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→ the nervous system produces movement in a perceptual world the brain constructs
• brain is plastic → neural tissue can adapt to changing circumstances y changing how its functions
are organized (e.g. blind person with enhanced auditory capacities)
• in order to learn something new, neural circuits are changed to represent and store knowledge
• neuroplasticity
• nervous systems potential for physical or chemical changes to compensate for injury or changing
circumstances
• phenotypic plasticity
• an individuals capacity to develop into more than one phenotype
• individuals genotype interacts with the environment to elect specific phenotype
• large genetic repertoire result from epigenetic influences
• e.g. specific diet adds chemical markers, epigenetic tags or specific genes
• anatomical organization
• brain and spinal cord together central nervous system
• nerve fibers radiating beyond and all neurons outside
brain and spinal cord form peripheral nervous system
(PNS) → carries sensory information into CNS and
motor information out of CNS
• functional organization
• neurons in somatic devision of PNS connect
through cranial and spinal nerves to receptors on
surface and muscles → gather sensory information
and convey information to move muscles
• autonomic devision helps govern internal organs
• enteric nervous system (sometimes considered part
of ANS) controls digestion and stomach
contractions
(I) CNS includes brain and spinal cord → nervous system core that mediates behavior
(II) somatic nervous system includes all spinal and cranial nerves carrying information to CNS from
muscles, joints and skin and transmits outgoing motor instructions that elicit movement
(III) autonomic nervous system balances internal organs by producing rest-and digest response
through parasympathetic nerves or fight or flight response through sympathetic nerves
(IV) enteric nervous system controls gut, communicates with CNS by ANS but mostly autonomously
afferent information is incoming sensory information to the CNS or one of its parts
efferent information is outgoing information leaving the CNS or one of its parts
Introduction to Brain & Behavior Chapter 2 2
Cerebral Geography
temporal lobe
part of the cerebral cortex that functions in
connection with hearing, language and musical
abilities, lies below lateral fissure, beneath the
temporal bone at side of skull
frontal lobe
part of the cerebral cortex, performing brain's
executive functions (decision-making), lies anterior to
central sulcus and beneath frontal bone of the skull
parietal lobe
part of the cerebral cortex, directs movements toward
a goal or to perform a task, lies posterior to central
sulcus and beneath parietal bone at top of the skull
occipital lobe
part of the cerebral cortex, where visual processing
begins, lies at back of the brain and beneath the
occipital bone
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• Meningitis
• harmful microorganisms invading meninges (especially in pia mater, arachnoid layer or CSF)
• symptoms include inflammation which presses pressure on brain and lead from delirium to even
coma, earliest symptoms headache and stiff neck (cervical rigidity) → head retraction (tilting head
backwards)
• Encephalitis
• infection of brain itself, different forms like encephalitis lethargica
• symptoms like sleep disturbance, symptoms of Parkinson's (tremors, difficulties with voluntary
movement)
• caused by death of substancia nigra
• radical treatment → hemispherectomy, surgical removal of affected hemisphere
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Introduction to Brain & Behavior Chapter 2 4
Cerebral Circulation
brains surface covered in blood vessels, stories feed blood to the brain and send it back through veins
in kidneys and lungs for cleaning and oxygenation
three major arteries send blood to cerebellum (anterior, middle and posterior cerebral arteries)
brain highly sensitive to blood loss, blockage or leak can lead to death of affected region → stroke
stroke characterized by sudden appearance of neurological symptoms as result of severely interrupted
blood flow, strokes disrupt different brain functions depending of affected artery
grey matter
areas of nervous system containing primarily cell body and capillary blood vessels that collects and
modify information of support this activity
white matter
areas of the nervous system rich in fat-heated neural axons that form the connections between brain
cells
ventricles
one of four cavities in brain that contain CSF to
cushion the brain, may play a role in maintaining
brain metabolism
corpus callosum
band of white matter containing about 200 million
nerve fibers that connects the two cerebral
hemispheres to provide a route for direct
communication between them
