Abstract

The dynamic computed tomographic (DCT) method of flow determination is based on the application
of venoarterial indicator dilution curves as they reflect flow. Using a simple model consisting of a tube
and a single mixing chamber, experimental parameters were optimized in a controlled manner to
achieve ideal mixing for flow determination. Under these ideal conditions, and using 16 consecutive
3-second scans of an 8-mm thick section, tube diameters of 8 mm and 20 mm, and flow range of 0.7-
2.7 liters per minute, the accuracy of the CT method of flow determination was good (17% error).
There was a correlation coefficient of 0.85 between measured flow (FM) and calculated flow (FC), and
the paired t-test for FM and FC indicated that there was no statistically significant difference (P = .25).
The DCT method of flow determination has been validated in this experiment preliminary to its
application to flow characterization in blood vessels in the animal model.

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Publication types
 Research Support, Non-U.S. Gov't
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 Research Support, U.S. Gov't, P.H.S.
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MeSH terms
 Blood Flow Velocity*
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 Models, Anatomic
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 Models, Cardiovascular
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 Rheology
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 Tomography, X-Ray Computed / methods*
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Grants and funding

 HLO7425/HL/NHLBI NIH HHS/United States

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