You are on page 1of 20

This eGuide is Part 1 of 3 The Ultimate Cancer

Prevention and Treatment Companion

PART 1

7 Ways to Stay Ahead


of the Cancer Curve:
Surprisingly Effective Strategies to
Reduce Your Cancer Risk
Isaac Eliaz, MD
Isaac Eliaz, MD, MS, LAc, is a pioneer in the field of integrative cancer
therapy with 30+ years of experience as a physician and researcher.
As an internationally recognized expert in the treatment of cancer and
other complex diseases, Dr. Eliaz embraces a whole-person approach
to healing, which blends his extensive training in Western medicine
and translational research, with traditional Asian medicine, Ayurveda,
and other complementary modalities. He also partners with some of
the nation’s leading research institutes, including Harvard and
Columbia University, to study and substantiate breakthrough
approaches to cancer and complex conditions.

“There are many different therapeutic


approaches when it comes to treating cancer,
and despite what we have been told, we are
never stuck with just one treatment method.
Cancer is a dynamic condition that changes
over time; therefore, we always have to adjust
and change treatments or try something
new.“ — Isaac Eliaz, MD, MS, LAc

This eGuide is Part 1 of 3 The Ultimate Cancer


Prevention and Treatment Companion

This information is for educational purposes only. All medical and treatment
decisions should be made with the guidance of your personal healthcare provider.
C
ancer — it’s only six letters long, but this little word carries with it such
enormous weight, instantly triggering feelings of fear and hopelessness.
It doesn’t help that we are continually bombarded with reminders of it,
from incessant commercials and online ads for cancer drugs to dire news
reports of rising cancer rates.

We’ve all heard the standard advice for preventing cancer — don’t smoke, maintain a
healthy weight, exercise, eat plenty of fresh vegetables, avoid fast food, practice safe
sex, and the list goes on.

There is no question that these and other lifestyle factors matter when it comes to your
cancer risk. In fact, according to a recent study in the prestigious journal The Lancet,
nearly 50% of all cancers worldwide are attributable to behavior — meaning lifestyle
factors that can be modified. Other sources put that number as high as 90%.

Even still, 89% of people polled believe genetics are the primary driver of cancer. Less
than half of those surveyed think lifestyle habits influence the risk of developing some
form of cancer. 1

That’s a lot of people who feel they have no control when it comes to cancer
prevention — and this just is not true. Many cases of cancer can be prevented.

What Does Cancer Prevention Really Mean?

We all know people who live exemplary lives when it


comes to health and yet they still get cancer. Why does
this happen? Cancer is a complicated, multi-faceted
disease that involves numerous factors beyond obvious
lifestyle choices.

In this eGuide, I’d like to introduce you to some


lesser-known prevention strategies that can help you
stay ahead of the cancer curve — and thrive.

While there is no foolproof way to guarantee a cancer-


free life, the following suggestions will cut your risk. It’s
possible to uncover your greatest healing potential and
start to map your own unique healing journey. Forging
your own path to healing is a series of choices.
Take that first step now.

To your life-long health,


Isaac Eliaz, MD, MS, LAc
01 Get Rid of Environmental + Agricultural Toxins
Do not skip this crucial step!

It’s no secret that we are living in a toxic world. No matter who you are or where you live,
you are going to encounter toxins in the food you eat, the air you breathe, and the
water you drink.

From the ubiquitous weed killer glyphosate to microplastics to heavy metals,


mycotoxins from mold, and much more, toxin exposure is inescapable. And these toxins
damage our health in multiple ways, including scrambling our DNA, wreaking havoc in
our microbiome, compromising the body’s detox functions, overtaxing the liver, and
throwing our immune systems out of balance. The human body simply did not evolve
to handle the endless barrage of chemicals on the planet today. So, supporting your
body’s detox pathways with gentle cleansing ingredients is essential.

One of the most important strategies is gentle detoxification to help remove pervasive
toxins — like cancer-causing glyphosate and other pesticides — and prevent them
from accumulating in tissues.

In my practice, I recommend a targeted pesticide detox formula that includes the


following natural binders and detox agents to help kick out glyphosate and other
pesticides — along with a wide range of other environmental toxins:

Algimate Modified A modified polysaccharide fiber derived from brown kelp.


