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Castleman disease

Castleman disease (CD) is a rare, nonclonal lymphoproliferative disorder having distinct subtypes
depending on its etiology, pathology, and clinical presentation. It can affect lymph nodes of any body
region, imitating both benign and malignant malformations, including the neck, chest, abdomen, and
pelvis.

What causes Castleman disease?

What causes Castleman disease? While the causes of UCD are unknown, an HHV-8 infection is
associated with MCD. You're at greater risk of developing HHV-8-associated MCD if you have HIV or
another condition that may make it difficult for your immune system to fight the HHV-8

Lymphangitis

Lymphangitis is defined as an inflammation of the lymphatic channels that occurs as a result of infection
at a site distal to the channel. (See Etiology.) The lymphatic system encompasses a network of vessels,
glands, and organs located throughout the body.

What is the main cause of lymphangitis?

Lymphangitis most often results from an acute streptococcal infection of the skin. Less often, it is caused
by a staphylococcal infection. The infection causes the lymph vessels to become inflamed. Lymphangitis
may be a sign that a skin or soft tissue infection is getting worse.

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