What is Stereochemistry in Chemistry?

• Stereochemistry, an important chemistry, involves the study of the relative spatial

arrangement of atoms that form the structure of molecules and their manipulation. For
this reason, it is also known as 3D chemistry in which the prefix "stereo" means "three-
dimensionality".

• Using this formulation of stereochemistry procedures, any chemist can work out the
relationships between different molecules that are made up of the same category of atoms.
They can even study the effect on the physical or biological properties these relationships
give molecules. An important part of stereochemistry is the study of chiral molecules and
this serves as a really useful part of the chemistry to the students which might help them
in the future.
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• Chemistry is really important and efficient for the research and study of living organisms
because it helps students and scientists to understand the life processes of every living
thing on earth at the molecular level. At any molecular level, every process of life takes
place due to the involvement of various minor or major chemical reactions.
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• Thus, it is important for the students to learn their chapters well and understand all the
chemistry concepts by practicing with a maximum number of past years’ question papers
and sample question papers available on the Vedantu website. This will help them to
understand the time management skill and learn the marking schemes that carry
maximum marks and plan which question needs what type of answers. Break down larger
portions into smaller effective points and write them down in a separate notebook so it
will help you in revising before the exams. Make note of the important questions that
keep repeating in the recent past year question papers and give more weightage to those
questions and prepare a little extra because it might repeat in the current year also. If you
have any doubts about the equations and chemical formulations that are taught during the
classes then try to spend some extra time in the lab and get to understand all the concepts
by trying out the experiments and practicing them really well. This will definitely help
you write your formulas and equations really well.
• Brief About Stereochemistry
• Stereochemistry is defined as the branch of chemistry which involves “the study of
various spatial arrangements of atoms present in molecules”.
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• Stereochemistry is described as the systematic presentation of a particular field of science
and technology traditionally requiring a short preliminary excursion into history.
Stereochemistry is also called the ‘chemistry of space ‘, which is stereochemistry that
deals with the spatial arrangements of groups and atoms in a molecule.
• More about Stereochemistry
• Stereochemistry is capable of tracing its roots to 1842 when the French chemist, named,
Louis Pasteur made an observation, which the salts of tartaric acid collected from a vessel
of wine production which has the ability to rotate plane-polarized light, whereas similar
salts from various sources did not hold this ability. This whole phenomenon is explained
by optical isomerism.
 • Types of Stereoisomers
• Different types of stereoisomers are tabulated below. Let us discuss more about them.

• Types of Stereoisomers
Atropisomers are stereoisomers resulting from hindered rotation
Atropisomerism about one or more single bonds. This is observed in case of many
drugs.
Cis-trans isomerism shares the same atoms which are joined to one
Cis-trans isomerism another in the same way but have a different configuration. This is
generally observed in the case of alkenes and complexes.
Conformational isomerism is a type of stereoisomerism in which
Conformational
isomers can only be converted by formally single bond rotations.
isomerism
This is observed in single-bonded systems like alkanes.
Diastereomers Diastereomers are optically active isomers that are not enantiomers.
An enantiomer is one of a pair of optical isomers, the structures of
Enantiomers which are not superimposable on their mirror images. Chirality
becomes the criteria here.

• Stereoisomerism
• Stereoisomerism refers to “the isomerism that is caused by the non-similar arrangements of
atoms or functional groups belonging to an atom in space”. These types of isomers have the
same constitutions, but different geometric arrangements of atoms. Stereoisomers can be broadly
classified into two types, namely enantiomers and diastereomers.
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• Stereoisomerism
• Stereoisomerism is known as “the isomerism, which is caused by the non-similar
arrangements of functional groups or atoms that belong to an atom in space”. These kinds
of isomers contain similar constitutions, but various geometric arrangements of atoms.
Stereoisomers are broadly classified into two types, which are enantiomers and
diastereomers.
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• Enantiomers
• When two isomers are explained as the mirror images of each other, such type of
isomerism is known as enantiomerism, and these types of isomers are called enantiomers.
• Enantiomers are the isolable and stable compounds that vary in their spatial
arrangements in 3-D space.
• Generally, they exist as discrete pairs.
• The properties of enantiomers are identical. However, their interaction with any plane of
the polarized light can differ.
• The direction, towards which they rotate the plane-polarized light is much different, it
means, if one rotates in the right direction, the other rotates towards the left direction.
• Diastereomers
• When any two isomers are not behaving as mirror images of each other, they are referred
to as diastereomers.
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• A molecule with an ‘n’ number of asymmetric carbon atoms can have up to ‘2n’
diastereomers.
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• When two diastereomers vary at only one stereocenter, they are called epimers.
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• These isomers change in both physical properties and chemical reactivity.
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• A representation of enantiomers which are mirror images of each other is given below.
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• Importance of Stereochemistry - Thalidomide Disaster
• The atoms arrangement in three-dimensional space plays a major part in the molecule
properties.
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• An example of the stereochemistry significance is observed in the thalidomide disaster
which struck Germany in 1957.
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• This drug thalidomide was sold in the form of an over-the-counter drug, where it was
initially intended to combat nausea. It can also be used by pregnant women to alleviate
morning sickness.
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• However, it was discovered that this drug underwent racemization and was produced as
an enantiomers mixture in the human body because of the metabolism process.
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• One of these enantiomers can be believed to cause some genetic damage in the
development of embryos and lead to baby birth defects.
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• This is based on the data that over 5000 babies were born with the deformed limbs shortly
after thalidomide sold commercially as an over-the-counter drug.
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• This unforeseen effect of the drug has led to the imposition of stricter drug regulation
laws (only 40 per cent of the born babies with these deformities survived).
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• This disaster signifies stereochemistry's importance.
• Facts about Stereochemistry
• The structure of the molecule can change according to the three-dimensional arrangement
of the atoms that constitute this. Also, Stereochemistry deals with the atom’s arrangement
manipulation.
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• Commonly, this branch of chemistry can be referred to as 3-D chemistry because it
focuses on the stereoisomers (which are the chemical compounds with similar chemical
formulas but with a different spatial arrangement in these three dimensions).
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• A branch of stereochemistry deals with the molecule’s study that exhibits chirality, which
is a property of the geometry of molecules that makes them non-superimposable on their
mirror images.
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• Another branch of the three-dimensional chemistry, which is called dynamic
stereochemistry, involves the study of the effects of various spatial arrangements of the
atoms, present in a molecule on the rate of a chemical reaction.
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• Stereochemistry and Regiochemistry
• The arrangement of stereoisomers can be described by stereochemistry. The key
distinction between stereochemistry and regiochemistry is, the final result’s atomic
structure of a chemical reaction can be represented using regiochemistry, whereas
stereochemistry describes the atomic arrangement and the modification of these
molecules.