Professional Documents
Culture Documents
SCHOOL OF MEDICINE
NDOLA CAMPUS
PUBLIC HEALTH UNIT
SIN: 18131638
SUPERVISOR(S): PROF V MWANAKASALE
COURSE CODE: MCS 310
LECTURER: HERBERT TATO NYIRENDA
The proposal has been prepared in fulfilment of the guidelines for Bachelor of
Medicine and Surgery (MBCHB) at the COPPERBELT UNIVERSITY, School of
Medicine.
CANDIDATE’S DECLARATION
The proposal has been prepared by the required guidelines for a Bachelor of
It has not been submitted for a degree at this or any university. Therefore, I do
hereby bear absolute responsibility for the contents, errors, defects and any
omissions herein.
DATE: ……………………………………………………………………………………………………
SUPERVISOR’S DECLARATION
have checked this project proposal and that it is the original work of the author. I
DATE: …………………………………………………………………
i
ABSTRACT
Introduction
Prostate cancer is the second most prevalent cancer after cervical cancer and the
number one cancer in Zambian men with a standardized incidence rate of 60.03 per
100,000 males (Kalubula, 2018). Proper doctor and public health interventions can
prostate cancer (Kalubula, 2018). The study aims to assess the knowledge, attitude and
practice about risk factors and treatment of prostate cancer among male patients
attending the urology clinic at Ndola Teaching Hospital (NTH). The general objective
of this study is to assess knowledge, attitude and practice about risk factors, screening
and treatment of prostate cancer among adult male patients attending the urology
Methodology
questionnaire will be used which will elicit information from the selected participants
with the view of assessing the knowledge and attitude of male patients towards
prostate cancer screening. The study will target admitted male patients attending the
participant’s knowledge about prostate cancer, knowledge and attitude and knowledge
and practice. A total of 384 study participants will be enrolled into the study. Data will
ii
ACKNOWLEDGEMENTS
My sincere gratitude and appreciation go to the almighty GOD for the strength and
courage to carry on this task. I would also like to recognize the tireless efforts,
seeing to it that I take the necessary steps in coming up with a sound and productive
research topic. Not forgetting the Copperbelt University Management for the help they
invested both directly and indirectly in terms of materials, knowledge and parental
guidance. I would also like to extend my heartfelt gratitude to the Chilembo family,
Mrs. Sarah Chilembo and Irene Chilembo for the ideas and condiments to this
research. Lastly, my gratitude goes to my family, friends and roommates for their
iii
Table of Contents
DECLARATION FORM...............................................................................................................................i
ABSTRACT...............................................................................................................................................ii
ACKNOWLEDGEMENTS..........................................................................................................................iii
LIST OF ABBREVIATIONS........................................................................................................................iv
CHAPTER ONE...................................................................................................................................1
1.2 STATEMENT OF THE PROBLEM.............................................................................................2
1.3 RATIONALE/ JUSTIFICATION....................................................................................................2
1.4 LITERATURE REVIEW.................................................................................................................3
Global perspective..............................................................................................................................3
1.4.1 Regional Perspective.....................................................................................................................4
1.4.2 National Perspective......................................................................................................................5
1.5 OBJECTIVES..................................................................................................................................6
1.5.1 General Objectives........................................................................................................................6
1.5.2 Specific Objectives........................................................................................................................6
1.6 RESEARCH QUESTION................................................................................................................6
1.7 MEASUREMENT............................................................................................................................6
1.7.1 OPERATIONAL DEFINITION ACCORDING TO THIS STUDY.............................................6
1.7.2 MEASUREMENT SCALE...........................................................................................................7
1.8 CONCEPTUAL FRAMEWORK.....................................................................................................8
CHAPTER TWO....................................................................................................................................9
2.0 METHODOLOGY.....................................................................................................................9
Study site................................................................................................................................................9
Target population...................................................................................................................................9