Alginate Complex It works in the GI tract to help prevent pesticide accumulation
while also binding and eliminating other toxins and heavy
metals.

Glycine The pesticide glyphosate mimics glycine, so your body stores


glyphosate mistakenly. Taking glycine, an essential amino acid,
helps counteract this problem. Glycine also supports
production of glutathione — your body’s master detox
antioxidant.

Organic Rich in essential minerals such as iodine, this whole kelp


Icelandic Kelp powder helps prevent toxins and radioactive ions from being
absorbed into the thyroid gland.

Fulvic Acid A mineral-rich humic acid substance that provides broad-


spectrum detoxification, immune, and gut health benefits.

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 01
Addressing Carcinogenic Mycotoxins

The above-mentioned pesticide detox formula featuring fulvic acid and


other superior binders is also used to help remove mycotoxins from the body
while helping to restore gut-wall integrity and reverse leaky gut. Since
mycotoxins are considered carcinogenic and linked with cancer
development, along with many other health problems, it’s crucial to address
2
these damaging toxins with gentle yet effective natural approaches.

03 Remove Heavy Metal Accumulation with this


“Super Nutrient”

For advanced, safe chelation and detoxification, I recommend clinically proven


Modified Citrus Pectin (MCP). Extracted from the pith of certain citrus fruits, MCP is a
potent toxic metal binder, proven to remove heavy metals such as lead, mercury, and
arsenic from the body without depleting essential minerals. It also has clinically
documented anti-cancer benefits, which I’ll discuss later.

Why MCP versus regular citrus pectin? MCP is a special form of citrus pectin — a
“super nutrient” of sorts — that has been modified to a smaller size molecule, which
allows it to absorb into your bloodstream, bind to heavy metals and toxins, and gently
remove them. Importantly, the researched form of MCP is one of the most gentle yet
effective binders that can work wonders for people who are sensitive to other, harsher
detox binders. And thanks to its wealth of additional benefits that I’ll expand on shortly,
MCP acts as much more than just a binder — helping to remove toxins AND repair the
damage they’ve done to cells, tissues, and organ systems — including the immune
system. 3

Another gentle binder is alginate from seaweed. In addition to using for pesticide detox,
alginates also pair especially well with MCP. Together, MCP and alginates form a
powerful yet gentle combination that is clinically proven to remove toxic metals and
radioactive elements from the body while preventing the reabsorption of toxins — a big
problem in many other detox programs. 4

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 02
03 Boost Your Detox and Immune Defenses
with Antioxidants

Replenishing antioxidants is key during detoxification. Many toxins generate oxidative


stress, which can damage cells down to their DNA, while depleting critical antioxidants
in your body. Supplementing with added antioxidant nutrients and compounds can
help counteract this damage. Brightly colored fruits and vegetables offer good
antioxidant support. Antioxidants are also important for healthy immune function.

Medicinal mushrooms, as well as aromatic spices and culinary botanicals, are also
excellent sources of antioxidants. Other key antioxidants include vitamin C, alpha lipoic
acid, and Honokiol, an extract of the magnolia tree that offers an extensive array of
other benefits, including powerful anti-cancer actions.

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 03
Unlock the Secret of Antioxidant-Rich Spices

Certain spices are supercharged with potent phytochemicals known to help inhibit
cancer. Here are the top five — work into your meals, drinks, smoothies, and snacks as
much as possible.

Allspice Not a combination of spices but a single spice from the dried
berries of a South American tree, allspice is rich in phytochemicals,
phenolic acid, and flavonoids; some research shows that
concentrated amounts of allspice help curb cancer growth.5

Cinnamon It’s the active ingredient cinnamaldehyde that gives this sweet
and savory spice its anticancer powers, including against bladder
cancer and blood cancers such as myeloma and lymphoma;
other research has shown that cinnamon helps balance blood
sugar — a surefire way to slash your cancer risk since cancer
feeds on sugar. 6,7

Garlic Eating large amounts of garlic has been linked to a lower risk of
colorectal cancer in studies; researchers theorize that garlic’s
high sulfur content explains part of its benefits. 8

