Practical 6

Questions for pharmacology practical class on 31-05-2023

Solve the problems :

How many milligrams of noradrenaline are in 2 ml of 1: 1000 solution?

How many mg of lignocaine are in a 10 ml ampoule of 2 % lignocaine ?
How many ml of a 1:10,000 solution would you need to obtain 1 mg of adrenaline?

The Unit head orders intravenous administration of 10 % (W/V) solution of mannitol

in a dose of 0.5 gm/kg body weight. How many milliliter of mannitol should be
administered to a patient weighing 60 Kg ?

If a physician orders a 25 mg test dose of sodium thiopental prior to anaesthesia,

how many milliliters of 2.5% (W/V) solution of sodium thiopental should be used?

A physician order calls for the I.V. administration of 0.005% concentration of

nitroglycerine in 300 ml dextrose saline, how many milliliters of 8 mg/ml
nitroglycerine should be added to obtain the final concentration ?

How many milliliters of purified water should be added to 25 ml of 1:500 solution of

Benzalkonium chloride to prepare a 1:5000 Benzalkonium solution for wet dressing
?

Calculate the amount of sodium chloride required to prepare 500 ml of normal

saline?

A physician order to add 5 ml of 25 % (W/V) solution of potassium iodide to 1000 ml

of D5W for parenteral infusion. What is the percentage strength of potassium iodide
in the infusion solution?

The dose of Gentamicin is 2.5 mg/kg administrated 12 hourly. What would be the
daily dose for the new born weighing 2.6 kg?

The daily dose of cefadroxil 50 mg/kg/day to be given at 12 hours interval. How

many teaspoons of reconstituted cefadroxil suspension containing 250 mg/5ml
should be administrated to a pediatric patient weighing 10 kg ?

A child weighing 20 kg is suffering from fever. Calculate the dose of paracetamol for
that child?
Calculate the iron required for a patient weighing 60 kg diagnosed as severe
anaemia with the Hb level 6gm/dl ?

On the basis of renal impairment a medication order calls to administer 40% of the
usual dose of Gentamicin in a patient weighing 60 kg, If the usual dose of
Gentamicin is 3mg/kg/day in three equally divided doses, how much should be
administrated per dose?

Calculate thedose of Metronidazole in a 5 year old boy having amoebic dysentery

using Dilling’s formula. [Adult dose=400mg]

A medication order calls of taxol 135mg/m2 for the management of metastatic

cancer. How much should be given to a patient weighing 48 kg and 150 cm tall ?

Calculate the daily dose of acyclovir in a 110kg male suffering from Herpes Simplex
Virus Encephalitis. [Adult dose=10mg/kg i.v every 8 hrs].

Calculate the dose of Paracetamol in an 8 year old girl having fever using Young’s
formula. [Adult dose=500mg]

Calculate the dose of an anticancer drug ‘X’ for a child having Body Surface Area
(BSA) of 0.82m2. [Adult dose = 10mg/day]

Prescribed : 600,000 units of penicillin po q6h.

Available : 400,000 units per scored tablet.
How many tablets will you administer?

How many tablets of (a) 125 mg chloroquine phosphate (b) 100mg chloroquine
phosphate should be prescribed for a total dose of 300 mg chloroquine base?
How many ml of syrup of the syrup chloroquine sulphate should be prescribed.?
250 mg chloroquine phosphate = 155 mg chloroquine base
200mg chloroquine phosphate = 150 mg chloroquine base
Syrup chloroquine phosphate 68mg/5ml (= chloroquine base 50mg/5ml)

21. A 40 year old lady weighing 50kg is suffering from acute urinary tract infection
and advised Gentamicin 5 mg/kg. She was having impaired renal functions and her
serum creatinine was found to be 1.8 mg/dl. Calculate the dose of Gentamicin for
this lady.

Hepatic blood flow of 70 kg patient is 90L/h/70kg. Morphine clearance in the same

person was 60L/h/70kg. Considering morphine absorption is 100%, what would be
the extraction ratio and bioavailability.