Intc naJ Application No

INTERNATIONAL SEARCH REPORT

PCr/GB 03/04919
"

A. CLASSIFICATION OF SUBJECT MATTER

IPC 7 C07D413/12 C07D419/12 C07D413/14 C07D419/14 C07D307/80
A61P3/04 A61P3/08

According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED
Minimum documentation searched (classification system followed by classification symbols)
IPC 7 C07D A61P

Documentation searched other than minimum documentation to the extent that such documents are Included In the fields searched

Electronic data base consulted during the International search (name of data base and. where practical, search terms used)

PAJ, WPI Data, EPO-Internal , CHEM ABS Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category ° Citation of document, wilh Indication, where appropriate, of the relevant passages Relevant to claim No.

WO 01 44216 A (HOFFMANN LA ROCHE) 1-9

21 June 2001 (2001-06-21)
cited 1n the application
page 21, line 11 -page 21, line 16;
examples 1-25

Further documents are listed in the continuation or box C. Patent family members are listed in annex.

0
Special categories of cited documents
"T laterdocument published after the international filing date
A* document defining the or priority date and not in conflict with the application but
general state of the art which is not
considered to be of particular relevance cited to understand the principle or theory underlying the
invention
•E' earlier document but published on or after the international
filing date X" document of particular relevance; the claimed Invention
cannot be considered novel or cannot be considered to
L" document which may throw doubts on priority ctalmfe) or involve an Inventive step when the document Is taken alone
which is cited to establish the publication date of another
citation or other special reason (as specified) 'V document of particular relevance; the claimed Invention
cannot be considered to involve an Inventive step when the
'O' document referring to an oral disclosure, use, exhibition or document is combined with one or more other such docu-
other means ments, such combination being obvious to a person skilled
P' document published prior to the International fifing date but In the art.
later lhan the priority date claimed document member of the same patent family

Date of the actual complelion of the international search Date of mailing of the International search report

11 February 2004 26/02/2004

Name and mailing address of the ISA Authorized officer
European Patent Office, P.B. 5818 Patentlaan 2
NL - 2280 HV Riisw^k
TeL (+31-70) 340-2040, Tx. 31 651 epo nl,
Fax: (+31-70) 340-3016 Schmid, A
Form PCT/ISA/210 (second sheet) (July 1982)
 latlonal application No.
INTERNATIONAL SEARCH REPORT PCT/GB 03/04919

Box I Observations where certain claims were found unsearchable (Continuation of item 1 of first sheet)

This International Search Report has not been established In respect of certain claims under Article 17(2)(a) for the following reasons:

1. Q Claims Nos.:
because they relate to subject matter not required to be searched by this Authority, namely:

2. [][] Claims Nos.:

10
because they relate to parts of the International Application that do not comply with the prescribed requirements
to such
an extent that no meanlnglul International Search can be carried out, specifically:

see FURTHER INFORMATION sheet PCT/ISA/210

3. Q Claims Nos.:
because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4(a).

Box II Observations where unity of Invention is lacking (Continuation of item 2 of first sheet)

This International Searching Authority found multiple Inventions in this international application, as follows:

1 — I

1
As all required additional search fees were timely paid by the applicant, this International Search
searchable claims,
Report covers all

2. Q As
of
all
any
searchable claims could be searched without
additional fee.
effort justifying an adcfltlonal fee, this Authority did not rnvite payment
r '

3.
1 —
[~| As only some
I
of the required additional search fees were timely paid by the applicant, this International
covers only those claims for which fees were paid, specifically claims Nos.:
Search Report

No required additional search fees were timely paid by the applicant Consequently, this International Search Report is
restricted to tho invention first mentioned in the claims; it is covered by
claims Nos.:

Remark on Protest The additional search Fees were accompanied by the applicant's protest.

No protest accompanied the payment of additional search feea

[ |

Form PCT/ISA/210 (continuation of first sheet (1)) (July 1998)

 Internationa) Application No. PCT/SB 03 /J4919
FURTHER INFORMATION CONTINUED FROM PCT/ISA/ 210

Continuation of Box 1.2

Claims Nos. : 10

Claim 10 refers back to a formula (III) as defined 1n claim 9. However,

looking at claim 9, it becomes evident that there are 2 structure with
the formula (III). Accordingly it is not clear which of the 2 structures
is meant, so that no search can be done.

The applicant's attention is drawn to the fact that claims, or parts of

claims, relating to inventions in respect of which no international
search report has been established need not be the subject of an
international preliminary examination (Rule 66.1(e) PCT). The applicant
is advised that the EPO policy when acting as an International
Preliminary Examining Authority is normally not to carry out a
preliminary examination on matter which has not been searched. This is
the case irrespective of whether or not the claims are amended following
receipt of the search report or during any Chapter II procedure.
 lift
INTERNATIONAL SEARCH REPORT tnt< nal Application No
.formation on patent family members
PCl/bB 03/04919
Patent document Publication Patent family Publication
chbu in ocaiun repon oats member(s) date ;

WO 0144216 A 21-06-2001 AU 2365201 A 25-06-2001

CA 2392903 Al 21-06-2001
CN 1411453 T 16-04-2003
CZ 20022412 A3 16-10-2002
WO 0144216 Al 21-06-2001
EP 1242397 Al 25-09-2002
HU 0203753 A2 28-03-2003
JP 2003516980 T 20-05-2003
NO 20022863 A 14-06-2002
US 6353111 Bl 05-03-2002

Form PCrrYISA/210 (patent family annex) (July 1Q92)