You are on page 1of 1

Powered by AI

Bing
I'm sorry, but I'm unable to provide images or diagrams. However, I can
describe the process in detail.
The biosynthesis of pyrimidines involves several steps 34:
1. Synthesis of Carbamoyl Phosphate: The process begins with the
combination of carbon dioxide and ammonia to form carbamoyl
phosphate. This reaction is catalyzed by the cytosolic enzyme carbamoyl
phosphate synthetase-II1.
2. Synthesis of Carbamoyl Aspartate: The carbamoyl phosphate then
combines with aspartate to form carbamoyl aspartate. This reaction is
catalyzed by the enzyme aspartate transcarbamoylase 3.
3. Ring Closure to form Dihydroorotate: The carbamoyl aspartate
undergoes ring closure and dehydration to form dihydroorotate 8.
4. Oxidation of Dihydro Orotate: Dihydroorotate is then oxidized to form
orotic acid3.
5. Addition of Ribose Phosphate Moiety: The orotic acid is then
combined with phosphoribosylpyrophosphate (PRPP) to form orotidyl
monophosphate (OMP)3.
6. Decarboxylation to form UMP: Finally, OMP is decarboxylated to form
the first pyrimidine nucleotide, UMP3.
The pyrimidine ring is synthesized first and then attached to ribose
phosphate1. Unlike purines, pyrimidines originate as bases that later attach to
the ribose sugar5.
I hope this helps! If you need more detailed information, I recommend
checking out some biochemistry textbooks or online resources that contain
diagrams and more detailed explanations. They can provide a visual aid that
can help you understand the process better.

Source(s)
1. 7.10: Pyrimidine de novo Biosynthesis - Biology LibreTexts
2. Purine & Pyrimidine Synthesis (de-novo) | EasyBiologyClass
3. Biosynthesis of Purine Nucleotides, Pyrimidine Nucleotides and ...
4. http://www.columbia.edu/cu/biology/courses/w3034/Larry/readings/PurineChapter/
PurineChapter.html
5. Purines and Pyrimidines - Science Notes and Projects
6. https://bing.com/search?q=biosynthesis+of+pyrimidines+with+structures
7. Pyrimidine Metabolism - CliffsNotes
8. https://biochemden.com/pyrimidine-synthesis/
9. https://link.springer.com/article/10.1007/s000180300027

You might also like