Ginger Gingerol, the active compound in ginger, is packed with


antioxidant and anti-inflammatory properties that are
activated when heated or dried. Several studies highlight
the herb’s cancer-protective properties, including lung and
colon cancers. 9

Turmeric Numerous anti-cancer properties have been identified in this


brightly colored spice, which plays a starring role in Indian and
Southeast Asian cuisine; in lab studies, curcumin (the active
ingredient in turmeric) exhibited chemo-preventive effects. 10

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 04
04 Pay Attention to Your Oral Health

Do your gums bleed when you brush or floss? Do they look red or puffy? Are you
concerned about loose teeth? If you answered yes to any of those questions, you’re one
of the millions of people suffering from at least some degree of gum disease.

Dental health connects to your whole-body health. If your teeth or gums are in bad
shape, you’re much more likely to have other conditions or illnesses. The issues start
with the buildup of harmful bacteria in the mouth, which then trigger inflammation, eat
away at gum tissue, and break down bone tissue (the latter two hold your teeth in
place).

Chronic dental health problems lead to chronic inflammation in your body. That gets
compounded when a pro-cancer alarm protein called galectin-3 gets activated.
Galectin-3 keeps the inflammation cascade going and makes you much more
vulnerable to all kinds of infectious and chronic diseases — especially cancer.

As unbelievable as it sounds, problems in your mouth can lead to the most dreaded
diseases — even premature death. And there are stacks upon stacks of research
11,12
proving that connection.

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 05
Scientific studies show clear links between poor dental health and higher risk
of the following diseases:

Cancer, especially breast cancer Diabetes


Heart attack and stroke Autoimmune diseases
Osteoporosis and bone loss Lung diseases, including
Alzheimer’s disease and cognitive decline pneumonia and COPD
Rheumatoid arthritis Premature death

Honokiol, the compound mentioned above that is extracted from magnolia bark,
delivers strong antimicrobial and anti-inflammatory action — exactly what you need
when you’re working to improve your dental health. In fact, a new study concludes that
13
honokiol has the potential to “cure or fight oral diseases.”

This powerful natural plant Actinobacillus actinomycetemcomitans


extract — honokiol— Porphyromonas gingivalis
successfully helps fight the Prevotella intermedia
bacteria that cause gum Micrococcus luteus
disease, including:
Streptococcus mutans

In addition to honokiol, there is a time-honored herbal remedy based on a traditional


“cooling” Tibetan formula, which has been studied through decades of clinical
research. The 19 botanical ingredients in this formula work together through the
principles of Tibetan medicine to combat heat in the body and revitalize circulation.

Those properties allow this Calm painful inflammation


natural formula to: Reduce damaging oxidative stress
Boost immune function
Fight infectious microbes
Support healthy blood flow

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 06
All those actions can help significantly improve dental health — and that includes helping
you avoid dreaded root canals. A clinical study found that this Tibetan formula effectively
treated toothaches caused by chronic dental pulpitis, where the pulp of the tooth
becomes inflamed and painful.

The Tibetan herbal formula 55% of patients were pain-free within 1 month
worked so well that: 81% became pain-free in 2 to 3 months
24% remained free of dental pain for more than 3 years

Best of all, those patients were able to avoid root canals and tooth extractions after using
this classical Tibetan formula. 14

05 Address Your Stress

We all struggle with stress. But long-term stress adds an


enormous strain on your body and overall health. It takes the
biggest toll on your immune system. And when you’re already
feeling anxious and worried, the last thing you need is a
stressed-out immune system. Stress sets you up for long-term
health conditions that develop over time — including cancer. 15
Here are some proven ways to de-stress:

Meditation

The direct mind-body connection is something that Eastern philosophies have taught for
millennia, and recent research has supplied us with a revealing new technical perspective.
Clinical studies show that chronic stress may have a profound effect on our DNA by shortening
our DNA telomeres. Telomere deterioration puts us at a higher risk of developing cancer and
other harmful conditions. The good news: There’s an ancient and well-known mind-body
practice that is now proving successful in physically repairing this telomere DNA damage while
restoring peace of mind at the same time. What is this practice? Simple meditation. 16

If you’ve never tried meditation before, you might feel like you’re doing it wrong — but there is
no wrong here. There are many different methods and techniques, so keep trying until you find
a practice you feel good about. As you practice meditation over time, you’ll notice how much
clearer and calmer your mind and emotions become. That helps your body better adapt to
rapidly changing situations and helps block unhealthy stress responses more easily.

