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The 12th Accounting Period

From January 1, 2022


To June 30, 2022

※ Disclaimer
This document was disclosed voluntarily for foreign investors. The original Korean version of the
disclosure can be found on KIND(http://kind.krx.co.kr), DART(http://dart.fss.or.kr). If and when
there is any discrepancy between the English and Korean versions, the Korean text shall prevail.
Therefore, it is essential for the investors to consult the Korean text before making investment
decisions.

To. Financial Services Commission


Korea Exchange August 16, 2022

Type of Corporation Subject to Submit Stock-listed Corporation

Reason for Exemption Not applicable

Name of Company Samsung Biologics Co., Ltd.

CEO Rim John Chongbo

Place of Principal Office 300, Songdo Bio-daero, Yeonsu-gu, Incheon, Korea


(Songdo-dong, Samsung Biologics Co., Ltd.)
(Tel.) 82-032-455-3114
(Homepage) http://www.samsungbiologics.com

Principal Officer (Title) Director of Business Support Center


(Name) Kim Dongjoong
(Tel.) 82-032-455-3114
I. Company Overview

1. Company Overview

A. Consolidated subsidiaries overview(summary)

Number of consolidated subsidiaries Number of


Classification major
Beginning End subsidiaries
Increase Decrease
of period of period

Listed - - - - -

Unlisted 1 13 - 14 1

Total 1 13 - 14 1

※ For details, refer to XII. Table of Information – 1. Consolidated subsidiaries overview

B. Change of consolidated subsidiaries

Subsidiary Reason
Transfer from joint venture to subsidiary
13
Newly consolidated by acquiring additional shares
- -
- -
No longer consolidated
- -

C. Legal and commercial name


The Company’s name is ‘SAMSUNG BIOLOGICS CO., LTD.’

D. Establishment date
Samsung Biologics Co., Ltd. was established on April 22, 2011.

E. Address, telephone number, and homepage


Address of head office : 300, Songdo Bio-daero, Yeonsu-gu, Incheon, South Korea
(Songdo-dong, Samsung Biologics Co., Ltd.)
Telephone number : 82-032-455-3114
Homepage : www.samsungbiologics.com

F. Status of SME
Samsung Biologics Co., Ltd. (hereinafter, Samsung Biologics or the Company) does not fall within small
and medium enterprises (SMEs) in accordance with Article 2 of the Framework Act of Small and Medium
Enterprises and Article 3 of the Enforcement Decree of the Framework Act on Small and Medium
Enterprises as of the date when the report is submitted.

Small Enterprises Not Applicable


Venture company Not Applicable

Medium Enterprises Not Applicable

G. Main business
The Company consists of two business segments: CDMO (Contract Development and Manufacturing
Organization) business; and biopharmaceutical development and commercialization business. The
CDMO division provides contract production and cell line process development services for
biopharmaceuticals, and the biopharmaceutical division engages in biopharmaceutical development
and commercialization. In the current period, revenue generated from CDMO product, services,
biopharmaceutical product development and commercialization product account for 80.8%, 6.4% and
12.8% of the total revenue respectively. By region, the Company has generated the total revenue from
the following regions: Europe – 66.7%, United States – 19.4%, Korea – 7.2%, and Others – 6.7%.
Refer to「II. Business Overview」for more details about the business.

H. Credit rating

Credit Rating Agency


Date Securities Ratings Note
(Rating Range)
6-1,6-2 Private Korea Investors Service
2020.02.07 - Non-periodic rating
non-guaranteed bond (AAA~D)
6-1,6-2 Private Korea Investors Service
2020.05.07 - Non-periodic rating
non-guaranteed bond (AAA~D)
6-1,6-2 Private Korea Investors Service
2020.07.15 - Non-periodic rating
non-guaranteed bond (AAA~D)
7-1,7-2 Public Korea Investors Service
2021.07.26 A+ Initial rating
non-guaranteed bond (AAA~D)
7-1,7-2 Public Korea Investors Service
2021.08.05 A+ Initial rating
non-guaranteed bond (AAA~D)
7-1,7-2 Public Korea Investors Service
2022.04.28 AA- Periodic rating
non-guaranteed bond (AAA~D)
7-1,7-2 Public Korea Investors Service
2022.05.09 AA- Periodic rating
non-guaranteed bond (AAA~D)
※ The credit rating for 6-1.6-2 private bonds is not provided under the non-disclosure agreement.

[Credit rating system]


- Korea Investors Service : Corporate Bond Ratings
Corporate bond rating scale is composed of 10 broad rating categories from AAA to D that indicate
different levels of likelihood of interest and principal payment as illustrated in the table below. Securities
rated between AAA to BBB indicate adequate (or stronger) capacity to meet financial commitments.
Securities rated between BB and C are judged to have speculative elements and are subject to
substantial credit risk.

Rating Definition

AAA An ‘AAA’ rating indicates the highest likelihood of interest and principal payment.

An ‘AA’ rating indicates very high likelihood of interest and principal payment. The likelihood may,
A
nevertheless, be slightly lower than is the case for the highest rating category (AAA).
An ‘A’ rating indicates high likelihood of interest and principal payment. The likelihood may,
B nevertheless, be more susceptible to changes in circumstances and in economic conditions than
is the case for higher rating category (AA).

A ‘BBB’ rating indicates moderate likelihood of interest and principal payment, but changes in
BBB circumstances and in economic conditions are more likely to impair this likelihood than is the case
for higher rating category (A).

A ‘BB’ rating indicates some uncertainty over the likelihood of interest and principal payment and
BB
speculative elements.

A ‘B’ rating indicates substantial uncertainty over the likelihood of interest and principal payment
B
and is considered more speculative than higher rating category (BB).

A ‘CCC’ rating indicates high risk of default and questionable likelihood of interest and principal
CCC
payment.

A ‘CC’ rating indicates very high risk of default and extremely low likelihood of interest and principal
CC
payment.

A ‘C’ rating indicates extremely high risk of default and lack of likelihood of interest and principal
C
payment.

D A ‘D’ rating indicates default.


※ '+' or '-' modifier can be attached to ratings through AA to B to differentiate ratings within broader rating categories.

- Korea Ratings : Rating of Bonds

Rating Definition

AAA Capacity for timely payment is extremely strong.

AA Capacity for timely payment is very strong, but somewhat less than 'AAA'

A Capacity for timely payment is strong, but somewhat susceptible to external changes in the future.

Capacity for timely payment is adequate, but more likely to be weakened by future market
BBB
changes.

BB Capacity for timely payment faces no immediate problems, but speculative in its future stability.

B Capacity for timely payment is poor and speculative.

CCC Contain the possibility of default.

CC Contain more possibility of default.

C Highly likely default.

D In default at the present time.


※ The ratings from 'AA' to 'B' may be modified by the addition of a plus(+) or minus(-) sign to show relative standing within the
major rating categories.
※ For preliminary rating, "P" is added in front of the relevant rating symbol.
※ For undisclosed grades, add "U" in front of the grade symbol.

I. Whether the Company is listed (or registered or designated) and matters related to special
listed companies
Listing Date listed Subject to regulations for
Special listed company
(or registered or designated) (or registered or designated) special exception companies

Stock market (KOSPI) 2016.11.10 Not applicable Not applicable


2. Company History

A. Company location changes

Changes in the place of principal office since the establishment of the Company are as follows :
Date Address Remarks

2011.04.22 104B, Pilot Plant, 7-50, Songdo-dong, Yeonsu-gu, Incheon, South Korea Establishment

3003, Songdo Technopark IT Center M, 172-1, Songdo-dong, Yeonsu-gu,


2012.01.26 -
Incheon, South Korea

2012.06.26 201-2, Songdo-dong, Yeonsu-gu, Incheon, South Korea -

Changed to
125, Cheomdan-daero, Yeonsu-gu, Incheon, South Korea road name-
2014.01.07
(Songdo-dong, Samsung Biologics Co., Ltd.) based
address
Changed to
300, Songdo Bio-daero, Yeonsu-gu, Incheon, South Korea road name-
2016.07.04
(Songdo-dong, Samsung Biologics Co., Ltd.) based
address

B. Important changes in management executives

(1) Change of Chief Executive Officer


- On December 16, 2020, John Rim was appointed as the Chief Executive Officer

※ On December 16, 2020, Executive director John Rim was appointed as the new Chief Executive
Officer and Kim Taehan resigned from his position of Chief Executive Director during the 10 th board of
director’s meeting.
Type of Appointment
Date shareholder Expiry or Dismissal
meeting Initial Extension
Executive director
Kim Dongjoong
Annual
Independent director Independent director Independent director
2019.03.22 General
Heo Geunnyeong Jeong Seokwoo Yoon Byungchul
Meeting
Independent director
Kwon Soonjo
Executive director
Annual John Rim Executive director
2020.03.20 General -
Independent director Kim Taehan
Meeting
Eunice Kim

Independent director Executive director Independent director


Annual Lee Changwoo Kim Dongjoong Jeong Seokwoo
2022.03.29 General
Meeting Independent director Independent director Independent director
Bahk Jaewan Heo Geunnyeong Kwon Soonjo
As of the reporting date, the Company's Board of Directors (BOD) consists of three Executive directors
(Kim Taehan, John Rim, and Kim Dongjoong) and four Independent directors (Heo Geunnyoung, Eunice
Kim, Lee Changwoo, and Bahk Jaewan).

C. Changes in the largest shareholder

Date Before After Remarks

Samsung Everland (Old) Cheil Industries The change of the largest


2014.07.04
Samsung Electronics Samsung Electronics shareholder’s name

Following the merger between


(Old) Cheil Industries and
(Old) Cheil Industries (Old) Samsung C&T Corporation,
2015.09.02 Samsung C&T Corporation
Samsung Electronics the company name of
(Old) Cheil Industries was changed to
Samsung C&T Corporation.

D. Company name changes


- Not applicable

E. Details and results in case the Company went through or currently goes through
compositions, reorganization proceedings, and other equivalents
- Not applicable

F. Mergers and Acquisitions

(1) Transfer of Samsung Bioepis Shares


Biogen Therapeutics Inc. has a call option that allows it to purchase up to 50%-1 shares of Samsung
Bioepis under an agreement between shareholders on December 6, 2011.

The transfer of assets is related to the report on major issues on June 29, 2018 (decision to transfer
shares and equity securities of other corporations). On November 7, 2018, the transfer of shares and
payment were completed, and the transaction was closed.

Category Dates

Contract Between Shareholders 2011.12.06

Evaluation of external evaluation agencies 2018.06.22 ~ 2018.06.29

Key item report submission date 2018.06.29

Transfer of shares and payment date 2018.11.07

(2) Transfer of Samsung Bioepis Shares


The Company entered into a stock sales contract on January 28, 2022 to acquire an additional stake in
Samsung Bioepis held by Biogen Therapeutics Inc., and acquired 10,341,852 shares on April 20, 2022
to secure 100% of the stake and gained the control of Samsung Bioepis.

For details on the acquisition of shares, please refer to the Report on Major Matters (Decision to acquire
stocks and investment securities of other corporations) first published on January 28, 2022.

Category Dates

Contract Between Shareholders 2022.01.28

Evaluation of external evaluation agencies 2021.12.21 ~ 2022.01.28

Key item report submission date 2022.01.28

Transfer of shares and payment date 2022.04.20

G. Important changes in the Company’s business


- Not applicable

H. Other important matters related to the management activities

[Samsung Biologics]
Date Details
2011.04.22 Established Samsung Biologics Co., Ltd.
2011.04.28 Signed a lease agreement for the plant site in Songdo
2011.05.06 Started the construction of Songdo Plant 1
2012.02.28 Established Samsung Bioepis Co., Ltd.
2013.07.18 Signed a contract with BMS regarding DS manufacturing
2013.09.23 Started the construction of Songdo Plant 2
2013.10.18 Signed a contract with Roche regarding DS manufacturing
Signed a contract with BMS regarding DS manufacturing enhancement and
2014.04.16
DP manufacturing
2014.06.23 Established a joint venture, Archigen Biotech Ltd.
Changed the largest shareholder’s company name
2014.07.04
(Samsung Everland Inc. → Cheil Industries Inc.)
Changed the largest shareholders (Before: Samsung Electronics Co., Ltd. 46.79%, Cheil
Industries Inc. 46.79%, Samsung C&T Corporation 4.25%
2015.09.02
→ After: Samsung C&T Corporation 51.04%, Samsung Electronics Co., Ltd. 46.79%)
2015.11.12 Started the construction of Songdo Plant 3

2015.11.30 Obtained an approval of Songdo Plant 1’s manufacturing license from FDA
(no observation)

2016.04.01 Signed a contract with Samsung Bioepis regarding biosimilar manufacturing


2016.05.03 Signed a contract with a US pharmaceutical company regarding DP manufacturing
2016.07.29 Obtained an approval of Songdo Plant 1’s manufacturing license from EMA
2016.11.10 Became listed on the KOSPI
2016.11.16 Signed a contract with Cilag regarding DS manufacturing
2017.01.24 Signed a contract with a Swiss pharmaceutical company regarding DS manufacturing
2017.07.04 Signed a contract with Sun Pharma regarding DS manufacturing
2017.07.20 Signed a contract with a Europe pharmaceutical company regarding DS manufacturing
Date Details
2017.09.06 Signed LOI with Ichnos Science regarding DS manufacturing
2017.09.22 Obtained an approval of Songdo Plant 2’s manufacturing license from FDA
2017.11.08 Signed a contract with a US pharmaceutical company regarding DS manufacturing
2017.12.21 Obtained an approval of Songdo Plant 2’s manufacturing license from EMA
2017.12.21 Signed a contract with UCB regarding DS manufacturing
2018.02.01 Signed an additional contract with a Asia pharmaceutical company regarding DS manufacturing
2018.02.21 Signed a contract with an US pharmaceutical company regarding DS manufacturing
2018.04.30 Signed an additional contract with a Europe pharmaceutical company regarding DS manufacturing
2018.06.01 Signed a contract Ichnos Sciences S.A. regarding DS manufacturing
2018.06.29 Biogen’s execution of call option and Stock transfer decision
2018.08.14 Signed a contract with an Asia pharmaceutical company regarding DS manufacturing
2018.09.11 Signed a contract with Immunomedics, Inc. regarding DS manufacturing
2018.11.07 Transfer of 9,226,068 Samsung Bioepis’ shares to Biogen Therapeutics Inc.
2019.04.01 Signed a contract with Cytodyn Inc. regarding DS manufacturing
2019.04.26 Signed a contract with an Asia pharmaceutical company regarding DS manufacturing
2016.04.26 Signed a contract with an Asia pharmaceutical company regarding DS manufacturing
2019.05.14 Signed a contract with an Asia pharmaceutical company regarding DS manufacturing
2019.05.17 Signed a contract with UCB regarding DS manufacturing
2019.11.05 Signed an additional contract with Ichnos Sciences S.A. regarding DS manufacturing
2019.11.28 Signed a contract with an Asia pharmaceutical company regarding DS manufacturing
2019.12.03 Signed a contract with an US pharmaceutical company regarding DS manufacturing
2019.12.24 Signed a contract with a Swiss pharmaceutical company regarding DS manufacturing
2020.01.29 Established Samsung Biologics America, Inc.
2020.04.23 Signed an additional contract with Immunomedics regarding DS manufacturing
2020.07.27 Signed a contract with Eli Lilly and Company regarding DS manufacturing
2020.08.05 Signed a contract with GlaxoSmithKline Trading Limited regarding DS manufacturing
2020.08.05 Launched the proprietary cell line technology, S-CHOice
2020.09.21 Signed a contract with AstraZeneca UK Ltd. regarding DS/DP manufacturing
2020.10.29 Established CDO R&D center in San Francisco, U.S.
2020.11.18 Started the construction of Songdo Plant 4
2021.01.15 Signed a contract with Roche regarding DS manufacturing
2021.05.21 Signed a contract with Moderna regarding DP manufacturing
2021.06.11 Issued the first Sustainability Report
2021.09.13 Participated in a FSS-led climate risk management model
2021.09.22 Launched the CDO-accelerating platform, S-Cellerate
2021.09.28 Signed an additional contract with Roche regarding DS manufacturing
2021.09.29 Signed LOI with MSD regarding DS manufacturing
Supplied its first batch of domestically produced Moderna COVID-19 mRNA for domestic
2021.10.28
use
Awarded ‘A’ rating in Comprehensive ESG Assessment for the first time as a
2021.11.01
biopharmaceutical company
2021.11.03 Signed a Land Purchase Agreement for Plant 5 in Songdo District 5
2021.11.13 Joined Dow Jones Sustainability Index (DJSI) for the first time as a Life Science company
Signed a contract with GreenLight Biosciences regarding DS manufacturing of mRNA
2021.11.25
vaccine candidate substances
Date Details
2021.12.07 Obtained the international standard for a Quality Management System (ISO 9001)
Obtained a marketing authorization from the Ministry of Food and Drug Safety of Korea for
2021.12.14
Moderna’s COVID-19 vaccine
2022.01.28 Agreed to acquire Biogen’s stake in Samsung Bioepis
2022.03.28 Signed an additional contract with Eli Lily Kinsale Limited regarding DS manufacturing
2022.03.29 Agreed to a Land Purchase Agreement for Second Bio Campus in Songdo Disctrict 11
2022.03.29 Invested in Samsung Life Science Fund, U.S. Cell and Gene Therapy Developer
2022.04.20 Acquired 100% of Samsung Bioepis shares
2022.04.28 Additional stock listing from paid-in capital increase
2022.06.07 Signed a contract with Novartis regarding DS manufacturing

[Samsung Bioepis]
Date Details
2012.02.28 Established Samsung Bioepis Co., Ltd.
2013.02.18 Signed the marketing partnership contract with Merck
2013.12.13 Signed the marketing partnership contract with Biogen
2015.09.07 Sales approval of ETOLOCE(Enbrel Biosimilar) in Korea
2015.12.04 Sales approval of REMALOCE (Remicade Biosimilar) in Korea
2016.01.14 Sales approval of BENEPALI(Enbrel Biosimilar) in Europe
2016.05.26 Sales approval of FLIXABI(Remicade Biosimilar) in Europe
2017.04.21 Sales approval of Renflexis(Remicade Biosimilar) in US
2017.08.24 Sales approval of IMRALDI(Humira Biosimilar) in Europe
2017.09.20 Sales approval of ADALLOCE(Humira Biosimilar) in Korea
2017.11.08 Sales approval of SAMFENET(Herceptin Biosimilar) in Korea
2017.11.15 Sales approval of ONTRUZANT(Herceptin Biosimilar) in Europe
2019.01.18 Sales approval of ONTRUZANT(Herceptin Biosimilar) in USA
2019.04.25 Approval of ETICOVO(Enbrel Biosimilar) in USA
2019.07.23 Sales approval of HADLIMA(Humira Biosimilar) in USA
2019.11.05 Signed additional marketing partnership contract with Biogen
2019.12.19 Acquired the WHO PQ certification of ONTRUZANT(Herceptin Biosimilar)
2020.11.03 Awarded the global generic and biosimilar award(Leading company of the year)
2020.11.19 Awarded the excellent product design award(Brand design Ministerial Award)
2021.01.25 Moved into new building in Songdo
2021.03.11 Sales approval of ONBEVZITM(Avastin Biosimilar) in Korea
2021.04.22 Awarded the iF design award in communication and packaging part
2021.08.18 Sales approval of BYOOVIZ(Lucentiz Biosimilar) in Europe
2021.09.17 Sales approval of BYOOVIZ(Lucentiz Biosimilar) in USA
2021.12.21 Issued the first Sustainability Report
2022.05.13 Sales approval of AMELIVU(Lucentiz Biosimilar) in Korea
3. Changes in Paid-in Capital

Status of capital increase (decrease)


(Unit: KRW, share)

Type of Classificati 12th


11th 10th 9th 8th
share on (1H)
Number of
Issued 71,174,000 66,165,000 66,165,000 66,165,000 66,165,000
shares
Ordinar
Par value
y share 2,500 2,500 2,500 2,500 2,500
per share
Total
177,935,000,000 165,412,500,000 165,412,500,000 165,412,500,000 165,412,500,000
equity
Number of
Issued -
Preferr shares
ed Par value
-
share per share
Total
-
equity
Number of
Issued -
shares
Others Par value
-
per share
Total
-
equity
Total
Total 177,935,000,000 165,412,500,000 165,412,500,000 165,412,500,000 165,412,500,000
equity
※ On January 28, 2022, the Board of Directors of the Company resolved to increase its capital for the

acquisition of construction-in-progress and securities of other entity. The Company issued additional
5,009,000 shares of common stock totaling 71,174,000 shares of common stock issued by the end of
1H.
4. Stock Information

A. Total number of shares


(As of June 30, 2022) (Unit: share)

Type of stocks
Classification Note
Common Preferred Total

Ⅰ. Authorized shares 500,000,000 - 500,000,000 -

Ⅱ. Issued shares (cumulative) 71,174,000 - 71,174,000 -

Ⅲ. Decrease in number of shares (cumulative) - - - -

1. Capital reduction - - - -

2. Cancellation - - - -

3. Redemption - - - -

4. Other - - - -

Ⅳ. Issued shares (Ⅱ-Ⅲ) 71,174,000 - 71,174,000 -

Ⅴ. Treasury shares - - - -

Ⅵ. Outstanding shares (Ⅳ-Ⅴ) 71,174,000 - 71,174,000 -

B. Treasury Shares
- Not applicable

C. Types of Registered Stock


- Not applicable

5. Articles of Incorporation
Amendment record

Date of change Meeting name Description Reason


Article 8 (Classes of Shares and Share Certificates)
Section 7 – Deleted
- Amendment/Deletion of relevant
Article 8-2 (Electronic registration on Rights to be
articles following the enactment
Indicated on Shares and Certificate of Preemptive
of the Act on Electronic
Right to new stocks)
Registration of Stocks, Bonds,
Section 3 – Introduced
etc.
Article 9 (Transfer agent) Section 3 – Amended
Article 10 (Shareholders’ Obligation to report on
- Reflection of flexible operation
address, name and signet or signature) – Deleted
8th Annual scheme and exception regulation
2019.03.22 Article 17-2 (Electronic registration on Rights to be
General Meeting of BOD following the leave of
Indicated on Bonds and Certificate of Preemptive
CEO/Member of Audit committee
Right to new stocks) – Introduced
Article 18 (Applicable Provisions regarding Issuance
- Reflection of changes in rights to
of Bonds) – Post-amendment Review of Section
appoint an external auditor
Article 33 (Duties of Directors) Section 3 – Amended
following the amendment of the
Article 42 (Composition of Audit Committee)
Act on External Audit of Stock
Section 7 – Introduced
Companies
Article 43 (Duties, etc. of Audit Committee)
Section 6 – Amended
※ The latest date of change in the Company’s articles of incorporation is March 22, 2019.
No change was made at the Company’s 11th Annual General Meeting, held on March 29, 2022.
II. Business Overview

1. Business Overview

The Company is organized into two segments consisting of CDMO and biopharmaceutical development
and commercialization businesses. The CDMO business provides clients with the service of
manufacturing biopharmaceuticals and development of cell line, and the biopharmaceutical
development and commercialization business focuses on development and commercialization of
biopharmaceuticals. The Company acquired an additional 10,341,852 shares of Samsung Bioepis Co.,
Ltd to secure a 100% stake in the company. As a result, biopharmaceutical development and
commercialization of Samsung Bioepis Co., Ltd. was added as a separate business segment.

The Company achieved annual sales of 1.568 trillion won in 2021, and sales of biopharmaceuticals
were 1.442 trillion won in product sales and 126 billion won in service revenue from CDMO business
segment. From the consolidated sales of 1.163 trillion won in the half year of 2022, sales of CDMO
goods, etc. were 938.9 billion won, service sales were 74 billion won, and biopharmaceutical
development and commercialization segment product sales were 149.4 billion won.

(1) CDMO
Samsung Biologics offers a wide range of services focusing on the development and commercialization
of biosimilar and CMO service of manufacturing biopharmaceuticals and development of cell line,
manufacturing process, characterization, and analysis method for pipelines ranging from cell line
development to early stage clinical phase.

The Company operates commercial manufacturing capacity of 360,000L (Plant 1 – 30,000L, Plant 2 –
150,000L, Plant 3 – 180,000L) and clinical manufacturing capacity of 4,000L in Incheon Free Economy
Zone (Songdo region). This is the largest manufacturing capacity in the global CMO industry. The

Company established an overseas subsidiary, Samsung Biologics America, Inc. in the United States to
secure stable sales growth and overseas expansion. In addition, the Company achieved a fruitful
performance in both CDO and Drug Product(DP) businesses, remarked by its DP production of
Moderna’s mRNA vaccine. Meanwhile, the company’s subsidiary, Samsung Bioepis is a
biopharmaceuticals Research & Development firm that is working on the development and
commercialization of biosimilars.

In 2022, the global biopharmaceutical market is valued at USD 359 billion, which accounts for 29.7%
of the entire pharmaceutical market. The biopharmaceutical market is expected to increase with an
average growth rate of 10.6% by 2026. The rapid growth is expected to boost the expansion of the
overall pharmaceutical market. In addition, the recent trend shows the greater reliance on CMO
companies by global pharmaceutical companies (Evaluate Pharma, May 2022). The CDMO industry is
expected to increase from USD 14.3 billion in 2022 to USD 20.3 billion in 2026 with an average growth
rate of 10.1%, based on the following factors (Frost&Sullivan, Jul 2021).

The growth engines for biopharmaceutical market include:


1) Consistent development of blockbuster biopharmaceuticals
2) Increasing production outsourcing by pharmaceutical companies and biotechs
3) Increasing demand of end-to-end CDMO services
4) Increasing demand of dual sourcing for securing supply stability

The Company is a contract manufacturer specializing in mammalian cell-based antibody drugs, which
is a major component of the biopharmaceutical market. The market is oligopolistic, dominated by a few
players with large-scale manufacturing facilities. As of 2022, there are three companies with a global
production capacity of over 300,000L production: Korea-based Samsung Biologics, Switzerland-based
Lonza, and Germany-based Boehringer Ingelheim. The Company runs 364,000L production facilities
as of now and plans to concrete its leading position as it completes the construction of Plant 4 with
256,000L capacity by 2023.

The Company is currently widening the scope of business to CDO services, mRNA, and cell/gene
therapy manufacturing to transform into a global biopharmaceutical company. The CDO business
provides cell line and process development and characterization services for small and medium-size
biotechs, which do not have their own development facilities. The Company launched a high-performing
cell line ‘S-CHOice’, which delivers high productivity and viability, and ‘S-Cellerate’, which is a platform
that innovatively shortens the development period through a standardized process for each
development stage. Furthermore, the Company opened its first global CDO R&D center in the renowned
San Francisco Biopharma Cluster in October 2020 and currently plans to widen the scope of the market
to Boston, Europe, and China.

The Company has implemented mRNA production capacity within its existing manufacturing plant,
which is cGMP ready in April 2022. Additionally, the Company is under review for various options
including construction and M&A, considering overall technology trends, marketability and profitability
related to cell and gene therapy.

(2) Biopharmaceutical development and commercialization

Samsung Bioepis conducts business focusing on the development and commercialization of


biopharmaceuticals, and is promoting R&D in various disease areas such as autoimmune diseases,
tumor diseases, ophthalmic diseases, and blood diseases. Since the establishment of the company in
2012, six biosimilars (Remicade, Herceptin, Enbrel, Humira, Avastin, and Lucentis similar) have been
released to date, and are actively sold throughout the world, including the United States, Europe,
Canada, Australia, and Brazil. As such, the Company has succeeded in the approval and
commercialization of biosimilar products ranging from autoimmune diseases and oncological diseases
to ophthalmic diseases. In addition, the Company is developing biosimilars for Soliris for blood diseases,
Eylea for eye disease, Prolia for endocrine disease, and Stelara for immune disease. Soliris similar is
preparing to apply for approval in major countries after completing phase 3 clinical trials, and Eylea,
Prolia, and Stelara's similar products are currently undergoing phase 3 clinical trials. Based on the
experience in development and commercialization of biosimilars, the Company expects to expand its
future business and continue to innovate.

[Financial Status Summary by Business Division]

The revenue in the first half of 2022 was 1.163 trillion won with an operating profit of 346.1 billion won.

(Unit: KRW Mil)

1H 2022 2021 2020


Business Unit Type
Amount Share Amount Share Amount Share
1. Revenue 1,013,351 87.2% 1,568,007 100.0% 1,164,777 100.0%
2. Operating
CDMO 348,647 100.7% 537,309 100.0% 292,787 100.0%
Profit/Loss
3.Asset 7,577,957 48.4% 7,970,011 100.0% 6,424,201 100.0%
Biopharmaceutical 1. Revenue 149,376 12.8% - - - -
development and 2. Operating (2,557) -0.7% - - - -
commercialization Profit/Loss
(*1) 3.Asset 8,081,485 51.6% - - - -
1. Revenue 1,162,727 100.0% 1,568,007 100.0% 1,164,777 100.0%

Total 2. Operating 346,090 100.0% 537,309 100.0% 292,787 100.0%


Profit/Loss
3.Asset 15,659,442 100.0% 7,970,011 100.0% 6,424,201 100.0%
※ Consolidated basis in accordance with K-IFRS

(*1) The Company acquired an additional 10,341,852 shares of Samsung Bioepis Co., Ltd to secure a 100% stake in the company.
As a result, biopharmaceutical development and commercialization of Samsung Bioepis Co., Ltd. was added as separate sales
segment.
(*2) Operating profit and loss excluding the impact of amortization on the fair value of identifiable assets due to the business
combination for biopharmaceutical development and commercialization is 30 billion won. The operating profit or loss is the amount
calculated after the biopharmaceutical development and commercialization sector was incorporated into the company.

