Expesimend~0| af I2/r02 3 To carry out pre forrrulahion s Auclse, of Paracetormol . Aim- Te cany out the prefermruletion shes of Pore cetarmo/. = Keguirement= emsuming eytinder, flnnel, bueth stand, bak density apparedes referinalation 2 aan as the phase 6 Yestavch in cohich prefrrealation 4 development Shidies “Characterized Pogsreal ac of 2 Anug rrolecule. 17 oncte fo Aesage A hernical Wee develop safe, offective ard Stable form “The objective of. Pre forrila ten Sticly bie Po eter elope the Clegant stable, bs ty fftive ard safe aesage fe ; A 7 Lj_ coraprarta bility 25 bab lishing Kinetic vate pre pith the other tng medrerts and etablsbh 2 eis olne peysile cherital parameter f re 2 substones » bib The ragyon pre ft npilation SMe or granu la ae as follows ov pera mokeasBulk density - 2 bas defined poral to the gives an 14a as ratio of tebol may of tee bulk volume go Peader. ff about tab? ponosity and ah time Anol qe latronships Ltth arsinie gnaten hardness of 2 tablet: jt Ree cacures| by Pomay weighed pousder Ynto glinder and te volume 1% pottd How Loft 1s cmpperesser! 30 DIL and te given by @B- % Sa M hOheve, Ms mas of Powder : Vo = BGutkovetarme f pooder a measuring prs: dlens i by ~ + lod YH ts defined as ratio of total mass of the powder to Phe tmppeal vlurne of powder eh by Papp? Tappet velarde te TREC The prowaer Zp constant ee ot mh expresses bo in grfol ond qt vs y= 4 ones Vy Where, Me mass of porter Ve= topped volume of powder Angle of repose) oh Ts The raaximure angle posseble Sun face f pit f powder betweerdo Measure frictional prs: in lan be see a powder Lohee, 02 angle tan = la ‘ repose. - = hesght of inelexc- poricless (an compressibility See Sci case with which heap 4j indicts ch tHy Go, matental 647 be ynduced to flow St ws expressed Gs bye Oz = Pe xo B re a pPereentage and ts given Where, Dr= tapned, lens; Dz = Balk ensity Heusnes 's vyactio - Ge tndveates the flow prepentics of the OT cake. by Cicer pout okt bulk density. tapped density te the Housnes's ratio = tapped densi Bulk cleasity Jf heusner's veto is befveen je (rtproved by foe te be foe PRR fe addifren glidant— ‘Datecwatelte Bulk & tapped densety- ' eG quan dity of ere ma flieen? ifs tmough 9 s1eve if necessary do bneak up aggiar erates a A complete The datize a measuring tydinder of loonh gerft, poithout wmpacting approximately tn Produce \ogm of the tad sarple and gh. 9 Carefully iy necessary volume to the 4 lalulak the afotpruta : The Papped volurre Aapping the rreasurirg Sample of 'Ogr* pred clase wey elas to Nominal mate of 300 anaps/rih until 9 lonst vol. 7 obsenvee: (.Then calla the tapped density *% ting The devel tpi Powder eithout ompectin and nead the unsetdle Apparent neanest graduated unt bute dlenstly by anr'sing te is obtained by reechanivally egdinden tontaining The ae e : 2. Aft getty the value Z bufc Perit 4 tapped density , COV aut hausnes's vor oS formule Poole f° a 26 66°/- houvgnes’> refio = (+36 Angle f vatie: = 38: 6S Ef on, Phe obtained! | “a Guam Obsenveed that the paracetarral foes fave poor for propenhy » / — Hence, the panticl SIRE and Shape shoul be —Ttron of lubnitarkt Lontelled and by the addit’ 4 labaicerte € kay x3 tan fraprre the fer PPPS ~XV 7 awVe. Bulk dansk. Mas 10 Bulk voleme 30 ~ 9:3 Tapped aso , tapped volume Progle of Repose [fre es prem [i Te | 42255 } eellent ae Gooof ores Passa ble ! am poer PIE Soe fal Housperss yah - Teyqred densi ~ Blk dens, aba, 4 rR fh, laws tnclex Corn aress iby hity lavped density Balk denciby a Hi er eee Index ae ae Caves Be 4 and ex J i YU Sais Excellent ces Sood : (€-22 Fair 23 ~30 Pao 33-38 Veny poor 4 Ebene Peer