Study design...........................................................................................................................................9
Sample size............................................................................................................................................9
TABLE 1. O Sampling components.....................................................................................................10
Sampling procedure..............................................................................................................................11
Inclusion criteria...................................................................................................................................11
Exclusion criteria..................................................................................................................................11
2.1 Plan for data collection...................................................................................................................11
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2.1.2 Data Management........................................................................................................................11
2.2 Plan for Data Analysis....................................................................................................................11
2.3 Ethical Consideration.....................................................................................................................11
2.4 Study Limitation.............................................................................................................................12
References............................................................................................................................................13
APPENDIX..........................................................................................................................................15
1.0 Budget......................................................................................................................................15
2.0 INFORMATION SHEET...............................................................................................................16
2.0 RESPONDENT’S CONSENT FORM.....................................................................................18
3.0 QUESTIONNAIRE..................................................................................................................19
2.4 ACTION PLAN.............................................................................................................................21
v
LIST OF ABBREVIATIONS
vi
Vi
CHAPTER ONE
1.0 INTRODUCTION
Prostate cancer also called prostate adenocarcinoma is cancer that occurs in the prostate
gland. The prostate is a small walnut-shaped gland in males that produces the seminal
fluid that nourishes and transports sperm. It is located inferior to the bladder and
anterior to the rectum. It surrounds the urethra. The urethra is a tube that carries urine
from the bladder out through the penis. This is why men with an enlarged prostate have
difficulty urinating.
Prostate cancer is the second-leading cause of cancer deaths for men in the U.S.A.
According to the American Cancer Society’s estimates for prostate cancer in the United
States for 2021, about 1 in 9 men will be diagnosed with prostate cancer in their
lifetime, with 248,530 new cases and about 34,130 deaths from prostate cancer. Thus,
represented the sixth leading cause of cancer death worldwide with 1,111,700 new
In Europe in 2012, according to the population-based cancer registries (CR), there were
400,364 new cases and regarding mortality, there were 92,328 deaths. In 2015, it was
estimated that 3,037,127 Italians had been previously diagnosed with cancer and
1
Prostate cancer is the number one cancer in males in Africa, both in terms of incidence
and mortality, accounting for 40,000 (13%) male cancers and 28,000 (11%) male
countries, most cancer victims are diagnosed at a late stage, with incurable tumours,
pointing to the need for education schemes and better detection programs.
Zambia is not an exception to this global trend. It has one of the highest cases of
Possible causes of prostate cancer are unclear although increasing age, race and
previous family history of the disease are known risk factors. All men are at risk for
prostate cancer, but African-American men are more likely to get prostate cancer, for
some men, genetic factors may put them at risk for prostate cancer. It has a high
incidence in men above the age of 50. Most prostate cancers (89%) are found when
the disease is in only the prostate and nearby organs. This is referred to as the local or
regional stage. The 5-year survival rate for most people with local or regional prostate
cancer is nearly 100%. For people diagnosed with prostate cancer that has spread to
other parts of the body, the 5-year survival rate is 30%. (Cancer Facts and Figures,
2021).
The two most common tests done to screen for prostate cancer are the Digital Rectal
Examination (DRE) and the Prostate Specific Antigen (PSA) test. Understanding the
attitude of patients towards prostate cancer and how it affects screening and treatment
is important for physicians and public health practitioners as this information clarifies
existing knowledge and provides valuable information for the design of public health
2
programs to reduce the disease burden of prostate cancer. Thus, this study seeks to
assess the knowledge, attitude and practice about risk factors and treatment of prostate
cancer among male patients attending the urology clinic at Ndola Teaching Hospital
(NTH).
Prostate cancer has been the second most prevalent cancer and number one cancer in
Zambian men with a standardized incidence rate of 60.3 per 100,000 male Patients.