2. Key Products and Service

A. Major products
(Unit: KRW Bil)

1H 2022 2021 2020


Business Unit Type Item
Amount Share Amount Share Amount Share
CDMO Goods Biologics 938.9 80.8% 1,442.0 92.0% 1,102.6 94.7%
Services Others 74.4 6.4% 126.0 8.0% 622 5.3%

Biopharmaceutical
development and
commercialization Goods Biosimilar 149.4 12.8% - - - -
(*1)

Total 1,162.7 100.0% 1,568.0 100.0% 1,164.8 100.0%


※ Consolidated basis in accordance with K-IFRS.
(*1) The Company acquired an additional 10,341,852 shares of Samsung Bioepis Co., Ltd to secure a 100% stake in the company.
As a result, biopharmaceutical development and commercialization of Samsung Bioepis Co., Ltd. was added as a separate
business segment.

B. Price fluctuation of major products

(1) CDMO
The selling price of the product to be produced by the Company is adjusted according to the ratio of
reflecting the CPI (Consumer Price Index) announced every year to the initial sales price determined
under the contract with the customer, or it may be adjusted according to the terms of the contract, such
as increasing by the fixed ratio stated in the contract

(2) Biopharmaceutical development and commercialization


The direct sales channel adjusts the sales price according to the market conditions, while in the case
of indirect sales through a distributor, the product price is calculated by considering the country's market
price of the product, various deductions, and the partner's margin according to the contract with the
distributor.
3. Raw Materials

A. Purchase of major raw materials


(Unit: KRW Bil)
Amount of Remarks
Business Unit Type Item
purchase (place of purchase)
- Global Life Sciences Solutions Singapore,
Raw
Resin, etc. 231.6 Life Technologies Corporation, Sigma-
materials
CDMO Aldrich Korea etc.
Auxiliary - Merck Limited, Satorious Korea Biotech,
Filter, etc. 102.5
materials Imarket Korea, etc.
Raw
Biopharmaceutical Resin, etc. 22.1 -
materials
development and
Spare
commercialization Syringe, etc. 8.1 -
parts
Total 364.3
※ The CDMO business generally receives a full refund of raw/auxiliary materials and handling fees in form of BOM (Bill of
Material) from customers.
※ In the biopharmaceutical development and commercialization sector, the procurement is made to order by the purchaser due
to the nature of the business, and in the case of major purchasers, the detailed information is omitted according to the
competitive situation and the contents of the mutual contract.

B. Raw materials price trends and major components


(1) CDMO
The major raw materials used in the pharmaceuticals are either confirmed by the customer for reasons
such as quality control or purchased through the vendor assigned by the customer. Pre- or post-
settlement (reimbursement) is made by the customer for the purchased raw materials and incidental
expenses. Due to these terms and conditions, the risks associated with the purchase of raw materials,
such as price fluctuations, are limited. Meanwhile, the Company signs a long-term contract with raw
material suppliers to obtain a stable supply of raw materials, and applies the inflation rate (approx.
1~2%) level of raise to a price increase. Therefore, risks relating to price fluctuation due to the limited
contract terms.

(2) Biopharmaceutical development and commercialization


Samsung Bioepis' main raw materials for biopharmaceuticals have relatively low price liquidity due to
mid- to long-term supply, and are less affected by economic trends. The global supply risk caused by
COVID-19 that occurred in some items was resolved through close management of business partners,
and the supply situation has been gradually stabilizing since the first half of the year. In order to respond
to recent inflation and rising raw material prices, Samsung Bioepis is focusing on securing safety stocks
and suppressing the increase in total cost through close cooperation with raw and subsidiary material
suppliers.

C. Production capacity, production performance and operating rate

The Company calculates operating rate by separating actual working time from non-working time of key
production facilities, where the annual production capability is calculated by considering the Slowdown
and Product Changeover period per Drug Substance production plant.
(Unit: batch)

1H 2022 2021 2020


Production capacity 220 455 392
Production performance 177 367 237
Operating rate 80.5% 80.7% 60.5%

D. Manufacturing facilities and investment

(1) Manufacturing facilities


(Unit: KRW Mil)
Acquisition Other
Beginning End
Assets Acquisition due to Disposal Depreciation increase/ Remarks
of period of period
business reduction
Land - 186 combination
133,036 - - 7,843 141,065 Note 1)
Building 719,023 274 165,426 - (11,192) 26,703 900,234 -
Fixtures 9,297 - 2,532 - (145) - 11,684 -
Machinery 876,566 - 15,106 (161) (62,327) 43,713 872,897 -
Vehicles 163 - - - (34) 25 154 -
Others 18,655 1,762 4,556 - (4,783) 4,214 24,404 -
Assets under
583,360 410,605 6,380 (42) - (82,139) 918,164 -
construction
Total 2,207,064 412,827 327,036 (203) (78,481) 359 2,868,602 -

Note 1) The Company is exempted from paying rental fees as the Company satisfied the requirements for rental fee exemption
in accordance with the Ordinance of Common Property Management of Incheon Metropolitan City by signing a lease
agreement with Incheon Metropolitan City.
※ Fair value is excluded as an objective estimation for major tangible assets is difficult.
※ The manufacturing facilities status of 1H 2022 is based on consolidated basis in accordance with K-IFRS.

(2) Investments
(Unit: KRW Bil)

Business Segment Classification Investment Period Target assets Investment Amount

New, extended, Manufacturing


CDMO 2022.01~2022.06 427.9
supplemented, etc. facilities, etc.

4. Sales

A. Sales performance

(1) Sales performance by product type


(Unit: KRW Bil)

1H 2022 2021 2020


Business Unit Type Item
Amount Share Amount Share Amount Share
Goods Biologics 938.9 80.8% 1,442.0 92.0% 1,102.6 94.7%
CDMO
Services Others 74.4 6.4% 126.0 8.0% 62.2 5.3%

Biopharmaceutical
development and
commercialization Goods Biosimilar 149.4 12.8% - - - -
(*1)

Total 1,162.7 100.0% 1,568.0 100.0% 1,164.8 100.0%


※ Consolidated basis in accordance with K-IFRS.
(*1) The Company acquired an additional 10,341,852 shares of Samsung Bioepis Co., Ltd to secure a 100% stake in the company.
As a result, biopharmaceutical development and commercialization of Samsung Bioepis Co., Ltd. was added as a separate
business segment.

(2) Sales performance by location


(Unit: KRW Bil)

1H 2022 2021 2020


Location
Amount Share Amount Share Amount Share
Korea 83.8 7.2% 346.3 22.1% 296.6 25.5%
Europe 775.6 66.7% 753.8 48.1% 527.5 45.3%
US 225.9 19.4% 448.6 28.6% 289.5 24.8%
Others 77.4 6.7% 19.3 1.2% 51.2 4.4%
Total 1,162.7 100.0% 1,568.0 100.0% 1,164.8 100.0%
※ Consolidated basis in accordance with K-IFRS.

B. Sales channel

(1) CDMO
The most important thing for Samsung Biologics’s sales activities is to sign contracts with customers
since the CMO business in which the Company is engaged is a contract-based industry. It usually takes
6~12 months to win an order (from the date when a customer’s request for proposal was received until
the date when a contract is concluded), and is implemented as follows :

[Order-winning process]
Category Details
• Inspect the status of customers (organization, number of products,
Discover a
Contact the clinical test progress, capacity, etc.)
potential
customer • Contact a customer when participating in exhibitions and introduce
customer
CMO services
Request for Meeting of • Email, telephone, visit and meeting, etc.
the persons in charge • Take the minutes of a meeting
customer’s Check the volume • Sign a confidential agreement, provide corporate profile data (incl.
CMO(RFP) to order capacity), attract to visit the Songdo site
• Review related divisions of each field
• Financial risk: review differentiated batch prices
Review risks
• Legal risk: existing products ordered, noncompetitive review with
Samsung Biologics’ products
Submit a
• Suggest contract terms in which the customer’s conditions for
proposal
manufacturing process are reflected
Review terms and
• Consider conditions including contract period, time available to
conditions
manufacture, price, scope of services, minimum volume
guaranteed, capacity reserve, etc.
Select candidate
• A customer selects 2~3 candidate CMOs
CMOs
Select a CMO
Select a preferred
• A customer selects a preferred CMO through final evaluation
CMO
• Review related divisions of each field
• Financial risk: minimum volume guaranteed/reserve volume,
Review risks
service sales item, etc.
• Legal risk: liability scope, noncompetitive clauses, etc.
Consult on
Consult on basic • Negotiate on and adjust major conditions
contract terms
contract terms • Prepare MOU and LOI
Consult on
detailed contract • Consult on conditions for master service agreement
terms
Exchange a final
Win a contract • Develop a final contract
contract

Following these procedures, the Company recognizes sales at the point of quality release (QR) by the
customer for the products manufactured, and delivers the customer’s inventory stored in the Company’s
warehouse to a location designated by the customer (generally a customer’s carrier) in accordance with
the contract. Meanwhile, the Company does not have separate sales channels or agencies.

(2) Biopharmaceutical Development and Commercialization


Samsung Bioepis products can be divided into two sales channel.

① Company → Partner → Wholesale/Hospital

Established partnerships with global or national pharmaceutical companies, and sells products to
wholesalers/hospitals by country through partnership.

② Company → Wholesale/Hospital

Products are sold to wholesalers or hospitals in some European countries through direct bidding or
contract.

C. Sales method and conditions

(1) CDMO
The sales method and conditions for biopharmaceutical manufactured by the Company are separately
determined by a contract with the customer. According to the contract, annual minimum volume of
production is determined, and the volume requested for PO by the customer is manufactured and
delivered to the designated location. Sales recognition and billing are implemented at the time when
the customer’s quality approval is obtained for the products manufactured, and the payment is collected
within 30~60 days after billing.

(2) Biopharmaceutical Development and Commercialization


Samsung Bioepis manages the entire process related to development and production and hands over
the manufactured products to its partners. The sales method differs depending on the contract terms
with each partner, and sales are recognized through distribution of profits from products sold through
the partner company.

D. Sales strategy

(1) CDMO
The Company provides company information such as cutting-edge manufacturing facilities,
technological competence, and excellent manpower through various methods including homepage,
advertisements, press releases, overseas exhibitions/conferences, company presentations, and virtual
due diligence and exhibition hall while striving to raise its profile worldwide as a bio-company of
Samsung Group. Based on these efforts, the Company has participated every year in the BioPhorum,
a conference of executives from global biopharmaceutical manufacturers, since joining in 2012.

The Company will make new contracts and expand existing contracts by constantly communicating
about the Company’s production capacity, facility expansion progress, and future plans and by
maintaining relationships with existing/potential customers. The Company also leads strategic sales
activities by actively participating in various inner circle meetings to identify demand for
biopharmaceutical production and competitors’ production plans.

In addition, we are expanding our customers from large pharmaceutical companies to small and
medium-sized biotech companies, and to increase orders, we continue to strengthen our marketing
capabilities and expand our global network. Besides, we are enhancing our potential customers'
confidence in our production and quality control capabilities through thorough track record management.

(2) Biopharmaceutical Development and Commercialization


Samsung Bioepis sells 6 types (3 autoimmune diseases, 2 cancer treatments, 1 eye disease) of
biosimilar products in various parts of the world, including the US and Europe, through partnerships
with global pharmaceutical companies. Bioepis is also selling 5 types (3 autoimmune diseases, 2 cancer
treatments) of products domestically through partnerships. Recently, the first eye disease
treatment(Lucentis biosimilar) was released in the US, and one autoimmune disease treatment(Humira
biosimilar) and one cancer treatment(Avastin biosimilar) were first released. Samsung Bioepis plans to
continuously lay the foundation for future growth as a global biosimilar leader by expanding our portfolio
of various biosimilar products including autoimmune diseases, cancer treatment, eye disease treatment
and rare diseases.

E. Sales condition

Initial
Total
Business commercial Delivered Order
Item Deadline Case amount of
Segment production amount backlog
contracts
year
Amount
7,944 3,703 4,241
Minimum Take (USD Mil)
or Pay Production
~2031 34,098,000 16,310,000 17,788,000
Antibody (Liter)
CDMO 2015 *Subject to
drugs each contract Amount
Expected demand 12,603 3,703 8,900
(USD Mil)
when the customers
develop the productsProduction
50,572,000 16,310,000 34,262,000
(Liter)
Note 1) Total contract amounts may also increase after the consultation depending on the increase in customers’ demands.
Note 2) Total contract amounts above exclude raw material revenue from raw materials and supplies that have been put into
production and service revenue from production process improvements and additional services such as quality analysis.

5. Financial Risk Management and Derivative Instruments

A. Financial Risk Management

The Company’s risk management policies are established to identify and analyze the risks faced by the
Company, to set appropriate risk limits and controls, and to monitor risks and adherence to limits. Risk
management policies and systems are reviewed regularly to reflect changes in market conditions and
the Company’s activities. The Company, through its training and management standards and
procedures, aims to maintain a disciplined and constructive control environment in which all employees
understand their roles and obligations. The Board of Directors oversees how management monitors
compliance with the Company’s risk management policies and procedures and reviews the adequacy
of the risk management framework in relation to the risks faced by the Company.

B. Credit Risk

Credit risk is the risk of financial loss to the Company if a customer or counterparty to a financial
instrument fails to meet its contractual obligations and arises principally from the Company’s receivables
from customers. The carrying amount of financial assets represents the maximum credit exposure. The
maximum exposures to credit risk at the end of 1H 2022 and 2021 are as follows:
(Unit: KRW Thousand)

Description End of 1H 2022 End of 2021

Cash and cash equivalents(*) 212,988,316 47,410,384

Short-term financial instruments 1,182,929,000 450,000,000


Financial assets at fair value
1,751,492,354 850,039,877
through profit or loss
Long-term financial instruments 7,214,024 189,491

Accounts receivable and other receivables 666,008,656 354,616,237

Derivative assets 20,455,459 4,091,971

Guarantee deposits 61,141,186 46,812,354

Total 3,902,228,995 1,753,160,314


(*) The cash amount held by the Company is excluded.

C. Liquidity Risk

Liquidity risk is the risk that the Company will encounter difficulty in meeting the obligations associated
with its financial liabilities which are settled by delivering cash or other financial assets. The Company’s
approach to managing liquidity is to ensure, as much as possible, that it will always have sufficient
liquidity to meet its liabilities when they are due, under both normal and stressed conditions, without
incurring unacceptable losses or risking damage to the Company’s reputation.

The ultimate responsibility for liquidity risk management remains with the Board of Directors, which
establishes fundamental policies to adequately manage short-term, medium- and long-term financing
and liquidity management regulations. To maintain adequate liquidity, the Company manages liquidity
risk by periodically forecasting and adjusting its capital balance.

Contractual maturity dates of financial liabilities as of the 1H 2022 and 2021 are as follows. The amount
includes interest paid and excludes the impact of netting agreements. The Company does not anticipate
that the cash flow included in the maturity analysis could occur significantly earlier or at different
amounts.
(1) End of 1H 2022

(Unit: KRW Thousand)


Contractual More than
Description Book Value In 1 year 1-2 years 2~3 years
Cash Flow 3 years
Accounts payable and
2,061,985,139 2,095,784,093 1,528,774,554 556,967,998 - 41,541
other payables

Lease liabilities 16,726,841 17,943,661 8,772,283 5,406,570 3,469,758 295,050

Bonds 538,791,048 567,859,868 50,991,276 9,853,121 383,913,816 123,101,655

Short-term borrowings 460,653,000 464,512,563 464,512,563 - - -

Long-term borrowings 1,218,077,000 1,252,822,309 519,305,999 539,462,955 194,053,355 -

Total 4,296,233,028 4,398,922,494 2,572,356,675 1,121,690,644 581,436,929 123,438,246

(2) End of 2021


(Unit: KRW Thousand)
Contractual More than
Description Book Value In 1 year 1-2 years 2~3 years
Cash Flow 3 years
Accounts payable and
345,578,834 345,578,834 342,930,338 2,648,496 - -
other payables

Lease liabilities 18,208,298 19,043,888 7,699,851 5,212,986 5,329,081 801,970

Bonds 538,553,996 573,433,181 11,239,000 50,279,070 387,507,876 124,407,235

Short-term borrowings 50,000,000 50,812,192 50,812,192 - - -

Long-term borrowings 685,985,000 711,781,531 123,454,360 435,842,182 152,484,989 -

Total 1,638,326,128 1,700,649,626 536,135,741 493,982,734 545,321,946 125,209,205

D. Foreign Exchange Risk

The Company is exposed to currency risk on sales, purchases, and borrowings. The currencies in which
these transactions primarily are denominated are USD and so forth. The Company establishes a plan
to manage currency risk through currency forwards and so forth, if considered necessary.
(1) Exposure to currency risk
The Company’s level of exposure to foreign currency risk is as follows :
(Unit: KRW Thousand)

End of 1H 2022 End of 2021


Description
USD EUR JPY GBP Others USD EUR JPY GBP

Assets:

Cashable
161,736,471 63,456 - 3,123,611 199,130 2,609 - - -
asset
Short-term
financial 12.929.000 - - - - - - - --
instruments
Trade and
other 591,810,508 1,354,702 - 4,613,373 3,305,802 320,350,462 100,535 - 608,143
receivables
Contract
33,462,946 - - - - 27,999,271 - - -
asset

Subtotal 799,938,925 1,418,158 - 4,613,373 3,305,802 348,352,342 100,535 - 608,143

Liability:

Borrowings
181,006,000 - - - - 11,855,000 - - -
(*)
Trade and
other 1,550,960,747 24,605,150 3,267,499 1,314,383 10,498,550 4,839,226 2,362,327 2,001 142,919
payables

Subtotal 1,731,966,747 24,605,150 3,267,499 1,314,383 10,498,550 16,694,226 2,362,327 2,001 142,919

Total (932,027,822) (23,186,992) (3,267,499) (3,298,990) (7,192,748) 331,658,116 (2,261,792) (2,001) 465,224

(*) Swap-covered borrowings are excluded as they are not exposed to currency risk.

(2) Exchange rate


The exchange rate applied during 1H 2022 and 2021 are as follows :
(Unit: KRW)

1H 2022 2021
Description
Average End Average End
USD 1,232.94 1,292.90 1,144.42 1,185.50
EUR 1,346.94 1,350.05 1,352.79 1,342.34
JPY(100¥) 1,002.94 946.45 1,041.45 1,030.24
GBP 1,599.65 1,567.32 1,573.96 1,600.25

(3) Sensitivity analysis


The Company regularly estimates the foreign exchange risk for fluctuations in KRW exchange rates.
The impact of fluctuations in exchange rates on income before income taxes when KRW exchange
rates change by 10% to each foreign currency as of the end of 1H 2022 and 2021 are as follows :
(Unit: KRW Thousand)

End of 1H 2022 End of 2021


Category
Increase of 10% Decrease of 10% Increase of 10% Decrease of 10%

USD (93,202,782) 93,202,782 33,165,812 (33,165,812)


EUR (2,318,699) 2,318,699 (226,179) 226,179
JPY (326,750) 326,750 (200) 200
GBP 329,899 (329,899) 46,522 (46,522)
Others (719,275) 719,275
Total (96,237,607) 96,237,607 32,985,955 (32,985,955)

E. Interest Rates Risk

The Company is exposed to interest rate risk because it raised funds with interest paid at a variable
rate. If the interest rate changes by 0.5% as of the current and previous quarters, the effect of the
change in the interest rate on the income before income tax is as follows :
(Unit: KRW Thousand)

1H 2022 1H 2021
Description
Increase of 0.5% Decrease of 0.5% Increase of 0.5% Decrease of 0.5%

Increase(Decrease) in
(1,640,076) 1,640,076 (664,493) 664,493
Interest expense

F. Capital Management

The Company’s capital management is for the purpose of maximizing the shareholders’ interest by
maintaining an optimal capital structure. To achieve optimal capital structure, the Company may improve
its financial structure by monitoring financial ratios, such as the debt-to-equity ratio.

Debt ratio as of the end of 1H 2022 and 2021 are as follows :


(Unit: KRW Thousand)

Description End of 1H 2022 End of 2021


Liabilities (A) 7,179,559,648 2,978,908,646
Capital (B) 8,479,882,264 4,991,102,141
Debt ratio (A/B) 84.67% 59.68%

G. Derivative Instruments and Put-back Options

[Samsung Biologics]
The Company has established contracts for financial derivatives for foreign currency borrowings for
the purpose of hedging exchange rate risk of foreign currency receivables/debts and interest rate, and
the details are listed below.

(1) Currency Interest Swap Contract


Currency Committed Interest rate(%)
Financial Contract Contract Maturity
Classification Category exchange
institution Amount Date Date
Sell Buy rate Received Paid

Currency
USD Libor(3M)
Trading interest Hana bank 2018.05.31 2023.05.31 USD KRW 1,080 3.70
30,000,000 + 1.70
swap
Currency
USD Libor(3M)
Trading interest Woori bank 2021.08.30 2024.08.30 USD KRW 1,164 2.15
30,000,000 + 1.20
swap

(2) Interest Swap Contract

Interest rate(%)
Financial Contract Contract Maturity
Classification Category
institution Amount Date Date
Received Paid

Interest KRW CD(91Days)


Trading Woori bank 2020.09.28 2023.10.02 2.25
swap 50,000,000,000 + 1.23

(3) Derivative liabilities related to the acquisition of investment securities by other corporations
(conditional consideration)
The Company entered in an agreement to acquire 10,341,852 shares of Samsung Bioepis Co., Ltd.
owned by Biogen Therapeutics Inc. on January 28, 2022. The Company will determine whether the
conditions for payment of contingent considerations are satisfied by year according to the sales
performance of the investee company through the seller, and then decide the size of the contingent
consideration during 2027. The nominal amount that the Company is likely to pay in the future in
accordance with the above arrangement is in the range of USD 0 - 50,000,000. At the acquisition date,
the fair value of the contingent consideration was estimated as 20,541,985 thousand won using the
option valuation model.

(4) Gain and Loss on Valuation


Accumulated Other
Classification Gain on Valuation Loss on Valuation
Comprehensive Income

Currency Interest swap KRW 8,243,993,964 - -

Interest swap KRW 786,184,547 - -


Contingent considerations in
- KRW 1,843,510,147 -
the stock purchase

[Samsung Bioepis]
The Company has established contracts for financial derivatives for foreign currency borrowings for the
purpose of hedging exchange rate risk of foreign currency receivables/debts and interest rate, and the
details are listed below.

(1) Currency Interest Swap Contract


Currency Committed Interest rate(%)
Financial Contract Contract Maturity
Classification Category exchange
institution Amount Date Date
Sell Buy rate Received Paid

Currency
USD Libor(3M)
Trading interest Hana bank 2020.12.17 2023.12.14 USD KRW 1,089 2.40
30,000,000 + 1.80
swap

(2) Interest Swap Contract

Interest rate(%)
Financial Contract Contract Maturity
Classification Category
institution Amount Date Date
Received Paid

Interest KRW CD(91Days)


Trading Hana bank 2019.09.23 2022.09.23 3.52
swap 75,000,000,000 + 2.22

Interest KRW CD(91Days)


Trading Hana bank 2020.07.28 2022.07.28 2.87
swap 100,000,000,000 + 1.90

(3) Gain and Loss Valuation of Derivative Liabilities


Accumulated Other
Classification Gain on Valuation Loss on Valuation
Comprehensive Income

Currency Interest swap KRW 836,835,599 - -

Interest swap - KRW 124,935,845 -

6. Major Contracts for Business Management

※ For detailed information, refer to 'Table-4, R&D Performance(Details)'

A. License-Out Contracts
- Not applicable

B. License-In Contracts
- Not applicable

C. Sales Contracts

[Samsung Biologics]
As of the date of preparation of the disclosure document, the current status of major sales contracts
signed by the Company are as follows.
(Unit: USD Mil)

Contract Contract Payment


Company name Details Amount Remarks
start date end date method

Biopharm Cilag GmbH International CMO 2016.11.15 - 291.8 Cash -


Biopharm Sun Pharma Global FZE CMO 2017.07.04 - 55.5 Cash -
Biopharm U.S. based pharma CMO 2017.07.20 - 14.9 Cash -
Biopharm Checkpoint Therapeutics, Inc., CMO 2017.11.08 2022.11.09 7.2 Cash -
Biopharm UCB CMO 2017.12.21 - 41.7 Cash -
Biopharm TG Therapeutics, Inc. CMO 2018.02.21 2026.12.31 50.3 Cash -
Swiss based subsidiary of a global
Biopharm CMO 2018.04.30 2025.12.31 449.4 Cash -
pharma
Biopharm Ichnos Sciences CMO 2018.06.01 - 15.1 Cash -
Biopharm Asia based pharma CMO 2018.08.14 - 127.6 Cash -
Biopharm Gilead Sciences, Inc. CMO 2018.09.11 2025.12.31 266.5 Cash -
Biopharm Immunovant Sciences GmbH CMO 2018.12.18 2029.12.31 43.5 Cash -
Biopharm CytoDyn Inc. CMO 2019.04.01 2027.12.31 50.2 Cash -
Biopharm Asia based pharma CMO 2019.04.26 - 17.1 Cash -
Biopharm Asia based pharma CMO 2019.04.26 - 32.0 Cash -
Biopharm Asia based pharma CMO 2019.05.14 - 29.8 Cash -
Biopharm UCB CMO 2019.05.17 - 33.8 Cash -
Biopharm H. Lundbeck A/S CMO 2019.09.27 2031.12.31 27.9 Cash -
Biopharm Asia based pharma CMO 2019.11.28 - 19.1 Cash -
Biopharm U.S. based pharma CMO 2019.12.03 - 58.2 Cash -
GlaxoSmithKline Trading Services
Biopharm CMO 2020.05.21 2028.12.31 505.4 Cash -
Limited
Biopharm Eli Lilly and Company CMO 2020.07.27 2026.08.30 268.3 Cash -
GlaxoSmithKline Trading Services
Biopharm CMO 2020.08.05 2023.12.31 226.9 Cash -
Limited
Biopharm AstraZeneca UK Ltd., CMO 2020.09.21 2023.12.31 16.0 Cash -
Biopharm AstraZeneca AB CMO 2020.09.21 2028.12.31 377.5 Cash -
Biopharm Checkpoint Therapeutics, Inc., CMO 2020.10.06 2030.10.02 19.7 Cash -
Biopharm U.S. based pharma CMO 2020.11.03 2030.12.31 16.1 Cash -
Biopharm FibroGen, Inc. CMO 2020.11.09 2022.12.31 51.5 Cash -
Biopharm F.Hoffmann-La Roche Ltd CMO 2021.01.15 2024.12.31 202.3 Cash -
Biopharm F.Hoffmann-La Roche Ltd CMO 2021.01.15 2024.12.31 550.2 Cash -
Letter of
Biopharm MSD International Business GmbH CMO 2021.09.29 - 41.5 Cash
Intent
Letter of
Biopharm Europe based pharma CMO 2021.10.30 2022.12.31 56.6 Cash
Intent

Biopharm Eli Lilly Kinsale Limited CMO 2022.03.28 2029.12.31 92.0 Cash -

Letter of
Biopharm Europe based pharma CMO 2022.04.25 - 124.1 Cash
Intent
Letter of
Biopharm Novartis Pharma AG CMO 2022.06.04 - 81.0 Cash
Intent

[Samsung Bioepis]

Contracting Contract Contract Payment


Product Contract purpose, condition, etc Amount Remarks
party start date end date method

SB2 (Remicade biosimilar) Marketing, sales, and supply


SB3 (Herceptin biosimilar) of products are carried out US,
Organon
SB5 (Humira biosimilar) with exclusive sales rights for 2013.02.18 Note 1 Note 1 Cash Europe,
LLC
SB8 (Avastin biosimilar) contracted products within the etc
SB4 (Enbrel biosimilar) target area.

Marketing, sales, and supply


SB2 (Remicade biosimilar) Biogen of products are carried out
Europe,
SB4 (Enbrel biosimilar) International with exclusive sales rights for 2013.12.13 Note 1 Note 1 Cash
etc.
SB5 (Humira biosimilar) Holding Ltd contracted products within the
target area.
Marketing, sales, and supply
of products are carried out US,
SB11 (Lucentis biosimilar) Biogen MA
with exclusive sales rights for 2019.11.05 Note 1 Note 1 Cash Europe,
SB15 (Eylea biosimilar) Inc
contracted products within the etc
target area.
Note 1) Details are not provided as they are considered as trade secrets.

D. Other Contracts

[Samsung Biologics]

(1) Contract signed to construct plant #4


At the Board of Directors meeting on October 26, 2021, the Company and Samsung Engineering Co.,
Ltd. decided to sign the contract. The actual signing was on October 29, 2021. The down payment
was KRW 911 billion (VAT excluded).

(2) Purchase of site for Knowledge & Information Industrial Complex


On November 3, 2021, the Company signed a contract with the Incheon Free Economic Zone
Authority to purchase the site at 218-3 Songdo-dong. The purchase price was KRW 7.8 billion.

(3) Signed a contract to acquire full ownership of Samsung Bioepis


For the diversification of its portfolio and enhancement of business competitiveness as a
Biopharmaceutical company, the Company agreed to acquire 10,341,852 shares of Samsung Bioepis
Co., Ltd. owned by Biogen Therapeutics Inc. in accordance with the resolution of the Board of Directors
on January 28, 2022. The total transaction payment amount of USD 2,300,000,000 comprises of the
purchasing price and contingent consideration amounting to USD 2,250,000,000 and USD 50,000,000,
respectively. On April 20, 2022, the Group acquired 10,341,852 shares of Samsung Bioepis Co., Ltd.
and secured control of the investee by obtaining 100% of the shares.

