Clinicopathological correlation of cancer stem cell

Original Article

markers Oct-4 and CD133 expression as prognostic

factor in malignant lesions of gallbladder: An
immunohistochemical study
Naseem Fatima, Anand Narain Srivastava, Jaya Nigam1, Nishi Tandon, Rumana Ahmad2, Vijay Kumar3
Departments of Pathology and 2Biochemistry, Era’s Lucknow Medical College and Hospital, Departments of 1Surgical
Gastroenterology and 3Surgical Oncology, King George’s Medical University, Lucknow, Uttar Pradesh, India

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ABSTRACT Access this article online

Website: www.ijpmonline.org
Background: Gallbladder cancer (GBC) is the most frequent biliary tract PMID: xxxxxxxxx (when available)
DOI: 10.4103/IJPM.IJPM_134_19
and invasiveness. No reliable biomarkers are available for detection of GBC Quick Response Code:
progression. Aim: To investigate the immunohistochemical expression of

parameters. Settings and Design:

conducted in medical college background. Materials and Methods: A total
n
and nonneoplastic lesions (simple epithelial hyperplasia; n = 35 and chronic
cholecystitis; n

correlation between their expressions with clinicopathological parameters. and radiotherapy.[4] Convincing evidences
Statistical Analysis: report that gallbladder stones are found to
be strongly associated factor that causes
Results: inflammation, which is considered as
main carcinogenic mechanism for GBC
gallbladder (P
P P development, but their exact role as a
P P P cause for GBC is still not clear.[5]
P
P Detection of the cancer at an earlier stage
survival. Conclusion: can have a greater chance for surgical
may provide a new insight for the prognosis of the disease in terms of clinical
staging and grade.
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INTRODUCTION the new creations are licensed under the
identical terms.
In India, gallbladder cancer (GBC) is the third most common malignancy of biliary tract For reprints contact: reprints@medknow.com
as per the Indian Council of Medical Research registry of 2006--2008; it is ten times more
common in North India than in South Indian population.[1,2] GBC is a leading cause of cancer How to cite this article: Fatima N,
Srivastava AN, Nigam J, Tandon N, Ahmad R,
death in women. Most of the GBC cases are typically diagnosed at the advanced stages Kumar V. Clinicopathological correlation of
because of lack of clinical appearance, which are nonspecific and majority of cases are found cancer stem cell markers Oct-4 and CD133
expression as prognostic factor in malignant
incidentally at the time of histopathological examination for cholecystectomy.[3] GBC is lesions of gallbladder: An immunohistochemical
reported with high rate of recurrence and metastasis due to poor response to chemotherapy study. Indian J Pathol Microbiol 2019;62:384-90.

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