Mortality is relatively much higher in third-world countries like Zambia due to a lack
of awareness of the risk factors and screening for prostate cancer. Treatment is
According to the statistics adapted from the American Cancer Society’s (ACS)
publication, Cancer Facts and Figures 2021, and the ACS website, the Prostate cancer
incidence rate rose sharply in the late 1980s and early 1990s due to increased
screening with the PSA test. But from 2013 and 2017, incidence rates have stayed
steady. Around 60% of cases are diagnosed in men aged 65 or older. The disease
rarely occurs in those younger than 40. The number of new cases diagnosed in black
men is nearly 80% higher than the number of new cases diagnosed in white men.
Seeing that similar research studies had been conducted in line with the assessment of
knowledge, attitude and practice towards prostate cancer. These studies were more
concerned about patients/ men’s views towards prostate cancer and prostate cancer
screening. With the literature being reviewed, no standing detail has been made on
3
assessing men’s knowledge, attitude and practice about risk factors and treatment for
prostate cancer. This is the gap of interest this research is trying to tackle and bring to
Treatment of prostate cancer is dependent on its stage. Treatment should begin if the
results of the tests done during active surveillance (watchful waiting) show signs of
the cancer becoming more aggressive or spreading, if the cancer causes pain, or if the
cancer blocks the urinary tract. (Cancer.Net Editorial Board, 09/2020). Therefore, this
study aims at determining people’s knowledge and practice about risk factors and
treatment which are the core for the progression of prostate cancer.
This study will help improve the health system with knowledge about people’s
attitudes about the risk factors and treatment of prostate cancer and will strive to
involve the community in the awareness of this prevalent and morbid disease. This
will broaden the physician's view on various strategies to use to help reduce the
cancer screening, risk factors and treatment which will eventually change the statistics.
It will also show the associations of the mentioned characteristics with the prevalence
of prostate cancer in males. Further, this study will help to come up with ideas and
This section contains reviews on various related research literature and scholarly
4
towards prostate cancer. The review highlights descriptions of prostate cancer,
from studies in multiple research areas. It also summarizes global perspectives and
Global perspective
stage prostate cancer is usually asymptomatic. More advanced disease has similar
symptoms with benign prostate conditions such as weak or interrupted urine flow,
commonly spreads to bones and causes pain in the hips, spine or ribs [4]. The
commonly used screening methods for prostate cancer are digital rectal examination
(DRE) and prostate-specific antigen (PSA) tests. (Gift et al. Afr J Urol, 2020).
A study was conducted in Italy, and the study aimed to evaluate the knowledge,
attitudes and behaviours towards prostate cancer and its prevention. A cross-sectional
survey was conducted on a random sample of 625 fathers of students attending eight
Knowledge about prostate cancer and the prostate-specific antigen (PSA) test,
perception of risk towards prostate cancer, perception of the benefits of having a PSA
test, willingness to receive the PSA-test and sources of and needs of information
regarding prostate cancer and the PSA-test (Morlando M, Pelullo CP, DiGiuseppe G
(2017) outlined the findings of this study, according to their results 72.7% of
respondents had heard about the PSA-test and 51.1% of those had heard about it
5
through their physicians. This knowledge was higher: in men with older age, in those
who had a higher level of education, in those who had a relative with prostrate
problems or prostate cancer and in those with prostate problems. Perceived personal
risk of contracting prostate cancer was associated with a higher level of education, in
those who had received information about prostate cancer from a physician and in
those with prostate problems. Only 29.6% of men had undergone a PSA test and
59.4% were willing to do so in the future. The significant predictors of the willingness
to receive a PSA test were the belief that the PSA test was useful, the perception of not
very good personal health status, and the need for additional information about the
PSA test (Morlando M, Pelullo CP, DiGiuseppe G (2017) concluded their research by
stating that Respondents had moderate knowledge about prostate cancer and a good
Several researches were conducted in the region. A certain research was done among
Ugandan men in 2013. “This study assessed the current knowledge, attitudes and
practices of adult Ugandan men regarding prostate cancer.” (H. Nakandi et al, 2013).
questionnaires and focus group discussions among 545 adult men aged 18–71 years,
residing in Kampala, the capital of Uganda. Quantitative data were analyzed with
SPSS version 20. Qualitative data were collected using audio-recorded focus group
6
In their results the majority of the respondents (324, 59.4%) were aged 18–28 years,
295 (54.1%) had heard about prostate cancer and 250 (45.9%) had never heard about
it. The commonest source of information about prostate cancer was the mass media.