E. R&D Activities

(1) R&D organization

[Samsung Biologics]
The Company has R&D organizations as follows: Technology Support Center, Contract Development
Organization R&D Team, Advanced Research Team, and Samsung Biologics America R&D Team.
These organizations provide technical support for clients’ manufacturing production and R&D services
for cell line development.

[Job description]
Category Details

1) Research services for improving client manufacturing production


Technical support for 2) Technology transfer
manufacturing production - R&D project between a client for products which are to be produced in the Company’s site
- Technology transfer or development service of analysis method

1) Cell line development service (develop high-productivity cell lines)


2) Process development service (improve the productivity through process development)
Cell line and process
- R&D by combining process conditions and culture medium to improve a tire when culturing cells
research/ development
- R&D for the process to improve target protein refining yield
- R&D related to quality analysis

[Samsung Bioepis]
Samsung Bioepis R&D is carried out in the development headquarters (CD team, PD team, QE team,
etc.) and production headquarters, and is in charge of cell line and process research/development,
clinical medicine-related activities, and production-related technical support.
[Job description]

Category Details

1) Cell line development service (develop high-productivity cell lines)


2) Process development service (improve the productivity through process development)
Cell line and process
- R&D by combining process conditions and culture medium to improve a tire when culturing cells
research/development
- R&D for the process to improve target protein refining yield
- R&D related to quality analysis
1) Clinical related activities
- Preparation of clinical planning and protocol, preparation of clinical trial result report
- Clinical operation such as selection/management of clinical outsourcing companies, project
Clinical medicine execution, etc.
related activities - Management of clinical trial result data statistics and clinical data
2) Medical related activities
- Proof of medical excellence through external academic presentations, etc.
- Drug safety management and action in case of adverse events

1) Research services for improving client manufacturing production


Technical support for 2) Technology transfer
manufacturing production - R&D project between a client for products which are to be produced in the Company’s site
- Technology transfer or development service of analysis method

(2) R&D Manpower Status

[Samsung Biologics]
As of the reporting date, the Company has 430 staff members assigned to research and development
activities, with 58 holding doctorate degrees and 179 holding master’s degrees. The details are as
follows :

(Unit: person)

Team Ph.D M.S. Other Total


Technology Support Center 22 101 132 255
CDO R&D Team 17 74 57 148
Advanced Technology Team 18 4 2 24
SBA R&D Team 1 - 2 3
Total 58 179 193 430

[Samsung Bioepis]

As of the reporting date, the Company has 500 staff members assigned to research and development
activities, with 98 holding doctorate degrees and 194 holding master’s degrees. The details are as
follows :

(Unit: person)

Team Ph.D M.S. Other Total


Development headquarter 92 157 173 422
Manufacturing headquarter 6 37 35 78
Total 98 194 208 500

(3) Key R&D Personnel

[Samsung Biologics]
The details of the Company’s key R&D personnel are as follows:
Name Position Function Career R&D Performance
[Theses]
- Bioreactor Operation for Transgenic
Nicotiana tabacum Cell Cultures and
Continuous Production of Recombinant
Human Granulocyte-Macrophage
- MSAT Business Unit Leader,
Colony-Stimulating Factor by Perfusion
Technology Samsung Biologics
Culture (2004, Enzyme Microb. Technol.)
Lee Vice Support - Global Management Leader,
- Effects of Pluronic F-68 on Cell Growth
Sangyoon President Center Celltrion
of Digitalis lanata in Aqueous Two-Phase
Leader - Doctor of Biotechnology,
Systems (2004, J. Microbiol. Biotechnol.)
Inha University
- Perfusion Cultivation of Transgenic
Nicotiana tabacum Suspensions in
Bioreactor for Recombinant Protein
Production (2006, J. Microbiol.
Biotechnol.)
Name Position Function Career R&D Performance
[Theses]
- A phase II trial of the pan-HER inhibitor
poziotinib, in patients with HER2-positive
metastatic breast cancer who had
received at least two prior HER2-
directed regimens: results of the
NOV120101-203 trial (2018,
International Journal of Cancer)
- CDO Business Unit Leader, - Once-Weekly Efpeglenatide Dose-
Samsung Biologics Range Effects on Glycemic Control and
- CEO, Lumebio Body Weight in Patients With Type 2
- Clinical Research & Development Diabetes on Metformin or Drug Naive,
Vice President, Referenced to Liraglutide (2019,
Head of
Kang Vice Hanmi Pharmaceutical Company Diabetes Care)
CDO
Jahoon President - Senior Clinical Project Manager, - Body weight management and safety
Division
Novartis with efpeglenatide in adults without
- Clinical Research Associate, diabetes: A phase II randomized study.
Chong Kun Dang (2019, Diabetes Obes Metab.)
- Doctor of Pharmacy, Sookmyung - Efficacy and safety of oncemonthly
Women’s University efpeglenatide in patients with type 2
diabetes: Results of a phase 2
placebocontrolled, 16-week randomized
dose-finding study (2020, Diabetes
Obes Metab.)
- Pharmacokinetic and dose-finding
studies on efpeglenatide in patients with
type 2 diabetes. Diabetes (2020, Obes
Metab.)
[Theses]
- Phytosphingosine and C2-
- USP2 Part Leader, phytoceramide induce cell death and
CDO
Samsung Biologics inhibit carbachol- stimulated
Lee Vice R&D
- Yuhan Corporation phospholipase D activation in Chinese
Jaesun President Team
- Doctor of Biochemistry, hamster ovary cells expressing the
Leader
Chungbuk National University Caenorhabditis elegans muscarinic
acetylcholine receptor (2001, FEBS
letters)

[Samsung Bioepis]
The details of the Company’s key R&D personnel are as follows:
Name Position Function Career R&D Performance
[Theses]
- Samsung Bioepis QE Team Leader - Clb-independent degradation of Met:
Executive Development - Samsung Electronics Advanced way to avoid agonism of bivalent Met
Kim
Vice Division Institute of Technology targeting antibody (2012, Oncogene)
Kyungah
President Leader - Doctor of Toxcology, The Johns - Mitogenic influence of R-Spondin 1
Hopkins University Protein on the Intestinal Epithelium
Neurotrophin (2005, Science)

[Theses]
- Factor Xia-specific IgG and a reversal
agent to probe intrinsic pathway function
in thrombosis and hemostasis (2016,
- Catalent Pharma
Kim Vice CD Team Science Translational Medicine)
- Pfizer
YunCheol President Leader - Inhibitors of My D88-dependent
- Doctor of Microbiology, UCLA
proinflamatory cytokine production
identified utilizing a novel RNA
interference screening approach (2010,
Plos One)
[Theses]
- Real-time monitoring of glycerol and
- Molecular Templates methanol to enhance antibody
Kim Vice PD Team - Merck production in industrial Pichia pastoris
Sehoon President Leader - Doctor of Chemical Engineering, bioprocesses (2015, Biocherrical
Texas A&M University Engineering Journal)
- Inhibition of prostate cancer osteoblastic
progression with VEGF121/rGel, a
Name Position Function Career R&D Performance
single agent targeting osteoblasts,
osteoclasts, and tumor neovasculature
(2011, Clin Cancer Res)

F. R&D Expenses

(Unit: KRW Bil, %)


1H 2022 2021 2020
Raw material expenses 10.6 16.4 19.3
Labor expenses 34.7 44.4 35.7
Type of Depreciation expenses 10.3 16.0 10.5
expenses Outsourcing expenses 9.7 - -
Others 11.5 15.1 13.1
Total R&D expenses 76.9 91.9 78.6
SG & A expenses 20.6 3.4 5.1
Manufacturing expenses 48.6 88.5 73.5
Accounting
classification Development expenses
7.7 - -
(Intangible Assets)
Total R&D expenses 76.9 91.9 78.6
R&D expenses/ Sales Ratio
6.6% 5.9% 6.7%
[Total R&D expenses / Sales*100]
Note 1) Consolidated basis in accordance with K-IFRS.
Note 2) The Company is not applicable to government subsidies.

G. R&D Performance

[Samsung Biologics]

(1) R&D Progress Status and Future Plans


The Company provides Contract Manufacturing Organization (CMO) and Contract Development
Organization (CDO) services to clients. The Company operates four R&D organizations; Technology
Support Center, Contract Development Organization R&D team, Advanced Research Lab, and SBA
R&D team. These organizations are dedicated to providing technical support for manufacturing
production and R&D services for cell line and process development. In addition, the Company is
currently expanding its presence in contract R&D services for cell line development for further
expansion. While widening the scope of the business area, the Company is doing its utmost to become
the global CDMO provider.

(2) R&D Completion Performance


The Company provides a wide range of technical services to clients, including Cell Line Development
and Method Development. The Company currently has no completed pipelines.

[Samsung Bioepis]

(1) R&D Progress Status and Future Plans


As of the date of preparation of disclosure document, the current status of new medicines(including
incrementally modified drug, generic drugs(biosimilar), etc.) under R&D is as follows:

Current status
Research
Type Product Application Approval Remarks
start date Phase(Country)
date
New Partnership
SB26 Acute pancreatitis 2017 Phase I(US) 2018
medicine with Takeda
Paroxysmal nocturnal Phase III Self-
SB12 2014 2019
hemoglobinura (Korea, EU, etc) development
Neovascular age-related
macular degeneration,
Phase III Self-
SB15 Macular Edema Following 2015 2020
(Korea, EU) development
Retinal Vein Occlusion,
Diabetic macular edema
Biosimilar Phase III Self-
SB16 Osteoporosis 2015 2020
(Korea, EU) development
Self-
Plaque psoriasis Phase I(EU) 2021
development
Psoriatic arthritis,
SB17 2015
Crohn's disease Phase III Self-
2021
Ulcerative colitis, (Korea, EU) development
Pediatric plaque psoriasis
※ For detailed information, refer to 'Table-4, R&D Performance(Details)'

(2) R&D Completion Performance


As of the date of preparation of disclosure document, the current status of new medicines (including
generic drugs(biosimilar), etc.) that have been developed is as follows:

Research Current Remarks


Type Product Application
end date Sales status (Partner company)
Psoriatic arthritis, Crohn's disease,
Ankylosing Myelitis,
SB2 2015 Korea, US, EU Biogen, Organon, Yuhan
Rheumatoid and psoriatic arthritis
psoriasis
SB3 Breast cancer 2017 Korea, US, EU Organon, Boryung
Biosimilar
SB4 Rheumatoid arthritis 2015 Korea, US, EU Biogen, Organon
Rheumatoid arthritis,
SB5 2017 Korea, US, EU Biogen, Organon, Yuhan
psoriatic arthritis
SB8 Colorectal cancer 2020 Korea, EU Biogen, Organon, Boryung
SB11 Macular degeneration 2021 US Biogen, Samil pharm
※ For detailed information, refer to 'Table-4, R&D Performance(Details)'

7. Other Information

A. Laws and Regulations Affecting Business Operation

Pharmaceutical manufacturer is under strict government regulation throughout all phases (pre-clinical
phase, clinical phase, IND approval, production and distribution, etc.) due to their nature of providing
products which bring significant impact on human lives.
Laws Details
- Regulate overall matters concerning medicine manufacturing business such as quality
control and manufacturer designation
Pharmaceutical Affairs
- Obtain a manufacturing license according to the Act
Act
- Impose administrative measures (revocation of license) or criminal punishments
(imprisonment or punishment of a fine)

Unfair Competition
and Prevention and
- Regulate the act of unjustifiably using or disclosing trade secrets of clients
Trade Secret
Protection Act

Act on the
Registration and - Regulate the registration, evaluation, and management of chemical substances that are
Evaluation, Etc. of not controlled as drug and quasi-drug by the Pharmaceutical Affairs Act
Chemical Substances, - Registration and evaluation requires cost and time to import the drug substances that fall
Toxic Chemicals under chemical substances subject to the Act
Control Act

Transboundary
Movement, Etc. of - Inspect the risks posed by living modified organisms
Living Modified - Regulate the import of living modified organisms and registration of the research facility
Organisms Act

- Regulate unfair trading practices and unfair collective practices across the entire business
area including winning an order for CDMO project, building manufacturing facilities, and
Fair Trade Act
purchasing materials
- Impose corrective measures, penalty, fine, etc. if related matters are violated

B. Business-related Important Intellectual Property Rights

[Samsung Biologics]

During the first half of 2020, Samsung Biologics launched its proprietary cell line development platform
S-CHOice. As of the end of 2021, The brand name S-CHOice has officially obtained its trademarks in
six countries (Korea, US, EU, UK, China, and Japan). In addition, S-Cellerate, a CDO platform brand
that compiles our accumulated know-how, expertise, and innovative technology across all areas of
consignment development service, was completed the registration of domestic trademarks in December
2021. The Company completed the trademark registration of the slogan Driven. For Life. in South Korea
and Madrid as of the end of 2021. In addition, the Company strives to secure intellectual property/
trademark rights, including related patent and trademark rights, through continuous research
development related to biopharmaceutical manufacturing.

[Samsung Bioepis]
As of the filing date of the disclosure document, Samsung Bioepis has 47 registered trademarks in
Korea, including Samfenet, Remaloce, Etoloce, and Onbevezy, and 145 international trademarks in
relation to the products launched by Samsung Bioepis. In addition, the Company secured a number of
related patents through the development of biopharmaceuticals, and are striving to secure various
intellectual property rights through continuous R&D.
C. Environmental Regulations

With an environmental policy placing environmental contaminant reduction and green values at the top
of its priorities, the Company commits itself to do all it can to prevent undesired environmental events
and make utmost efforts to lead the sustainable future.
To put this into practice, the Company strives to achieve compliance with environmental regulations and
reduce contaminant generation in addition to actively being engaged in chemical accident prevention
by implementing a life cycle management system for all chemicals handled in its business sites. In
addition, the Company follows regulatory requirements for contaminant emission standards, reports the
amount of greenhouse-gas emission and energy usage and transparently discloses relevant
information to its stakeholders in order to meet the government’s low-carbon growth policies and
responses to climate change.

(Business site management, compliance with environmental regulations and contaminant reduction)
The Company has installed and is operating various facilities for water pollution prevention, air pollution
prevention, waste storage, noise control, etc. to minimize emission of contaminants generated from
biomedicine manufacturing processes so that impact on the surrounding social environment can be
minimized. For business site environment management, regular self-inspections in addition to
management and supervision of relevant authorities have been carried out. As such, the Company’s
excellent environment control capability was acknowledged by being selected as the Best Company for
Environment Management by the City of Incheon three times, in 2015, 2018 and 2021.
The Company discloses transparent information on environmental emission performance and operational
status each year and is making efforts for regulatory compliance and contaminant reduction through
continued investment.

- The Company has built a continuous monitoring system for basic


TMS System
environmental facilities to monitor contaminant emission standards and is
Operation
making constant efforts to prevent environmental pollution accidents.

- The Company is striving to reduce waste through various activities


including garbage separation and recycling systems for the wastes
Waste Resource discharged from its business sites. While the Company keeps an eye on
Circulation the entire process from waste emission to final disposal, it also carries out
regular inspections/ evaluations on outsourced waste disposal companies
on annual basis.

Investment on - The Company is making continuous investment on basic environmental


Environmental facilities for the sake of preventing and improving environmental pollution
Improvement of its business sites and local community.

(Chemical Substance Management)


The Company has built an integrated chemical substance management system in order to comply with
the [Chemical Substances Control Act] and the [Act on Registration, Evaluation, etc. of Chemicals.]
The Company is working actively to prevent chemical accidents by having all chemical substances go
through pre-evaluation before warehousing and managed throughout the process up to disposal.
Regular training is performed for those handling chemical substances, and safety management
activities are thoroughly executed by conducting training sessions on protective equipment wearing,
emergency response drilling, etc.

Integrated Chemical
- The Company is making efforts to prevent chemical accidents across the
Substance
Company by managing the lifecycle (entire process) of chemical
Management
substances using the chemical substance management system.
System

Management of - In an effort to manage and improve chemical substance handling facilities,


Hazardous the Company has installed double piping, sensors, emergency shutdown
Chemical facilities, etc. to prevent accidents from these facilities and regular
Substance Handling inspections on these installations are performed annually by specialized
Facilities agencies.

- The Company is operating and managing the 24-hour operated emergency


All-time Monitoring
response center (CCR: Central Control Room) for real-time monitoring of
System
abnormal signs and immediate emergency response.

(Response to Climate Change)


In accordance with Article 8 of the Act on the Allocation and Trading of Greenhouse-Gas Emission
Permits, the Company has followed relevant regulatory standards since 2017. The Company also
reports to the government its greenhouse-gas emission and energy use after 3rd party verification and
transparently discloses the report to its stakeholders.
In addition, the Company is reinforcing its management on unexpected risks including climate change,
natural disasters, etc. through certification of the international standard for Business Continuity
Management System (ISO 22301).

Greenhouse-Gas - Each year, the Company manages and discloses greenhouse-gas


Emission Control emission monitoring plans and statements through 3rd party verification.

- The Company is making efforts to reduce emission of contaminants


Total Air Pollution including nitrogen oxides, dusts, etc. that can impact climate warming
Load Management through monitoring on air contaminant emission sources and operating
highly efficient reduction systems.

- The Company is making investments to introduce and improve highly


Energy Use efficient facilities for sustained energy/greenhouse-gas reduction activities
Reduction and is also taking the lead in making efforts to reduce greenhouse-gas
emission through regular energy diagnosis from external agencies.

Greenhouse-gas emission and energy consumption for the recent five years are as follows :
Annual Greenhouse Gas Emissions (ton) Annual Energy Consumption (TJ)
Year
Direct Indirect Total Gas Electricity Steam Total

2017 29,587 55,727 85,314 579 1,147 - 1,726

2018 40,967 75,612 116,579 803 1,557 - 2,360

2019 40,166 79,625 119,791 788 1,639 - 2,427

2020 41,793 83,014 124,807 820 1,709 - 2,529

2021 44,032 86,835 130,867 863 1,815 - 2,678

※ The subjects are our plant, shuttle bus, rental building, etc.
※ The data provided above is submitted to the “National Greenhouse Gas Management System.”
※ Emissions and energy consumption may change depending on the verification results of external verification agencies.
※ Refer to H. Green management in 4. Subsequent events under XI. Other Information for details.

D. Industry Overview

[Samsung Biologics]

(1) Nature of Industry


The biopharmaceutical Contract Manufacturing Organization (CMO) business provides drug
development and manufacturing services to global pharmaceutical companies on a contract basis to
allow them to focus on R&D activities and marketing.
The Company operates primarily in the antibody drug segment, which requires large investments in
commercial plants and at least a three-year period to complete the commercialization process including
plant design, construction, and validation. In addition, antibody drug requires a high degree of quality
control management which ensures Good Manufacturing Practices (GMP) throughout all processes
using mammalian cells including cell culture, purification, and filling.
Furthermore, pharmaceutical companies spend typically over two years to complete technology transfer,
test production, multinational regulatory GMP certificates and other necessary steps to produce
commercial drugs using CMOs. Therefore, each CMO contract is usually long-term between five to ten-
year period.

(2) Growth Potential


1) Continuous Development of Blockbuster Biopharmaceuticals

Blockbuster biopharmaceuticals released around the year 2000 (immunosuppressant drugs, anticancer
drugs, antidiabetic drugs, etc.) still show a high level of sales growth, and new promising antibody drugs
for hyperlipidemia, Alzheimer’s disease, and atopic dermatitis along with immune checkpoint inhibitors
continue to be released.
2) Expansion of Production Outsourcing by Global Biopharma companies

Pharmaceutical companies are expanding the areas of production outsourcing to specialized CMOs
where massive capital investments are required to minimize the uncertainty in marketing authorization
and sales forecasting of drugs. This market change gives a new opportunity to CMOs.

3) Increasing Demand for End-to-end CDMO Service to Biopharma Companies

Global CDMO companies are aiming for a one-stop shop model that can provide end-to-end services
to reduce pharmaceutical companies' development to production, clinical development to
commercialization needs, and complexity of a single project.

4) Increasing Demand for Dual Sourcing to Secure Supply

Recently, regulatory authorities across the world have strongly recommended pharmaceutical
companies to secure a source for stable drug production. The U.S. Food and Drug Administration (FDA)
requested pharmaceutical companies to establish a contingency plan, believing that supply stability
cannot be guaranteed in case the drug is manufactured in a single site. Accordingly, pharmaceutical
companies are making use of CMOs to run multiple manufacturers for a single drug.

In 2022, the global biopharmaceutical market is valued at USD 359 billion, which accounts for 29.7%
of the entire pharmaceutical market. The market is expected to increase with an average growth rate of
10.6% in 2026, boosting the growth of the overall pharmaceutical industry.

Biopharmaceutical Market Size

Source: EvaluatePharma, May 2022


The global bio-CDMO market is valued at USD 14.3 billion in 2022 and is forecasted to reach USD 20.3
billion by 2026 at an average growth rate of 10.1% for the next five years.

Bio CDMO Market Size


Source: Evaluate Pharma and Frost&Sullivan (Jul 2021)

(3) Economic Fluctuation


- Not applicable

[Samsung Bioepis]

(1) Nature of Industry


A biosimilar is a drug that is replicated from an existing biologic. In the field of synthetic drugs, such
drugs are called generic drugs, whereas in the field of biopharmaceuticals, they are called biosimilar.
Unlike the structure and production process of synthetic drugs, biopharmaceutical is impossible to
duplicate with 100% identical structure and efficacy as it starts from a living organism and only possible
to develop and produce a drug with similarity over a certain standard. The global biosimilar industry has
become a favorable market environment for biosimilar development, reflecting the continued expiration
of patents for original drugs, increased market demand for cheaper biosimilars compared to original
drugs, and changes in government policies. Domestic biosimilar companies are becoming more
prominent in the global biosimilar market, and according to the Ministry of Food and Drug Safety,
domestic biosimilar exports increased more than 7 times over 7 years from $204.77 million in 2014 to
$1.60965 billion in 2020.

(2) Growth Potential


As the patent protection period of major original biopharmaceuticals expires in the future, the size of
the biosimilar, which is equally effective as original biologics and competitive in terms of price, market
is expected to continue to expand. In particular, it is predicted that the growth of the biosimilar industry
will continue as more than 15 biopharmaceutical patents expire by 2032. According to EvaluatePharma,
a market research firm, the biosimilar market is expected to grow at an average annual growth rate of
7% from $11.1 billion in 2021 to $18.1 billion in 2028.

(3) Economic Fluctuation


1) Life cycle
Compared to other industries, the life cycle of the pharmaceutical industry has long and stable
characteristics due to the monopoly rights of pharmaceuticals recognized by law in most countries.

2) Economic fluctuations and accountability


Similar to the characteristics of the biopharmaceutical industry, which treats cancer, autoimmune
diseases, and chronic diseases, the biosimilar industry is not prone to economic fluctuations or seasonal
issues.

3) Alternative market status


Pharmaceuticals can only be sold after getting approved through the approval process of the strict
standards set by the Country. In particular, it is difficult to form an alternative market compared to other
industries because specialty drugs are institutionally protected so that they can only be purchased with
a doctor's prescription.

E. Competition Status

[Samsung Biologics]

The Company has emerged as a global bio CMO based on production facilities by securing a total
capacity of 364,000 liters with 360,000L (Plant 1 – 30,000L, Plant 2 – 150,000L, Plant 3 – 180,000L) of
commercial production facilities and 4,000L of clinical production facilities in Songdo Free Economic
Zone (Songdo District) in Incheon. As of 2022, competitors with similar capacity of more than 300,000
liters include Switzerland-based Lonza and Germany -based Boehringer Ingelheim. In addition, China-
based Wuxi Biologics and US-based Fujifilm diosynth are aggressively expanding capacity both
domestically and internationally.

[Samsung Bioepis]
The Company's main competitors include Pfizer and Amgen (US), Sandoz (Switzerland) and Celltrion
(Korea). The Company competes with other biosimilars in major countries such as US and Europe
against 3 types from Pfizer (Remicade, Herceptin, Avastin), 4 types from Amgen (Humira, Herceptin,
Avastin, Remicade), 3 types from Sandoz (Remicade, Enbrel, Humira), 3 types from Celltrion (Humira,
Remicade, Herceptin).
F. Competitiveness
[Samsung Biologics]

In CMO industry, it is essential to integrate 1) good quality management to secure adequate


environment for manufacturing biopharmaceuticals, 2) quick operational systems to serve clients in
timely manner, and 3) reliable sales activities for winning contracts.
The Company complies with global GMP standards in each stage of operations, and the clients have
rights to carry out audits and inspections of all manufacturing processes. In addition, the Company
ensures full documentation of each step and result throughout manufacturing process.
The Company’s global contract sales division is in charge of new business operation and sales activities,
and supports the activities for winning new contracts utilizing local manpower in main strongholds in the
Eastern and Western states of the United States including San Francisco, Boston, and New Jersey.
The sales division regularly holds meetings with global pharmaceutical companies and provides them
with information on the Company’s CMO services and manufacturing facilities at the meetings. The
division also continuously sends sales and marketing representatives to overseas bio-conferences to
identify latest technology trends in the market and contact potential customers as part of strategy to
maintain a strategic relationship with customers. In addition, the company has established non-face-to-
face platforms such as virtual exhibition halls and live virtual tour and inspection systems to minimize
the impact of COVID-19 prolonged period, and is strengthening non-face-to-face activities such as video
conferencing with customers and Webinars.

[Samsung Bioepis]
Since the establishment, the Company released 6 types of biosimilar (Remicade, Herceptin, Enbrel,
Humira, Avastin, and Lucentis similars). In this process, the Company shortened the development
period compared to other companies by developing a process that satisfies the quality requirements of
the permitting agency and conducted clinical trials efficiently. In addition, as a result of securing cost
competitiveness by developing process technology with high productivity, the Company launched
products that secured profitability despite a drop in market prices. The company will continue to develop
technologies to improve process optimization and operation efficiency to release products with
competitive advantages in the future.

G. New Business and Market Prospect

[Samsung Biologics]

The Company is currently widening the scope of business to CDO services, mRNA and cell/gene
therapy to transform into global biopharmaceutical company. The CDO business provides cell line and
process development and characterization services for small and medium-size Biotechs, which do not
have own development facilities. The Company launched high-performing cell line ‘S-CHOice’, which
delivers high productivity and viability, and ‘S-Cellerate’, which is a platform that innovatively shortens
the development period through a standardized process for each development stage. Furthermore, the
Company opened its first global CDO R&D center in the renowned San Francisco Biopharma Cluster
in October 2020 and currently plans to widen the scope of the market including Boston, Europe, and
China. Additionally, the Company implemented mRNA production capacity within its existing
manufacturing plant to meet the demand of the rapidly emerging market, and completed the preparation
of Current Good Manufacturing Practice (cGMP) Regulations in April 2022.
III. Financial Affairs

1. Financial Statements
Refer to Audited Financial Statements published on the Company’s Website.

2. Consolidated Financial Statements


Refer to Audited Financial Statements published on the Company’s Website.

3. Notes to Consolidated Financial Statements


Refer to Audited Financial Statements published on the Company’s Website.

4. Separate Financial Statements


Refer to Audited Financial Statements published on the Company’s Website.

5. Notes to Separate Financial Statements


Refer to Audited Financial Statements published on the Company’s Website.
6. Dividends

A. Articles of Incorporation Regarding Dividends

In accordance with the Articles of Incorporation, the Company can pay out dividends of profits in cash
or shares, with the approval granted by the Board of Directors. For shareholders’ value enhancement,
dividends will be determined, considering the Company’s investment plan, financial status, and
dividends sustainability. We plan to review whether to pay cash dividends within 10% of free cash flow
(FCF) for the year after 2025.
The Company’s articles of incorporation regarding dividends are provided in the Articles 48 and 49.
Article Content

1. Dividends may be paid in either cash or stock.


Article 48 (Dividends) 2. Dividends under Paragraph 1 shall be paid to shareholders or pledgees registered in the
current Register of Shareholders as of the end of each fiscal year.

1. The Company may distribute interim dividends to current shareholders as of the date
determined by a resolution of the BOD under Article 462-3 of the Commercial Code.
2. Interim dividends under Paragraph 1 shall be distributed by a resolution of the BOD.
3. Interim dividends shall be limited to the amount calculated by deducting each of the
following sums from the net asset value in the balance sheet for the immediately
preceding fiscal year:
(1) Amount of the capital of the immediately preceding fiscal year;
(2) Sum of capital reserves and legal reserves accumulated up to the immediately
preceding fiscal year;
(3) Unrealized gains stipulated in the Enforcement Decree of the Commercial Code;
Article 49 (4) Amount determined by the ordinary general meeting of shareholders of the
(Interim Dividends) immediately preceding fiscal year for distribution of dividends;
(5) Discretionary reserves accumulated for specific purpose under applicable provisions of
these Articles of Incorporation or by a resolution of the general meeting of
shareholders until the immediately preceding fiscal period
(6) Profit reserve to be accumulated during the settlement period according to interim
dividends
4. In connection with interim dividends on shares issued by rights issues, bonus issues,
stock dividends, conversion of convertible bonds or exercise of bonds with warrants after
the commencement of applicable fiscal year and prior to the record date in Paragraph 1,
new shares shall be deemed to have been issued at the end of the fiscal year
immediately preceding the fiscal year when such shares were actually issued.

