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PDF Uas Makalah Farmakokinetik Dan Farmakodinamik Elsyahrani 191320004 2 Compress
PDF Uas Makalah Farmakokinetik Dan Farmakodinamik Elsyahrani 191320004 2 Compress
EDZMDCGOIFDMIC
Gkab<
^amji
amjimj
mjif
if`
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ydbr
brik
ik Xdmsi
dmsi,, X.E
X.Edr
drm
m., M.Xi.,
Xi.,D
Dpt
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ODE_DZ IXI.................................
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4. ^af`artidf
^af`artidf Matdjgkisma
Matdjgkisma Gjdt......
Gjdt...........
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:. Edctgr-edctg
Edctgr-edctgrr ydf` Mampaf`drubi
Mampaf`drubi Matdjgkisma
Matdjgkisma Gjdt......
Gjdt...........
..........
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8. _ampdt
_ampdt Matdjgkisma
Matdjgkisma Gjdt......
Gjdt...........
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ODE_DZ ^QX_DCD................................
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i
CD_D ^AF@DF_DZ
Oaf`df
Oaf`df maf`u
maf`uhdp
hdpcdf
cdf puli
puli syucur
syucur cabdoi
cabdoirdt
rdt Dkkdb
Dkkdb XP_,
XP_, ydf`
ydf` tak
takdb
db
makimpdbcdf rdbmdt odf biodydb-Fyd sabif``d pafukis mampargkab casabdtdf
odf cacudtdf
cacudtdf uftuc odpdt mafyakasdic
mafyakasdicdf
df mdcdkdb
mdcdkdb Edrmdsaticd
Edrmdsaticd ydf` jarluouk
‛Zadcsi Matdjgkisma”.
Qhdpdf tarimd cdsib pafukis sdmpdicdf capdod sakurub pibdc, cbususfyd
capdod
capdod og
ogsaf
saf pamjim
pamjimjif
jif`
` dtds casaoi
casaoiddf
ddffyd
fyd odkdm
odkdm mamjim
mamjimjif
jif`
` sabif`
sabif``d
`d
mdcdkdb ifi odpdt tarsakasdicdf.
^afukis mafydodri sapafubfyd dtds catarjdtdsdf ikmu mdupuf odri sa`i
pafydmpdidf ydf` mafldoicdf mdcdkdb ifi mdsib ldub odri sampurfd. Gkab
cdrafd itu, critic odf sdrdf ydf` mamjdf`uf sdf`dt oiparkucdf odri samud pibdc
uftuc sampurfdfyd mdcdkdb ifi.
^afyusuf
ii
JDJ I
^AFODBQKQDF
ydf` odpdt
ydf` odpdt jartif
jartifodc
odc sajd`d
sajd`dii mutd`a
mutd`af
f dtdu
dtdu cdrsif
cdrsifg`a
g`af.
f. Gkab
Gkab sajdj
sajdj itu parku
parku
oijdbds
oijdbds maf`afdi
maf`afdi gjdt ydf` maf`dkdmi
maf`dkdmi jigtrdfsegr
jigtrdfsegrmdsi
mdsi oaf`df
oaf`df jarjd`di
jarjd`di dcijdt
ydf` odpdt tarldoi.
4
4.8 _uludf ^afukisdf
_uludf pafukisdf mdcdkdb ifi dodkdb<
4. Qftuc mamdbdmi
mamdbdmi racdsi
racdsi matdjgkisma
matdjgkisma gjdt oiodkdm
oiodkdm tujub.
tujub.
:
JDJ II
^AMJDBDXDF
4. ^af`ar
^af`artid
tidf
f Mat
Matdjg
djgkis
kisma
ma Gjdt
Gjdt
Matdjg
Matdjgkism
kismaa dtdu jigtrdf
jigtrdfseg
segrmd
rmdsi
si dodkdb
dodkdb radcsi
radcsi parujd
parujdbdf
bdf zdt
cimi
cimidd odkd
odkdm
m ld
ldri
rif`
f`df
df jigk
jigkg`
g`ii ydf`
ydf` oi
oicd
cdtd
tdki
kiss gk
gkab
ab af
afzi
zim
m mafl
mafldo
doii
matdjgkitfyd. Lumkdb gjdt odkdm tujub odpdt jarcurdf` cdrafd prgsas
matd
matdjg
jgki
kism
smaa odf
odf acsc
acscra
rasi
si.. Bd
Bdti
ti maru
marupd
pdcd
cdf
f gr
gr`d
`df
f ut
utdm
dmdd ta
tamp
mpdt
dt
matdjgkisma gjdt. @ifldk tiodc dcdf aeactie maf`acsrasi gjdt ydf` jarsiedt
kipgei
kipgeikk cdrafd
cdrafd maracd
maracd dcdf
dcdf maf`dk
maf`dkdmi
dmi radjsgr
radjsgrpsi
psi oi tujuku
tujukuss satakdb
satakdb
makdku
makdkuii eiktrd
eiktrdsi
si `kgmak
`kgmakuru
urus.