Only 12.5% of the respondents obtained information about prostate cancer from a
health worker, 37.4% did not know the age group that prostate cancer affects and
50.2% could not identify any risk factor for prostate cancer. Participants in the focus
group discussions confused prostate cancer with gonorrhea and had various
misconceptions about the causes of prostate cancer. Only 10.3% of the respondents
had good knowledge of the symptoms of prostate cancer and only 9% knew about
serum prostate-specific antigen (PSA) testing. Although 63.5% thought they were
specific antigen 9(PSA) testing and only 3.5% had ever undergone a serum PSA test.
health education programs about prostate cancer are greatly needed for this
population.
In addition, a similar study design in Johannesburg, South Africa was undertaken. The
study aimed to describe the knowledge, attitudes and practices of men living in
Muldersdrift, South Africa, concerning prostate cancer. The setting was Ward 23,
survey was conducted. The convenience sampling method was used on a sample size
of n=183. Data were collected using structured interviews and a questionnaire served
as the data collection instrument. The data were analyzed through descriptive statistics
7
and the Fisher’s Exact Test was used to calculate statistically significant differences
between the variables. Of the sample (n=183) about half were above the age of 70
years (48.1%; n=88), mean of 52.4, SD ±9.5 and median 50. Over a third of
respondents were from the Tswana cultural group (36.6%; n=67) and the highest
prostate cancer and only 9.8% (n=18) had ever heard of the disease.
Baaitse, 2018).
The author further concluded that the study provided evidence that the men living in
the study setting had limited knowledge of prostate cancer. “However, they presented
with a positive attitude regarding prostate cancer, and high percentages were ready to
perform prostate cancer screening and to learn about the disease.” (Bontshwanetse
Baaitse, 2018).
8
1.4.2 National Perspective
assessing knowledge, practice and attitude towards prostate cancer screening among
male patients aged 40 years and above at Kitwe Teaching Hospital, Zambia.
A total of 200 men took part in the study (response rate = 100%). Of the 200
respondents, 67 (33.5%) had heard about prostate cancer and 58 (29%) expressed
knowledge of prostate cancer out of which 37 (63.8%) had low knowledge. Twenty-
six participants (13%) were screened for prostate cancer in the last 2 years. 98.5% of
the participants had a positive attitude towards prostate cancer screening. Binary
logistic regression results showed that advanced age (p = 0.017), having secondary or
cancer (p = 0.002) were more likely to practice prostate cancer screening. (Sakala Gift,
2020).
The study revealed low knowledge of prostate cancer, low prostate cancer screening
practice and positive attitudes of men towards prostate cancer screening. “These
cancer and its screening tests to improve public understanding about the disease with
9
1.5 OBJECTIVES
To assess knowledge, attitude and practice about risk factors, screening and treatment
of prostate cancer among adult male patients attending urology clinic at Ndola
1. To determine the knowledge about risk factors, screening and treatment of prostate
cancer
3. To determine the practice of risk factors, prostate cancer screening and treatment
screening and treatment? What are some of the perceptions about prostate cancer
screening? What are some of the practices among participants to prostate cancer
10
1.7 MEASUREMENT
STUDY
Prostate cancer screening – Tests used to detect prostate cancer. It can be PSA or
DRE
chemotherapy etc.
11
1.7.2 MEASUREMENT SCALE
12
Independent Religion Nominal
EXTRANEOUS VARIABLES
Race
Genetic factors
Income
INTERVENING VARIABLES
Extent of sensitization
from media, doctors and
public health services.
