Ophthalmology We are focused on pioneering therapies to prevent vision loss, working to discover and develop innovative solutions, aiming to redefine standards of care for people living with vision impairment. Challenge Aglobalissue Worldwide, more than 1 billion people live with vision impairment that could have been prevented or has yet to be addressed."Focus Millions of people live with eye conditions that increase their risk of sight loss.’ Visual impairment can have a devastating impact on those people affected, including patients and their caregivers. Change in sight With new approaches to the diagnosis and treatment of ophthalmic conditions being explored as we speak, this is a global health challenge that we at Roche are committed to and excited to tackle, alongside the low vision community. Atop priority Our team is built around the experience of ophthalmologists, ophthalmic surgeons and retinal specialists, who bring on-the- ground insights to their work at Roche every day. We are innovating to improve diagnosis and transform patient experience and outcomes - by understanding the biology of ophthalmic conditions and what this means in practice to people living with vision loss. Personalised approach We partner with researchers, clinicians and patient groups from the low vision community to ensure we understand the needs of people experiencing vision loss - so we can try to meet these needs through our approach to innovation, our clinical trial programme and our medicines and technologies in development, This means examining new data and analytical sources such as real world data, exploring new technologies like artificial intelligence and machine learning. Importantly, we're developing digital health solutions to help better detect and monitor disease progression and pioneering new therapeutic options like gene therapy, working to deliver a personalised approach to eye healthReferences 1. Word Health Organization. Blindness and vision impairment. [Internet; cited September 2021]. Available from: https://www.who.int/news-room/fact-sheets/detail/blindness-and- visual-impairment 2. Flaxman SR, Bourne RRA, Resnikoff S, et al. Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. Lancet Glob Health. 2017; 5:1221-1234 Featured stories World Sight Day: supporting Global eye Change Makers health Series Innovation and collaboration in oohthalmoloavShaping the _future of vision Hear more about Roche's unique approach to ophthalmology from CEO Severin Schwan Meet Ophthalmology team CC There is hope in sight Dr Christopher Brittain ‘ ‘ Meet Sascha Fauser Meet Sascha Fauser, Global Head of Ophthalmology, Roche Pharma Research and Early Development CC tim proud to work at Rachel FrizbergVice President, Global Head of Ophthalmology Senior Vice President of Global Immunology, Infectious Product Development Disease and Ophthalmology 1/5 > Stories of Ophthalmology See more stories -> Series Looking beyond the horizon to Dr Konstantinos Balaskas, United change the trajectory for vision loss Kingdom April 12, 2023 February 02, 2023New Frontiers of Cell Therapy January 05, 2023More focus areas View all focus areas > P..~ el Cardiometabolic diseases > Diabetes > 1/3 > Discover more Look beyond limits: The a reality of retinal disease A look at the impact of retinal disease and current therapy limitations. Saving sight from diabetic a eye disease We partnered on a survey that identified a significant gap in the understanding of diabetes and vision loss.Ophthalmic implants: history (7 of a breakthrough A quick look at the surprising history and promising future of ophthalmic implants