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1. Water equilibrium. The endocrine system controls water equilibrium by regulating the
solute concentration of the blood.
2. Growth, metabolism, and tissue maturation. The endocrine system controls the
growth of many tissues, like the bone and muscle, and the degree of metabolism of
various tissues, which aids in the maintenance of the normal body temperature and
normal mental functions. Maturation of tissues, which appears in the development of
adult features and adult behavior, are also determined by the endocrine system.
3. Heart rate and blood pressure management. The endocrine system assists in
managing the heart rate and blood pressure and aids in preparing the body for physical
motion.
4. Immune system control. The endocrine system helps regulate the production and
functions of immune cells.
5. Reproductive function controls. The endocrine system regulates the development
and the functions of the reproductive systems in males and females.
6. Uterine contractions and milk release. The endocrine system controls uterine
contractions throughout the delivery of the newborn and stimulates milk release from
the breasts in lactating females.
7. Ion management. The endocrine system regulates Na +, K+, and Ca2+ concentrations
in the blood.
8. Blood glucose regulator. The endocrine system controls blood glucose levels and
other nutrient levels in the blood.
9. Direct gene activation. Being lipid-soluble molecules, the steroid hormones can
diffuse through plasma membranes of their target cells; once inside, the steroid
hormone enters the nucleus and binds to a specific receptor protein there; then, the
hormone-receptor complex binds to specific sites on the cell’s DNA, activating certain
genes to transcribe messenger RNA; the mRNA then is translated in the cytoplasm,
resulting in the synthesis of new proteins.
10. Second messenger system. Water-soluble, nonsteroidal hormones-protein, and
peptide hormones- are unable to enter the target cells, so instead, they bind to
receptors situated on the target cell’s plasma membrane and utilize a second
messenger system.
Compared to other organs of the body, the organs of the endocrine system are small and
unimpressive, however, functionally the endocrine organs are very impressive, and when their
role in maintaining body homeostasis is considered, they are true giants.
Hypothalamus
The major endocrine organs of the body include the pituitary, thyroid, parathyroid, adrenal, pineal
and thymus glands, the pancreas, and the gonads.
Pituitary Gland
The pituitary gland is approximately the size of a pea.
Location. The pituitary gland hangs by a stalk from the inferior surface of the
hypothalamus of the brain, where it is snugly surrounded by the “Turk’s saddle” of the
sphenoid bone.
Lobes. It has two functional lobes- the anterior pituitary (glandular tissue) and the
posterior pituitary (nervous tissue).
Thyroid Gland
The thyroid gland is a hormone-producing gland that is familiar to most people primarily because
many obese individuals blame their overweight condition on their “glands” (thyroid).
Location. The thyroid gland is located at the base of the throat, just inferior to the
Adam’s apple, where it is easily palpated during a physical examination.
Lobes. It is a fairly large gland consisting of two lobes joined by a central mass,
or isthmus.
Composition. Internally, the thyroid gland is composed of hollow structures
called follicles, which store a sticky colloidal material.
Types of thyroid hormones. Thyroid hormone often referred to as the body’s major
metabolic hormone, is actually two active, iodine-containing hormones, thyroxine or
T4, and triiodothyronine or T3.
Thyroxine. Thyroxine is the major hormone secreted by the thyroid follicles.
Triiodothyronine. Most triiodothyronine is formed at the target tissues by conversion
of the thyroxine to triiodothyronine.
Function. Thyroid hormone controls the rate at which glucose is “burned” oxidized,
and converted to body heat and chemical energy; it is also important for normal tissue
growth and development.
Calcitonin. Calcitonin decreases blood calcium levels by causing calcium to be
deposited in the bones; calcitonin is made by the so-called parafollicular cells found
in the connective tissues between the follicles.
Parathyroid Glands
Location. The parathyroid glands are located on the posterior surface of the thyroid
gland.
Parathormone. The parathyroids secrete parathyroid hormone (PTH) or
parathormone, which is the most important regulator of calcium ion homeostasis of the
blood; PTH is a hypercalcemic hormone (that is, it acts to increase blood levels of
calcium), whereas calcitonin is a hypocalcemic hormone.; PTH also stimulates the
kidneys and intestines to absorb more calcium.
Adrenal Glands
Although the adrenal gland looks like a single organ, it is structurally and functionally two
endocrine organs in one.
Hormones of the Adrenal Cortex
The adrenal cortex produces three major groups of steroid hormones, which are collectively
called corticosteroids– mineralocorticoids, glucocorticoids, and sex hormones.
Pancreatic Islets
The pancreas, located close to the stomach in the abdominal cavity, is a mixed gland.