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 07
Time in Nature
Spending time outdoors in nature helps your body and mind
relax. Go for a walk in the woods, dip your feet in the ocean, or
relax on a hammock in your backyard. Taking even ten minutes
in nature can lift your mood and reduce your stress level.

Yoga and Mind-Body Exercises


Practicing yoga promotes relaxation for your mind and body. Yoga
involves more than stretching your muscles. It involves focused,
mindful breathing and spiritual engagement. Regular yoga practice
helps regulate your nervous system and reduces the harmful effects
of stress. Qi Gong is another powerful yet gentle mind-body exercise
that helps to increase the body’s vital healing energy, or Qi. Research
shows that regular Qi Gong can be a beneficial practice for
immunity and cancer prevention. 17,18

Practice forgiveness
A recent study revealed that the simple act of forgiving someone can
have a profound effect on your overall health.19 Similarly, practicing
gratitude is one of the most powerful tools for unleashing our bodies’
infinite healing ability and achieving optimal health — and this is true
regardless of where you are on the wellness spectrum. Recent studies
show that practicing gratitude can improve inflammatory markers
and other risks.20 Gratitude can open the door for healing on every
level: physical, mental, emotional, and psycho-spiritual.

Find your purpose


Having a sense of purpose can help fight off loneliness, according to a
new study in the journal Psychology and Aging. Researchers found that
people who reported living a purpose-driven life were less likely to feel
lonely. And the less lonely you feel, the healthier and less stressed you are.
Purpose can mean different things to different people, but it might
include making a difference in your community, gardening, supporting
your family, or feeling successful at work.20

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 08
06 Clean Up Your Personal Care Products
You might not think about it, but the beauty and personal care products you put on your body
can be absorbed into your body — and unfortunately, many popular products contain
chemicals linked to cancer and other health problems. According to the Campaign for Safe
Cosmetics, some of the worst offenders are:

Aluminum Primarily found in deodorants, this heavy metal has been seen to build up
in breast tissue, and aluminum is believed to cause gene toxicity by
altering DNA.

Carbon Black This dark powder adds color to cosmetics such as mascara and eyeliners;
it can contain coal tar and other carbon-based products, which are
associated with higher cancer risk.

Formaldehyde This toxic chemical is known to have cancer-causing properties. You will
find it in nail products (polish remover and nail hardeners), as well as
certain hair products, makeup, and body washes.

Glycerol Used in a variety of cosmetic and personal care products, glycerol propylene
Propylene glycol is closely related to car antifreeze; this chemical causes dermatitis,
Glycol dry skin, rashes, kidney and liver issues and cell membrane damage.

Mineral Oil You'll find this ingredient in many hand and body lotions; while mineral oil is
considered safe by some when applied topically, it is still a highly
processed petroleum product, and petroleum can contain impurities that
may increase cancer risk.

Nitrosamines Cocamide DEA, a foaming agent often added to shampoos, reacts with
nitrosating agents to form nitroso diethanolamine (NDEA), a potent
carcinogen that can penetrate skin. As a result, some manufacturers test
their finished products for nitrosamines. Studies have found nitrosamines in
more than half of all body care products.

Parabens These cosmetic preservatives are used to eliminate bacteria and fungi;
they have been linked to increased estrogen levels, which can lead to
hormonal disorders and even cancer.

Phthalates These chemicals are known endocrine disruptors, associated with


developmental and reproductive toxicity and cancer; phthalates are
banned in the European Union, but are still used in many products in the U.S.

Quaternium-15 This ingredient, found in hair care products, is known to release


formaldehyde; it’s a skin, eye, and respiratory irritant, and it has also been
linked to cancer, specifically leukemia.

Talc This proven carcinogen is present in many baby powders and cosmetics,
including body powders and powder foundations — read labels carefully
(may also be listed as talcum).