B. Key Dividend Index

Classification Type of Shares 1H 2022 2021 2020

Par value per share (KRW) 2,500 2,500 2,500

Consolidated net profit (KRW mil) 298,983 393,589 240,975

Separate net profit (KRW mil) 243,127 423,177 250,969

Consolidated EPS (KRW) 4,378 5,949 3,642

Total cash dividend (KRW mil) - - -

Total stock dividend (KRW mil) - - -

Consolidated dividend payout ratio (%) - - -


Classification Type of Shares 1H 2022 2021 2020

Common - - -
Cash dividend yield (%)
Preferred - -

Common - -
Share dividend yield (%)
Preferred - -

Common - -
Cash dividend per share
(KRW)
Preferred - -

Common - -
Stock dividend per share
(share)
Preferred - -

C. Dividend History

Number of Consecutive Dividend Payout Average Dividend Payout

Quarterly(Interim) Dividend Annual Dividend 3-year 5-year

- - - -
※ The Company has no dividend payout history in the past five years.
7. Matters About Financial Through the Issuance of Securities
7-1. Financing Through the Issuance of Securities
[Issuance of Equity Securities]

Status of Capital Increase (reduction)


(As of June 30, 2022) (Unit: KRW, Share)

Date of stock Details of issued(reduced) shares


issuance Type of issuance (reduction) Face value Amount issued
(reduction) Class Volume Remarks
per share (reduced) per share

2011.04.22 - Common 1,500,000 5,000 50,000 Establishment

Capital increase with consideration


2011.09.07 Common 1,500,000 5,000 50,000 Increase rates of 100%
by allocation to shareholders

Capital increase with consideration


2012.01.18 Common 1,500,000 5,000 50,000 Increase rates of 50%
by allocation to shareholders

Capital increase with consideration


2012.02.23 Common 2,916,567 5,000 48,000 Increase rates of 65%
by allocation to shareholders

Capital increase with consideration


2012.04.19 Common 1,500,000 5,000 50,000 Increase rates of 20%
by allocation to shareholders

Capital increase with consideration


2012.08.21 Common 1,355,931 5,000 47,200 Increase rates of 15%
by allocation to shareholders

Capital increase with consideration


2013.02.19 Common 866,007 5,000 46,189 Increase rates of 8%
by allocation to shareholders

Capital increase with consideration


2013.08.20 Common 748,520 5,000 43,345 Increase rates of 7%
by allocation to shareholders

Capital increase with consideration


2014.02.20 Common 4,181,064 5,000 40,516 Increase rates of 35%
by allocation to shareholders

Capital increase with consideration


2014.08.21 Common 4,298,560 5,000 38,478 Increase rates of 27%
by allocation to shareholders
Date of stock Details of issued(reduced) shares
issuance Type of issuance (reduction) Face value Amount issued
(reduction) Class Volume Remarks
per share (reduced) per share

Capital increase with consideration


2015.02.24 Common 3,538,930 5,000 37,695 Increase rates of 17%
by allocation to shareholders

Capital increase with consideration


2015.08.20 Common 3,663,142 5,000 36,526 Increase rates of 15%
by allocation to shareholders

2016.09.12 Stock split Common 27,568,721 2,500 - -

Capital increase with consideration


2016.11.07 Common 11,027,558 2,500 136,000 Increase rates of 20%
by allocation to shareholders

Capital increase with consideration


2022.04.16 Common 5,009,000 2,500 639,000 Increase rates of 8%
by allocation to shareholders
※ On January 28, 2022, the Board of Directors of the Company resolved to increase its capital for the acquisition of construction-in-progress and securities
of other entity. The Company issued additional 5,009,000 shares of common stock totaling 71,174,000 shares of common stock issued by the end of 1H.

[Issuance of Debt Securities]


A. List of Issued Debt Securities

(As of June 30, 2022) (Unit: KRW Mil, %)

Issuing Type of Issuance Date of Total nominal Rating


Interest rate Maturity date Payment status Underwriter
company securities method Issuance amount (rating institution)

- - - - - - - - - -

- - - - - - - - - -
Issuing Type of Issuance Date of Total nominal Rating
Interest rate Maturity date Payment status Underwriter
company securities method Issuance amount (rating institution)

Total - - - - - - - - -
B. Commercial Paper Balance

(As of June 30, 2022) (Unit: KRW Mil)

Under Above 10 days Above 30 days Above 90 days Above 180 days Above 1 year Above 2 years
Issuing company Above 3 years Total
10 days /under 30 days /under 90 days /under 180 days /under 1 year /under 2 years /under 3 years

Public - - - - - - - - -

Balance Private - - - - - - - - -

Total - - - - - - - - -

C. Short Term Bond Unredeemed Balance

(As of June 30, 2022) (Unit: KRW Mil)

Under Above 10 days Above 30 days Above 90 days Above 180 days
Issuing company Total Issue limit Balance limit
10 days /under 30 days /under 90 days /under 180 days /under 1 year

Public - - - - - - - -

Balance Private - - - - - - - -

Total - - - - - - - -
D. Corporate Bond Unredeemed Balance

(As of June 30, 2022) (Unit: KRW Mil)

Under Above 1 year Above 2 years Above 3 years Above 4 years Above 5 years
Issuing company Above 10 years Total
1 year /under 2 years /under 3 years /under 4 years /under 5 years /under 10 years

Public - - 380,000 - 120,000 - - 500,000

Unredeemed
Private 40,000 - - - - - - 40,000
Balance

Total 40,000 - 380,000 - 120,000 - - 540,000

E. Hybrid Bond Outstanding Balance

(As of June 30, 2022) (Unit: KRW Mil)

Under Above 1 year Above 5 years Above 10 years Above 15 years Above 20 years
Issuing company Above 30 years Total
1 year /under 5 years /under 10 years /under 15 years /under 20 years /under 30 years

Public - - - - - - - -

Unredeemed
Private - - - - - - - -
Balance

Total - - - - - - - -
F. Contingent Convertible Bond Outstanding Balance

(As of June 30, 2022) (Unit: KRW Mil)

Above 1 year Above 2 years Above 3 years Above 4 years Above 5 years Above 10 years Above 20 years Above
Issuing company Under 1year Total
/under 2 years /under 3 years /under 4 years /under 5 years /under 10 year / under 20 years / under 30 years 30 years

Public - - - - - - - -

Balance Private - - - - - - - -

Total - - - - - - - -

G. Details and Compliance of the Bond Management Contract

(As of June 30, 2022) (Unit: KRW Mil, %)

Settlement date of bond Debenture management


Name of security Date of issuance Maturity date Issued amount
management contract company
Samsung Biologics
2021.09.03 2024.09.03 380,000 2021.08.24 Korea Securities Depository
7-1 Unguaranteed Bond
Samsung Biologics
2021.09.03 2026.09.03 120,000 2021.08.24 Korea Securities Depository
7-2 Unguaranteed Bond

(As of June 30, 2022)

Contract details Consolidated debt ratio remains under 300%


Financial ratios
Implementation status Fulfilled (84%)

Contract details Total collateral value remains under 200% of consolidated equity
Constraint on collateral
Implementation status Fulfilled (0%)

Constraint on disposal of assets Contract details Total restricted value remains under 80% of consolidated assets
(excl. financial assets and inventories)

Implementation status Fulfilled (No disposal of assets exceeding KRW 6.1 trillion)

Contract details The entity remains as a member firm of Samsung Group


Constraint on governance
Implementation status Fulfilled

Submission of implementation report Implementation status Fulfilled(2022.04.15)


* The date of implementation status is when the most recent financial statements were prepared.
The constraint on governance is as of the reporting date.

7-2. Use of Funds Financed Through the Issuance of Securities

A. Use of Publicly Raised Funds


(As of June 30, 2022) (Unit: KRW Mil)

Plan Actual
Classification Name of bond Date of issuance Reason for difference
Purpose Amount raised Purpose Amount used
7-1 Public Investment in Investment in
Corporate bond 2021.09.03 380,000 380,000 -
non-guaranteed bond manufacturing plant manufacturing plant
7-2 Public Investment in Investment in
Corporate bond 2021.09.03 120,000 78,556 -
non-guaranteed bond manufacturing plant manufacturing plant

Paid-in capital - 2022.04.15 Facility Investment 1,998,351 Facility Investment 170,989

Funds to acquire shares Funds to acquire shares of


Paid-in capital - 2022.04.15 1,202.400 1,202.400 -
of Samsung Bioepis Samsung Bioepis

B. Use of Privately Raised Funds


(As of June 30, 2022) (Unit: KRW Mil)

Plan Actual
Classification Name of bond Date of issuance Reason for difference
Purpose Amount raised Purpose Amount used

- - - - - - - -
C. Unused Funds Management Report
(As of June 30, 2022) (Unit: KRW Mil)

Type of financial instrument Name of financial instrument Amount Contract period Investment term

Savings account MMF 1,350,059 2022.06 ~ 2022.07 1 month

Savings account MMF 347,303 2022.04 ~ 2022.10 6 months

Savings account Fixed deposits 130,000 2022.04 ~ 2022.10 6 months

Total 1,827,362 -
8. Other Financial Information

A. Restatement of Financial Statements and Other Matters to Note

- Other matters requiring attention in relation to the use of the financial statements

(1) Emphasis of matter and key audit matters in auditor’s report


Period Emphasis of matter Key audit matter

- Administrative lawsuit against


2022 measures imposed by Securities
- Not Applicable
1H & Futures Commission and
Prosecution charge

- Administrative lawsuit against - Impairment test of investment in associates and joint


measures imposed by Securities - Appropriateness of CMO revenue recognition
2021
& Futures Commission and - Existence of Construction in Progress and Occurrence of
Prosecution charge Acquisition transaction

- Administrative lawsuit against


measures imposed by Securities
- Impairment test of investment in associates and joint
& Futures Commission and
2020 ventures
Prosecution charge
- Appropriateness of CMO revenue recognition
- Initial adoption of K-IFRS in
separate financial statements

(2) Ruling of the securities and Futures Commission in relation to the accounting for investment
in Samsung Bioepis Co., Ltd., the related administrative lawsuit and the indictment

Refer to Note 25 in Notes to Consolidated Financial Statements, published on the Company’s website
for detailed information about the litigation.
B. Allowance for Bad Debt

(1) Allowance for bad debt by account for the past 3 years
(Unit: KRW Mil, %)

Receivables amount Allowance amount Allowance (%)

Trade receivables 575,743 20,998 3.65%

2022 Other receivables 132,761 53 0.04%


1H Accruals 9,424 - 0.00%

Total 717,928 21,051 2.93%

Trade receivables 351,884 4,845 1.38%

Other receivables 17,985 12 0.07%


2021
Accruals 5,747 - 0.00%

Total 375,616 4,857 1.29%

Trade receivables 238,764 - 0.00%

Other receivables 4,020 - 0.00%


2020
Accruals 3,820 - 0.00%

Total 246,604 - 0.00%


※ Consolidated basis in accordance with K-IFRS

(2) Allowance for bad debt by year


(Unit: KRW Mil)

1H 2022 2021 2020

Beginning Balance 4,857 - -

Bad debt expense 16,194 4,857 -

Write off - - -

Ending balance 21,051 4,857 -


※ Consolidated basis in accordance with K-IFRS

(3) The guideline for bad debt allowance for account receivables
- Calculation of bad debt allowance
Calculation of bad debt allowance by applying the expected credit loss model that considers the
expected bad debt in the future to the balance of trade and other receivables as of the reporting date.

- Calculation basis of write-off experience rate and future expected bad debt
1. Write off experience rate is calculated using credit loss rate of all account receivables for all
historical period
2. Future expected bad debt is determined taking into consideration cases of debtor bankruptcy,
compulsory execution, death, disappearance, credit information of debtor and forward-looking
information.
(4) The outstanding period of account receivables
(As of June 30, 2022) (Unit: KRW Mil)

Less than 6 months ~ 1 year ~ More than 3


Classification Total
6 months 1 year 3 years years

Amount 639,035 5,489 42,929 - 687,453

Ratio 92.95% 0.80% 6.25% 0.00% 100%

※ Consolidation basis in accordance with K-IFRS.


※ Receivables amount in net present value.

C. Inventory

(1) Inventory status for the past three years


(Unit: KRW Thousand)

Division Classification 1H 2022 2021 2020

Finished goods 272,560,744 236,941,382 92,867,573


Work in
261,021,916 277,567,820 196,982,909
progress
CDMO Raw material 413,780,179 305,886,540 208,859,070
Material in
186,961,354 192,475,049 147,250,544
transit
Subtotal 1,134,324,193 1,012,870,791 645,960,096

Finished goods 523,718,574 - -


Work in
Biopharmaceutical 513,262,291 - -
progress
development and
commercialization Raw material 135,121,800 - -

Subtotal 1,172,102,665 - -

Total 2,306,426,858 1,012,870,791 645,960,096


Inventory ratio (%)
14.7% 12.7% 10.1%
[Inventory / Total Assets]
Inventory turnover (times)
[Yearly COGS /
0.8 1.0 1.4
{Beginning inventory + Ending inventory} /
2]
※ The inventory status does not include unrealized inventory on intercompany transactions (Consolidation basis)

(2) Inventory counts

① Inspection date
• External auditors join and observe the inspection once a year near year-end (Late Dec. -
Early Jan.). In accordance with the internal regulation, internal inspection is carried out once
a month.
• For the difference in inventories between the inspection date and the end of the year, the
Company checks using warehouse record to confirm the inventories as the date of financial
statements.

② Inspection methodology
• All items for monthly internal inspection.
• External auditors join and observe the inspection and carry out sample test to check the
existence and completeness of inventory.

③ Obsolete Inventory
• If the net realizable value of inventories falls below the acquisition cost, the valuation loss
allowance is recognized to determine the value of the inventory assets in the statement of
financial position;
• The evaluation details of inventories as of June 30, 2022 are as follows.

(As of June 30, 2022) (Unit: KRW Thousand)

Inventory Ending
Classification Acquisition cost Gross inventory
write-down Balance

Finished goods 796,677,589 796,677,589 (398,270) 796,279,319

Work in progress 783,991,503 783,991,503 (9,707,296) 774,284,207

Raw material 550,266,708 550,266,708 (1,364,730) 548,901,978

Material in transit 191,201,148 191,201,148 (4,239,794) 186,961,354

Total 2,322,136,948 2,322,136,948 (15,710,090) 2,306,426,858

※ Consolidated basis in accordance with K-IFRS.

D. Fair Value Evaluation Details

(1) Financial Assets

① Classification

The Group classifies its financial assets in the following measurement categories
- Financial assets measured at amortized cost
- Financial assets measured at fair value through other comprehensive income, and
- Financial assets measured at fair value through profit or loss.

The classification depends on the Group’s business model for managing the financial assets and the
contractual terms of the cash flows. For financial assets measured at fair value, gains and losses will
either be recorded in profit or loss or other comprehensive income. For investments in debt instruments,
this will depend on the business model in which the investment is held. The Group reclassifies debt
investments when, and only when its business model for managing those assets changes.

For investments in equity instruments that are not held for trading, this will depend on whether the
Group has made an irrevocable election at the time of initial recognition to account for the equity
investment at fair value through other comprehensive income. Changes in fair value of non-designated
equity investment are recognized in profit or loss.

② Measurement

At initial recognition, the Group measures a financial asset at its fair value plus, in the case of a financial
asset not at fair value through profit or loss, transaction costs that are directly attributable to the
acquisition of the financial asset. Transaction costs of financial assets carried at fair value through profit
or loss are expensed in profit or loss. Financial assets with embedded derivatives are considered in
their entirety when determining whether their cash flows are solely payment of principal and interest.

②-① Debt Instruments

Subsequent measurement of debt instruments depends on the Company’s business model for
managing the asset and the cash flow characteristics of the asset. The Company classifies its debt
instruments into one of the following three measurement categories:

A. Amortized cost
Assets that are held for collection of contractual cash flows where those cash flows represent solely
payments of principal and interest are measured at amortized cost. A gain or loss on a debt investment
that is subsequently measured at amortized cost and is not part of a hedging relationship is recognized
in profit or loss when the asset is derecognized or impaired. Interest income from these financial assets
is included in ‘finance income’ using the effective interest rate method.

B. Fair value through other comprehensive income


Assets that are held for collection of contractual cash flows and for selling the financial assets, where
the assets’ cash flows represent solely payments of principal and interest, are measured at fair value
through other comprehensive income. Movements in the carrying amount are taken through other
comprehensive income, except for the recognition of impairment loss (reversal of impairment loss),
interest income and foreign exchange gains and losses which are recognized in profit or loss. When
the financial asset is derecognized, the cumulative gain or loss previously recognized in other
comprehensive income is reclassified from equity to profit or loss.

C. Fair value through profit or loss


Assets that do not meet the criteria for amortized cost or fair value through other comprehensive income
are measured at fair value through profit or loss. A gain or loss on a debt investment that is subsequently
measured at fair value through profit or loss and is not part of a hedging relationship is recognized in
‘finance income or costs’.

②-② Equity instruments

The Company subsequently measures all equity investments at fair value. Where the Company’s
management has elected to present fair value gains and losses on equity investments, which are held
for long-term investments or strategic purposes, in other comprehensive income, there is no subsequent
reclassification of fair value gains and losses to profit or loss following the derecognition of the
investments. Dividend income from such investments continue to be recognized as ‘finance income’
when the right to receive payments is established.

Changes in the fair value of financial assets at fair value through profit or loss are recognized in ‘finance
income and expenses’. Impairment loss (reversal of impairment loss) on equity investments measured
at fair value through other comprehensive income are not reported separately.

③ Impairment

The Company assesses on a forward-looking basis the expected credit losses associated with its debt
instruments carried at amortized cost and fair value through other comprehensive income. The
impairment methodology applied depends on whether there has been a significant increase in credit
risk. For trade receivables and lease receivables, the Company applies the simplified approach, which
requires expected lifetime credit losses to be recognized from initial recognition of the receivables.

④ Recognition and derecognition

Regular way purchases and sales of financial assets are recognized or derecognized on the trade-date,
the date on which the Company commits to purchase or sell the asset. Financial assets are
derecognized when the rights to receive cash flows from the financial assets have expired or have been
transferred and the Company has transferred substantially all the risks and rewards of ownership.
If a transfer does not result in derecognition because the Company has retained substantially most of
the risks and rewards of ownership of the transferred asset, the Company continues to recognize the
transferred asset in its entirety and recognizes a financial liability for the consideration received.

⑤ Offsetting of financial instruments

Financial assets and liabilities are offset and reported in the statement of financial position where there
is a legally enforceable right to offset the recognized amounts and there is an intention to settle on a
net basis or realize the assets and settle the liability simultaneously. The legally enforceable right must
not be contingent on future events and must be enforceable in the normal course of business and even
in the event of default, insolvency or bankruptcy of the Group or the counterparty.

(2) Financial Liabilities


① Classification and measurement

The Group’s financial liabilities at fair value through profit or loss are financial instruments held for
trading. A financial liability is held for trading if it is incurred principally for the purpose of repurchasing
in the near term. A derivative that is not designated as a hedging instrument and an embedded
derivative that is separated are also classified as held for trading.

The Group classifies non-derivative financial liabilities, except for financial liabilities at fair value through
profit or loss, financial guarantee contracts and financial liabilities that arise when a transfer of financial
assets does not qualify for derecognition, as financial liabilities carried at amortized cost and present
as ‘trade and other payables’ and ‘debentures and borrowings’ in the statement of financial position.

② Derecognition

Financial liabilities are removed from the statement of financial position when it is extinguished; for
example, when the obligation specified in the contract is discharged or cancelled or expired or when
the terms of an existing financial liability are substantially modified. The difference between the carrying
amount of a financial liability extinguished or transferred to another party and the consideration paid
(including any non-cash assets transferred or liabilities assumed) is recognized in profit or loss.

(3) Derivative Instruments


Derivatives are initially recognized at fair value on the date when a derivative contract is entered into
and are subsequently re-measured at their fair value at the end of each reporting period. Changes in
the fair value of any derivative instrument that does not qualify for hedge accounting are recognized
immediately in profit or loss based on the nature of transactions.

(4) Financial Instruments by Category

(1) Financial assets


Details of financial instruments by category as of the end of 1H 2022 and 2021, are as follows :
(Unit: KRW Thousand)

End of 1H 2022 End of 2021


Financial Financial Financial Financial
assets at fair assets assets at fair assets
Total Total
value through measured at value through measured at
profit or loss amortized cost profit or loss amortized cost
Current assets
Cash and
cash - 213,005,106 213,005,106 - 47,410,384 47,410,384
equivalents
Short-term
financial - 1,182,929,000 1,182,929,000 - 450,000,000 450,000,000
instruments
Financial
assets at fair
value 1,751,492,354 - 1,751,492,354 850,039,877 - 850,039,877
through profit
or loss
Trade and
other - 653,133,610 653,133,610 - 350,187,893 350,187,893
receivables
Deposits
- 36,135,743 36,135,743 - 23,984,945 23,984,945
provided
Derivatives
6,702,973 - 6,702,973
assets
Subtotal 1,758,195,327 2,085,203,459 3,843,398,786 850,039,877 871,583,222 1,721,623,099
Non-current
assets
Long-term
financial - 7,214,024 7,214,024 - 189,491 189,491
instruments
Financial
assets at fair
value 4,113,608 - 4,113,608 - 4,428,344 4,428,344
through profit
or loss
Trade and
other - 12,875,046 12,875,046
receivables
Deposits
-- 25,005,443 25,005,443 - 22,827,408 22,827,408
provided
Derivative
instrument 13,752,486 - 13,752,486 4,091,971 - 4,091,971
assets
Subtotal 13,866,094 45,094,513 62,960,607 4,091,971 27,445,243 31,537,214
Total 1,776,061,421 2,130,297,972 3,906,359,393 854,131,848 899,028,465 1,753,160,313

(2) Financial liabilities


Details of financial instruments by category as of the end of 1H 2022 and 2021, are as follows :
(Unit: KRW Thousand)

End of 1H 2022 End of 2021


Financial
Financial
liabilities
Other Other liabilities at Other
at Total Total
liabilities liabilities amortized liabilities
amortized
cost
cost
Current
liabilities
Trade and
other - 1,531,027,096 - 1,531,027,096 342,930,338 - 342,930,338
payables
Debentures - 39,971,068 - 39,971,068 50,000,000 - 50,000,000
Short-term
- 460,653,000 - 460,653,000 109,855,000 - 109,855,000
borrowings
Current
portion of
- 496,716,000 - 496,716,000 - - -
long-term
borrowings
Lease
- - 7,935,909 7,935,909 - 7,537,132 7,537,132
liabilities
Subtotal - 2,528,367,164 7,935,909 2,536,303,073 502,785,338 7,537,132 510,322,470
Non-current
liabilities
Trade and
other - 530,958,042 - 530,958,042 2,648,496 - 2,648,496
payables
Debentures - 498,819,980 - 498,819,980 538,553,996 - 538,553,996
Long-term
- 721,361,000 - 721,361,000 576,130,000 - 576,130,000
borrowings
Derivative
22,385,495 - - 22,385,495 - 10,671,166 10,671,166
liabilities
Lease
- - 8,790,932 8,790,932
liabilities
Subtotal 22,385,495 1,751,139,022 8,790,932 1,782,315,449 1,117,332,492 10,671,166 1,128,003,658
Total 22,385,495 4,279,506,186 16,726,841 4,318,618,522 1,620,117,830 18,208,298 1,638,326,128

(3) Fair value of financial assets

Carrying amount and fair value of financial assets as of the end of 1H 2022 and 2021 are as follows :
(Unit: KRW Thousand)

End of 1H 2022 End of 2021


Description
Carrying amount Fair value Carrying amount Fair value
Financial assets measured at fair value :
Financial
assets at fair
1,755,605,962 1,755,605,962 850,039,877 850,039,877
value through
profit or loss
Derivative
20,455,459 20,455,459 4,091,971 4,091,971
assets
Subtotal 1,776,061,421 1,776,061,421 854,131,848 854,131,848
Financial assets not measured at fair value :
Cash and
cash 213,005,106 213,005,106 47,410,384 47,410,384
equivalents(*)
Short-term
financial 1,182,929,000 1,182,929,000 450,000,000 450,000,000
instruments
Long-term
financial 7,214,024 7,214,024 189,491 189,491
instruments
Trade and
other 666,008,656 666,008,656 354,616,237 354,616,237
receivables
Deposits
61,141,186 61,141,186 46,812,354 46,812,354
provided
Subtotal 2,130,297,972 2,130,297,972 899,028,466 899,028,466
Total 3,906,359,393 3,906,359,393 1,753,160,314 1,753,160,314
Financial liability carried at fair value :
Derivative
22,385,495 22,385,495 - -
liabilities
Financial liability carried at amortized cost :
Trade and
other 2,061,985,138 2,061,985,138 345,578,834 345,578,834
payables
Debentures 538,791,048 538,791,048 538,553,996 538,553,996
Borrowings 1,678,730,000 1,678,730,000 735,985,000 735,985,000
Subtotal 4,279,506,186 4,279,506,186 1,620,117,830 1,620,117,830
Total 4,301,891,681 4,301,891,681 1,620,117,830 1,620,117,830

(4) Fair value hierarchy


Financial instruments measured at fair value are classified according to the fair value hierarchy, and
the levels of justice are as follows.
- Level 1 : Quoted prices in active markets for identical assets or liabilities that the entity can access
at the measurement date.
- Level 2 : Inputs other than quoted market prices included within Level 1 that are observable for the
asset or liability, either directly or indirectly.
- Level 3 : Unobservable inputs for the asset or liability.
The following presents financial instruments measured and recognized at fair value as of the end of
1H 2022 and 2021, are as follows :

① End of 1H 2022
(Unit: KRW Thousand)
Level 1 Level 2 Level 3 Total
Financial assets :
Financial assets at
fair value through 4,113,607 1,751,492,354 - 1,755,605,962
profit or loss
Derivative financial
- 20,455,459 - 20,455,459
instrument assets
Financial liabilities :
Derivative financial
instrument - - 22,385,495 22,385,495
liabilities

② End of 2021
(Unit: KRW Thousand)
Level 1 Level 2 Level 3 Total
Financial assets :
Financial assets at
fair value through 850,039,877 - 850,039,877
profit or loss
Derivative financial
4,091,971 - 4,091,971
instrument assets

(5) Valuation techniques and inputs

Valuation techniques and significant inputs used in measuring the fair value of financial instruments
classified as level 2 of the fair value hierarchy, are as follows :

(Unit: KRW Thousand)


Fair Value
Fair value Significant
Level
End of 1H 2022 End of 2021 measurement unobservable inputs

Financial assets at
Market
fair value through 1,751,492,354 850,039,877 2 -
approach
profit or loss
Derivative financial Currency forward
instrument assets rate, interest rate,
18,859,438 3,475,382
(currency interest Discounted discount rate, and
swap) 2 cash flow others
Derivative financial model Interest rate,
instrument assets 1,596,021 616,589 discount rate, and
(interest swap) others
Derivative financial Interest rate,
Option pricing
instrument liabilities 22,385,495 - 3 discount rate, and
model
(stock warrants) others
(6) Net gains or losses by category of financial instruments

Net gains or losses on each category of financial instruments as of the end of 1H 2022 and 2021, are
as follows :
(Unit: KRW Thousand)
Interest income
Gain on valuation Other income (*) Net income (loss)
(expenses)
2022 2021 2022 2021 2022 2021 2022 2021
1H 2H 1H 2H 1H 2H 1H 2H
Financial
assets at
16,739,815 4,604,869 - - 37,897,054 3,944,083 54,636,869 8,548,952
amortized
cost
Financial
assets at
fair value
- - 1,565,753 16,779 198,642 61,849 1,764,395 78,628
through
profit or
loss
Derivative
- - 9,742,078 2,229,926 - - 9,742,078 2,229,926
assets
Financial
liabilities
at (17,573,765) (6,601,730) - - (70,633,517) 2.283.999 (88,207,282) (4,317,731)
amortized
cost
Derivative
- - (1,843,510) - - - (1,843,510) -
liabilities
Other
(112,333) (397,731) - - - - (112,333) (397,731)
liabilities
Total (946,283) (2,394,592) 9,464,321 2,246,705 (32,537,821) 6,289,931 (24,019,783) 6,142,044

(*) Other income and expenses include gain (loss) on foreign currency translations and transactions, and gain
(loss) on disposal of financial assets at fair value through profit or loss.

(5) Re-measurement details of fixed assets

No re-measurement of fixed assets was carried out during the reporting period.
IV. Directors’ Management Discussion & Analysis

Pursuant to the reporting guidelines set forth by the Financial Supervisory Service of the Republic of
Korea, the Management Discussion and Analysis section, reported in annual report, is not included in
the quarterly and half year reports.
V. Auditor’s Report

1. Matters Regarding Independent Auditor

A. Auditor’s name and opinion

Business
Auditor Auditor’s opinion Emphasis, etc. Key Audit Matters
year

- Securities & Futures


2022 Not applicable Commission’s ruling and
Samil PwC - Not applicable
1H (*) administrative litigation and
prosecution investigation

- Inspect investment stocks in


associates and joint ventures for
- Securities & Futures impairment
Unqualified Commission’s ruling and - Appropriateness of CMO revenue
2021 Samil PwC
opinion administrative litigation and Recognition
prosecution investigation - Construction in Progress asset’s
existence and the occurrence of the
acquisition transaction

- Securities & Futures


- Inspect investment stocks in
Commission’s ruling and
associates and joint ventures for
Unqualified administrative litigation and
2020 Samil PwC impairment
opinion prosecution investigation
- Appropriateness of CMO revenue
- Initial adoption of K-IFRS in
recognition
separate financial statements

(*) A review of the quarterly financial statements was conducted and all matters were presented fairly, in all material respects.
※ First half of 2022 is a review opinion on both separate and consolidate financial statements. 2021 and 2020 are audit opinions
on both separate and consolidated financial statements.

