ALTEPLASE - (ACTIVASE, TPA)

USUAL DILUENTS
NS, D5W
Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
Note: Sterile water without preservative
[50 mg vial] [50 ml - SW] [UD]
[100 mg vial] [100 ml - SW ] [UD]
Peripheral arterial occlusive disease: Continuous infusion of alteplase: 0.5 to 2 mg/hr x 6 to 72 hours
depending on location. Preparation: Dilute alteplase with sterile water as above, then further dilute
with NS to produce one of the following concentrations below:

Concentration (0.1 mg/ml)

[25 mg] [250ml]
[50 mg] [500 ml]

Concentration (0.2 mg/ml)

[50 mg] [250ml]

Alternatives:
-------------------------------------------
Concentration (0.025 mg/ml)
[12.5 mg] [500ml]

Concentration (0.05 mg/ml)

[25 mg] [500ml]
STABILITY
EXP: 8 hours (RT). Prepare just before use. Results in concentration of 1 mg/ml. May be infused at this concentration or may
dilute further with equal volume of normal saline or D5W (0.5 mg/ml).

STABILITY DATA:

Stability Stability Room Reconstituted Vial/ P-Insert

Drug Refrigerated Temp. Powder Notes Updated
Store
lyophilized
Activase under
refrigeration
not to exceed
(2-8°C/36-
46°F). Protect Store lyophilized
the lyophilized Activase at