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 09
07 Consider Your Epigenetic Tendencies

A growing field in the study of cancer is cancer epigenetics. The field of epigenetics
investigates certain genetic tendencies we inherit from previous generations — as well
as from direct environmental influences — due to lifestyle, dietary, and environmental
factors. These factors — such as unhealthy diet, profound emotional stress, toxin
exposure, or erratic sleep habits — affect gene expression and can increase cancer risks
and aggressiveness. But crucially, such tendencies can be reversed.

Researchers studying epigenetics are making groundbreaking discoveries, showing how


we can “hack our DNA” with targeted foods, botanicals, therapies, and other stimuli to
turn on health-promoting genes and turn off disease-promoting ones. Immune health is
one area where epigenetics can give us a quantum edge. Revolutionary findings in this
field are showing how simple it can be to activate genes for optimal immunity:

One study from the Linus Pauling Institute showed that


two plant-based compounds — resveratrol from red
grapes, and pterostilbene from blueberries — worked
with vitamin D3 to increase the expression of a gene
known as “CAMP”. The CAMP gene plays a major role
in human immune function, helping to support
immunity against bacteria, viruses, and even cancer. 21

Other research found that curcumin, the bright yellow


active ingredient from turmeric root, also influences
the CAMP gene to increase immune function. 22

Another study says that eating green vegetables can


have a significant impact on immunity — especially at
the genetic level. The study showed that green
vegetables like broccoli activate a gene called T-bet.
This gene boosts immune cells that protect the
digestive tract from harmful invaders. 23

One study showed that the mushroom Phellinus


linteus influenced anti-cancer genes to enhance the
body’s ability to control abnormal cell growth.24

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 10
Avoid the Top Cancer-Promoting Foods

Research has linked the following foods and ingredients to an increased risk of
cancer: 25

Processed meats: This includes any that have been cured, smoked, salted,
canned, or dried
Red Meat

Super hot drinks: One study linked hot tea consumption (140 degrees or higher)
to esophageal cancer, caused by thermal damage to the cells of the esophagus

Dairy: One study showed high dairy consumption increased prostate cancer risk

Sugar, particularly refined, highly processed forms

Refined carbohydrates

Alcohol

Saturated fats

Artificial sweeteners (sucralose, saccharin, aspartame)

Microwave popcorn: The bags are lined with perfluorinated compounds (PFCs),
which can break down and turn carcinogenic, according to some researchers

Food dyes: Red No. 3, Red No. 40, Yellow No. 5, and Yellow No. 6 are known to
contain carcinogens that cause cancer in lab animals.

Conclusion
Cancer does not have to be a part of your future — no matter what genetic
tendencies or health issues you have. Empower yourself by creating a cancer
prevention plan, focusing on removing toxins, supplementing with advanced,
multi-targeted nutrients, integrating mind-body therapies into your daily life,
and utilizing other powerful strategies backed by science and clinical success.

7 Ways to Stay Ahead of the Cancer Curve | Isaac Eliaz, MD, MS, LAc 11
Amitabha Medical Clinic & Healing Center

A preeminent medical facility specializing in highly individualized treatment protocols,


Amitabha Clinic (pronounced ah-mee-TAH-bah) is located in the heart of Sonoma County
and surrounded by the abundant natural beauty of Northern California.

Since 2001, the driving mission of Amitabha Clinic is to provide comprehensive and
compassionate care for life’s most pressing and difficult health challenges — while also
empowering people on their journey to life-long health and vitality.

Amitabha Clinic is an internationally recognized leader in integrative cancer treatment and


prevention, as well as the treatment of other chronic conditions. Every patient receives an
expertly tailored plan that combines cutting-edge advancements in modern medicine
with the power and wisdom of traditional healing systems.

This synergistic model encourages clinical results that are simply unparalleled — the focus
is always on building health with a true holistic approach, while fighting disease using
research-based therapeutics. Contact amitabhaclinic.com to learn more.

Learn more DrEliaz.org

Portions of this eGuide have been excerpted from The Survival Paradox: Reversing the
Hidden Cause of Aging and Chronic Disease by Isaac Eliaz, MD.