[2022 Audit and Review Schedule]


Item Date
Preliminary Review '22.03.21 ~ 03.25
1Q
Review '22.04.18 ~ 05.13

Preliminary Review '22.06.15 ~ 06.21


1H
Review '22.07.11 ~ 08.12

※ The schedule above is for the audit and review of separate and consolidated financial statements.
Subsidiaries Auditor
Samsung Bioepis Co., Ltd. KPMG Samjong Accounting Corp
SVIC 36 New Technology Investment Association KPMG Samjong Accounting Corp
SAMSUNG BIOEPIS IL LTD GUBERMAN
SAMSUNG BIOEPIS HK Limited Korchina TNC CPA Limited

B. Audit service contract


(Unit: KRW Thousand, hour)

Contract Actual
Business
Auditor Details
year Audit Audit Audit Audit
fee hour fee hour
- Review of the interim separate/consolidated financial statements
2022 Samil
- Audit of separate/consolidated financial statements 1,480,000 9,828 840,000 3,918
1H PwC
- Audit of Internal Control over Financial Reporting (ICFR)

- Review of the interim separate/consolidated financial statements


Samil
2021 - Audit of separate/consolidated financial statements 1,490,000 10,228 1,490,000 10,229
PwC
- Audit of Internal Control over Financial Reporting (ICFR)

- Review of the interim separate/consolidated financial statements


Samil
2020 - Audit of separate/consolidated financial statements 1,280,000 9,102 1,280,000 9,412
PwC
- Audit of Internal Control over Financial Reporting (ICFR)

C. Status of signing audit services related to the investee under the equity method with auditors
(Unit: KRW Thousand, hour)

Business year Contract date Service details Service period Service fee Remarks

2022 Audit of specific financial ‘22.03 ~


2022.04.15 300,000 -
1H information for consolidated purpose ‘23.02

Audit of financial information of equity ‘21.03 ~


2021 2021.03.18 190,000 -
method investees ‘22.02

Audit of financial information of equity ‘20.03 ~


2020 2020.03.31 150,000 -
method investees ‘21.02

D. Non-audit service contract


(Unit: KRW Thousand, USD)

Business year Contract date Service details Service period Service fee Remarks

2022
- - - - -
1H

Consulting service on matters regarding ‘21.02 ~


2021 2021.02.23 USD 295,000 -
overseas manufacturing plants ‘21.03

Consulting service on the establishment of ‘20.01 ~


2020 2020.01.02 KRW 490,000 -
overseas subsidiary ‘20.12

E. Contents of discussions about financial statements


Date Attendees Type Contents of discussion
Audit committee : 3 members
- Progress of key audit matters
Independent director: 1 director
1 2022.01.24 Face-to-face - Progress of annual accounting audit (financial
Company : Audit team leader & 4 others
statements/internal control over financial reporting)
Auditor : 1 Partner & 2 others
Audit committee : 3 members
Diagnostic committee : 2 external experts
- Interim report on the progress of diagnosis committee’s
2 2022.02.04 Independent director: 1 director Face-to-face
investigation
Company : Audit team leader & 2 others
Auditor : 1 Partner & 2 others
- Conclusion of management and governing body
Audit committee : 3 members, 3 external based on the results of diagnosis committee's
experts investigation
3 2022.02.25 Independent director: 1 director Face-to-face - Results of key audit matters
Company : Audit team leader & 2 others - Year-End audit result and other essential
Auditor : 1 Partner & 1 others communication factors at the completion stage of the
audit
Audit committee : 3 members
4 2022.04.27 Company : Audit team leader & 1 other Face-to-face - Key audit matters from 1Q Review
- Plan of annual accounting audit
Auditor : 1 Partner & 2 others
Audit committee : 3 members, 2 external
experts - Key audit matters from 1H Review
5 2022.07.27 Face-to-face - Audit plan for key audit items
Company : Audit team leader & 1 others
- Annual audit progress status
Auditor : 1 Partner & 2 others

F. Change of external auditor

On July 12, 2018 and November 14, 2018, the Company was notified of the designation of auditors for
3 years as a result of actions by the Securities and Futures Commission, and concluded an audit
contract with Samjong KPMG LLC and the external auditor of the 7th and 8th business years, while
signing a new contract with the designated auditor, Hanyoung EY. The Company has appointed Samil
PwC as an external auditor for three consecutive business years since 2019 in line with the Audit
committee's evaluation process in accordance with the Audit committee's operational regulations, as
the application to suspend the ruling of a request to withdraw the measure recommended by the
Securities & Futures Commission has been cited.

In accordance with Article 10 (4) of the Act on external audits of corporations and others and Article 12
(1) of the Enforcement Decree of the Same Act, the audit committee held a face-to-face meeting on
November 19, 2021 to appoint Samil Accounting Firm as the external auditor for 2022 and three
consecutive business years. Accordingly, the Company signed the audit contract to appoint Samil
Accounting Firm as the 12th~14th external auditor.

2. Matters Regarding Internal Control

Business
Auditor Audit opinions Remarks
year

2022 Samil
- -
1H PwC
As of December 31, 2021, the Company maintained, in all material
Samil
2021 respects, effective Internal Control over Financial Reporting based on -
PwC
the ‘Internal Control-Integrated Framework’

As of December 31, 2020, the Company maintained, in all material


Samil
2020 respects, effective Internal Control over Financial Reporting based on -
PwC
the ‘Internal Control-Integrated Framework’
VI. Matters Regarding Executive Organizations
Including the Board of Directors

1. Matters Regarding the Board of Directors

A. Overview of the Board of Directors


The Company's Board of Directors (BOD) consists of three Executive directors (Kim Taehan, John Rim,
and Kim Dongjoong) and four Independent directors (Heo Geunnyoung, Eunice Kim, Lee Changwoo,
and Bahk Jaewan).
The BOD consists of the Management Committee, Audit Committee, Compensation Committee,
Independent Director Recommendation Committee, Related Party Transaction Committee, and ESG
Committee.
The Company currently separates the CEO and the Chairman position to enhance the independence
and transparency of the BOD. The board appointed the former CEO Kim Taehan as the Chairman, as
his managerial experiences enable him to mediate different opinions of Directors and make himself
most qualified to manage board activities.
The Company is undergoing a mid- and long-term review of whether to increase board members, as
the scale of business continuously expands.

Changes in Independent Directors


(Unit: person)

No. of independent Changes in independent directors


No. of directors
directors Appointment Dismissal Resignation
7 4 2 2 -

B. Agendas and Voting Results


Director
(Attendance rate)
No Date Agenda Result Kim John Kim Jeong Kwon Heo Eunice Lee Bahk
Tae Rim Dong Seok Soon Geun Kim Chang Jae
han joong woo jo nyung woo Wan
(100%) (100%) (100%) (100%) (100%) (100%) (100%) (100%) (100%)
※ Reported items:
1. Approval of FY2021 financial Approved For For For For For For For N/A N/A
statements and annual business report
1st ‘22.01.24 2. Approval of transactions with related Approved For For For For For For For N/A N/A
parties
3. Approval of charitable contribution of idle Approved For For For For For For For N/A N/A
raw materials
1. Signed stock purchase agreement Approved For For For For For For For N/A N/A
2nd ‘22.01.27
2. Paid-in capital increase Approved For For For For r For For For N/A N/A

1. Cancellation of signed stock purchase


3rd ‘22.01.27 agreement and paid-in capital increase Approved Absent For Absent For For For For N/A N/A
resolution
1. Signed stock purchase agreement Approved For For For For For For For N/A N/A
4th ‘22.01.28
2. Paid-in capital increase Approved For For For For For For For N/A N/A
※ Reported items:
- - - - - - - - - -
1. FY2021 Audit Committee activities
5th ’22.02.25 2. Operation status of internal
accounting management system - - - - - - - - - -
3. Evaluation and audit report of internal
accounting management system - - - - - - - - - -
Director
(Attendance rate)
No Date Agenda Result Kim John Kim Jeong Kwon Heo Eunice Lee Bahk
Tae Rim Dong Seok Soon Geun Kim Chang Jae
han joong woo jo nyung woo Wan
(100%) (100%) (100%) (100%) (100%) (100%) (100%) (100%) (100%)
4. FY2021 Audit performance report - - - - - - - - - -
5. Approval of payment of legal services fee
for management’s litigation - - - - - - - - - -
6. Assignment of employee stock ownership

※ Resolution Items: Approved For For For For For For For N/A N/A
1. Approval of meeting and objectives of
general meetings of shareholders.
1. Nomination of Board of Director's Approved For For For N/A N/A For For For For
6th ’22.03.29
committee members
1. Participation in paid-in capital increase by
Approved For For For N/A N/A For For For For
related parties
th 2. Review of compensation limit for directors
7 ‘22.03.29 Approved For For For N/A N/A For For For For
3. Signed contract to purchase 2nd
Approved For For For N/A N/A For For For For
4. Approval of 2022 Health and Safety
Approved For For For N/A N/A For For For For
management system
※ Reported items:
- - - - N/A N/A - - - -
1. 1Q 2022 interim business result
- - - - N/A N/A - - - -
2. Progress of important matters

8th '22.04.27 ※ Resolution Items:


1. Approval of transactions with related Approved For For For N/A N/A For For For For
parties
2. Approval of transaction with major Approved For For For N/A N/A For For For For
shareholders

※ From 11th Board of Directors meeting held on March 29, 2022, independent directors Kwon Soonjo and Jeong Seokwoo
resigned, and Lee Changwoo and Bahk Jaewan were newly appointed as independent directors.

※ Jan 24, 2022 (1st round), Details of “Approval of transactions with related parties”

- Company name : Samsung Engineering


- Content : P5, P6 project basic design service contract
- Amount : KRW 100 million
- Period : Feb. 2022 ~ Jun. 2022

※ Jan 28, 2022 (4th round), Details of “Approval of stock purchase agreement resolution”

- Company name : Biogen Therapeutics Inc.


- Content : Acquired 10,341,852 shares of Samsung Bioepis
- Amount : USD 2,300,000,000
(Purchase amount USD 2,250,000,000 and contingent consideration amount USD 50,000,000)

※ Mar 29, 2022 (7th round), Details of “Participation of paid-in capital with related parties”

- Company name : Samsung C&T Corporation, Samsung Electronics


- Content : Preemptive subscription rights due to paid-in capital increase
- Amount : 1) Samsung C&T Corporation : KRW 1,216.8 billion
2) Samsung Electronics : KRW 882.1 billion

※ Apr 27, 2022 (8th round), Details of “Participation of paid-in capital with related parties”

- Company name : Samsung Engineering


- Content : Site suspension and installation of temporary facility of Plant 2
- Amount : KRW 24.4 billion

※ Apr 27, 2022 (8th round), Details of “Approval of transaction with major shareholders”

- Company name : Samsung C&T Corporation


- Content : Landscaping of Plant 4
- Amount : KRW 3.5 billion
C. Committees of the BOD

(1) Committees
Committee
Composition Name Purpose & authority Remarks
Name

[Purpose]
To deliberate the matters entrusted by the BOD out of
the Company’s material management information,
matters often entrusted by the BOD, and matters
(Chairperson) entrusted by the BOD as other material management
Management information
2 Executive John Rim
committee -
directors
(‘11.04.22) [Main authorities]
Kim Dongjoong
① General management
② Matters regarding finance
③ Other related matters

[Purpose]
To secure objectivity and transparency in determining
director compensation

[Main authorities]
(Chairperson)
3 Independent Bahk Jaewan ① Matters regarding the compensation limit of
Compensation
directors registered directors
committee -
1 Executive Heo Geunnyung
(‘16.08.10) ② Matters regarding performance evaluation criteria
director Eunice Kim
Kim Dongjoong of registered directors
③ Matters regarding the compensation system of
registered directors
④ Matters entrusted by the Board of Directors
regarding director compensation

[Purpose]
To deliberate large-scale related party transactions in
order to strength internal control over related party
transactions and external control over shareholders
and to enhance the efficiency of supervision over
illegal support
Related party (Chairperson)
transaction 3 Independent Heo Geunnyung
[Main authorities] -
committee directors
(‘16.08.10) Lee Changwoo ① To approve related party transactions
② To listen to the report of related party transactions
③ To order an ex-offcio investigation of related party
transactions
④ To suggest a corrective action against related
party transactions
Committee
Composition Name Purpose & authority Remarks
Name

[Purpose]
To deliberate policies regarding Environmental,
Social, and Corporate Governance issues including
Corporate Social Responsibilities, shareholder value
(Chairperson) enhancement, customer value enhancement and
Eunice Kim shareholding structure.
ESG
4 Independent
Committee -
directors Heo Geunnyung
(‘21.02.26) [Main authorities]
Lee Changwoo
Bahk Jaewan
① Matters regarding ESG strategy and policy

② Annual donation plan

③ Other important matters delegated by the Board

※ The composition of committees is as of June 30, 2022.


※ On March 29, 2022, independent directors Kwon Soonjo and Jeong Seokwoo’s terms expired, and Lee Changwoo and Bahk
Jaewan were newly appointed as independent directors.
※ The Audit Committee and Independent Director Recommendation Committee were excluded according to Corporate
Disclosure Guidelines set forth by the Financial Supervisory Service Authority of the Republic of Korea.

(2) Committee activities


※ The Audit Committee and Independent Director Recommendation Committee were excluded

according to Corporate Disclosure Guidelines set forth by the Financial Supervisory Service Authority
of the Republic of Korea.

① Management committee

Director
(Attendance rate)
Date Details of agendas Result
John Rim Kim Dongjoong
(100%) (100%)

1. Extension of the due date of Woori Approved For For


Bank credit limit
2. Extension of the due date of Shinhan Approved For For
'22.05.13
Bank credit limit
3. Extension of the due date of Hana Approved For For
Bank credit limit
'22.06.07 1. Approval of new manufacturing contract Approved For For

② Compensation committee

Director
(Attendance rate)
Bahk Heo Eunice Kim
Date Details of agendas Result Kwon
Jae Geun Kim Dong
Soonjo
Wan nyung joong
(100%)
(100%) (100%) (100%) (100%)
1. Assignment of employee stock ownership Approved For N/A For For For
2. Review of 2022 individual annual income Approved For N/A For For For
‘22.02.25 of executive directors
3. Review of 2022 compensation limit for Approved For N/A For For For
registered directors
'22.04.27 1. Appointment of compensation chairman Approved N/A For For For For

※ As of March 29, 2022, independent directors Kwon Soonjo resigned, and Bahk Jaewan were newly appointed as independent
directors.

③ Related party transaction committee

Director
(Attendance rate)
Date Details of agendas Result Heo Lee Bahk
Geunnyung Changwoo Jaewan
(100%) (100%) (100%)
1. Appointment of chair of related party Approved For For For
transaction committee
‘22.03.29
2. Participation in paid-in capital increase by Approved For For For
related parties
'22.04.27 1. Landscaping of Plant 4 Approved For For For

※ Details of March 29, 2022 agendas

- Content : Participation in paid-in capital increase by related parties


- Company name : Samsung C&T Corporation, Samsung Electronics
- Content : Subscription of stock warrant from paid-in capital increase
- Amount : 1) Samsung C&T Corporation : KRW 1,216.8 billion
2) Samsung Electronics : KRW 882.1 billion

※ Details of April 27, 2022 agendas

- Content : Landscaping of Plant 4


- Company name : Samsung C&T Corporation
- Amount : KRW 3.5 billion

④ ESG committee

Director
(Attendance rate)
Details of Eunice Jeong Kwon Heo Lee Bahk
Date Result
agendas Kim Seok Soonjo Geun Chang Jae
woo nyung woo wan
(100%) (100%) (100%) (100%) (100%) (100%)
[Bill]
1. Approval of
charitable Approve
‘22.01.24 For For For For N/A N/A
contribution of d
idle raw
materials
[Reported items]
'22.04.27 - - N/A N/A
ESG plan for 2022
[Reported items]
1. Result of
'22.06.07 Frontier-1.5D - - N/A N/A
2. Progress of ESG
initiatives and plan
※ On March 29, 2022, independent directors Kwon Soonjo and Jeong Seokwoo’s terms expired, and Lee Changwoo and Bahk
Jaewan were newly appointed as independent directors.

D. Independence of Directors
(1) Independence of directors
Directors are appointed at the general meeting of stockholders, and director candidates to be appointed
by the general meeting of stockholders are recommended by the Board of Directors, which is decided
as a bill to be submitted to the general meeting of stockholders. The Company ensures directors’
independence to make them objectively oversee the company business.
(As of June 30, 2022)

Relationship
Consecutive
Term with the
Name terms Appointment background Nominator Responsibility
expiration largest/major
(No.)
shareholder

- A professional enterpriser who


has been working as the CEO
since the foundation of the
Company and has been
improving the Company by
making important decisions with
a long-term view Executive
Kim ‘23 O Board of Affiliate
- Representative of South Korea’s Director,
Taehan AGM (3) Directors Executive
bio industry with high awareness Chair of BOD
and reliability in relation to global
pharmaceutical companies
- The company expects to lead
the company’s future contracts
and new business projects

- Served as CFO through sales /


marketing, production / RM /
SCM at global
biopharmaceutical companies
Genentech, Roche, etc., and the
possesses world's best global CEO,
John ‘23 network and expertise Board of Chair of Affiliate
X
Rim AGM Directors Management Executive
- Based on a high understanding
committee
of the industry as a whole, he is
expected to contribute to
strengthening business
capabilities and competitiveness
and expanding new orders.

- Contributed to the
transplantation of advanced
company management system
to the Company based on past
experience of working for
Samsung Electronics
Executive
Kim ‘25 O Board of Affiliate
- Expected to contribute to the Director
Dongjoong AGM (2) Directors Executive
Company's continued growth by CFO
overseeing HR, IT, Finance,
Business planning and Business
Innovation departments, which
are the company's key
management functions.
Relationship
Consecutive
Term with the
Name terms Appointment background Nominator Responsibility
expiration largest/major
(No.)
shareholder

- As a legal expert (lawyer),


Served as presiding judge at the
Seoul Central District Court and
a professor at the Judicial
Independent
Research and Training institute Independent
director,
Heo ‘25 O director Affiliate
- As a legal expert with Chair of Related
Geunnyung AGM (1) recommendation Executive
considerable experience in legal party transaction
committee
practice and academic fields, the committee
Company looks forward to the
inspection and reinforcement of
existing legal system

- Global leader with excellent


knowledge in legal services and
communication skills based on
her experience as an in-house
lawyer, an executive and
independent director in a
number of financial companies
Independent Independent
Eunice ‘23 - In the process of collaborating director director, Affiliate
X
Kim AGM with global pharmaceutical recommendation Chair of ESG Executive
companies, communication skills committee Committee
and legal knowledge will be a
great asset, and she is expected
to reflect diversity in the
operation of the Board of
Directors as female independent
director.

- As an accounting expert (CPA)


and professor of business
administration major served as
chair of ethics committee at the
Korea Institute of Certified Public
Accountants
Independent
- Expected to perform objective Independent
director,
Lee ‘25 management role based on director Affiliate
X Chair of Related
Changwoo AGM accounting and management recommendation Executive
party transaction
expertise, and the Company committee
committee
looks forward to enhancing
financial soundness and
management transparency
based on financial management
and risk management
knowledge
Relationship
Consecutive
Term with the
Name terms Appointment background Nominator Responsibility
expiration largest/major
(No.)
shareholder

- Possess a high level of


understanding of the operation
of the Board of Directors from
experience as multiple
independent directors
Independent
- Based on the experience of Independent
director,
Bahk ‘25 serving as the chairman of the director Affiliate
X Chair of
Jaewan AGM Board of Directors of global recommendation Executive
Compensation
companies and high-ranking committee
Committee
political positions, preemptive
risk review for business growth
and rational presentation of
management strategy for
business growth are expected.

※ From 11th Board of Directors meeting held on March 29, 2022, executive director Kim Dongjoong and independent director
Heo Geunnyung were re-appointed, and audit committee member Lee Changwoo and independent director Bahk Jaewan
were newly appointed.

(2) Independent director recommendation committee


The Company has created the independent director recommendation committee on August 10, 2016
for the recommendation of independent director candidates, and the committee will review their
competence and recommend qualified persons.
Director
Name of (Attendance rate)
committe Date Details of agendas Result Kwon Jeong Kim Lee Bahk Eunic Kim
e Soon Seok Tae Chang Jae e Dong
jo woo han woo Wan Kim Joong
(100%) (100%) (100%) (100%) (100%) (100%) (100%)
※ Reported items:
1. Establishment of internal
operating standards for a - - - - N/A N/A - N/A
Independent
recommendation of
director
’22.02.2 candidates for
recommend
5 independent director
ation
committee
[Bill] Recommendation of Approved For For For N/A N/A For N/A
an independent director
candidate
[Bill] Appointment of the
chairman of the
Recommend
'22.04.2 independent director
ation Approved N/A N/A N/A For For For For
7 candidate
committee
recommendation
committee

E. Expertise of Independent Directors

The Company operates the Board of Directors Secretariat consisting of 6 full-time staff, to support
independent directors perform their professional duties. The staff provide the directors with reference
materials corresponding to the meeting agendas well in advance the meeting. This enables directors
study and review each agenda discussed during the Board of Directors/Committee meetings. If
necessary, the Directors are provided with separate information sessions on any agenda and they are
also frequently provided updates on other key management issues.

(1) Secretariat for Independent directors


Name Number Department/Position Task

1 Center Leader, 1 Team Leader,


General management and
HR Support Center 6 1 Group Leader, and 3 Pros
operation of Secretariat
(Average 2.4 years)

※ Average years refer to time performing work relevant to support activity

(2) Education program for Independent Directors


Reasons for
Date Educator Attendant Education contents
absence

- PwC CORPORATE DIRECTORS


2020.01.07 PwC Jeong Seokwoo -
EXHCNAGE (~1.08)

Jeong Seokwoo
2020.01.13 JP Morgan Kwon Soonjo - - JP Morgan Healthcare conference(~01.17)
Heo Geunnyung
Jeong Seokwoo
Korea Health Industry Kwon Soonjo
2020.05.18 - - BIO KOREA 2020 (Online)(~05.23)
Development Institute Heo Geunnyung
Eunice Kim

- 1st Forum for auditor and audit committee


2020.07.07 Audit Committee Forum Jeong Seokwoo -
members(2020)

- KPMG Webinar: study of audit committee


2020.07.24 Samjong KPMG Jeong Seokwoo -
practices through videos
Jeong Seokwoo - BIO KOREA 2021
Korea Health Industry Kwon Soonjo (Conference on biopharmaceutical
2021.06.07 -
Development Institute Heo Geungnyeong industry, Exhibition of recent technology
Eunice Kim and product)(~06.21)
Jeong Seokwoo - Business Transformation seminar for
Kwon Soonjo Carbon Neutral(Net Zero Transformation,
2021.09.13 Samil PwC -
Heo Geungnyeong Green Financing and Improvement of
Eunice Kim Transparency in Corporate Disclosures)

Heo Geungnyeong
Korea Health Industry Eunice Kim
2022.05.11 - - BIO KOREA 2022(Online)(~05.13)
Development Institute Lee Changwoo
Bahk Jaewan

2. Audit System

A. Profile of the Member of the Audit Committee


Indepen Accounting and Finance expertise
Name dent Career Applicab
director Expert type Related experience
le status
- Chair of ethics committee, Korea Institute of ② Degree - Basic qualifications :
Certified Public Accountants (2020~present) holder in Acquisition of a master's
the field degree or higher related
Lee - Professor, Seoul National University Business
of to accounting and
Chang Yes School (1992~present) Yes
accounti finance
woo - Chairman of Board of Director, Korea Institute
ng and ㆍDoctor of Business
Association (2011~2013)
finance Administration, UC
- Ministry of Economy and Finance, Head of (Type 2) Berkeley (1987)
Indepen Accounting and Finance expertise
Name dent Career Applicab
director Expert type Related experience
le status
management evaluation team of Quasi- ㆍMaster of accounting
Government Institution (2009-2011) science, University of
- President, Korea Accounting Association (2008- Illinois Urbana-
2009) Champaign (1982)
- Work experience :
Over five years of overall
work experience as a
researcher or assistant
professor in accounting
or finance fields at a
research institute or a
university
ㆍProfessor, Seoul
National University
Business School
(1992~present)

- Legal Advisor, Pyeongan Law Firm (2019~Present)


- Managing Partner, Pyeongan Law Firm
(2016~2019)
Heo - Lawyer, GILDO Law Firm (2011~2016)
Geun Yes - Senior Judge, Seoul Central District Court - - -
nyung (2004~2007)
- Professor, Judicial Research and Training Institute
(2001~2004)
- Chief Judge, Cheongju District Court (1999~2001)

- Member, Korea Corporate Governance Service


(2006~Present)
- Professor, Ewha W. University Law School
(2010~2021)
Eunice - Vice President/Chief Compliance Officer, Hana
Yes - - -
Kim Financial Group (2008~2010)
- Chief Compliance Officer, Japan Citi Bank
(2007~2008)
- Executive Vice President, Deputy Minister for Legal
Affairs, Korea Citi Bank (2004~2007)
※ On March 29, 2022, the audit committee member Jeong Seokwoo and independent director Kwon Soonjo's terms expired.
※ On March 29, 2022, independent director Heo Geunnyung was re-appointed as an audit committee member, and Lee
Changwoo and Eunice Kim were newly appointed as independent directors.
B. Independence of Audit Committee Members
Relation
Relati
ship with
onship
Recom Reappoi the
with
Name Appointment Background mendati Term ntment largest/
the
on (No.) major
Comp
sharehol
any
der

- As an accounting expert (KICPA and AICPA) and


doctorate of Business Administration, he has high Indepen
level of understanding in corporation from multiple dent
Affiliate
independent director experiences. director
Lee Executiv
Recom 2022.03~2
Chang - Expects contribution to enhancement of X - e
mendati 025.03
woo competitiveness and increasing the rights and (SBL)
on
interests of stakeholders, including shareholders, Committ
by performing objective management supervisory ee
roles based on expertise and active board activities

- As an expert in legal field (lawyer), he served as Indepen


presiding judge at the Seoul Central District Court dent
and a professor at the Judicial Research and Affiliate
director
Heo Training institute Executiv
Recom 2022.03~2 O
Geun - e
- With considerable experience in legal practice and mendati 025.03 (1)
nyung (SBL)
academic fields, he will play a crucial role in on
inspection and reinforcement of the Company’s Committ
legal system ee

- Successfully performed various positions such as


compliance attorney at the global company, Indepen
independent director, and professor. dent
Affiliate
director
- Expects high contribution in inspection and Executiv
Eunice Recom 2022.03~2
reinforcement of the Company’s compliance X - e
Kim mendati 023.03
monitoring system and practice of ethical (SBL)
on
management system. Expects diverse and Committ
strengthened internal control system as a first ee
female independent director.

※ Independent director Lee Changwoo was recommended by Independent Director Recommendation Committee and appointed
at the General Meetings of Shareholders.