Islets of Langerhans.The islets of Langerhans also called pancreatic islets, are little
masses of hormone-producing tissue that are scattered among the enzyme-producing
acinar tissue of the pancreas.
Hormones. Two important hormones produced by the islet cells
are insulin and glucagon.
Islet cells. Islet cells act as fuel sensors, secreting insulin and glucagon appropriately
during fed and fasting states.
Beta cells. High levels of glucose in the blood stimulate the release of insulin from the
beta cells of the islets.
Alpha cells. Glucagon’s release by the alpha cells of the islets is stimulated by low
blood glucose levels.
Insulin. Insulin acts on just about all the body cells and increases their ability to
transport glucose across their plasma membranes; because insulin sweeps glucose
out of the blood, its effect is said to be hypoglycemic.
Glucagon. Glucagon acts as an antagonist of insulin; that is, it helps to regulate blood
glucose levels but in a way opposite that of insulin; its action is
basically hyperglycemic and its primary target organ is the liver, which it stimulates to
break down stored glycogen into glucose and release the glucose into the blood.
Pineal Gland
The pineal gland, also called the pineal body, is a small cone-shaped gland.
Location. The pineal gland hangs from the roof of the third ventricle of the brain.
Melatonin. Melatonin is the only hormone that appears to be secreted in substantial
amounts by the pineal gland; the levels of melatonin rise and fall during the course of
the day and night; peak levels occur at night and make us drowsy as melatonin is
believed to be the “sleep trigger” that plays an important role in establishing the
body’s day-night cycle.
Thymus Gland
The thymus gland is large in infants and children and decreases in size throughout adulthood.
Location. The thymus gland is located in the upper thorax, posterior to the sternum.
Thymosin. The thymus produces a hormone called thymosin and others that appear
to be essential for normal development of a special group of white blood cells (T-
lymphocytes, or T cells) and the immune response.
Gonads
The female and male gonads produce sex hormones that are identical to those produced by
adrenal cortex cells; the major difference are the source and relative amount produced.
Hormones of the Ovaries
The female gonads or ovaries are a pair of almond-sized organs.
Location. The testes are suspended in a sac, the scrotum, outside the pelvic cavity.
Male sex hormones. In addition to male sex cells, or sperm, the testes also produce
male sex hormones, or androgens, of which testosterone is the most important.
Testosterone. At puberty, testosterone promotes the growth and maturation of the
reproductive system organs to prepare the young man for reproduction; it also causes
the male’s secondary sex characteristics to appear and stimulates male sex drive;
Testosterone is also necessary for the continuous production of sperm.
Besides the major endocrine organs, pockets of hormone-producing cells are found in fatty tissue
and in the walls of the small intestine, stomach, kidneys, and heart- organs whose chief functions
have little to do with hormone production.
Placenta
The placenta is a remarkable organ formed temporarily in the uterus of pregnant women.
Function. In addition to its roles as the respiratory, excretory, and nutrition delivery
systems for the fetus, it also produces several proteins and steroid hormones that help
to maintain the pregnancy and pave the way for delivery of the baby.
Human chorionic gonadotropin. During very early pregnancy, a hormone called
human chorionic gonadotropin (hCG) is produced by the developing embryo and then
by the fetal part of the placenta; hCG stimulates the ovaries to continue producing
estrogen and progesterone so that the lining of the uterus is not sloughed off in the
menses.
Human placental lactogen (hPL). hPL works cooperatively with estrogen and
progesterone in preparing the breasts for lactation.
Relaxin. Relaxin, another placental hormone, causes the mother’s pelvic ligaments
and the pubic symphysis to relax and become more flexible, which eases birth
passage.
Although hormones have widespread effects, the major processes they control are reproduction,
growth, and development; mobilizing the body’s defenses against stressors; maintaining
electrolyte, water, and nutrient balance of the blood; and regulating cellular metabolism and
energy balance.
The key to the incredible power of the endocrine glands is the hormones they produce and
secrete.
Although the blood-borne hormones circulate to all the organs of the body, a given hormone
affects only certain tissue cells or organs.
Target cells. For a target cell to respond to the hormone, specific protein receptors
must be present on its plasma membrane or in its interior to which that hormone can
attach; only when this binding occurs can the hormone influence the workings of cells.
Function of hormones. The hormones bring about their effects on, the body cells
primarily by altering cellular activity- that is, by increasing or decreasing the rate of a
normal, or usual, metabolic process rather than stimulating a new one.
Changes in hormone binding. The precise changes that follow hormone binding
depend on the specific hormone and the target cell type, but typically one or more of
the following occurs:
What prompts the endocrine glands to release or not release their hormones?