s. Gkab
Gkab cdrafd
cdrafd itu,
itu, gjdt
gjdt ydf`
ydf` kipgei
kipgeikk bdrus
bdrus
oimatdjgkisma tarkajib odbuku mafldoi safydwd ydf` kajib pgkdr supdyd
radjsgrpsifyd jarcurdf` sabif``d muodb oiacscrasi (Mdrolgfg, Mdbdr,
:>>0).
^rgsas matdjgkisma tarjd`i mafldoi jajardpd edsa, edsa I marujdb
safydw
safydwdd kipgei
kipgeikk mafldo
mafldoii safydw
safydwdd ydf`
ydf` mampu
mampufyd
fydii `u`us
`u`us euf`si
euf`sigfd
gfdkk
saparti GB, FB:, odf HGGB. Ifi jartuludf d`dr safydwd kajib muodb
maf`
maf`dk
dkdm
dmii pr
prgs
gsas
as pa
paru
rujd
jdbd
bdf
f sakdf
sakdflu
lutf
tfyd
yd.. Bdsi
Bdsikk matd
matdjg
jgki
kism
smaa edsa
edsa I
muf`
muf`ci
cif
f mamp
mampaf
af`d
`dru
rubi
bi ae
aeac
ac edrmd
edrmdcg
cgkg
kg`i
`ify
fyd.
d. Matd
Matdjg
jgki
kism
smaa ed
edsa
sa I
cajdfydcdf maf``ufdcdf afzim sitgcrgm ^?1> ydf` jdfydc tarodpdt oi
sak bapdr odf @I. Afzim ifi lu`d jarpardf paftif` odkdm mamatdjgkisma
zdt afog`af saparti stargio, kamdc odf oatgcsieicdsi zdt acsg`af. Fdmuf
oamicidf, dod lu`d matdjgkisma edsa I ydf` tiodc maf``ufdcdf afzim
sitgcrgm ^?1>, saparti pdod gcsiodsi cdtacgkdmif, bistdmifa odf atdfgk
(Mdrolgfg, Mdbdr, :>>0).
Zadcsi edsa II dtdu radcsi cgflu`dsi tarldoi licd zdt jakum hucup
pgkdr satakdb maf`dkdmi matdjgkisma edsa I, ifi tarutdmd tarldoi pdod zdt
ydf`
ydf` sdf`dt
sdf`dt kipgei
kipgeik.
k. Cgflu`
Cgflu`dsi
dsi idk
idkdb
db radcsi
radcsi paf``d
paf``djuf
juf`df
`df dftdrd
dftdrd gjdt
gjdt
oaf`df zdt afog`af saparti dsdm `kucgrgfdt, dsdm sukedt, dsdm dsatdt odf
dsdm dmifg. Bdsik radcsi cgflu`dsi jarupd zdt ydf` sdf`dt pgkdr odf tiodc
8
dctie
dctie sahdrd
sahdrd edrmdcg
edrmdcgkg`
kg`i.
i. @kucgr
@kucgrgfi
gfiods
odsii dodkdb
dodkdb radcsi
radcsi cgflu`
cgflu`dsi
dsi ydf`
ydf`
pdkif` umum odf pdkif` paftif` odkdm acscrasi odf ifdctiedsi gjdt
(Mdrolgfg, Mdbdr, :>>0).
odf cukit, lu`d oi kumaf cgkgf (gkab ekgrd usus) (Mdrolgfg, Mdbdr, :>>0).
_uludf matdjgkisma gjdt dodkdb maf`ujdb gjdt ydf` fgf pgkdr
(kdrut kamdc) mafldoi pgkdr (kdrut dir)d`dr odpdt oiacscrasicdf makdkui
`ifldk
`ifldk dtdu
dtdu ampaou
ampaou.oa
.oaf`d
f`df
f parujd
parujdbdf
bdf ifi gjdt
gjdt dctie
dctie umumfy
umumfydd oiujdb
oiujdb
mafldoi
mafldoi ifdctie._dp
ifdctie._dpii sajd`idf
sajd`idf jarujdb
jarujdb mafldoi
mafldoi kajib dctie(licd
dctie(licd dsdkfyd
dsdkfyd
prgoru`),curdf` dctie,dtdu mafldoi tgcsic (Mdrolgfg,
(Mdrolgfg, Mdbdr, :>>0).