The Company’s Audit committee is formed in accordance with Article 542-11 of the Commercial Act,
and three independent directors who constitute the Audit committee as stated above meet eligibility
requirements for both Independent directors and Audit committee members.
Details Qualifications Remarks

Consists of 3 directors Qualified(3) Article 415-2 Clause 2

More than 2/ Qualified


Article 415-2 Clause 2
3 of independent directors (All independent directors)

More than one member must be an


Qualified
accounting or financial specialist
(1, Independent director: Article 542-11 Clause 2
prescribed by Presidential Decree.
Lee Changwoo)
Qualified
Representative of Audit committee must
(Independent director: Article 542-11 Clause 2
be an independent director
Lee Changwoo)

Other qualification
(Related parties of the largest Qualified Article 542-11 Clause 3
shareholders, etc)

One member of the Audit Committee is


Qualified
appointed by the resolution of the general
(Independent director: Article 542-12 Clause 2
meeting of shareholders after being
Lee Changwoo)
separated from other directors

Meanwhile, the Audit committee is eligible to request reports on business performance and financial
status from Directors and requests additional reviews and supplementation of data as needed.
C. Activities of Audit Committee

Director
(Attendance rate)
Date Details of agendas Result
Jeong Kwon Heo Lee Eunice
Seokwoo Soonjo Geunnyung Changwoo Kim
(100%) (100%) (100%) (100%) (100%)
※ Reported Items:
1. 2021 financial statements and annual - - - -
‘22.01.24
business report
2. Audit activities by external auditor - - - -
※ Reported Items:
1. 2nd interim report from 3rd Assessment - - - -
committee
2. Audit activities by external auditor - - - -
3. Results of internal accounting - - - -
performance evaluation by the CEO
‘22.02.04 4. Performance and independence of - - - -
the Audit committee
5. Assessment result of the internal audit - - - -
department
6. Report on audit results of 1H 2021 - - - -
7. Report on the progress of major
issues - - - -
※ Reported Items:
‘22.02.15 1. 2nd Report on the progress of major - - - - Not Not
issues Applicable Applicable
(Newly (Newly
※ Reported Items: appointed) appointed)
1. 2nd Report on the results of internal - - -
-
accounting performance evaluation by
the CEO
2. 2nd Report on performance and - - -
‘22.02.21 -
independence of the Audit committee
3. 2nd Report on assessment result of - - -
-
the internal audit department
4. 3rd Report on the progress of major - - -
-
issues
※ Reported Items:
1. Operation status of internal - - - -
accounting control system
2. Progress of the assessment on - - - -
‘22.02.25 internal accounting control system by
PA
3. Progress of the end-of-year audit - - - -
※ Resolution Items:
1. Approval of agenda for the 11th AGM Approved For For For
※ Reported Items:
1. Entry education for newly appointed - - - -
auditors
2. Annual operation plan of the Audit - - - -
committee
‘22.03.29 - -
3. Annual plan of Internal accounting - -
management system
※ Resolution Items:
1. Appointment of chairman of audit Approved Not Not For For For
committee Applicable Applicable
※ Reported Items: (End of (End of
-
1. 1Q 2022 interim business result term) term)
- - - -
2. 2022 annual audit plan - -
'22.04.27 3. Progress of 1Q 2022 accounting - -
Review
1. Establishment of internal audit
Approved For For For
performance indicators
※ Reported Items:
'22.04.27 1. Annual plan of internal audit team - - - -
2. Evaluation of 2021 external audit firm - - - -
3. Appointment of audit committee as PA - - - -
4. Establishment of phase 2 of - - - -
consolidated internal accounting
management system

D. Education Plan & Status of Audit Committee

(1) 2022 Education program for Audit Committee

Education plan

Name of education Educator

‘22.04 - Audit and Inspection conference Audit Committee Forum

‘22.05 - BIO KOREA 2022 Korea Health Industry Development Institute

‘22.07 - Audit committee seminar with external experts Internal Control Operation Group

(2) Previous education program

Reasons for
Date Educator Attendant Education contents
absence

Internal Lee Changwoo


- Entry education for newly appointed
2022.03.29 Accounting Heo Geunnyung -
auditors
Operation Group Eunice Kim

Lee Changwoo
Audit Committee (Personal reason) - Disclosure of ESG and audit committee
2022.04.19 Eunice Kim
Forum Heo Geunnyung supervising points
(Personal reason)

Korea Health
Lee Changwoo
Industry
2022.05.11 Heo Geunnyung - - BIO KOREA 2022(Online)(~05.13)
Development
Eunice Kim
Institute

※ In order to enhance the Audit committee's understanding of internal accounting and business through communication with the
Audit committee, the Company has been delivering various information to the auditors in the form of newsletter, including
biweekly work, trends related to internal accounting, and the status of the Company and pharmaceutical industry.

E. Support Team for Audit committee


No. of Position
Department Details
employee (Average service period)

1 Group Leader, 1 Pro - Operation of Audit Committee


Internal Control Operation Group 2
(3.0years) - Assessment of Internal Control

1 Team leader, 2 Pro - Support operation for Audit Committee


Audit Team 3
(1.0years) - Inspection of Internal Control process

※ Service years refer to time performing work relevant to support activity.

F. Compliance Officer
Name Career Qualification
- Master degree in Laws, Seoul National University (1996),
Moon 45th bar exam. Qualified
Hyung - Lawyer, Law firm KIM CHANG & LEE (2006~2017) (Article 542-13 Clause 5
Woo - Team leader, Legal Compliance Team, No. 1 of Commercial Act)
Samsung Biologics Co., Ltd. (2017~present)

G. Major Compliance Activities


The Company conducts regular/non-regular compliance activities at the workplace, and based on the
results of the activities, the Company is effectively supporting compliance activities so that the Company
and its employees can comply with all laws and regulations by reflecting the issues that need
improvement.

Dates Major Inspection & Activity details


2022.01 - Compliance education for experienced employees
2022.02 - Compliance education for entrance-level employees
- Compliance education for experienced employees
2022.03
- Compliance PR(Capital Markets Act, etc.)
2022.04 - Compliance PR(In-house broadcasting/Quiz)
2022.05 - Risk evaluation(anti-corruption)
2022.06 - Compliance education(ISO37001, anti-corruption)

H. Support Team for the Compliance Officer


Department No. Position (Service Period) Details
Legal - Inspection and education of CPs such as fair
9 Lawyers (3.2years)
Compliance 12 trade and anti-graft law
3 Pros (3.8years)
Team - Review of contracts and in-house regulations

3. Matters Regarding the Exercise of Shareholders’ Voting Rights

A. Voting System
(As of March 31, 2022)

Type Cumulative voting. Paper voting Electronic voting

Introduction Not Applicable Not Applicable Applicable

10th (2021)
Implementation - -
Annual General Meeting

B. Minority Shareholders’ Rights


No minority shareholders' rights were exercised during the reporting period.

C. Competition over Management Rights


No competition over management rights occurred during the reporting system.
D. Voting Shares

The Company has 71,174,000 shares of common stock outstanding, which account for 14.23% of the
total number of authorized shares (500 million shares). The number of shares available for exercising
the voting right is 71,122,407 shares excluding 51,593 shares in a special account of Samsung Life
Insurance, the Company’s financial affiliate company.

(As of June 30, 2022) (Unit: share)

Number of
Classification Remarks
shares
Common stock 71,174,000 -
Number of outstanding shares (A)
Preferred stock - -

Number of shares with no voting rights Common stock - -


(B) Preferred stock - -

Common stock - -
Number of shares with no voting rights
according to articles of incorporation (C) Preferred stock - -
Restricted by the
Insurance Business Act
Common stock 51,593
Number of shares with limited voting (Special account -
rights under relevant laws (D) Samsung Life Insurance)
Preferred stock - -

Common stock - -
Number of shares with revived voting
rights(E) Preferred stock - -

Number of shares with voting rights Common stock 71,122,407 -


(F = A - B - C - D + E) Preferred stock - -

E. Stock affairs
Article 11 (Issuance and allocation of shares)
① The Company may issue new shares with a resolution of the BOD by:
1. Granting the shareholders opportunities to subscribe for new shares in proportion to their
respective shareholding;
2. Granting specific persons (including the shareholders of the Company) opportunities to
subscribe for new shares to the extent of not exceeding 30/100 of the total number of
issued and outstanding shares (the total number of issued and outstanding shares herein
shall include new shares to be issued under this Sub-Paragraph) by a method other than
that under Sub-Paragraph 1 (i.e. private placement) for managerial purpose of the
Company such as improvement of financial structure, introduction of new technology,
Details of stock
strategic partnership, etc.;
warrants in the
3. Granting general public (including the shareholders of the Company) opportunities to
articles of
subscribe for new shares and allocating new shares to those who subscribe for such
incorporation
shares to the extent of not exceeding 50/100 of the total number of issued and
outstanding shares (the total number of issued and outstanding shares herein shall
include new shares to be issued under this Sub-Paragraph) by a method other than that
under Sub-Paragraph 1.
② When allocating new shares under Sub-Paragraph 3 of Paragraph 1 above, the Company
shall allocate new shares with a resolution of the BOD by::
1. Allocating new shares to unspecified subscribers without differentiating the types of
persons who are granted opportunities to subscribe for new shares;
2. Allocating new shares to the members of the Employee Stock Ownership Association
pursuant to applicable laws and granting general public opportunities to subscribe for new
shares, including unsubscribed shares;
3. Granting the shareholders opportunities to subscribe for new shares first and, if there are
any unsubscribed shares, then to general public opportunities to be allocated;
4. Granting specific types of persons opportunities to subscribe for new shares in accordance
with reasonable standards stipulated in applicable statutory provisions, such as demands
forecast to be made by investment trader or investment broker as underwriter or arranger.
③ When new shares are allocated under Sub-Paragraph 2 or 3 of Paragraph 1 above, the
items set forth in Section 416 (1), (2), (2-2), (3) and (4) of the Commercial Code shall be
notified to shareholders by way of individual or public notices no later than two (2) weeks
prior to the date of payment of the subscription price; provided, however, that such an
individual notice and public notice may be substituted by publishing a Report of Major Items
to the Financial Services Commission and the stock exchange under Article 165-9 of the
Financial Investment Services and Capital Markets Act.
④ The class, number, and issuance price of the new shares that are to be issued under any of
the provisions in Paragraph 1 shall be determined by a resolution of the BOD.
⑤ Any of the new shares that are not subscribed for or paid therefor by applicable payment
date shall be handled by a resolution of the BOD in accordance with applicable laws and
regulations.
⑥ Disposal of fractional shares created in the course of allocation of new shares shall be
determined by a resolution of the BOD.
⑦ In case of allocation of new shares under Sub-Paragraph 1 of Paragraph 1 above, the
Company shall issue the certificates of preemptive rights to the shareholders.
General Shareholders’ Within 3 months after the
Closing date December 31
Meeting business year ends
Closing date of
December 31
stockholders’ list
Closure of
From January 1 to January 31
stockholders’ list
Type of share
-
certificates
Transfer agent Korea Securities Depository
Privileges of
Not Applicable
shareholders
Homepage (https://www.samsungbiologics.com)
Public notice
In unavoidable circumstances, related information is published on Joongang Daily
※ With Act on Electronic Registration of Stocks, Bonds, etc. (“Electronic Securities Act”) taking effect Sep 16, 2019, rights
specified on stocks and subscription warrants are subject to mandatory electronic registration, therefore, “Stock types” are no
longer applicable.

F. Summary of Annual General Meeting Minutes


Date Agenda Result
- Approval of 9th period (2019.01.01~2019.12.31) financial statement
- Appointment of directors (Executive director – Kim Taehan and
2020.03.20 Approved
John Rim; & Independent director – Eunice Kim)
- Approval of compensation limit for Directors
- Approval of 10th period (2020.01.01~2020.12.31) financial statement
2021.03.19 Approved
- Approval of compensation limit for Directors
- Approval of 11th period (2021.01.01~2021.12.31) financial statement
- Appointment of directors (Executive director – Kim Dongjoong; &
Independent directors –Heo Geunnyung and Bahk Jaewan)
- Appointment of independent director to serve as an Audit
2022.03.29 Approved
Committee member (Independent director – Lee Changwoo)
- Appointment of Audit Committee member (Heo Geunnyung and
Eunice Kim)
- Approval of compensation limit for Directors
VII. Matters Regarding Shareholders

1. Stocks Held by the Largest Shareholder and Related Parties

A. Stocks held by the largest shareholder and related parties


(As of June 30, 2022) (Unit: Share, %)

Share number and ratio

Class of Beginning of period End of period


Name Relationship Remarks
stock
Shares Ratio Shares Ratio

Samsung C&T Largest Common Participation in


28,742,466 43.44 30,646,705 43.06 capital
Corporation shareholder stock
increase
Participation in
Samsung Common
Related party 20,836,832 31.49 22,217,309 31.22 capital
Electronics stock
increase
Samsung Life
Common Open market
Insurance Related party 56,026 0.08 51,593 0.07
stock transaction
(special account)
Participation in
capital
Common
Kim Taehan Related party 16,400 0.02 12,600 0.02 increase,
stock
Open market
transactions

Common Participation in
Kim Dongjoong Related party 4,300 0.01 4,632 0.01 capital
stock
increase
Common
49,656,024 75.04 52,932,839 74.37 -
stock
Total
Preferred
- - - - -
stock

B. Overview of the largest shareholder

(1) Corporation information

Number of Chief Executive Officer Business Executive Largest Shareholder


Investors (Representative Member) (Business Member) (Largest Investor)
Name
(Number of
persons) Name Share(%) Name Share(%) Name Share(%)

Lee Jae Yong


Koh Jung Suk 0.00 - - 33.46
and others
Samsung
C&T 200,027 Oh Se Chul 0.00 - - - -
Corporation
Han Seung Hwan 0.00 - - - -

※ The number of investors above is the number of common stock shareholders of Samsung C&T Corporation recorded up to
the latest shareholder list closure date which is December 31, 2021. The shares of Chief Executive Officer, Business
Executive, and Largest Shareholder are recorded up to the disclosure date June 30, 2022.
Details of changes in Chief Executive Officer, Business Executive, and Largest Shareholder

Chief Executive Officer Business Executive Largest Shareholder


Date of (Representative Member) (Business Member) (Largest Investor)
change
Name Share(%) Name Share(%) Name Share(%)
2018.03.22 Choi Chi Hun - - - - -
2018.03.22 Kim Shin - - - - -
2018.03.22 Kim Bongyung - - - - -

2018.03.22 Lee Youngho - - - - -


2018.03.22 Koh Jung Suk 0.00 - - - -
2018.03.22 Chung Keumyong - - - - -
2021.03.19 Lee Youngho - - - - -
2021.03.19 Chung Keumyong - - - - -
2021.03.19 Oh Se Chul 0.00 - - - -

2021.03.19 Han Seunghwan 0.00 - - - -


※ On March 22, 2018, Co-Chief Executive Officers Choi Chi Hun, Kim Shin and Kim Bong Yung resigned. Lee Young Ho, Koh
Jung Suk and Chung Keum Yong were newly appointed as Co-Chief Executive Officers.
※ On March 19, 2021, Co-Chief Executive Officers Lee Young Ho and Chung Keum Yong resigned. Oh Se Chul and Han Seung
Hwan were newly appointed as new Co-Chief Executive Officers.
※ For changes in the share ownership status during the period of public disclosure, changes in ownership and statement by
dates are separately disclosed in the electronic disclosure system, so please refer to the "1H 2022 report" by Samsung C&T
Corporation.

(2) Financial status


(Unit: KRW Mil)

Samsung C&T Corporation


Total assets 55,245,423
Total liabilities 21,892,979
Total stockholder’s equity 33,352,444
Sales 34,455,182
Operating income 1,195,983
Current net income 1,829,084
※ The values above are based on the consolidated financial statements as of December 31, 2021.

(3) Business status

Samsung C&T Corporation, the largest shareholder of Samsung Biologics Co., Ltd., is located in 26,
Sangil-ro 6-gil, Gangdong-gu, Seoul, Republic of Korea, and engages mainly in business areas at home
and abroad: the engineering & construction sector including building, civil infrastructure, plant, and
housing; the trading & investment sector including natural resources, steel, chemical & industrial
materials, and living industrial; the fashion sector including apparel products manufacturing, sales
business and textile processing; the resort sector including landscaping and Everland (drier park),
Caribbean Bay (water park), golf club, and catering (Samsung Welstory) and the biopharmaceutical
outsourcing & biosimilar sector.
※ For more details regarding largest shareholders, please refer to the "1H 2022 report" by Samsung &T Corporation disclosed

in the electronic disclosure system.

2. Changes of the Largest Shareholder

Changes of the largest shareholder during the time period subject to disclosure are as follows:

(As of June 30, 2022) (Unit: share, %)


No. of stocks Cause of
Date Largest shareholder Share ratio Remarks
held Change
2011.04.22 (Old) Cheil Industries 600,000 40,00% Establishment -

2011.04.22 Samsung Electronics 600,000 40.00% Establishment -

2015.09.02 Samsung C&T Corporation 14,069,833 51.04% Note1) Note2)


Note1) Samsung C&T Corporation is the sole largest shareholder, as Cheil Industries Inc., a survival corporation after merger
between Samsung C&T Corporation and (old) Cheil Industries Inc. which was the largest shareholder was renamed to
Samsung C&T Corporation.
Note2) Currently, the largest shareholder Samsung C&T Corporation has 30,646,705 shares which is 43.06% stake.

3. Distribution of Shares

A. Shareholders with over 5% ownership and stocks held by the employee stock
ownership association
(As of June 30, 2022) (Unit: share)
Number of shares
Classification Name of shareholders Share ratio Remarks
owned
Samsung C&T Corporation 30,646,705 43.06% -
Shareholders with
Samsung Electronics 22,217,309 31.22% -
over 5% ownership
National Pension Service 4,418,387 6.21% -

Employees Share Ownership Association 640,496 0.90% -

B. Minority shareholders
(As of June 30, 2022) (Unit: share)
Shareholders Shares owned
Category No. of No. of Remarks
No. of total No. of total
Minority Ratio Minority Ratio
shareholders shares
shareholders shares
Shareholders
Minority holding stocks
114,266 114,305 99.97 14,809,433 71,174,000 20.81
shareholders below 1/100 of total
stocks issued

4. Share Price and Stock Transactions


(Unit: KRW, share)
Class '22.06 '22.05 '22.04 '22.03 '22.02 '22.01

Highest 852,000 847,000 839,000 844,000 790,637 900,338

Share
Lowest 784,000 766,000 790,000 764,000 731,339 703,667
price
Average 814,450 809,333 814,429 808,905 758,365 813,566
Common
stock Highest
250,445 94,179 111,394 84,286 173,657 172,096
(day)
Trading Lowest
38,656 27,315 23,476 31,750 33,523 38,010
volume (day)
Monthly
1,434 974 1,005 1,019 1,089 1,521
(thousand)
※ The Company was listed on the stock market as of November 10, 2016.
VIII. Matters Regarding Executives and Employees

1. Executives and Employees

A. Registered executives
(As of June 30, 2022) (Unit: share)

No. of shares held Term


Date of Registered Full/ Length of expiration
Name Gender Position Responsibility Career
birth Executive Part-time service
Common Preferred

- Former CEO, Samsung Biologics


Executive Chair of the 11 years
Kim Taehan M 1957.11 President Full-time - Doctor of Chemical Engineering, University 12,600 - 2023.03.20
Director Board 4 months
of Texas, Austin

- Center Leader, CMO2 Center, Samsung


Executive Biologics 3 years
John Rim M 1961.10 President Full-time CEO - - 2023.03.20
Director - Master of Business Administration, 10 months
Northwestern University
- Head of Office, Corporate Management
Office, Samsung Biologics
Senior Business - Head of Planning Support Team,
Kim Executive Mechatronics & Manufacturing Technology 7 years
M 1965.02 Vice Full-time Support Center 4,632 - 2025.03.21
Dongjoong Director Center, Samsung Electronics 8 months
President Leader
- Master of Business Administration, Ajou
University
- Chair of
Related Party
Transaction - Managing Partner, Pyeong An Law Firm
Heo Independent 3 years
M 1956.01 Director Part-time Committee, - Senior Judge, Seoul Central District Court - - 2025.03.21
Geunnyung Director 3 months
- Audit - Master of Law, Seoul National University
Committee
Member
- Member, Korea Corporate Governance
Eunice Independent Chair of ESG Service 2 years
W 1959.03 Director Part-time - - 2023.03.20
Kim Director Committee - Professor, Ewha W. University Law School 3 months
- Juris Doctor, Yale University Law School

- Honorary professor, Seoul National


University Business School
Lee Independent Chair of Audit - Chair of Ethic Committee, Korean Institute of
M 1954.01 Director Part-time - - 4 months 2025.03.21
Changwoo Director Committee Certified Public Accounts
- Doctor of Business Administration, UC
Berkeley
- Honorary professor, Public Administration
Chair of department, Sungkyunkwan University
Bahk Independent
M 1955.01 Director Part-time Compensation - - 4 months 2025.03.21
Jaewan Director - Chairman of the director, Hansun Foundation
Committee
- Doctor of Public Policy , Harvard University

※ From 11th Board of Directors meeting held on March 29, 2022, Lee Changwoo and Bahk Jaewan were newly appointed as independent directors, and independent directors Kwon Soonjo and
Jeong Seokwoo resigned due to end of term.
※ Number of shares held by executives as of June 30, 2022. For subsequent changes, please refer to the ownership report of executives and major shareholders at the DART (Data Analysis,
Retrieval and Transfer System
B. Unregistered executives
(As of June 30, 2022) (Unit: share)
No. of shares
owned
Date of Registration Employment Term of
Name Gender Position Responsibility Career With Without
birth status status service
voting voting
rights rights

- Center Leader, DS center, Samsung Biologics


Executive EPCV Center 1 year
Lo Kun M 1963.01 Unregistered Full-time - Doctor of Chemical Engineering, Seoul National - -
Vice President Leader 7 months
University

- Team Leader, Global BD Team 2, Samsung


Global Business Biologics
Executive 6 years
James Park M 1966.04 Unregistered Full-time Operation Center 1,900 -
Vice President - Master of Industrial Engineering, Columbia 8 months
Leader
University

- Quality Executive, Lonza


Sam Executive Quality Center 3 years
M 1963.03 Unregistered Full-time - Master of Atomic Nucleophysics, Concordia 1,824 -
MacHour Vice President Leader 1 month
University

- Center Leader, DP&SCM Center, Samsung


Yoon Executive Biologics 10 years
M 1963.08 Unregistered Full-time Executive Advisor 1,668 -
Hoyeol Vice President - Master of Technology Management, State 8 months
University of New York, Stony Brook

Global Information& - Team Leader, GIO Team, Samsung Biologics


James Executive 7 years
M 1967.08 Unregistered Full-time Marketing Center - Master of Business Administration, University of 796 -
Choi Vice President 11 months
Leader Southern California

Pierre Executive Manufacturing - Site Head, Lonza


M 1968.09 Unregistered Full-time - - 10 months
Catignol Vice President Center Leader - Master of Industrial Engineering, ECAM Lyon

- Center Leader, Global Support Center(HR),


Kim Executive Business Operation Samsung Biologics 6 years
M 1964.05 Unregistered Full-time 1,107 -
Yongsin Vice President Center Leader - Russian Language & Literature, Kyung Hee 7 months
University

- Business Unit Leader, DS, Samsung Biologics


Daniel Manufacturing 8 years
M 1951.01 Vice President Unregistered Full-time - Bachelor of biology, Florida International - -
Slone Center Executive 7 months
University
Business -Team Leader, IR team, Samsung Biologics
Kim
W 1974.05 Vice President Unregistered Full-time Development Team - - 8 months
Changsook - Master of Pharmacology, University of Arizona
Leader

- CEO, Lumebio
Kang
W 1972.09 Vice President Unregistered Full-time CDO Division - Master of Medicine, Sookmyung Women’s - - 8 months
Jahoon
University

- Managing Director, Global Operations Division,


Lee Technology Support Celltrion
M 1972.11 Vice President Unregistered Full-time - - 7 months
Sangyoon Center Leader
- Doctor of biotechnology, Inha University

- Team Leader, Facility Maintenance Team,


Lee Facility Technology Samsung Biologics 5 years
M 1969.12 Vice President Unregistered Full-time - -
Chungwoo Team Leader - Bachelor of Electrical Engineering, Hanyang 1 month
University

Shim - Team Leader, PI Team, Samsung Biologics 4 years


M 1968.01 Vice President Unregistered Full-time Executive Advisor 321 -
Byunghwa - Bachelor of Economics, Sogang University 4 months

- Quality & Compliance Executive Director, Arkon


Corporate QA Pharma
Keith Ellis M 1967.08 Vice President Unregistered Full-time - - 1 year
Division Executive
- Bachelor of Microbiology, University of Memphis

- Group Leader, Information Security


Group(Mobile), Samsung Electronics 2 years
Kim Kijoong M 1969.08 Vice President Unregistered Full-time ISA Team Leader 20 -
- Bachelor of Inorganic Material Engineering, 6 months
Kyoungbuk National University

- Team Leader, DS3 Cell Culture Team, Samsung


Park Biologics 2 years
M 1973.12 Vice President Unregistered Full-time EPM Team Leader 356 -
Segang - Bachelor of Chemical Engineering, Inha 5 months
University

- Team Leader, Process Support Team, Samsung


Jin Biologics 2 years
M 1966.10 Vice President Unregistered Full-time DP Division 182 -
Yonghwan - Doctor of Molecular Biology, Seoul National 5 months
University

Moon Compliance Team - Lawyer, Kim Chang & Lee Law Firm 1 year
M 1970.01 Vice President Unregistered Full-time - -
Hyungwoo Leader - Master of Law, Seoul National University 6 months
- Team Leader, Corporate Engineering Team,
Seo Business Strategy Samsung Biologics 1 year
M 1979.01 Vice President Unregistered Full-time 755 -
Sangwon Team Leader 6 months
- Master of Life Science, POSTECH

- Team Leader, Business Strategy Team, Samsung


Lim Business Consulting Biologics 1 year
M 1975.06 Vice President Unregistered Full-time - -
Heekyun Team Leader 6 months
- Bachelor of Life Science, POSTECH

- Team Leader, Human Resource Team(North


Park HR Support Center America), Samsung Electonics
M 1972.12 Vice President Unregistered Full-time - - 7 months
Yong Leader - Doctor of Business Administration, Chung-ang
University

- Team Leader, Operational Excellence, Samsung


Jo Biologics
M 1975.01 Vice President Unregistered Full-time DS Division 268 - 7 months
Youngjin - Master of Food Engineering, Seoul National
University

Operational - Team Leader, Plant #3, Samsung Biologics


Kim
W 1981.09 Vice President Unregistered Full-time Excellence Team - Master of food science and biotechnology, Seoul 2 - 7 months
Heejung
Leader National University

Lee CDO Development - Part Leader, USP2, Samsung Biologics


M 1973.12 Vice President Unregistered Full-time 324 - 7 months
Jaesun Team Leader - Master of Biochemistry, Chungbuk University

Heo Finance Team - Business Support Group, Samsung Electronics


M 1975.12 Vice President Unregistered Full-time - - 7 months
Doyoung Leader - MBA, Indiana University

- Team Leader, Alliance Management, Samsung


Kevin Strategic Operations Biologics
M 1976.01 Vice President Unregistered Full-time - - 7 months
Sharp Team Leader - Master of Business Administration, Temple
University

- Quality Operations Team, Samsung Biologics


Jo Beth Quality Operations
W 1965.12 Vice President Unregistered Full-time - Master of Neuroscience, University of California, - - 7 months
DeFreitas Team Leader
San Francisco

※ Number of shares held by executives is as of June 30, 2022. For subsequent changes, refer to the ownership report of executives and major shareholders at the DART (Data Analysis, Retrieval
and Transfer System)
C. Registered executives with concurrent positions
Interlocking executive Interlocking company

Name Position Name Position


Lo Kun Executive Vice President Samsung Bioepis Other non-executive director 2022.02 ~ present
Eunice Kim Independent director U-young Industrial Executive director 2018.06 ~ present
Hanwha General
Lee Changwoo Independent director Independent director 2021.03 ~ present
Insurance
Bahk Jaewan Independent director Hankook & Company Independent director 2022.03 ~ present
※ As of February 9, 2022, President John Rim's term as an interlocking executive of the Company has expired, and Vice
President Lo Kun has been appointed as a non-executive director of Samsung Bioepis Co., Ltd.

D. Changes of unregistered executives after reporting date


No changes of unregistered executives occurred during the reporting period.

E. Employees
(As of June 30, 2022) (Unit: KRW Mil)
Employee Non-Employee
No. of employees
Per
Regular Average Gross Remarks
Business Fixed-term workers capita
Gender workers Total length of annual M W Total
unit average
(Part-time (Part-time service salary
All All salary
worker) worker)
Manufacturing M 1,334 - 85 - 1,419 3.3 - -
Manufacturing F 643 - 55 - 698 2.8 - -
Research M 564 - 105 - 669 3.5 - -
Research F 730 - 50 - 780 3.7 - -
Support M 470 - 23 - 493 4 - - 418 239 657
Support F 260 - 10 - 270 3.9 - -
Total no. of M 2,368 - 213 - 2,581 3.5 88,502 36
employees F 1,633 - 115 - 1,748 3.4 53,453 32
Total 4,001 - 328 - 4,329 3.4 141,955 34 -
※ Gross annual salary is based on gross salary in the statement of earned income payments to be submitted to a competent tax
office in accordance with Article 20 of the Income Tax Act.
※ The number of employees above is based on headquarters and registered executives (7 members) are excluded.
The number of employees includes those on leave of absence.
※ The average salary per person was calculated based on the annual average number of employees of 4,120 (male: 2,463,
female: 1,657).

F. Compensation of unregistered executives


(As of June 30, 2022) (Unit: KRW Mil)

No. Gross annual salary Per capita average salary Remarks

Unregistered executives 27 5,884 218 -

※ In the case of unregistered executives who were elected in the current year, only the compensation paid after the date of
election was calculated.

2. Executive Compensation
<Compensation of Directors and auditors>

(1) Compensation approved at the Annual General Meeting of shareholders


(Unit: KRW Mil)

Category No. Amount approved Remarks


Executive directors
(Excluding independent
3 - -
directors, member of audit
committee)
Independent directors
(excluding member of audit 1 - -
committee)

Members of Audit committee 3 - -

Total 7 15,000 -
※ The approval amount at the shareholders’ general meeting is compensation limit for directors approved through the
resolution by the shareholders’ general meeting on March 29, 2022 in accordance with Article 388 of the Commercial Act
and the articles of incorporation.

(2) Compensation paid


2-1. Total compensation paid for directors and auditors
(Unit: KRW Mil)
Average compensation
Number of persons Total compensation Remarks
per person
7 2,423 346 -

2-2. Compensation paid, by Director type


(Unit: KRW Mil)
Avg. compensation
Category Number of persons Total compensation Remarks
per person
Executive directors 3 2,206 735 -

Independent directors 1 28 28 -

Members of Audit
3 189 63 -
committee

Auditors - - - -

※ The Audit committee consists of three independent directors.


※ The number of persons is as of June 30, 2022.
※ Total compensation is the amount of income paid based on the Income Tax Act to registered directors in office or retired,
independent directors, and members of Audit committee as the status of registered executive during the business year in
accordance with Article 159 of the Financial Investment Services and Capital Market Act and Article 168 of the Enforcement
Decree of the Act.
※ Average compensation per person is calculated by dividing total compensation by number of persons.

(3) Criteria and methodology


- Compensation for registered directors (3 Executive directors and 4 Independent directors) is paid
within the compensation limit approved by the Annual General Meeting in accordance with Article
40 of the Company’s Articles of Incorporation.
- Total compensation is the amount exclusive of labor costs for appropriation. Average
compensation per capital is calculated by dividing total compensation by number of persons.