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• most behaviors are product of many interacting brain areas and levels
• hierarchical organization affects all human behavior
• experiments with oculus show that invertebrates also display intelligent behavior (e.g. learning by
observation)
Spinal Cord
• executes most movements elicited by brain or autonomously via somatic nervous system
• each spinal segment receives information from one part of body and sends commands to that area
• spinal nerves (part of SNS) carry sensory information from skin, muscle etc. to spinal cord and send
motor instructions to control muscles → spinal reflex when tapping knee cap
Brainstem
• receives afferent nerves from all body senses & sends out efferent nerves to cord to control body
• responsible for most unconscious behavior, separated intro three sections
• hindbrain → most important in motor functions
• midbrain → most important in sensory functions
• diencephalon ("between brain") → most important for integrative sensorimotor tasks
• hindbrain and midbrain extension of spinal cord, sensory structures lying posterior (dorsal in
animals) and motor structures anterior (ventral in animals), all regions carry out more than one
function
principle VII: sensory and motor devisions permeate the nervous system
Introduction to Brain & Behavior Chapter 2 6
(I) Hindbrain
• hindbrain
• evolutionary the oldest part of brain
• contains pons, medulla, reticular formation and cerebellum
• structures that coordinate and control most voluntary and involuntary movement
• cerebellum
• size of cerebellum increases with physical speed & dexterity of species (e.g. leopard large
cerebellum)
• size of cerebellum associated with cognitive capacity in humans
• reticular formation
• midbrain area, nuclei (grey matter) and fiber pathways (white matter) mixed → netlike
appearance
• associated with sleep-wake rhythm and behavioral arousal, each nuclei has a special function
• pons
• contains substructures that control many vital body movements
• nuclei receive inputs from cerebellum, form bridge from cerebellum to rest of brain
• medulla
• contains substructures that control many vital body movements
• nuclei regulate breathing and cardio-vascular system
(II) Midbrain
• midbrain
• central part of the brain
• contains neural circuits for hearings, seeing and orienting movements
• tectum
• roof of midbrain (are above the ventricle)
• functions are sensory processing and production of orienting movement (e.g. turning head to
detect source of auditory stimuli)
• visual information sent to superior colliculus
• auditory information sent to inferior colliculus
• tegmentum
• floor of midbrain (area below the ventricle)
• collection of nuclei with movement related, species-specific and pain perception functions
• red nucleus controls limb movement
• substancia nigra is connection to forebrain (important for initiating movements)
• periaqueductal gray matter (PAG) contains circuits controlling species-specific behavior and
important role in modulation of pain by opioid drugs
(III) Diencephalon
• diencephalon
• the between brain which integrates sensory and motor information on the way to cerebral cortex
• principle structures are thalamus and hypothalamus
• hypothalamus
• contains many nuclei (about 22) associated with temperature regulation, eating, drinking and
sexual behavior (sex differences found in some structures)
• control production of hormones via interaction with pituitary gland
• thalamus
• information from all sensory systems is integrated and projected into appropriate region of
neocortex
• optic tract send information to lateral geniculate nucleus (LGN) and thalamus send it to visual
region
• olfactory information passes dorsomedial thalamic nucleus on way to forebrain
Introduction to Brain & Behavior Chapter 2 7
Forebrain
• forebrain
• evolutionary newest part of the brain
• coordinates advanced cognitive functions like thinking, planning and language
• contains limbic system (regulates emotion and behaviors that produce and require memory) basal
ganglia (controls voluntary movement) and neocortex
Cerebral Cortex
Cortical Lobes
• human cortex almost symmetrical left and right hemisphere, separated by longitudinal fissure
• fissures often establish boundaries between lobes
• each hemisphere divided into four lobes: frontal, parietal, temporal and occipital
• posterior lobes have sensory functions: temporal → auditory, occipital → visual, parietal → tactile
• frontal lobe motor functions, integration of motor and sensory information, executive functioning
• Injuries to the distinctive lobes can produce:
• injury occipital lobe → deficits in processing visual information (light vs dark but no shape or color)
• injury parietal lobe → difficulties in identify/locate skin stimulation & deficits in directed movement