INDEPENDENT VARIABLE
DEPENDENT VARIABLE
Age
Education level Knowledge
Cultural group Attitude
Religion Practice
13
Fig 1.0. Schematic of a conceptual framework
CHAPTER TWO
2.0 METHODOLOGY
Study site
NTH in Ndola, Copperbelt province of Zambia. NTH also called Ndola Central Hospital
has a bed capacity of 851 beds and 97 baby cots. It is the second-largest health institution
Target population
This study focuses on male patients older than the age of 40 attending urology clinics at
NTH. The population is a choice for this study because one of the major risk factors of
prostate cancer is an older age and symptoms present mostly as urinary problems.
Study design
Sample size
The sample size will be ascertained using the ‘Statcalc’ function of Epi Info Version 7.
The following formula will be used to determine the required sample size using the
14
n (sample size)= Z21-a/2 P(1-P
e2
INDICATORS INFORMATION
(0.05)
15
Sampling procedure
The sampling procedure which will be employed in this study is the Simple Random
Sampling (SRS) probability sampling. This sampling technique is easy to use, and
cost-effective and also the level of accuracy will be increased. In addition, with this
Inclusion criteria
Exclusion criteria
study participants.
16
In the urology clinic, the objectives of the study will be explained to the
patients and then, written informed consent will be acquired from male patients
The questionnaire which will cover aspects of knowledge, attitude and practice
in “Appendix 3.0”.
The questionnaire will cover aspects of knowledge, attitude and practice about
It will also collect data on family history of cancer, age and level of education.
Data collected during the study will be checked for completeness and double-entered
into the Epi Info version 7 software. Frequency tables and graphs will be generated for
relevant variables (Gift et al, 2020). The data will be analyzed using Statistical
Data will be analyzed using Statistical Package for Social Sciences (SPSS) version 23.
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2.3 Ethical consideration
will be assured that confidentiality will not be breached and that the data obtained in
the study will not be used for any other purpose besides that specified in the study
protocol. Informed and written consent will be obtained from participants. During data
will be collected. They will be treated with the utmost respect and dignity and their
The generalizability of the findings of this study must be done with caution since this
will be a hospital-based study. There is thus a need for more studies to be done in
other institutions such as universities and colleges, urban and rural communities,
knowledge. In addition, certain aspects of knowledge are not assessed, for example,
that prostate cancer can present without symptoms. As such, the study findings were
limited to comparisons with studies that also did not assess the asymptomatic
18
References
ACS, A. C. S. 2014. Evolution of Cancer Treatments: Chemotherapy [Online].
Available: https://www.cancer.org/cancer/cancer-basics/history-of-cancer/cancer-
treatmentchemo.html [Accessed 01 May 2017].
Nwagwu SAJ, Ibebuike JE, Nwokike GI. Knowledge and attitude of men (50 years
and above) about prostate cancer in Umugolo, Ehime Mbano L.G.A
Imo state. Nurse Care Open Acces J.2020; 7 (2):39‒43. DOI:
10.15406/ncoaj.2020.07.00215
American Cancer Society. Facts and Figures 2021. American Cancer Society. Atlanta,
Ga. 2021
https://eu.europa.eu/jrc/en/knowledge/reference
Blandy J, Kaisary A (2009) Lecture notes urology, 6th ed. Wiley, Hoboken Shenoy
KR, Shenoy A (2019) Manipal manual of surgery, 4th ed. CBS Publishers Pvt Ltd.,
Shenoy Nagar
American Cancer Society (2019) Cancer facts and figures, 2019. American
Cancer Society, Atlanta
19
Awosan KJ, Yunusa EU, Agwu NP, Taofq S (2018) Knowledge of Prostate Cancer
and screening practices among men in Sokoto, Nigeria. Asian J Med Sci 9(6):51–56
Ito K (2014) Prostate cancer in Asian men. Nat Rev Urol 11:197Bontshwanetse
Baaitse (2018) Knowledge, attitude and practices of men towards prostate cancer in
Muldersdrift, South Africa.