<Compensation for Executive Directors and Auditors>


1. Individual compensation amount
(Unit: KRW Mil)
Amount excluded from
Name Position Total compensation
the Total Compensation
John Rim CEO 831 -
Kim Taehan President 1,066 -

2. Calculation standards and method


(Unit: KRW Mil)
Total
Name Type of compensation Calculation criteria and method
amount
In accordance with internal regulation for executive
treatment (Board resolution), compensation is
Gross payroll 734 determined based on his position(CEO), responsibilities,
and performance results. He was paid USD 64,286 on a
Earned monthly basis.
CEO income Bonus 47 - Traditional holiday bonus : 100% of monthly wage
John Rim Stock option
- Not applicable
execution profit
- Fringe benefits: treatment is offered in line with
Other 50
business commissioning contract.
Retirement income - Not applicable
Other income - Not applicable
In accordance with internal regulation for executive
treatment (Board resolution), compensation is
Gross payroll 395 determined based on his position(Chairman),
responsibilities, and performance results. He was paid
KRW 65.8 million on a monthly basis.
- Traditional holiday bonus: 100% of monthly wage
- Long-term performance incentive: Calculated to the
extent of compensation limit set by the General
Shareholders' Meeting based on three-year average
annual salary by evaluating ROE, PER, pre-tax profit
ratio, etc.; and paid over the course of 3 years.
Earned
President income Bonus 667
※ Incentive calculated base d on the fact that the
Kim Taehan
Chairman achieved the optimized business
environment for business expansion, as well as his
active contribution in signing contracts with
new/existing clients and improving production
efficiency and maximizing utilization.
Stock option
- Not applicable
execution profit
- Fringe benefits: treatment is offered in line with the
Other 4
executive treatment rules(Board resolution)
Retirement income - Not applicable
Other income - Not applicable

< Compensation status of top five individuals among individuals paid above KRW 500 million >

(1) Summary on compensation by director


Name Position Total Compensation Amount excluded in Total
Compensation
John Rim Chief Executive Officer 831 -
Kim Taehan President 1,066 -
Sam MacHour Executive Vice President 839 -

(2) Criteria and methodology


(Unit: KRW Mil)
Total
Name Type of compensation Calculation criteria and method
amount
In accordance with internal regulation for executive
treatment (Board resolution), compensation is
Gross payroll 734 determined based on his position(CEO), responsibilities,
and performance results. He was paid USD 64,286 on a
Earned monthly basis.
CEO income Bonus 47 - Traditional holiday bonus : 100% of monthly wage
John Rim Stock option
- Not applicable
execution profit
- Fringe benefits: treatment is offered in line with the
Other 50
separate service contract.
Retirement income - Not applicable
Other income - Not applicable
In accordance with internal regulation for executive
treatment (Board resolution), compensation is
Gross payroll 395 determined based on his position(Chairman),
responsibilities, and performance results. He was paid
KRW 65.8 million on a monthly basis.
- Traditional holiday bonus: 100% of monthly wage
- Long-term performance incentive: Calculated to the
extent of compensation limit set by the General
Shareholders' Meeting based on three-year average
annual salary by evaluating ROE, PER, pre-tax profit
ratio, etc.; and paid over the course of 3 years.
Earned
President income Bonus 667
※ Incentive calculated base d on the fact that the
Kim Taehan
Chairman achieved the optimized business
environment for business expansion, as well as his
active contribution in signing contracts with
new/existing clients and improving production
efficiency and maximizing utilization.
Stock option
- Not applicable
execution profit
- Fringe benefits: treatment is offered in line with the
Other 4
executive treatment rules(Board resolution)
Retirement income - Not applicable
Other income - Not applicable
In accordance with internal regulation for executive
treatment (Board resolution), compensation is
Gross payroll 249 determined based on his position (Executive Vice
President), responsibilities, and performance results. He
was paid USD 34,100 on a monthly basis.
- Long-term performance incentive: incentive calculated
Executive Earned by evaluating Key Performance Indicator, paid twice
Vice income Bonus 572 annually
- Performance incentive: paid once a year within 0~30%
President
of salary
Sam MacHour
Stock option
- Not applicable
execution profit
- Fringe benefits: treatment is offered in line with the
Other 18
separate service contract.
Retirement income - Not applicable
Other income - Not applicable

< Grant and execution of stock option>


Not applicable as of the date when the half year report is submitted.
IX. Matters Regarding Affiliates

A. Overview of Affiliates(Summary)

(1) Overview of affiliated group


The Company is an affiliate of the Samsung Group, according to 'Monopoly Regulation and Fair Trade Act'. As of June 30, 2022, Samsung Group has 61
domestic affiliates, with two additions of SHP Corporation and SKKU Techno Holdings since 2021. Among Samsung Group's 61 domestic affiliates, 16
affiliates including Samsung Biologics are listed, and 45 affiliates are unlisted.
(As of June 30, 2021)
Number of Affiliates
Name
Listed Unlisted Total
Samsung 16 45 61
※ For details, refer to XII. Table of Information – 2. Details of other companies

(2) Cross-shareholding status

① Domestic

※ Percent of ownership as of June 30, 2022 based on common shares (Unit: %)


Investee
Samsung Samsung Samsung Samsung Samsung
Samsung Samsung Samsung Samsung Samsung Samsung Samsung Multicampus
Investor C&T Life Electro- Heavy Fire & Marine
Biologics SDI SDS Engineering Electronics Securities Card Corporation
Corporation Insurance Mechanics Industries Insurance

Samsung C&T
Corporation 43.1 19.3 17.1 7.0 5.0 0.1
Samsung Biologics

Samsung Life Insurance 0.1 0.1 0.1 0.0 0.1 0.1 8.7 3.0 29.4 71.9 15.0 0.0
Samsung SDI 11.7 0.4
Samsung SDS 47.2
Samsung Electro-
Mechanics 2.1
Samsung Electronics 31.2 19.6 22.6 23.7 15.2
Samsung Heavy
Industries
Samsung Securities

Samsung Card
Samsung Fire & Marine
Insurance 0.2 1.5
S-1 Corporation

Cheil Worldwide 0.1


Hotel Shilla

Samsung Display
Samsung Asset
Management
Samsung Electronics
Service
Miracom
Samsung Economic
Research Institute (SERI) 15.2
Harman International
Industries
Total 0.1 74.3 19.3 19.7 39.7 19.0 23.8 15.2 20.8 29.4 71.9 15.0 62.4

※ Percent of ownership as of June 30 , 2022 based on common shares (Unit: %)


Investee Samsung
Samsung Life Samsung Samsung Samsung
S-1 Cheil Samsung Samsung Samsung Venture Samsung Samsung
Investor Hotel Shilla Service Claim Active Asset SRA Asset Asset
Corporation Worldwide Display Medison Bioepis Investment Futures Welstory
Adjustment Management Management Management
Corporation
Samsung C&T
Corporation
16.7 100.0
Samsung Biologics 100.0
Samsung Life Insurance 5.4 0.3 7.4 99.8 100.0 100.0
Samsung SDI 11.0 0.1 15.2 16.3
Samsung SDS
Samsung Electro-
Mechanics
17.0
Samsung Electronics 25.2 5.1 84.8 68.5 16.3
Samsung Heavy
Industries
17.0
Samsung Securities 1.3 3.1 16.7 100.0
Samsung Card 1.9 3.0 1.3
Samsung Fire & Marine
Insurance
1.0
S-1 Corporation

Cheil Worldwide

Hotel Shilla

Samsung Display
Samsung Asset
Management
100.0
Samsung Electronics
Service
Miracom INC
Samsung Economic
Research Institute (SERI)
Harman International
Industries
Total 20.7 28.6 17.0 100.0 68.5 100.0 100.0 99.8 100.0 100.0 100.0 100.0 100.0
※ Percent of ownership as of June 30, 2022 based on common shares (Unit: %)
Investee Samsung Samsung Samsung Samsung Steel
Samsung Samsung Samsung Samsung Suwon
Electronics Card Corning Samsung Fire Claim Structure
Electronics Electronics Electronics Hedge Asset SEMES Samsung
Investor Logitech Customer Advanced Service Adjustment Technologies
Service Service CS Sales Management Football Club
Corporation Service Glass Service (STECO)
Samsung C&T
Corporation
Samsung Biologics

Samsung Life Insurance

Samsung SDI

Samsung SDS
Samsung Electro-
Mechanics
Samsung Electronic 100.0 99.3 100.0 91.5 70.0
Samsung Heavy
Industries
Samsung Securities

Samsung Card 100.0


Samsung Fire & Marine
100.0 100.0
Insurance
S-1 Corporation

Cheil Worldwide 100.0

Hotel Shilla

Samsung Display 50.0


Samsung Asset
100.0
Management
Samsung Electronics
100.0
Service
Miracom
Samsung Economic
Research Institute (SERI)
Harman International
Industries
Total 100.0 99.3 100.0 100.0 100.0 50.0 100.0 100.0 100.0 91.5 100.0 70.0
※ Percent of ownership as of June 30, 2022 based on common shares (Unit: %)
investee Samsung
S1CRM HDC Shilla Economic
Shilla Stay SD Flex SBTM SUMaterials S-Core STM Open Hands Cheil Fashion Miracom Research
Investor Corporation Duty Free Retail Institute
(SERI)
Samsung C&T
100.0 1.0
Corporation
Samsung Biologics

Samsung Life Insurance 14.8

Samsung SDI 50.0 100.0 29.6

Samsung SDS 81.8 100.0 83.6


Samsung Electro-
23.8
Mechanics
Samsung Electronics 29.8
Samsung Heavy
1.0
Industries
Samsung Securities

Samsung Card
Samsung Fire & Marine
Insurance
S-1 Corporation 100.0 0.6 0.6

Cheil Worldwide 5.2 5.4

Hotel Shilla 100.0 100.0 50.0

Samsung Display 50.0


Samsung Asset
Management
Samsung Electronics
Service
Miracom 0.5
Samsung Economic
Research Institute (SERI)
Harman International
Industries
Total 100.0 50.0 100.0 100.0 50.0 88.1 100.0 50.0 100.0 100.0 89.6 100.0
※ Percent of ownership as of June 30, 2022 based on common shares (Unit: %)
Samsung Fire
Samsung Life Samwoo Harman
Samsung & Marine Seoul Lake CVnet SHP
Investee Financial Architects & SECUI International Human TSS
Lions Financial Side Corporation Corporation
Service Engineers Korea
Service
Investor
Samsung C&T
100.0 100.0 8.7 40.1
Corporation
Samsung Biologics

Samsung Life Insurance 100.0

Samsung SDI

Samsung SDS 56.5 9.4


Samsung Electro-
Mechanics
Samsung Electronics
Samsung Heavy
Industries
Samsung Securities

Samsung Card
Samsung Fire & Marine
100.0
Insurance
S-1 Corporation 100.0

Cheil Worldwide 67.5

Hotel Shilla 100.0

Samsung Display
Samsung Asset
Management
Samsung Electronics
Service
Miracom
Samsung Economic
Research Institute (SERI)
Harman International
100.0
Industries
Total 67.5 100.0 100.0 100.0 100.0 65.2 49.5 100.0 100.0 100.0
Overseas
※ Percent of ownership as of June 30, 2021 based on common shares
Share
Investor Investee
Ratio(%)
Samwoo Architects & Engineers Co., Ltd. SAMOO HU Designer and Engineering Services Limited 100.0

Samwoo Architects & Engineers Co., Ltd. SAMOO DESIGNERS & ENGINEERS INDIAPRIVATE LIMITED 100.0

Samwoo Architects & Engineers Co., Ltd. SAMOO (KL) SDN. BHD. 100.0

Samsung C&T America Inc. Meadowland Distribution 100.0

Samsung C&T America Inc. Samsung Green repower, LLC 100.0

Samsung C&T America Inc. Samsung Solar Construction Inc. 100.0

Samsung C&T America Inc. QSSC, S.A. de C.V. 20.0

Samsung C&T America Inc. Samsung Solar Energy LLC 100.0

Samsung C&T America Inc. Equipment Trading Solutions Group, LLC 70.0

Samsung C&T America Inc. FLOWFY COMMERCE SERVICE LLC 100.0

Samsung Renewable Energy Inc. SP Armow Wind Ontario LP 50.0

Samsung Renewable Energy Inc. SRE GRW EPC GP Inc. 100.0

Samsung Renewable Energy Inc. SRE GRW EPC LP 100.0

Samsung Renewable Energy Inc. SRE SKW EPC GP Inc. 100.0

Samsung Renewable Energy Inc. SRE SKW EPC LP 100.0

Samsung Renewable Energy Inc. SRE WIND PA GP INC. 100.0

Samsung Renewable Energy Inc. SRE WIND PA LP 100.0

Samsung Renewable Energy Inc. SRE GRS Holdings GP Inc. 100.0

Samsung Renewable Energy Inc. SRE GRS Holdings LP 100.0

Samsung Renewable Energy Inc. SRE K2 EPC GP Inc. 100.0

Samsung Renewable Energy Inc. SRE K2 EPC LP 100.0

Samsung Renewable Energy Inc. SRE KS HOLDINGS GP INC. 100.0

Samsung Renewable Energy Inc. SRE KS HOLDINGS LP 100.0

Samsung Renewable Energy Inc. SP Belle River Wind LP 42.5

Samsung Renewable Energy Inc. SRE Armow EPC GP Inc. 100.0

Samsung Renewable Energy Inc. SRE Armow EPC LP 100.0

Samsung Renewable Energy Inc. North Kent Wind 1 LP 35.0

Samsung Renewable Energy Inc. SRE Wind GP Holding Inc. 100.0

Samsung Renewable Energy Inc. South Kent Wind LP Inc. 50.0

Samsung Renewable Energy Inc. Grand Renewable Wind LP Inc. 45.0

Samsung Renewable Energy Inc. SRE North Kent 2 LP Holdings LP 100.0

Samsung Renewable Energy Inc. SRE Solar Development GP Inc. 100.0

Samsung Renewable Energy Inc. SRE Solar Development LP 100.0

Samsung Renewable Energy Inc. SRE Windsor Holdings GP Inc. 100.0

Samsung Renewable Energy Inc. SRE Southgate Holdings GP Inc. 100.0

Samsung Renewable Energy Inc. SRE Solar Construction Management GP Inc. 100.0

Samsung Renewable Energy Inc. SRE Solar Construction Management LP 100.0

Samsung Renewable Energy Inc. SRE DEVELOPMENT GP INC. 100.0

Samsung Renewable Energy Inc. SRE BRW EPC GP INC. 100.0

Samsung Renewable Energy Inc. SRE BRW EPC LP 100.0

Samsung Renewable Energy Inc. SRE North Kent 1 GP Holdings Inc 100.0

Samsung Renewable Energy Inc. SRE North Kent 2 GP Holdings Inc 100.0

Samsung Renewable Energy Inc. SRE Belle River GP Holdings Inc 100.0

Samsung Renewable Energy Inc. SRE NK1 EPC GP Inc 100.0

Samsung Renewable Energy Inc. SRE NK1 EPC LP 100.0

Samsung Renewable Energy Inc. SRE Summerside Construction GP Inc. 100.0

Samsung Renewable Energy Inc. SRE Summerside Construction LP 100.0

Samsung Green repower, LLC Monument Power, LLC 100.0


Share
Investor Investee
Ratio(%)
SP Armow Wind Ontario GP Inc SP Armow Wind Ontario LP 0.0

Samsung C&T Oil & Gas Parallel Corp. PLL Holdings LLC 83.6

Samsung C&T Oil & Gas Parallel Corp. PLL E&P LLC 90.0

SRE GRW EPC GP Inc. SRE GRW EPC LP 0.0

SRE SKW EPC GP Inc. SRE SKW EPC LP 0.0

PLL Holdings LLC Parallel Petroleum LLC 61.0

SRE WIND PA GP INC. SRE WIND PA LP 0.0

SRE GRS Holdings GP Inc. Grand Renewable Solar GP Inc. 50.0

SRE GRS Holdings GP Inc. SRE GRS Holdings LP 0.0

SRE K2 EPC GP Inc. SRE K2 EPC LP 0.0

SRE KS HOLDINGS GP INC. KINGSTON SOLAR GP INC. 50.0

SRE KS HOLDINGS GP INC. SRE KS HOLDINGS LP 0.0

SP Belle River Wind GP Inc SP Belle River Wind LP 0.0

SRE Armow EPC GP Inc. SRE Armow EPC LP 0.0

SRE Wind GP Holding Inc. SP Armow Wind Ontario GP Inc 50.0

SRE Wind GP Holding Inc. South Kent Wind GP Inc. 50.0

SRE Wind GP Holding Inc. Grand Renewable Wind GP Inc. 50.0

South Kent Wind GP Inc. South Kent Wind LP Inc. 0.0

Grand Renewable Wind GP Inc. Grand Renewable Wind LP Inc. 0.0

North Kent Wind 1 GP Inc North Kent Wind 1 LP 0.0

SRE Solar Development GP Inc. SRE Solar Development LP 0.0

SRE Solar Construction Management GP Inc. SRE Solar Construction Management LP 0.0

SRE BRW EPC GP INC. SRE BRW EPC LP 0.0

SRE North Kent 1 GP Holdings Inc North Kent Wind 1 GP Inc 50.0

SRE North Kent 2 GP Holdings Inc SRE North Kent 2 LP Holdings LP 0.0

SRE Belle River GP Holdings Inc SP Belle River Wind GP Inc 50.0

SRE NK1 EPC GP Inc SRE NK1 EPC LP 0.0

SRE Summerside Construction GP Inc. SRE Summerside Construction LP 0.0

Samsung Solar Energy LLC Samsung Solar Energy 1 LLC 100.0

Samsung Solar Energy LLC Samsung Solar Energy 2 LLC 100.0

Samsung Solar Energy LLC Samsung Solar Energy 3, LLC 100.0

Samsung Solar Energy 1 LLC CS SOLAR LLC 50.0

Samsung Solar Energy 3, LLC SST SOLAR, LLC 50.0

Samsung C&T Deutschland GmbH SungEel Recycling Park Thuringen GmbH 100.0

Samsung C&T Deutschland GmbH POSS-SLPC, S.R.O 20.0

Samsung C&T Deutschland GmbH Solluce Romania 1 B.V. 20.0

Samsung C&T Deutschland GmbH S.C. Otelinox S.A 99.7

Samsung C&T Malaysia SDN. BHD WARIS GIGIH ENGINEERING AND TECHNOLOGY SDN. BHD. 70.0

Samsung C&T Singapore Pte., Ltd. Samsung Chemtech Vina LLC 48.3

Samsung C&T Singapore Pte., Ltd. Samsung C&T Thailand Co., Ltd 0.2

Samsung C&T Singapore Pte., Ltd. PT. INSAM BATUBARA ENERGY 65.2

Samsung C&T Singapore Pte., Ltd. Malaysia Samsung Steel Center Sdn.Bhd 30.0

Samsung C&T Singapore Pte., Ltd. S&G Biofuel PTE.LTD 12.6

S&G Biofuel PTE.LTD PT. Gandaerah Hendana 95.0

S&G Biofuel PTE.LTD PT. Inecda 95.0


VISTA CONTRACTING AND DEVELOPMENT BANGLADESH
Vista Contracting and Investment Global Pte. Ltd. 100.0
LTD.
CHEIL HOLDING INC. SAMSUNG CONST. CO PHILS. 75.0

Samsung C&T Hongkong Ltd. Samsung C&T Thailand Co., Ltd 6.8

Samsung C&T Hongkong Ltd. SAMSUNG TRADING (SHANGHAI) CO., LTD 100.0

Samsung C&T Hongkong Ltd. Samsung Precision Stainless Steel(pinghu) Co.,Ltd. 45.0
Share
Investor Investee
Ratio(%)
Samsung Electronics Co., Ltd. Samsung Japan Corporation 100.0

Samsung Electronics Co., Ltd. Samsung R&D Institute Japan Co. Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics America, Inc. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Canada, Inc. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Mexico S.A. De C.V. 63.6

Samsung Electronics Co., Ltd. Samsung Electronics Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics (UK) Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Holding GmbH 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Iberia, S.A. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics France S.A.S 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Hungarian Private Co. Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Italia S.P.A. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Europe Logistics B.V. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Benelux B.V. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Overseas B.V. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Polska, SP.Zo.o 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Portuguesa, Unipessoal, Lda. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Nordic Aktiebolag 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Austria GmbH 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Slovakia s.r.o 55.7

Samsung Electronics Co., Ltd. Samsung Electronics Europe Holding Cooperatief U.A. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Display (M) Sdn. Bhd. 75.0

Samsung Electronics Co., Ltd. Samsung Electronics (M) Sdn. Bhd. 100.0

Samsung Electronics Co., Ltd. Samsung Vina Electronics Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Asia Pte. Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung India Electronics Private Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung R&D Institute India-Bangalore Private Limited 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Australia Pty. Ltd. 100.0

Samsung Electronics Co., Ltd. PT Samsung Electronics Indonesia 100.0

Samsung Electronics Co., Ltd. Thai Samsung Electronics Co., Ltd. 91.8

Samsung Electronics Co., Ltd. Samsung Malaysia Electronics (SME) Sdn. Bhd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Hong Kong Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Suzhou Samsung Electronics Co., Ltd. 69.1

Samsung Electronics Co., Ltd. Samsung (CHINA) Investment Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Suzhou Semiconductor Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Tianjin Samsung Electronics Co., Ltd. 48.2

Samsung Electronics Co., Ltd. Samsung Electronics Taiwan Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Tianjin Samsung Telecom Technology Co., Ltd. 90.0

Samsung Electronics Co., Ltd. Shanghai Samsung Semiconductor Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Suzhou Computer Co., Ltd. 73.7

Samsung Electronics Co., Ltd. Shenzhen Samsung Electronics Telecommunication Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Semiconductor (China) R&D Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung (China) Semiconductor Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung SemiConductor Xian Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Gulf Electronics Co., Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Egypt S.A.E 0.1

Samsung Electronics Co., Ltd. Samsung Electronics South Africa(Pty) Ltd. 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Latinoamerica(Zona Libre), S. A. 100.0

Samsung Electronics Co., Ltd. Samsung Eletronica da Amazonia Ltda. 87.0

Samsung Electronics Co., Ltd. Samsung Electronics Argentina S.A. 98.0


Share
Investor Investee
Ratio(%)
Samsung Electronics Co., Ltd. Samsung Electronics Chile Limitada 4.1

Samsung Electronics Co., Ltd. Samsung Electronics Rus Company LLC 100.0

Samsung Electronics Co., Ltd. Samsung Electronics Rus Kaluga LLC 100.0

Samsung Electronics Co., Ltd. Tianjin Samsung LED Co., Ltd. 100.0

Samsung Biologics Co., Ltd. Samsung Biologics America, Inc. 100.0

Samsung Bioepis Co., Ltd. Samsung Bioepis United States Inc. 100.0

Samsung Bioepis Co., Ltd. SAMSUNG BIOEPIS UK LIMITED 100.0

Samsung Bioepis Co., Ltd. Samsung Bioepis NL B.V. 100.0

Samsung Bioepis Co., Ltd. Samsung Bioepis CH GmbH 100.0

Samsung Bioepis Co., Ltd. Samsung Bioepis PL Sp z o.o. 100.0

Samsung Bioepis Co., Ltd. SAMSUNG BIOEPIS AU PTY LTD 100.0

Samsung Bioepis Co., Ltd. SAMSUNG BIOEPIS NZ LIMITED 100.0

Samsung Bioepis Co., Ltd. SAMSUNG BIOEPIS TW Limited 100.0

Samsung Bioepis Co., Ltd. Samsung Bioepis HK Limited 100.0

Samsung Bioepis Co., Ltd. SAMSUNG BIOEPIS IL LTD 100.0

Samsung Bioepis Co., Ltd. SAMSUNG BIOEPIS BR PHARMACEUTICAL LTDA 100.0

Samsung Display Co., Ltd. Intellectual Keystone Technology LLC 41.9

Samsung Display Co., Ltd. Samsung Display Slovakia, s.r.o. 100.0

Samsung Display Co., Ltd. Samsung Display Vietnam Co., Ltd. 100.0

Samsung Display Co., Ltd. Samsung Display Noida Private Limited 100.0

Samsung Display Co., Ltd. Samsung Display Dongguan Co., Ltd. 100.0

Samsung Display Co., Ltd. Samsung Display Tianjin Co., Ltd. 95.0

Samsung Display Co., Ltd. Novaled GmbH 9.9

SEMES Co., Ltd. SEMES America, Inc. 100.0

SEMES Co., Ltd. SEMES (XIAN) Co., Ltd. 100.0

Samsung Electronics America, Inc. NeuroLogica Corp. 100.0

Samsung Electronics America, Inc. Dacor Holdings, Inc. 100.0

Samsung Electronics America, Inc. Samsung HVAC America, LLC 100.0

Samsung Electronics America, Inc. SmartThings, Inc. 100.0

Samsung Electronics America, Inc. Samsung Oak Holdings, Inc. 100.0

Samsung Electronics America, Inc. Joyent, Inc. 100.0

Samsung Electronics America, Inc. TeleWorld Solutions, Inc. 100.0

Samsung Electronics America, Inc. Samsung Semiconductor, Inc. 100.0

Samsung Electronics America, Inc. Samsung Research America, Inc 100.0

Samsung Electronics America, Inc. Samsung Electronics Home Appliances America, LLC 100.0

Samsung Electronics America, Inc. Samsung International, Inc. 100.0

Samsung Electronics America, Inc. Harman International Industries, Inc. 100.0

Dacor Holdings, Inc. Dacor, Inc. 100.0

Dacor, Inc. Dacor Canada Co. 100.0

Samsung Semiconductor, Inc. Samsung Austin Semiconductor LLC. 100.0

Samsung Electronics Canada, Inc. AdGear Technologies Inc. 100.0

Samsung Research America, Inc SAMSUNG NEXT LLC 100.0

SAMSUNG NEXT LLC SAMSUNG NEXT FUND LLC 100.0

Samsung International, Inc. Samsung Mexicana S.A. de C.V 100.0

Samsung Electronics Mexico S.A. De C.V. Samsung Electronics Digital Appliance Mexico, SA de CV 100.0

Harman International Industries, Inc. Harman International Japan Co., Ltd. 100.0

Harman International Industries, Inc. Harman International Industries Canada Ltd. 100.0

Harman International Industries, Inc. Harman Becker Automotive Systems, Inc. 100.0

Harman International Industries, Inc. Harman Professional, Inc. 100.0

Harman International Industries, Inc. Harman Connected Services, Inc. 100.0


Share
Investor Investee
Ratio(%)
Harman International Industries, Inc. Harman Financial Group LLC 100.0

Harman International Industries, Inc. Harman Belgium SA 100.0

Harman International Industries, Inc. Harman France SNC 100.0

Harman International Industries, Inc. Red Bend Software SAS 100.0

Harman International Industries, Inc. Harman Inc. & Co. KG 66.0

Harman International Industries, Inc. Harman KG Holding, LLC 100.0

Harman International Industries, Inc. Harman Becker Automotive Systems Italy S.R.L. 100.0

Harman International Industries, Inc. Harman Finance International, SCA 100.0

Harman International Industries, Inc. Harman Finance International GP S.a.r.l 100.0

Harman International Industries, Inc. Harman Industries Holdings Mauritius Ltd. 100.0

Harman International Industries, Inc. Harman International Mexico, S. de R.L. de C.V. 99.9

Harman Becker Automotive Systems, Inc. Harman International Estonia OU 100.0

Harman Professional, Inc. AMX UK Limited 100.0

Harman Professional, Inc. Harman Singapore Pte. Ltd. 100.0

Harman Professional, Inc. Harman da Amazonia Industria Eletronica e Participacoes Ltda. 0.0

Harman Professional, Inc. Harman do Brasil Industria Eletronica e Participacoes Ltda. 0.0

Harman Connected Services, Inc. Harman Connected Services Engineering Corp. 100.0

Harman Connected Services, Inc. Harman Connected Services AB. 100.0

Harman Connected Services, Inc. Harman Connected Services UK Ltd. 100.0

Harman Connected Services, Inc. Harman Connected Services Corp. India Pvt. Ltd. 1.6

Harman Connected Services, Inc. Global Symphony Technology Group Private Ltd. 100.0

Harman Financial Group LLC Harman International (India) Private Limited 0.0

Harman Financial Group LLC Harman International Mexico, S. de R.L. de C.V. 0.1

Harman Financial Group LLC Harman de Mexico, S. de R.L. de C.V. 0.0

Samsung Electronics (UK) Ltd. Samsung Semiconductor Europe Limited 100.0

Samsung Electronics Holding GmbH Samsung Semiconductor Europe GmbH 100.0

Samsung Electronics Holding GmbH Samsung Electronics GmbH 100.0

Samsung Electronics Hungarian Private Co. Ltd. Samsung Electronics Czech and Slovak s.r.o. 31.4

Samsung Electronics Hungarian Private Co. Ltd. Samsung Electronics Slovakia s.r.o 44.3

Samsung Electronics Benelux B.V. Samsung Electronics Mexico S.A. De C.V. 36.4

Samsung Electronics Benelux B.V. SAMSUNG ELECTRONICS BALTICS SIA 100.0

Samsung Electronics Benelux B.V. Samsung Electronics West Africa Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics East Africa Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Saudi Arabia Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Egypt S.A.E 99.9

Samsung Electronics Benelux B.V. Samsung Electronics Israel Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Tunisia S.A.R.L 99.0