• injury temporal lobe → difficulty recognizing sounds but still know that they are hearing
something, difficulties in processing complex visual info (face)
• injury frontal lobe → difficulties organizing and evaluating ongoing behavior & planning for future
Cortical Layers
Basal Ganglia
• basal ganglia
• subcortical forebrain nuclei that coordinate voluntary of limbs and body
• connected to thalamus and to midbrain
• together with thalamus, substantia nigra and subthalamic forms system controlling voluntary
movement
• consists of three principle structures:
• caudate nucleus
• putamen
• globus palladius
Introduction to Brain & Behavior Chapter 2 8
• Parkinson's disease
• disorder of the motor system correlated with a loss of dopamine from the substantia nigra and
characterized by tremors, muscular rigidity and a reduction in voluntary movement
• Tourette syndrome
• disorder of the basal ganglia characterized by tics, involuntary vocalization (including curse words
and animal sounds) and odd, involuntary movements of the body, especially of the face and head
→ basal ganglia critical role in controlling and coordinating movements, not activation of muscle
Limbic system
• limbic system
• disparate forebrain structures lying between neocortex an brain stem that form a functional
system controlling affective and motivated behaviors and certain forms of memory
• includes many different structures
• cingulate cortex → participates in certain memory functions and controlling navigation in space
• amygdala → contribute to reward system of psychoactive drugs, addictive substances or
behaviors, removal of amygdala results in drastic behavioral changes
• hippocampus → participates in certain memory functions and controlling navigation in space
Olfactory System
• located at the very front of the brain, responsible for the sense of smell
• olfactory bulb sends input to pyriform cortex from there information guided by amygdala and
dorsomedial thalamus to frontal cortex
• in more simpler brain input directly to brain stem
• human olfactory bulb relatively small compared to cats and dogs but odors important for feeding
and sexual behavior
Cranial Nerves
• cranial nerves
• one of a set of 12 nerve pairs that control sensory
and motor functions of the head, neck and internal
organs, can have efferent or afferent functions, somer
nerves have both sensory and motor functions
• one set controls right side of the brain and other set
intros left side
• cranial nerves form part of the SNS
• contribute to maintaining autonomic functions by
connecting the brain and internal organs (vagus nerve,
cranial nerve X)
• influencing other autonomic responses such as salivation
Introduction to Brain & Behavior Chapter 2 9
Spinal Nerves
• dermatome
• body segment corresponding to a
segment of the spinal cord
• has sensory nerve to send information
from skin, joints and muscles to spinal
cord but also motor nerve to control
muscle movement in particular body
segment
• these sensory and motor nerves called
spinal (or peripheral) nerves function
equally to cranial nerves
• posterior (dorsal in animals) root of collection of afferent posterior fibers that gather when they enter a
spinal cord segment
• anterior (ventral in animals) root of collection of efferent fibers that exit spinal cord
• outer part of spinal cord consist of white matter (nerves) and inner part grey matter (cell bodies)
→ spinal cord segments are interconnected, integration does not require brain participation but close
working relation, brain and spinal cord can function independently, the two are intimately
connected in their CNS functions
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• Magendie found that cutting the dorsal roots caused loss of sensation and cutting the ventral roots
caused loss of movements
• Charles Bell found localized cranial motor nerve dysfunction - Bells Palsy
• facial paralysis that develops when motor part of the facial nerve on one side of the head becomes
inflamed, onset is typically sudden, most people fully recover although it might take months
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Introduction to Brain & Behavior Chapter 2 10
• sympathetic devision
• part of the autonomic nervous system
• arouses the body for action like fight-or-flight
response by increasing heart rate and blood
pressure
• parasympathetic devision
• part of the autonomous nervous system
• acts in opposite to sympathetic devision,
preparing the body to rest and digest by
reversing the alarm response or stimulating
digestion
Principle 1: The Nervous System Produces Movement in a Perceptual World the Brain Constructs
• nervous systems function is to produce behavior or movements that are related to outside objects,
places, memories etc.