Zadcsi matdjgkisma ydf` tarpaftif` dodkdb gcsiodsi gkab afzim
hytghrgma ^?1> (hyp)ydf` oisajut lu`d afzim mgfggcsi`afdsa dtdu MEG
(Mixao Euf`tigf Gxiodsa) odkdm afogpkdsmih ratihukum
(micrgsgm
(micrg sgm)bd
)bdti.
ti.Ift
Iftardc
ardcsi
si odkdm
odkdm matdjg
matdjgkism
kismaa gjdt
gjdt jarupd
jarupd ifoucs
ifoucsii dtdu
dtdu
ifbijisi afzim matdjgkisma,tarutdmd afzim hyp (Mdrolgfg, Mdbdr, :>>0).
Ifoucsi jardrti pafif`cdtdf sistam afzim matdjgkisma pdod tif`cdt
trdfscripsi sabif``d tarldoi pafif`cdtdf cahapdtdf matdjgkisma gjdt ydf`
mafldoi sujstrdt afzim ydf` jarsdf`cutdf (Mdrolgfg, Mdbdr, :>>0).
Ifbijisi afzim matdjgkisma jardrti bdmjdtdf ydf` tarldoi sahdrd
kdf`su
kdf`suf`
f` oaf`df
oaf`df dcijdt
dcijdt pafif`
pafif`cdt
cdtdf
df cdodr
cdodr sujstrd
sujstrdtt odri
odri afzim
afzim ydf`
ydf`
oibdmjdt lu`d tarldoi sahdrd kdf`suf`. (Mdrolgfg,:>>0,bdk 2)
^rgsas matdjgkisma
matdjgkisma odpdt mampaf`dru
mampaf`drubi
bi dctivitds
dctivitds jigkg`is,
jigkg`is, mdsd
carl
carld,
d, odf
odf tgcs
tgcsis
isit
itds
ds gjdt
gjdt.. Gk
Gkab
ab cd
cdra
rafd
fd itu
itu pa
paf`
f`at
atdb
dbud
udf
f ta
taft
ftdf
df`
`
?
matdjgkisma
matdjgkisma gjdt paftif`
paftif` odkdm stuoi. Xudtu gjdt odpdt mafimjukc
mafimjukcdf
df
sudtu raspgf jigkg`is oaf`df makdkui oud ldkur, yditu<
d. Gjdt
Gjdt dctie
dctie satakdb
satakdb mdsuc
mdsuc makdkui
makdkui paraodrdf
paraodrdf odrdb,kd
odrdb,kdf`s
f`sufs
ufs jarifta
jariftardc
rdcsi
si
:. Edctgr-e
Edctgr-edct
dctgr
gr ydf`
ydf` mampaf`
mampaf`drui
drui matdj
matdjgkism
gkismaa gjdt<
gjdt<
Matdjgkisma
Matdjgkisma gjdt sahdrd fgrmdk
fgrmdk makijdtcdf
makijdtcdf kajib odri sdtu prgsas
cim
cimidwi
idwi odf af
afzi
zim
mdtic
dtic sa
sabi
bif
f``
``dd maf
af`
`bd
bdsi
sikc
kcdf
df ka
kaji
jib
b od
odri
ri sd
sdtu
tu
matdjg
matdjgkit
kit.Lu
.Lumkd
mkdb
b matdjg
matdjgkit
kit oitaft
oitaftucd
ucdf
f gkab
gkab cdodr
cdodr odf dctivi
dctivitds
tds afzim
afzim
1
^arjaoddf ifoiviou pdod prgsas matdjgkisma salumkdb gjdt cdodf`-
cdodf` tarldoi odkdm systam cabioupdf.Bdk ifi mafufluccdf jdbwd
edhtgr `afatih dtdu caturufdf icut jarpardf tarbdodp dodfyd parjaoddf
o. ^arj
^arjao
aodd
ddf
f umu
umurr
Jdyi odkdm cdfouf`df dtdu jdyi ydf` jdru kdbir lumkdb afzim-afzim
micrgsgm bdti ydf` oiparkucdf uftuc mamatdjgkisma gjdt rakdtie mdsib
saoicit sabif``d sdf`dt pacd tarbdodp gjdt (@dfiswdrd, occ. 4991).
