine:
Species : Rabbit
Exposure time : 4h
Method : OECD Test Guideline 404
Result : No skin irritation
GLP : yes
Components:
Melamine:
Species : Rabbit
Method : Other
Result : No eye irritation
GLP : no
Components:
Melamine:
Test Type : Maximisation Test
Exposure routes : Skin contact
Species : Guinea pig
Method : OECD Test Guideline 406
Result : Not a skin sensitizer.
GLP : yes
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Components:
Melamine:
Genotoxicity in vitro : Test Type: Ames test
Test system: Salmonella typhimurium
Concentration: 50 - 5000 µg/plate
Metabolic activation: with and without metabolic activation
Method: Ames test
Result: negative
GLP: yes
Germ cell mutagenicity- : In vitro tests did not show mutagenic effects, In vivo tests did
Assessment not show mutagenic effects
Carcinogenicity
Product:
Remarks : not tested.
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Components:
Melamine:
Species : Rat, male and female
Application Route : oral (feed)
Exposure time : 103 w
Control Group : yes
Frequency of Treatment : daily
: 126 mg/kg bw/day
Method : Other
Result : equivocal
GLP : No information available.
Reproductive toxicity
Product:
Effects on fertility : Remarks: not tested.
Components:
Melamine:
Effects on fertility : Test Type: Fertility/early embryonic development
Species: Other
Method: Other
Remarks: Fertility and developmental toxicity tests did not
reveal any effect on reproduction.
Components:
Melamine:
Species : Rat, male and female
NOAEL : 72 mg/kg bw/day
Application Route : oral (feed)
Exposure time : 13 w
Dose : 750 - 18000 ppm nominal in die
Control Group : yes
Method : Repeated Dose Toxicity (subchronic study)
GLP : No information available.
Target Organs : Urinary system, Bladder
Aspiration toxicity
Components:
Melamine:
No aspiration toxicity classification
Components:
Melamine:
Assessment : The substance is considered to have endocrine disrupting
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Further information
Product:
Remarks : No data is available on the product itself.
The classification was made by the conventional (calculation)
method of the CLP Regulation (EC) No 1272/2008.
12.1 Toxicity
Product:
Toxicity to fish : Remarks: not tested.
Toxicity to microorganisms :
Remarks: not tested.
Components:
Melamine:
Toxicity to fish : LC50 (Oncorhynchus mykiss (rainbow trout)): > 3,000 mg/l
End point: mortality
Exposure time: 96 h
Test Type: semi-static test
Analytical monitoring: no
Method: Other
GLP: no
Remarks: The details of the toxic effect relate to the nominal
concentration.
Toxicity to daphnia and other : EC50 (Daphnia sp. (water flea)): 200 mg/l
aquatic invertebrates End point: Immobilization
Exposure time: 48 h
Test Type: static test
Analytical monitoring: no
Method: Regulation (EC) No. 440/2008, Annex, C.2
GLP: yes
Remarks: The details of the toxic effect relate to the nominal
concentration.
Components:
Melamine:
Biodegradability : Test Type: aerobic
Inoculum: activated sludge
Concentration: 100 mg DOC/l
Result: not rapidly degradable
Biodegradation: < 10 %
Related to: Dissolved organic carbon (DOC)
Exposure time: 28 d
Method: OECD Test Guideline 302B
GLP: No information available.
Components:
Melamine:
Bioaccumulation : Species: Cyprinus carpio (Carp)
Exposure time: 42 d
Concentration: 0.2 - 2 mg/l
Bioconcentration factor (BCF): 0.38 - 3.8
Method: Other
GLP: No information available.
Components:
Melamine:
Distribution among : Adsorption/Soil
environmental compartments Medium: water - soil
log Koc: 1.13 - 1.51
Method: estimated
Components:
Melamine:
Assessment : This substance is not considered to be persistent,
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Components:
Melamine:
Assessment : The substance is considered to have endocrine disrupting
properties according to REACH Article 57(f) for the
environment.
Additional ecological : The product should not be allowed to enter drains, water
information courses or the soil.
Avoid release to the environment.
Components:
Melamine:
Environmental fate and : no data available
pathways
15.1 Safety, health and environmental regulations/legislation specific for the substance or
mixture
Relevant EU provisions transposed through retained EU law
Council Regulation (EC) No 111/2005 laying down rules : Neither banned nor restricted
for the monitoring of trade between the Community and
third countries in drug precursors
Other regulations:
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
Not a hazardous substance or mixture according to the Globally Harmonised System (GHS).
VDI 2263 "Dust fires and explosions; Danger, Evaluation, Protection measures"
15.2 Chemical safety assessment
No Chemical Safety Assessment (CSA) is yet available for the substance, or for the component
substances, contained in this product.
Further information
Other information : Observe national and local legal requirements
This information corresponds to the present state of our knowledge and is intended as a general
description of our products and their possible applications. Clariant makes no warranties, express
or implied, as to the information's accuracy, adequacy, sufficiency or freedom from defect and
assumes no liability in connection with any use of this information. Any user of this product is
responsible for determining the suitability of Clariant's products for its particular application.
Nothing included in this information waives any of Clariant's General Terms and Conditions of
Sale, which control unless it agrees otherwise in writing. Any existing intellectual/industrial
property rights must be observed. Due to possible changes in our products and applicable
national and international regulations and laws, the status of our products could change. Material
Safety Data Sheets providing safety precautions, that should be observed when handling or
storing Clariant products, are available upon request and are provided in compliance with
applicable law. You should obtain and review the applicable Material Safety Data Sheet
information before handling any of these products. For additional information, please contact
Clariant.
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