HARAMAYA UNIVERSITY

COLLEGE OF HEALTH AND MEDICAL SCIENCE

SCHOOL OF PHARMACY

Assignment for 2nd year Pharmacy students on Medicinal Chemistry I

(Phar2111)
Individual Assignment (only submitted by hardcopy with handwriting)
Submitting late than exam date will not be accepted
Accounts 10%

1. What are local anesthetics? How do they differ from general anesthetics? Mention the
ideal characteristics that a local anesthetic should possess?
2. Write in details about SAR of indole acetic acid derivatives?
3. What are peripherally modified derivatives of morphine? Enumerate various peripherally
modified derivatives of morhine with their structures and uses?
4. Write the names and structures of H1-receptor antagonists possessing pyridine and
piperidine moieties?
5. What are general structural requirements for adrenoreceptor agonists? Describe the mode
of action of such drugs?
6. Discuss the general structural features of drugs associated with anticonvulsant activity.
7. Discuss the importance of hydrogen bonding, partition coefficient and chelation in
relation to biological activity?
8. With the help of appropriate examples, elucidate how different physicochemical
properties of drug molecules are related to their biological activity?
9. Explain the role of pKa in the biological activity of drugs?
10. Discuss the general structural features of drugs associated with anticonvulsant activity.