a. ^af`
^af`bd
bdmj
mjdt
dtdf
df afzim
afzim matd
matdjg
jgki
kism
sm
Cdodf`-cdo
Cdodf`-cdodf`
df` pamjaridf
pamjaridf tarkajib
tarkajib odbuku
odbuku dtdu sahdrd jarsdmd-sdmd
jarsdmd-sdmd
sudtu safydwd ydf` maf`bdmjdt carld afzim-afzim matdjgkisma odpdt
mafif`cdtcdf iftafsitdsf aeac gjdt, mamparpdfldf` mdsd carld gjdt, odf
camuf`cifdf lu`d mafif`cdtcdf aeac sdmpif` odf tgcsisitds (@dfiswdrd,
occ. 4991).
e. If
Ifou
oucs
csii afzi
afzim
m matd
matdjg
jgki
kism
sm
^amj
^amjar
arid
idf
f ja
jarsd
rsdmd
md-sd
-sdmd
md su
sudt
dtu
u sa
safy
fydw
dwdd od
odpd
pdtt mafi
mafif`
f`cd
cdtc
tcdf
df
cahapdtdf
cahapdtdf matdjgkisma
matdjgkisma gjdt odf mamparpafo
mamparpafoac
ac mdsd carld gjdt. Bdk ifi
oisajdjcdf safydwd tarsajut odpdt mafif`cdtcdf lumkdb dtdu dctivitds
afzim
afzim matdjg
matdjgkism
kismaa odf jucdf
jucdf Cdrafd
Cdrafd parmad
parmadjka
jkakitd
kitdss micrgs
micrgsgm
gm dtdu
dtdu
dodfydd radcsi paf`bdmjdtd
dodfy paf`bdmjdtdf.^af
f.^afif`cdt
if`cdtdf
df dctivitds
dctivitds afzim matdjgkisma
matdjgkisma
gj
gjdt
dt-gj
-gjdt
dt tarta
tartaft
ftu
u dtdu
dtdu pr
prgs
gsas
as if
ifou
oucs
csii af
afzim
zim mamp
mamparh
arhap
apdt
dt pr
prgs
gsas
as
matdjgkisma odf mafurufcdf cdodr gjdt jajds odkdm pkdsmd sabif``d
aeac edrmdcgkg`is gjdt mafuruf odf mdsd carldfyd mafldoi kajib sif`cdt.
5
Ifoucsi afzim lu`d mampaf`drubi tgcsisitds jajardpd gjdt cdrafd odpdt
mafif`cdtcdf matdjgkisma odf matdjgkit radctie (@dfiswdrd, occ. 4991).
8. _amp
_ampdt
dt mat
matdj
djgk
gkis
isma
ma gjd
gjdtt
^arujdbdf cimid gjdt odkdm tujub tarutdmd tarldoi pdod ldrif`df-
ldrif`df odf gr`df-gr`df saparti bdti,`ifldk,pdru odf sdkurdf harfd. Bdti
marupd
marupdcdf
cdf gr`df
gr`df tujub
tujub tampdt utdmd matdjg
matdjgkism
kismaa gjdt
gjdt gkab
gkab cdrafd
cdrafd
maf
maf`df
`dfouf`
ouf` af
afzi
zim-
m-af
afzi
zim
m matdj
atdjgk
gkis
ism
ma oij
ijdf
dfoi
oif
f` gr
gr`
`df kd
kdif
if..
Matdjgkisma gjdt oi bdti tarldoi pdod mamjrdfa ratihukum afogpkdsmd
sak. Zaticukum afogpkdsmd taroiri odri oud tipa ydf` jarjaod, jdic jaftuc
mdup
mdupuf
uf eu
euf`
f`sif
sifyd
yd.. _ipa
_ipa 4 mamp
mampuf
ufyd
ydii pa
parm
rmuc
ucdd
ddf
f mamj
mamjrdf
rdf yd
ydf`
f`
cd
cdsd
sdr,
r,tar
taroi
oiri
ri od
odri
ri ri
rijg
jgsg
sgm-
m-rij
rijgs
gsgm
gm yd
ydf`
f` ta
tarsu
rsusu
suf
f sahdr
sahdrdd cb
cbds
ds od
odf
f
0
Zadcsi
Zadcsi ifi curdf`
curdf` paftif
paftif`
` oijdfo
oijdfoif`
if` radcsi
radcsi gcsiod
gcsiodsi.
si. Zaoucs
Zaoucsii
tarutdmd jarpardf pdod fitrg`af odf turufdffyd (dzgic odf fitrdt),
cdodf`-cdodf` pdod cdrjgf. (Dfgfim, 4999). Bdfyd jajardpd gjdt
pdod edsa I. radcsi ydf` tarldoi pdod edsa II ifi ifi makiputi cgflu`dsi
`kucgrgfio
`kucgrgfiodsi,
dsi, dsikdsi, matikdsi,
matikdsi, pamjaftuc
pamjaftucdf
df dsdm marcdpturdt,
marcdpturdt, odf
cgflu`dsi sukedt (@grogf odf Xcatt, 4994).