Post-Treatment Prevention and Long-Term Health | Isaac Eliaz, MD, MS, LAc 09
Sources
1. GBD 2019 Cancer Risk Factors Collaborators. The global burden of cancer attributable to risk factors, 2010-

19: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2022 Aug 20;400(10352):563-

591.

2. Xue KS, Tang L, Sun G, et al. Mycotoxin exposure is associated with increased risk of esophageal

squamous cell carcinoma in Huaian area, China. BMC Cancer. 2019 Dec 16;19(1):1218.

3. Eliaz I, Raz A. Pleiotropic Effects of Modified Citrus Pectin. Nutrients. 2019 Nov 1;11(11):2619.

4. Eliaz I, Weil E, Wilk B. Integrative medicine and the role of modified citrus pectin/alginates in heavy metal

chelation and detoxification--five case reports. Forsch Komplementmed. 2007 Dec;14(6):358-64.

5. Gao J, Mamouni K, Kallifatidis G, et al. Abstract 5069: Breast cancer prevention by triterpenoids from

allspice. Cancer Res 1 July 2019; 79 (13_Supplement): 5069.

6. Aminzadeh, Z.; Ziamajidi, N.; Abbasalipourkabir, R. Anticancer Effects of Cinnamaldehyde Through

Inhibition of ErbB2/HSF1/LDHA Pathway in 5637 Cell Line of Bladder Cancer. Anticancer Agents Med. Chem.

2022; 22:1139–1148.

7. Khan, R., Sharma, M., Kumar, L., et al. Cinnamon extract exhibits potent anti-proliferative activity by

modulating angiogenesis and cyclooxygenase in myeloma cells. J. Herb. Med. 2016; 6:149–156.

8. Zhou X, Qian H, Zhang D, Zeng L. Garlic intake and the risk of colorectal cancer: A meta-analysis. Medicine

(Baltimore). 2020 Jan;99(1):e18575.

9. Tuntiwechapikul W, Taka T, Songsomboon C, et al. Ginger extract inhibits human telomerase reverse

transcriptase and c-Myc expression in A549 lung cancer cells. J Med Food. Dec 2010;13(6):1347-1354

10. Giordano A, Tommonaro G. Curcumin and Cancer. Nutrients. 2019 Oct 5;11(10):2376.

11. Kane SF. The effects of oral health on systemic health. Gen Dent. 2017 Nov-Dec;65(6):30-34.

12. Güven DC, Dizdar Ö, Akman AC, Berker E, Yekedüz E, Ceylan F, Başpınar B, Akbıyık İ, Aktaş BY, Yüce D, Erman
M, Hayran M. Evaluation of cancer risk in patients with periodontal diseases. Turk J Med Sci. 2019 Jun

18;49(3):826-831.

Sources | Isaac Eliaz, MD, MS, LAc 10


13. Chiu KC, Shih YH, Wang TH, et al.In vitro antimicrobial and anti pro-inflammatory potential of honokiol and
magnolol against oral pathogens and macrophages. J Formos Med Assoc. 2021 Feb;120(2):827-837

14. Füllemann F. Padma 28 in der Behandlung von chronischen Zahnpulpitiden: Eine Praxisbeobachtung an
49 Fällen [Padma 28 in the treatment of chronic dental pulpitis: an observational case study in 49
patients]. Forsch Komplementmed. 2006 Feb;13 Suppl 1:28-30. German

15. Moreno-Smith M, et al. Impact of stress on cancer metastasis. Future Oncol. 2010 Dec;6(12):1863-81.

16. Black DS, Slavich GM. Mindfulness meditation and the immune system: a systematic review of
randomized controlled trials. Ann N Y Acad Sci. 2016;1373(1):13-24.

17. Klein P. Qigong in Cancer Care: Theory, Evidence-Base, and Practice. Medicines (Basel). 2017 Jan 12;4(1):2.

18. Oh B, et al. Impact of medical Qigong on quality of life, fatigue, mood and inflammation in cancer
patients: a randomized controlled trial. Ann Oncol. 2010 Mar;21(3):608-14.

19. Ho MY, Worthington E, Cowden R, et al.International REACH Forgiveness Intervention: A Multi-Site


Randomized Controlled Trial. REACH. doi:10.31219/osf.io/8qzgw.