20
Makado E, Makado RK, Rusere MT (2015) An assessment of knowledge of and attitudes
towards prostate cancer screening among men aged 40 to 60 years at Chitungwiza Central
Hospital in Zimbabwe. Int J Humanit Soc Stud 3(4):45–55
Adibe MO, Oyine DA, Abdulmuminu I, Chibueze A (2017) Knowledge, attitudes and
perceptions of prostate cancer among male staff of the University of Nigeria. Asian Pac J
Cancer Prev 18(7):1961–1966
Ebuechi OM, Otumu IU (2011) Prostate screening practices among male staff of the
University of Lagos, Lagos, Nigeria. Afr J Urol 17(4):122–134
APPENDIX
1.0 Budget
Pens/ pencils 3 5 15
Report
questionnaire/
Consent
21
TOTAL 2,530
factors, screening and treatment of prostate cancer among male patients attending
INTRODUCTION
BRIEF DESCRIPTION
22
This study is aimed at determining the knowledge, attitude and practice about the risk
factors, screening and treatment of prostate cancer among male patients attending
urology clinic at Ndola Teaching Hospital (NTH). The study also aims at highlighting
You are therefore asked to take part in a research study to determine the knowledge,
attitude and practice towards prostate cancer screening and treatment. The research
has been approved by the Copperbelt University School of Medicine as well as the
school administration.
In this study, you will be asked to respond to the questions in the questionnaire
TIME COMMITMENT
CONFIDENTIALITY/ ANONYMITY
The data collected will be treated with confidentiality and will not be used for any
other purpose other than those specified in the objectives. No one will link the data
PARTICIPANT’S RIGHTS
You may decide to stop being a part of the research study at any time without
explanation. You have the right to ask that any data you have supplied to that point be
23
withdrawn or destroyed. You also have the right to omit or refuse to answer or
respond to any question that is asked of you as appropriate and without penalty. You
have the right to have your questions about the procedures answered (unless
answering these questions would interfere with the study’s outcome). If you have any
questions as a result of reading this information sheet, you should ask the researcher
There are no known risks for you in this study. Beneficial privileges of the study
include being enlightened about prostate cancer screening, risk factors and treatment.
Your participation in this study is voluntary. No credit will be given in return for your
participation.
If you have any concerns, I will be glad to answer your questions about this study at
Or contact me on +260967250856. If you want to find out about the final results of
this study, you should contact the HOD for Public Health Unity, CBU-SOM.
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2.0 RESPONDENT’S CONSENT FORM
CONSENT FORM
terms and conditions of this study and I hereby agree to participate in the above-
25
Signature of Research Participant: ………………………….…………….
Date……………….......
Date……………….
Date……………….
3.0 QUESTIONNAIRE
screening, risk factors and treatment among male patients attending urology clinic at
NAME OF INTERVIEWER: . . . . . . . . . . . . . . . . . . . . . . . .
DATE: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
1. Age: …………..…years
26
4. Educational level: Primary [] Secondary [] Tertiary []
No formal education []
(Please specify)
If Yes
If Yes,
Section C: Knowledge
If Yes,
i) Where did you hear it from Friends [] Read about it [] TV [] Radio [] Doctor []
Nurse [] Relative []
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iii) Which of the following factors could make a person more likely to develop
If yes,
a) How can it be prevented? Genital hygiene [] regular screening [] condom use [] use
12. Do you know any method of prostate cancer treatment? Yes [] No [] I don’t know
[]
16. Prostate cancer screening has side effects that can cause harmful effects to the
body Yes [] No []
17. Do think any diagnosis will lead to early treatment and survival? Yes [] No [] I
don’t know []
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Section D: practice
12. Have you been screened for prostate cancer within the last two years? Yes [] No []
If yes,
Negative []
13. Do you have any intention of getting screened shortly? Yes [] No [] I don’t know
[]
Thank you.
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2.4 ACTION PLAN
Present draft to
supervisor
Ethical approval
Data collection
Data entry
Data analysis
Report writing
Submission of report
30