Zadcsi edsa II taroiri odri <
4) Cgflu`
Cgflu`dsi
dsi dsdm
dsdm `kucgr
`kucgrgf
gfdt,
dt, cgflu`ds
cgflu`dsii oaf`df
oaf`df dsdm `kucgr
`kucgrgfd
gfdtt
marupd
marupdcdf
cdf hdrd cgflu`
cgflu`dsi
dsi umum
umum odkdm
odkdm prgsas
prgsas matdjg
matdjgkism
kisma.
a.
Bdmpir
Bdmpir samud
samud gjdt
gjdt maf`dk
maf`dkdmi
dmi cgflu`
cgflu`dsi
dsi ifi cdrafd
cdrafd salumkd
salumkdb
b
jasdr `u`us euf`sigfdk gjdt odpdt jarcgmjifdsi sahdrd afzimdtic
oaf`df dsdm `kucgrgfdt odf tarsaoidfyd O-dsdm `kucgrgfdt odkdm
2
Cgafzi
Cgafzim
m dftdrd
dftdrd (QO^@D
(QO^@D < urioif
urioifaa oipbgs
oipbgspbg
pbg`ku
`kuhgr
hgrifi
ifihh dhio )
jaradcsi oaf`df gjdt oaf`df jdftudf afzim QO^ `kucgrgfgsik-
trdfsea
trdfseardsa
rdsa (Q@_)
(Q@_) uftuc
uftuc mamifo
mamifodbc
dbcdf
df `kucgr
`kucgrgf
gfiod
iod ca dtgm
dtgm G
8) Cgflu`dsi
Cgflu`dsi Xukedt,
Xukedt, tarutdmd
tarutdmd tarldoi
tarldoi pdod
pdod safydwd
safydwd ydf`
ydf` maf`dfou
maf`dfouf`
f`
`u`us eafgk odf cdodf`-cdodf` lu`d tarldoi pdod safydwd dkcgbgk,
dmif
dmif drgmdt
drgmdtic
ic odf safydw
safydwdd F-bior
F-biorgcs
gcsi.
i. Cgflu`
Cgflu`dsi
dsi sukedt
sukedt pdod
pdod
umumfyd uftuc mafif`cdtcdf cakdrutdf safydwd odkdm dir odf
mamj
mamjud
udtt sa
safy
fydw
dwdd mafl
mafldo
doii tiod
tiodc
c tg
tgcs
csic
ic (X
(Xis
iswd
wdfo
fogf
gfg
g od
odf
f
Xgacdrolg,:>>>).
?) Dsatik
Dsatikdsi,
dsi, marupdc
marupdcdf
df ldkur matdjgki
matdjgkisma
sma gjdt ydf` maf`dfou
maf`dfouf`
f`
`u`us
`u`us dmif
dmif primar
primar,, sukegf
sukegfdmi
dmiod,
od, biordsi
biordsif,
f, biordsi
biordsio,
o, odf dmifd
dmifd
dkiedtic primar. Euf`si utdmd dsatikdsi dodkdb mamjudt safydwd
9
JDJ III
^AFQ_Q^
?.4 Casimpukdf
Matdjg
Matdjgkism
kismaa dtdu
dtdu jigtrdf
jigtrdfsegr
segrmds
mdsii dodkdb
dodkdb radcsi
radcsi parujd
parujdbdf
bdf zdt cimid
cimid
odkdm ldrif`df jigkg`i ydf` oicdtdkis gkab afzim mafldoi matdjgkitfyd. ^rgsas
matdjg
matdjgkism
kismaa tarjd`
tarjd`ii mafldo
mafldoii jajardp
jajardpdd edsa,
edsa, edsa I marujd
marujdb
b safydw
safydwdd kipgei
kipgeikk
mafldo
mafldoii safydw
safydwdd ydf`
ydf` mampuf
mampufydi
ydi `u`us
`u`us euf`si
euf`sigfd
gfdkk odf edsa II dtdu
dtdu radcsi
radcsi
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44