20. Redwine LS, Henry BL, Pung M, et al. Pilot Randomized Study of a Gratitude Journaling Intervention on Heart
Rate Variability and Inflammatory Biomarkers in Patients With Stage B Heart Failure. Psychosomatic
Medicine. 2016 78(6):667-676.

21. Guo C, Sinnott B, Niu B, et al. Synergistic induction of human cathelicidin antimicrobial peptide gene
expression by vitamin D and stilbenoids. Mol Nutr Food Res. 2014 Mar;58(3):528-536.

22. Guo C, Rosoha E, Lowry MB, et al. Curcumin induces human cathelicidin antimicrobial peptide gene
expression through a vitamin D receptor-independent pathway. J Nutr Biochem. 2013 May;24(5):754-9.

23. Lucille C Randkin, Joanna R Groom, Michael Chopin, et al. The transcription factor T-bet is essential for the
development of NKp46+ innate lymphocytes via the Notch pathway. Nature Immunology. Mar 2013;
14:389-395.

24. Hu X, Ganesan K, Khan H, et al. Critical Reviews on Anti-Cancer Effects of Edible and Medicinal Mushroom
Phellinus linteus and Its Molecular Mechanisms. Food Reviews International. 2023.

Sources | Isaac Eliaz, MD, MS, LAc 11


25. Wiseman, M. (2019). Nutrition and cancer: Prevention and survival. British Journal of Nutrition. 122(5), 481-
487.

26. Zheng Y, Wang N, Wang S, et al. Chronic psychological stress promotes breast cancer pre-metastatic
niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling. J Exp Clin Cancer Res. 2023 May
20;42(1):129.

27. Moreno-Smith M, et al. Impact of stress on cancer metastasis. Future Oncol. 2010 Dec;6(12):1863-81. doi:
10.2217/fon.10.142.

28. Jacobs TL, et al. Intensive meditation training, immune cell telomerase activity, and psychological
mediators. Psychoneuroendocrinology. 2011 Jun;36(5):664-81

29. Qu S, et al. Rapid gene expression changes in peripheral blood lymphocytes upon practice of a
comprehensive yoga program. PLoS One. 2013 Apr 17;8(4):e61910.

30. O’Donovan A, et al. Pessimism Correlates With Leukocyte Telomere Shortness and Elevated Interleukin-6
in Post-Menopausal Women. Brain Behav Immun. 2009 May; 23(4): 446–449.

31. Dong R, Zhang M, Hu Q, et al. Galectin-3 as a novel biomarker for disease diagnosis and a target for
therapy (Review). Int J Mol Med. 2018 Feb;41(2):599-614.

32. Ruvolo PP. Galectin 3 as a guardian of the tumor microenvironment. Biochim Biophys Acta. 2016
Mar;1863(3):427-437.

33. Dal Lin C, Marinova M, Rubino G, et al.Thoughts modulate the expression of inflammatory genes and may
improve the coronary blood flow in patients after myocardial infarction. J Tradit Complement Med. 2017
May 29;8(1):150-163.

34. Ong CP, Lee WL, Tang YQ, Yap WH. Honokiol: A Review of Its Anticancer Potential and Mechanisms. Cancers
(Basel). 2019 Dec 22;12(1):48.

35. Tian W, Deng Y, Li L, et al. Honokiol synergizes chemotherapy drugs in multidrug-resistant breast cancer
cells via enhanced apoptosis and additional programmed necrotic death. Int J Oncol. 2013 Feb;42(2):721-
32.

36. Hossein G, Keshavarz M, Ahmadi S, et al. Synergistic effects of modified citrus pectin an inhibitor of
Galectin-3 and paclitaxel on apoptosis of human SKOV-3 ovarian cancer cells. Asian Pac J Cancer Prev.
2013;14(12):7561-8.

Sources | Isaac Eliaz, MD, MS, LAc 12


37. Ahn WS, Kim DJ, Chae GT, et al.Natural killer cell activity and quality of life were improved by consumption
of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing
chemotherapy. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94.

38. Tehranian N, Sepehri H, Mehdipour P, et al. Combination effect of and Doxorubicin on viability, cell cycle
arrest and apoptosis in DU-145 and LNCaP prostate cancer cell lines. Cell Biol Int. 2012 Jul;36(7):601-10.

