CHOOSE THE CORRECT ANSWER ( 50 marks) a a 1. Floating tablets are used for all the followings drugs EXCEPT those that have narrow absorption re locally active on stomach ) stable jn intestine ; disturb normal colonic microbes eases a 9, “Selling system” of Gastroretentive tablets include: a. Colloidal gel b. Floating microspheres Calcium alginate beads Cy 3, Multiple-layer tablets ‘a, Are not suitable to separate two incompatible drugs. b. Are suitable for drugs that can not resist compression. > Te second layer needs lower compression force than the first layer. <@)Havea disadvantage of layer separation 4, Fast-Dispersible tablets ‘Are extended-release DDS. b, Superdisintegrants are not used. Are prepared by lyophilization oF direct compression _- {Less Hable torfrinbility than conven’ al tablets 5. Buccal DDSs ‘a. Can be semisolid, liquid or solid. e Bloadhesive polymers such as pol :rylic are used Buceal films are thinner than buc | tablets All Qaeetccnamaea= mie 6, Micro/Nanoparticles buccal DDSs care aqueous suspensions or aerso Incorporated in olntments b. Are solid dosage forms c. Have short duration of action d. All 7, Advantages of transdermal DDSs include all the followings EXCEPT ‘a. Avoid first-pass metabolism c b. Can provide extended-drug release K & Suitable for hydrophilic drugs— +. Good absorption due to large surface area of skin 8. What is “Macroflux” ? a, isan inhlation DDs. ba system applied on skin by electricity >a system composed of misropenjetions & “de fsa transdermal D ict ons coated with the drugs ‘that causes no allergy to the skin 2fi jontophoresis” tansdermal DDS works at ? 500 b. 50 5 ‘0, Sonophoresis (Phonophoresis) is a novel transdermal DDS. What is TRUE about this system 4 ‘a, The systems works at 100 MHz, 50-200 W/em? ‘The coupling system is usually a “ec. The physical force used is UV spectrum d, None 1.“Electroporation” is a transdermal DDS in which a high voltage of electricity is applied for iseconds ) b. seconds ¢. minutes d. hours SSS os i = 12. ‘Transferosomes” is a novel system that is composed of : a. Emulsions, surfactant and water ». Polymers, emulsifying agent and water Phospholipids, surfactant and water _ None 13.“ Neulast * (Pegfilgrastin) is a novel parenteral DDS in which monomethoxy polyethylene cl is conjugated with € Human granulocyte colony-stimulating factor (G-CSF) ‘b. Hepatitis B 15. What is “Glidel wafer” ? a. A transdermal DDS used for Alzheimer b. An ophthalmic DDS used for glaucoma ¢. An oral fast-dissolving tablet (QA parenteral DDS implanted into brain and used for cancer tere — Sel 16.“Sol-gel” Opthalmic DDS Is composed of polymeric solution + NaQH ~p.” Is applied as gel but converted in eye into solution c. Is used for fast drug -action in the eye d. All 17. The following is a novel ophthalmic DDS maded of insoluble polymer and used to treat eye diseases. a, Artificial tear insert e Inhalation DDSs d, Buccal DDSsAdvantage of intravaginal DDSs is that they can be used for both males and females. ’ Al . |. | Spinhaler and rotahaler are inhalation systems containing Wiese 30 | [6 | Buccal area has surface area smaller than sublingual area, >< | 7._| “Intraject “is a type of parenteral DDSs ~ Magnetophoresis is a sytem in which photochemical waves are used. __ Passive targeted DDSs are composed of a drug + carrier + homingUESTION III MATCH 20 Marks’ Answer 1, Peglayted dosage forms 2. Accuahaler 3. HPMA derivatives 4. Floating tablets e. Intravaginal DDS containing low dose of 5. Immunotoxin estradiol acetate - f. Solvent method and heat molding are used for | 6. ONTAK . preparation of ) g. Parenteral DDS containing fusion protein of 7. Femring t diphtheria toxin h. Inhalation DDS containing strips of small tablets ‘)) 8. Needleless free system i. Soluble polymer used to link with drugs or 9, Depot parenteral system homing in a targeted DDSs._S j- Monoclonal antibodies conjugated with 10. Powderject diphtheria toxin 5 a. Extended intramuscular injection system b. Microncedles transdermal DDS ¢. Parenteral conjugate of drug+PEG 7 d. High-speed gas that flows solid drug across the skin 10 | END OF EXAM # BEST WISHES DR. ANES THABIT ¥