• mental representation depends on information send to the brain
• brain of each animal species produces a reality that is adaptive for species to survive
Introduction to Brain & Behavior Chapter 2 11
• experience alters brain organization, crucial for learning, nervous system stores information only if
neural connections change
• plasticity can be beneficial in recovering from disorders (brain injures or diseases) and allows brain
to compensate for developmental abnormalities
• also negative effects like addiction related behavior
• most brain inputs and outputs are contralateral, explains brain lesions and produced impaired
function
• neural connections link both sides, biggest connection corpus callosum
• four important exceptions: olfactory sensation, somatic, autonomic and enteric PNS connection
• each addition to CNS added new level of behavioral complexity without discarding previous levels
of control, new levels not autonomous but integrated into existing neural system
• as mammals evolved they developed increased capacity to represent world in cortex → new maps
related and integrated to old maps
• cortical asymmetry is essential for integrative tasks, language and body control among them
• language control typically on left side and spatial tasks on right side
• hierarchical circuit in all regions concerned with particular functions (e.g. vision)
• functionally related brain structures are not always linked linearly, unconnected regions have widely
differing functions
• parallel circuits operate on two different processes running next to each other (e.g. perception o
shape and color in vision)
• brain subsystems organized into multiple parallel pathways but conscious experience always unified
Principle 8: The Brain Divides Sensory Input for Object Recognition and Motor Control
Principle 10: The Nervous System works by Juxtaposing Excitation and Inhibition
Key Terms
Term Description
autonomic nervous system part of the PNS that regulates internal organs and glands
basal ganglia subcortical forebrain nuclei, coordinates voluntary movement of limbs and
body, connected to thalamus and midbrain
cerebrospinal fluid (CSF) clear, salty solution that fill ventricles, circulates around brain and spinal
cord, beneath the arachnoid layer in subarachnoid space
cranial nerve twelve nerve pairs, control sensory and motor functions
enteric nervous system mesh of neurons in gut, controls gut, running from esophagus through colon
frontal lobe part of cerebral cortex, executive functions like decision-making lies anterior
to central sulcus and beneath frontal bone
Introduction to Brain & Behavior Chapter 2 13
Terms Description
gray matter mostly cell bodies and blood vessels, collect or modify information
gyri (sing. gyrus) small protrusion or bump formed by folding of the cerebral cortex
law of Bell and Magendie principle that sensory fibers are dorsal and motor fibers are ventral
meninges protective tissue (dura mater, arachnoid, pia mater) for brain & spinal cord
midbrain central part, contains neural circuits for hearing, seeing, orienting movement
neocortex outer layer (new bark) of forebrain, six layers gray matter, constructs reality
occipital lobe part of cerebral cortex for visual info, lies at back, beneath occipital bone
orienting movement movement related to sensory input (e.g. turning head to sound source)
parietal lobe part of cerebral cortex that directs movements toward a goal or performing
a task, posterior to central sulcus & beneath parietal bone at top of the brain
Parkinson disease disorder of motor system correlated to loss of substantia nigra (tremors…)
phenotypic plasticity individuals capacity to develop into more than one phenotype
reticular formation midbrain area with mixed nucleus and fiber pathways (netlike), associated
with sleep-wake behavior and behavioral arousal
somatic nervous system part of the PNS including cranial and spinal nerves
sulci (sing. sulcus) a groove in brain matter, most are in the neocortex or cerebellum
tectum roof of midbrain (area above ventricle), functions are sensory processing
(visual and auditory) and production of orientating movement
temporal lobe part of the cerebral cortex for hearing, musical abilities & language, lies
below lateral fissure, beneath temporal bone at side of the skull
Tourette syndrome disorder of basal ganglia with tics, involuntary vocalization & movement
tract large collection of axons running together inside of CNS
ventricle one of four cavities in brain that contain CSF to cushion brain, may be
responsible in maintaining brain metabolism
white matter areas of NS rich in fat-heated neural axons that connect brain cells
Introduction to Brain & Behavior Chapter 2 14