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PATHOPHYSIOLOGY
PATHOPHYSIOLOGY
INFLAMMATORY RESPONSE
ALVEOLI AND RESPIRATORY BRONCHIOLES FILL WITH SEROUS, BLOOD CELLS, FIBRIN, AND BACTERIA
PNEUMONIA
CAPLOW RISK CAP MODERATE RISK CAP HIGH RISK
STABLE VITAL SIGNS UNSTABLE VITAL SIGNS Any of the clinical feature of
moderate risk CAP plus any
- RR <30 BPM - RR 30 BPM of the following:
- PR<125 BPM - PR 125 BPM
- DBP ≥60 mmHg - TEMPERATURE 40 C 1. Shock or signs of hypo-
OR 35C perfusion
No or stable comorbid
conditions Unstable comorbid condition - Hypotension
- Altered mental state
No evidence of extra (congestive heart failure CLASS
pulmonary sepsis
II-IV, uncontrolled diabetes 2. Urine output <30 mL/hr
No evidence of aspiration\ mellitus, active malignancies,
progressing neurologic disease, 3. Hypoxia (PaO, <60
Chest X-ray renal failure on dialysis, mmHg)or acute hypercapnea
uncompensated \COPD, (PaCO2 >50 mmHg)
- Localized infiltrates
decompensate liver disease
- No evidence of CHEST X-RAY
pleural effusion nor
abscess - As in moderate risk
- Not progressive CAP
within 24 hours
- Fever PHARMACOTHERAPY
- Cough
- Dyspnea - Antibiotic Therapy
- Tachycardia - Antiviral Therapy
- Nasal Flaring
Supportive therapy includes:
- Wheezing
- Body Malaise - Fluids Therapy
- Restless - Oxygen Therapy
- Rales - Antipyretics Medications
- Sweating - Analgesics Medications
- Nebulization (Salbutamol)
- Mechanical Ventilator