39. Keizman D,. Frenkel MA, Peer A, et al. P-MCP treatment in non-metastatic biochemically relapsed prostate
cancer (BRPC-M0): Final long-term results of a prospective phase II study. Journal of Clinical Oncology
2023;41:(6_suppl): 162-162.

40. Alexander JL, Wilson ID, Teare J, et al. Gut microbiota modulation of chemotherapy efficacy and toxicity.
Nat Rev Gastroenterol Hepatol. 2017 Jun;14(6):356-365.

41. Farvid MS, Sidahmed E, Spence ND, et al. Consumption of red meat and processed meat and cancer
incidence: a systematic review and meta-analysis of prospective studies. Eur J Epidemiol. 2021
Sep;36(9):937-951.

42. Debras C, Chazelas E, Srour B, et al. Total and added sugar intakes, sugar types, and cancer risk: results
from the prospective NutriNet-Santé cohort. Am J Clin Nutr. 2020 Nov 11;112(5):1267-1279.

43. Michels N, Specht IO, Heitmann BL, Chajès V, Huybrechts I. Dietary trans-fatty acid intake in relation to
cancer risk: a systematic review and meta-analysis. Nutr Rev. 2021 Jun 4;79(7):758-776.

44. Aune D, Giovannucci E, Boffetta P, et al. Fruit and vegetable intake and the risk of cardiovascular disease,
total cancer and all-cause mortality-a systematic review and dose-response meta-analysis of
prospective studies. Int J Epidemiol. 2017 Jun 1;46(3):1029-1056.

45. Yerushalmi R, Bargil S, Ber Y, et al. 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on
breast density in healthy BRCA carriers. A prospective clinical trial. Carcinogenesis. 2020 Oct
15;41(10):1395-1401.

46. Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The Interplay between the Gut
Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of
Nutrition in Optimizing Treatment Strategies. Nutrients. 2021 Mar 9;13(3):886.

47. Byeongsang Oh, Frances Boyle, Nick Pavlakis, et al. Emerging Evidence of the Gut Microbiome in
Chemotherapy: A Clinical Review. Front Oncol. Sept. 2021; 11:706331.

Sources | Isaac Eliaz, MD, MS, LAc 13


48. Cerletti C, Esposito S, Iacoviello L. Edible Mushrooms and Beta-Glucans: Impact on Human Health.
Nutrients. 2021 Jun 25;13(7):2195.

49. Karaca B, Sürekçi A, Akata I, et al. Anti-Biofilm and Antimicrobial Activities of Five Edible and Medicinal
Macrofungi Samples on Some Biofilm Producing Multi-Drug Resistant Enterococcus Strains. Turkish
Journal of Agriculture - Food Science and Technology. 2020:8(1):69.

50. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and
Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634.

51. Davani-Davari D, Negahdaripour M, Karimzadeh I, et al. Prebiotics: Definition, Types, Sources, Mechanisms,
and Clinical Applications. Foods. 2019 8(3):92.

52. de Oliveira GLV, Leite AZ, Higuchi BS, Gonzaga MI, Mariano VS. Intestinal dysbiosis and probiotic
applications in autoimmune diseases. Immunology. 2017 152(1):1-12.

53. Dong L. Gut Microbiota and Immune Responses. Adv Exp Med Biol. 2020 1238:165-193.

54. Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the
normal gut microbiota. World J Gastroenterol. 2015 21(29):8787-8803.

55. Linares DM, Ross P, Stanton C. Beneficial Microbes: The pharmacy in the gut. Bioengineered. 2016 7(1):11-20.

56 Heng Xue, Rui Qiao, Laila Yan, et al. The Correlation Between Potential “Anti-Cancer” Trace Elements and
the Risk of Breast Cancer: A Case-Control Study in a Chinese Population. Frontiers in Oncology. Aug.
2021(11)

57 Eliaz, Isaac, MD. The Survival Paradox: Reversing the Hidden Cause of Aging and Chronic Disease.
Lioncrest Publishing, 2021.

Sources | Isaac Eliaz, MD, MS, LAc 13

You might also like