Samsung Electronics Benelux B.V. Samsung Electronics Pakistan(Private) Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics South Africa Production (pty) Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Turkey 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Industry and Commerce Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Semiconductor Israel R&D Center, Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Levant Co.,Ltd. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Maghreb Arab 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Venezuela, C.A. 100.0

Samsung Electronics Benelux B.V. Samsung Eletronica da Amazonia Ltda. 13.0

Samsung Electronics Benelux B.V. Samsung Electronics Chile Limitada 95.9

Samsung Electronics Benelux B.V. Samsung Electronics Peru S.A.C. 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Ukraine Company LLC 100.0

Samsung Electronics Benelux B.V. Samsung R&D Institute Ukraine 100.0


Share
Investor Investee
Ratio(%)
Samsung Electronics Benelux B.V. Samsung R&D Institute Rus LLC 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Central Eurasia LLP 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Caucasus Co. Ltd 100.0

Samsung Electronics Benelux B.V. Samsung Electronics Uzbekistan Ltd. 100.0

Samsung Electronics Benelux B.V. Corephotonics Ltd. 100.0

Zhilabs, S.L. Zhilabs Inc. 100.0

Samsung Electronics Nordic Aktiebolag Samsung Nanoradio Design Center 100.0

AKG Acoustics Gmbh Harman Professional Denmark ApS 100.0

AKG Acoustics Gmbh Studer Professional Audio GmbH 100.0

Harman Professional Denmark ApS Martin Professional Japan Ltd. 40.0

Harman Professional Denmark ApS Harman International s.r.o 100.0

Harman Becker Automotive Systems GmbH Harman International Romania SRL 0.0

Harman Holding Gmbh & Co. KG Harman Becker Automotive Systems GmbH 100.0

Harman Holding Gmbh & Co. KG Harman Deutschland GmbH 100.0

Harman Holding Gmbh & Co. KG Harman Becker Automotive Systems Manufacturing Kft 100.0

Harman Holding Gmbh & Co. KG Apostera GmbH 100.0

Harman Holding Gmbh & Co. KG Harman RUS CIS LLC 100.0

Harman Inc. & Co. KG Harman Holding Gmbh & Co. KG 100.0

Harman Inc. & Co. KG Harman Management Gmbh 100.0

Harman Inc. & Co. KG Harman Hungary Financing Ltd. 100.0

Harman Connected Services GmbH Harman Connected Services OOO 100.0

Harman KG Holding, LLC Harman Inc. & Co. KG 34.0

Harman Becker Automotive Systems Manufacturing Kft Harman Professional Kft 100.0

Harman Becker Automotive Systems Manufacturing Kft Harman Consumer Nederland B.V. 100.0

Harman Becker Automotive Systems Manufacturing Kft Harman International Romania SRL 100.0

Harman Becker Automotive Systems Manufacturing Kft Red Bend Ltd. 100.0

Harman Becker Automotive Systems Manufacturing Kft Harman do Brasil Industria Eletronica e Participacoes Ltda. 100.0

Harman Hungary Financing Ltd. Harman International Industries Limited 100.0

Harman Finance International GP S.a.r.l Harman Finance International, SCA 0.0

Harman Consumer Nederland B.V. AKG Acoustics Gmbh 100.0

Harman Consumer Nederland B.V. Harman Audio Iberia Espana Sociedad Limitada 100.0

Harman Consumer Nederland B.V. Harman Holding Limited 100.0

Harman Audio Iberia Espana Sociedad Limitada Harman France SNC 0.0

Harman Connected Services AB. Harman Finland Oy 100.0

Harman Connected Services AB. Harman Connected Services GmbH 100.0

Harman Connected Services AB. Harman Connected Services Poland Sp.zoo 100.0

Harman Connected Services AB. Harman Connected Services Solutions (Chengdu) Co., Ltd. 100.0

Harman International Industries Limited Harman Automotive UK Limited 100.0

Harman International Industries Limited Harman International Industries PTY Ltd. 100.0

Harman International Industries Limited Harman de Mexico, S. de R.L. de C.V. 100.0

Harman Connected Services UK Ltd. Harman Connected Services Morocco 100.0

Apostera GmbH Apostera UA, LLC 100.0

Samsung Electronics Austria GmbH Samsung Electronics Switzerland GmbH 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Samsung Electronics Czech and Slovak s.r.o. 68.6

Samsung Electronics Europe Holding Cooperatief U.A. Samsung Electronics Romania LLC 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Zhilabs, S.L. 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Porta Nuova Varesine Building 2 S.r.l. 49.0

Samsung Electronics Europe Holding Cooperatief U.A. Samsung Electronics Poland Manufacturing SP.Zo.o 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Samsung Electronics Greece S.M.S.A 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Samsung Electronics Air Conditioner Europe B.V. 100.0
Share
Investor Investee
Ratio(%)
Samsung Electronics Europe Holding Cooperatief U.A. FOODIENT LTD. 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Samsung Denmark Research Center ApS 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Samsung Cambridge Solution Centre Limited 100.0

Samsung Electronics Europe Holding Cooperatief U.A. Novaled GmbH 40.0

Samsung Electronics Singapore Pte. Ltd. Samsung Electronics Display (M) Sdn. Bhd. 25.0

Samsung Electronics Singapore Pte. Ltd. iMarket Asia Co., Ltd. 11.4

Samsung Asia Private Ltd. Samsung Electronics Japan Co., Ltd. 100.0

Samsung Asia Private Ltd. Samsung Electronics Singapore Pte. Ltd. 100.0

Samsung Asia Private Ltd. Samsung Electronics New Zealand Limited 100.0

Samsung Asia Private Ltd. Samsung Electronics Philippines Corporation 100.0

Samsung Asia Private Ltd. Samsung R&D Institute BanglaDesh Limited 100.0

Samsung Asia Private Ltd. Samsung Electronics Vietnam Co., Ltd. 100.0

Samsung Asia Private Ltd. Samsung Electronics Vietnam THAINGUYEN Co., Ltd. 100.0

Samsung Asia Private Ltd. Samsung Electronics HCMC CE Complex Co., Ltd. 100.0

Samsung India Electronics Private Ltd. Samsung Nepal Services Pvt, Ltd 100.0

Samsung India Electronics Private Ltd. Red Brick Lane Marketing Solutions Pvt. Ltd. 100.0

PT Samsung Electronics Indonesia PT Samsung Telecommunications Indonesia 100.0

Thai Samsung Electronics Co., Ltd. Laos Samsung Electronics Sole Co., Ltd 100.0

Samsung Electronics Hong Kong Co., Ltd. iMarket Asia Co., Ltd. 11.3

Suzhou Samsung Electronics Co., Ltd. Samsung Suzhou Electronics Export Co., Ltd. 100.0

Samsung (CHINA) Investment Co., Ltd. Suzhou Samsung Electronics Co., Ltd. 19.2

Samsung (CHINA) Investment Co., Ltd. Samsung Mobile R&D Center China-Guangzhou 100.0

Samsung (CHINA) Investment Co., Ltd. Samsung R&D Institute China-Shenzhen 100.0

Samsung (CHINA) Investment Co., Ltd. Tianjin Samsung Electronics Co., Ltd. 43.1

Samsung (CHINA) Investment Co., Ltd. Beijing Samsung Telecom R&D Center 100.0

Samsung (CHINA) Investment Co., Ltd. Samsung Electronics Suzhou Computer Co., Ltd. 26.3

Samsung (CHINA) Investment Co., Ltd. Samsung Electronics China R&D Center 100.0

Harman International (China) Holdings Co., Ltd. Harman (Suzhou) Audio and Infotainment Systems Co., Ltd. 100.0

Harman International (China) Holdings Co., Ltd. Harman Technology (Shenzhen) Co., Ltd. 100.0

Harman International (China) Holdings Co., Ltd. Harman (China) Technologies Co., Ltd. 100.0

Harman Holding Limited Harman Commercial (Shanghai) Co., Ltd. 100.0

Harman Holding Limited Harman International (China) Holdings Co., Ltd. 100.0

Harman Holding Limited Harman Automotive Electronic Systems (Suzhou) Co., Ltd. 100.0

Samsung Gulf Electronics Co., Ltd. Samsung Electronics Egypt S.A.E 0.1

Samsung Electronics Maghreb Arab Samsung Electronics Tunisia S.A.R.L 1.0

Harman Industries Holdings Mauritius Ltd. Harman International (India) Private Limited 100.0

Global Symphony Technology Group Private Ltd. Harman Connected Services Corp. India Pvt. Ltd. 98.4

Red Bend Ltd. Red Bend Software Ltd. 100.0

Samsung Electronics Latinoamerica(Zona Libre), S. A. Samsung Electronics Latinoamerica Miami, Inc. 100.0

Samsung Electronics Latinoamerica(Zona Libre), S. A. Samsung Electronica Colombia S.A. 100.0

Samsung Electronics Latinoamerica(Zona Libre), S. A. Samsung Electronics Panama. S.A. 100.0

Samsung Eletronica da Amazonia Ltda. Samsung Electronics Argentina S.A. 2.0


Harman do Brasil Industria Eletronica e Participacoes Ltda.
Harman da Amazonia Industria Eletronica e Participacoes Ltda. 100.0

Samsung Electronics Central Eurasia LLP Samsung Electronics Caucasus Co. Ltd 0.0

Samsung SDI Co., Ltd. Intellectual Keystone Technology LLC 41.0

Samsung SDI Co., Ltd. Samsung SDI Japan Co., Ltd. 89.2

Samsung SDI Co., Ltd. Samsung SDI America, Inc. 91.7

Samsung SDI Co., Ltd. Samsung SDI Hungary., Zrt. 100.0

Samsung SDI Co., Ltd. Samsung SDI Europe GmbH 100.0

Samsung SDI Co., Ltd. Samsung SDI Battery Systems GmbH 100.0
Share
Investor Investee
Ratio(%)
Samsung SDI Co., Ltd. Samsung SDI Vietnam Co., Ltd. 100.0

Samsung SDI Co., Ltd. Samsung SDI Energy Malaysia Sdn, Bhd. 100.0

Samsung SDI Co., Ltd. Samsung SDI India Private Limited 100.0

Samsung SDI Co., Ltd. Samsung SDI(Hong Kong) Ltd. 97.6

Samsung SDI Co., Ltd. Samsung SDI China Co., Ltd. 100.0

Samsung SDI Co., Ltd. Samsung SDI-ARN (Xi'An) Power Battery Co., Ltd. 65.0

Samsung SDI Co., Ltd. Samsung SDI(Tianjin)Battery Co.,Ltd. 80.0

Samsung SDI Co., Ltd. Novaled GmbH 50.1

Samsung SDI Co., Ltd. SAMSUNG SDI WUXI CO.,LTD. 100.0

Samsung SDI Co., Ltd. iMarket Asia Co., Ltd. 8.7

Samsung SDI(Hong Kong) Ltd. Samsung SDI India Private Limited 0.0

Samsung SDI(Hong Kong) Ltd. Tianjin Samsung SDI Co., Ltd. 80.0

Samsung Electro-Mechanics Co., Ltd. Samsung Electro-Machanics Japan Co., Ltd. 100.0

Samsung Electro-Mechanics Co., Ltd. Samsung Electro-Mechanics America, Inc. 100.0

Samsung Electro-Mechanics Co., Ltd. Samsung Electro-Mechanics GmbH 100.0

Samsung Electro-Mechanics Co., Ltd. Samsung Electro-Mechanics Philippines, Corp. 100.0

Samsung Electro-Mechanics Co., Ltd. Calamba Premier Realty Corporation 39.8

Samsung Electro-Mechanics Co., Ltd. Samsung Electro-Mechanics Pte Ltd. 100.0

Samsung Electro-Mechanics Co., Ltd. Samsung Electro-Mechanics Vietnam Co., Ltd. 100.0
Samsung Electro-Mechanics Software India Bangalore Private
Samsung Electro-Mechanics Co., Ltd. 99.9
Limited
Samsung Electro-Mechanics Co., Ltd. Dongguan Samsung Electro-Mechanics Co., Ltd. 100.0

Samsung Electro-Mechanics Co., Ltd. Tianjin Samsung Electro-Mechanics Co., Ltd. 81.8

Samsung Electro-Mechanics Co., Ltd. Samsung High-Tech Electro-Mechanics(Tianjin) Co., Ltd. 95.0

Samsung Electro-Mechanics Co., Ltd. Samsung Electro-Mechanics (Shenzhen) Co., Ltd. 100.0

Samsung Electro-Mechanics Co., Ltd. Kunshan Samsung Electro-Mechanics Co., Ltd. 100.0

Samsung Electro-Mechanics Co., Ltd. iMarket Asia Co., Ltd. 8.7

Calamba Premier Realty Corporation Batino Realty Corporation 100.0


Samsung Electro-Mechanics Software India Bangalore Private
Samsung Electro-Mechanics Pte Ltd. 0.1
Limited
Samsung Fire & Marine Insurance Co., Ltd. Samsung Fire & Marine Management Corporation 100.0
SAMSUNG FIRE & MARINE INSURANCE COMPANY OF
Samsung Fire & Marine Insurance Co., Ltd. 100.0
EUROPE LTD.
Samsung Fire & Marine Insurance Co., Ltd. PT. Asuransi Samsung Tugu 70.0

Samsung Fire & Marine Insurance Co., Ltd. SAMSUNG VINA INSURANCE COMPANY LIMITED 75.0

Samsung Fire & Marine Insurance Co., Ltd. Samsung Reinsurance Pte. Ltd. 100.0

Samsung Fire & Marine Insurance Co., Ltd. Samsung Property & Casualty Insurance Company(China), Ltd 100.0
Samsung Fire & Marine Insurance Management Middle East
Samsung Fire & Marine Insurance Co., Ltd. 100.0
Limited
Samsung Heavy Industries Co., Ltd Camellia Consulting Corporation 100.0

Samsung Heavy Industries Co., Ltd Samsung Heavy Industries India Pvt.Ltd. 100.0

Samsung Heavy Industries Co., Ltd SAMSUNG HEAVY INDUSTRIES (M) SDN.BHD 100.0

Samsung Heavy Industries Co., Ltd Samsung Heavy Industries(Ningbo) Co., Ltd 100.0

Samsung Heavy Industries Co., Ltd Samsung Heavy Industries(Rongcheng) Co., Ltd 100.0

Samsung Heavy Industries Co., Ltd SAMSUNG HEAVY INDUSTRIES NIGERIA LIMITED 100.0

Samsung Heavy Industries Co., Ltd Samsung Heavy Industries Mozambique LDA 100.0

Samsung Heavy Industries Co., Ltd Samsung Heavy Industries Rus LLC 100.0

SAMSUNG HEAVY INDUSTRIES NIGERIA LIMITED SHI - MCI FZE 70.0

Samsung Life Insurance Co., Ltd. Porta Nuova Varesine Building 2 S.r.l. 51.0

Samsung Life Insurance Co., Ltd. THAI SAMSUNG LIFE INSURANCE CO., LTD. 48.9

Samsung Life Insurance Co., Ltd. Beijing Samsung Real Estate Co., Ltd 90.0

Samsung Asset Management Co., Ltd. Samsung Asset Management (New York), Inc. 100.0

Samsung Asset Management Co., Ltd. Samsung Global SME Private Equity Manager Fund Co., Ltd. 100.0
Share
Investor Investee
Ratio(%)
Samsung Asset Management Co., Ltd. Samsung Asset Management U.S. Holdings, Inc 100.0

Samsung Asset Management Co., Ltd. Samsung Private Equity Fund 2022 GP, Ltd. 100.0

Samsung Asset Management Co., Ltd. Samsung Co-investment 2021 GP, Ltd 100.0

Samsung Asset Management Co., Ltd. Samsung Asset Management(London) Ltd. 100.0

Samsung Asset Management Co., Ltd. Samsung Private Equity Manager I Co., Ltd. 100.0

Samsung Asset Management Co., Ltd. Samsung Asset Management (Hong Kong) Ltd. 100.0

Samsung Asset Management (Hong Kong) Ltd. Samsung Asset Management (Beijing) Ltd. 100.0

Samsung C&T Corporation Samsung C&T Japan Corporation 100.0

Samsung C&T Corporation Samsung C&T America Inc. 100.0

Samsung C&T Corporation Samsung E&C America, INC. 100.0

Samsung C&T Corporation Samsung Renewable Energy Inc. 100.0

Samsung C&T Corporation QSSC, S.A. de C.V. 60.0

Samsung C&T Corporation Samsung C&T Oil & Gas Parallel Corp. 100.0

Samsung C&T Corporation Samsung C&T Lima S.A.C. 100.0

Samsung C&T Corporation Samsung C&T Deutschland GmbH 100.0

Samsung C&T Corporation Samsung C&T U.K. Ltd. 100.0

Samsung C&T Corporation Samsung C&T ECUK Limited 100.0

Samsung C&T Corporation Whessoe engineering Limited 100.0

Samsung C&T Corporation POSS-SLPC, S.R.O 50.0

Samsung C&T Corporation Solluce Romania 1 B.V. 80.0

Samsung C&T Corporation SAM investment Manzanilo.B.V 53.3

Samsung C&T Corporation Samsung C&T (KL) Sdn.,Bhd. 100.0

Samsung C&T Corporation Samsung C&T Malaysia SDN. BHD 100.0

Samsung C&T Corporation Erdsam Co., Ltd. 100.0


Samsung C&T Corporation Samsung Chemtech Vina LLC 51.7
Samsung C&T Corporation Samsung C&T Thailand Co., Ltd 93.0

Samsung C&T Corporation PT. INSAM BATUBARA ENERGY 90.0

Samsung C&T Corporation Samsung C&T India Private Limited 100.0

Samsung C&T Corporation Samsung C&T Corporation India Private Limited 100.0

Samsung C&T Corporation Malaysia Samsung Steel Center Sdn.Bhd 70.0

Samsung C&T Corporation Samsung C&T Singapore Pte., Ltd. 100.0

Samsung C&T Corporation S&G Biofuel PTE.LTD 50.5

Samsung C&T Corporation SAMSUNG C&T Mongolia LLC. 70.0

Samsung C&T Corporation Samsung C&T Eng.&Const. Mongolia LLC. 100.0

Samsung C&T Corporation S&WOO CONSTRUCTION PHILIPPINES,INC. 100.0

Samsung C&T Corporation VSSC STEEL CENTER LIMITED LIABILITY COMPANY 85.0

Samsung C&T Corporation Vista Contracting and Investment Global Pte. Ltd. 100.0

Samsung C&T Corporation SAMSUNG CONST. CO. PHILS. 100.0

Samsung C&T Corporation CHEIL HOLDING INC. 100.0

Samsung C&T Corporation Samsung C&T Hongkong Ltd. 100.0

Samsung C&T Corporation Samsung C&T Taiwan Co., Ltd. 100.0

Samsung C&T Corporation Samsung Precision Stainless Steel(pinghu) Co.,Ltd. 55.0

Samsung C&T Corporation SAMSUNG C&T (SHANGHAI) CO., LTD. 100.0

Samsung C&T Corporation Samsung C&T (Xi'an) Co., Ltd. 100.0

Samsung C&T Corporation WARIS GIGIH ENGINEERING AND TECHNOLOGY SDN. BHD. 30.0

Samsung C&T Corporation SAMSUNG C&T CORPORATION SAUDI ARABIA 100.0

Samsung C&T Corporation SAM Gulf Investment Limited 100.0

Samsung C&T Corporation Samsung C&T Chile Copper SpA 100.0

Samsung C&T Corporation SCNT Power Kelar Inversiones Limitada 100.0

Samsung C&T Corporation Samsung C&T Corporation Rus LLC 100.0


Share
Investor Investee
Ratio(%)
Samsung C&T Corporation Samsung SDI America, Inc. 8.3

Samsung C&T Corporation Samsung SDI(Hong Kong) Ltd. 2.4

Samsung C&T Corporation Beijing Samsung Real Estate Co.. Ltd 10.0

Samsung C&T Corporation Cheil Industries Corp., USA 100.0

Samsung C&T Corporation CHEIL INDUSTRIES ITALY SRL 100.0

Samsung C&T Corporation Samsung Fashion Trading Co. ,Ltd 100.0

Samsung C&T Corporation SAMSUNG C&T CORPORATION VIETNAM CO., LTD 100.0

Samsung C&T Corporation Samsung C&T Corporation UEM Construction JV Sdn Bhd 60.0

Samsung C&T Corporation iMarket Asia Co., Ltd. 19.3

Samsung Welstory Co., Ltd. WELSTORY VIETNAM COMPANY LIMITED 100.0

Samsung Welstory Co., Ltd. Shanghai Ever-Hongjun Business Mgt Service Co.,LTD 85.0

Samsung Welstory Co., Ltd. Shanghai Welstory Food Company Limited 81.6

Multicampus Corporation LANGUAGE TESTING INTERNATIONAL, INC. 82.4

Pengtai Greater China Company Limited PENGTAI CHINA CO.,LTD. 100.0

Pengtai Greater China Company Limited PengTai Taiwan Co., Ltd. 100.0

PENGTAI CHINA CO.,LTD. PENGTAI E-COMMERCE CO.,LTD 100.0

PENGTAI CHINA CO.,LTD. PENGTAI MARKETING SERVICE CO.,LTD. 100.0

PENGTAI INTERACTIVE ADVERTISING CO.,LTD Medialytics Inc. 100.0

PENGTAI INTERACTIVE ADVERTISING CO.,LTD Beijing Pengtai Baozun E-commerce Co., Ltd. 51.0

iMarket Asia Co., Ltd. iMarket China Co., Ltd. 80.0

Samsung Securities Co., Ltd. Samsung Securities (America), Inc. 100.0

Samsung Securities Co., Ltd. Samsung Securities (Europe) Limited. 100.0

Samsung Securities Co., Ltd. Samsung Securities (Asia) Limited. 100.0

Samsung SDS Co., Ltd. iMarket Asia Co., Ltd. 40.6

Samsung SDS Co., Ltd. SAMSUNG SDS America, Inc. 100.0

Samsung SDS Co., Ltd. SAMSUNG SDS GSCL Canada., Ltd. 100.0

Samsung SDS Co., Ltd. Neo EXpress Transportation (NEXT), Inc. 51.0

Samsung SDS Co., Ltd. Samsung SDS Europe, Ltd. 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Hungary, Kft. 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Slovakia, S.R.O. 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Poland Sp. Z.o.o. 100.0

Samsung SDS Co., Ltd. Samsung GSCL Sweden AB 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL France SAS 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Greece Societe Anonyme 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Italy S.R.L. A Socio Unico 100.0

Samsung SDS Co., Ltd. Samsung SDS Global Supply Chain Logistics Spain S.L.U 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Netherlands Cooperatief U.A. 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Germany GmbH 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Romania S.R.L 100.0

Samsung SDS Co., Ltd. Samsung SDS Asia Pacific Pte, Ltd. 100.0

Samsung SDS Co., Ltd. Samsung Data Systems India Private Limited 100.0

Samsung SDS Co., Ltd. Samsung SDS Vietnam Co., Ltd. 100.0

Samsung SDS Co., Ltd. PT. Samsung SDS Global SCL Indonesia 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Philippines Co., Ltd.Inc. 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Thailand Co.,Ltd 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Malaysia SDN.BHD. 100.0

Samsung SDS Co., Ltd. SAMSUNG SDS Global SCL Austraila Pty.,Ltd. 100.0

Samsung SDS Co., Ltd. SDS-ACUTECH CO., Ltd. 50.0

Samsung SDS Co., Ltd. ALS SDS Joint Stock Company 51.0

Samsung SDS Co., Ltd. SDS-MP Logistics Joint Stock Company 51.0
Share
Investor Investee
Ratio(%)
Samsung SDS Co., Ltd. Samsung SDS China Co., Ltd. 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Hong Kong Co., Ltd. 100.0

Samsung SDS Co., Ltd. SAMSUNG SDS Global SCL Egypt 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL South Africa (PTY) Ltd. 100.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Nakliyat ve Lojistik Anonim Sirketi 100.0
Samsung SDS Global Supply Chain Logistics Middle East DWC-
Samsung SDS Co., Ltd. 100.0
LLC
Samsung SDS Co., Ltd. Samsung SDS Latin America Solucoes Em Tecnologia Ltda. 99.7

Samsung SDS Co., Ltd. INTE-SDS Logistics S.A. de C.V. 51.0

Samsung SDS Co., Ltd. Samsung SDS Global SCL Rus Limited Liability Company 100.0

Miracom Inc Co., Ltd. MIRACOM INC ASIA PACIFIC LIMITED 100.0

Samsung SDS Global SCL America, Inc. Samsung SDS Mexico, S.A. DE C.V. 99.0

Samsung SDS Global SCL America, Inc. Samsung SDS Global SCL Panama S. A. 100.0

Samsung SDS Global SCL America, Inc. Samsung SDS Global SCL Chile Limitada 100.0

Samsung SDS Global SCL America, Inc. Samsung SDS Global SCL Peru S.A.C. 100.0

Samsung SDS Global SCL America, Inc. Samsung SDS Global SCL Colombia S.A.S. 100.0

Samsung SDS Global SCL America, Inc. Samsung SDS Latin America Logistica Ltda 0.3

Samsung SDS Europe, Ltd. Samsung SDS Global SCL Netherlands Cooperatief U.A. 0.0

Samsung SDS Global SCL Netherlands Cooperatief U.A. Samsung SDS Global SCL Poland Sp. Z.o.o. 0.0

Samsung SDS Global SCL Netherlands Cooperatief U.A. Samsung SDS Global SCL Greece Societe Anonyme 0.0

Samsung SDS Global SCL Netherlands Cooperatief U.A. Samsung SDS Global SCL Romania S.R.L 0.0

Samsung SDS Global SCL Netherlands Cooperatief U.A. Samsung SDS Global SCL Rus Limited Liability Company 0.0

Samsung IT Services (Beijing) Co., Ltd. Samsung SDS Global Development Center Xi'an 100.0

Samsung SDS China Co., Ltd. Samsung SDS Global SCL Beijing Co., Ltd 100.0

Samsung Engineering Co., Ltd. Samsung Engineering America Inc. 100.0

Samsung Engineering Co., Ltd. Samsung Engineering Hungary Ltd. 100.0

Samsung Engineering Co., Ltd. Samsung Engineering Italy S.R.L. 100.0

Samsung Engineering Co., Ltd. Samsung Engineering (Malaysia) SDN. BHD. 100.0

Samsung Engineering Co., Ltd. PT Samsung Engineering Indonesia Co., Ltd. 100.0

Samsung Engineering Co., Ltd. Samsung Engineering (Thailand) Co., Ltd. 81.0

Samsung Engineering Co., Ltd. Samsung Engineering India Private Limited 100.0

Samsung Engineering Co., Ltd. Samsung Engineering Vietnam Co., Ltd. 100.0

Samsung Engineering Co., Ltd. Samsung Engineering Construction(Shanghai) Co., Ltd 100.0

Samsung Engineering Co., Ltd. Samsung Engineering Construction Xi' an Co., Ltd. 100.0

Samsung Engineering Co., Ltd. Samsung Saudi Arabia Co., Ltd. 100.0

Samsung Engineering Co., Ltd. Muharraq Wastewater Services Company W.L.L. 99.8

Samsung Engineering Co., Ltd. Muharraq STP Company B.S.C. 6.6

Samsung Engineering Co., Ltd. Muharraq Holding Company 1 Ltd. 65.0


Samsung Ingenieria Mexico Construccion Y Operacion S.A. De
Samsung Engineering Co., Ltd. 99.9
C.V.
Samsung Engineering Co., Ltd. Samsung Engineering Trinidad Co., Ltd. 100.0

Samsung Engineering Co., Ltd. Samsung Ingenieria Manzanillo, S.A. De C.V. 99.9

Samsung Engineering Co., Ltd. Grupo Samsung Ingenieria Mexico, S.A. De C.V. 100.0

Samsung Engineering Co., Ltd. Samsung Ingenieria Energia S.A. De C.V. 100.0

Samsung Engineering Co., Ltd. Samsung Engineering Bolivia S.A 100.0

Samsung Engineering Co., Ltd. Samsung Ingenieria DUBA S.A. de C.V. 100.0

Samsung Engineering Co., Ltd. Samsung Engineering Kazakhstan L.L.P. 100.0

Samsung Engineering America Inc. SEA Construction, LLC 100.0

Samsung Engineering America Inc. SEA Louisiana Construction, L.L.C. 100.0

Samsung Engineering (Malaysia) SDN. BHD. Muharraq Wastewater Services Company W.L.L. 0.3

Samsung Engineering India Private Limited Samsung Saudi Arabia Co., Ltd. 0.0
Share
Investor Investee
Ratio(%)
Samsung Saudi Arabia Co., Ltd. Samsung EPC Company Ltd. 75.0

Muharraq Holding Company 1 Ltd. Muharraq Holding Company 2 Ltd. 100.0

Muharraq Holding Company 2 Ltd. Muharraq STP Company B.S.C. 89.9

Samsung Ingenieria Manzanillo, S.A. De C.V. Asociados Constructores DBNR, S.A. de C.V. 49.0

S-1 Corporation S-1 CORPORATION HUNGARY LLC 100.0

S-1 Corporation S-1 CORPORATION VIETNAM CO., LTD 100.0

S-1 Corporation Samsung Beijing Security Systems 100.0

Cheil Worldwide Inc. PENGTAI INTERACTIVE ADVERTISING CO.,LTD 100.0

Cheil Worldwide Inc. Cheil USA Inc. 100.0

Cheil Worldwide Inc. Cheil Central America Inc. 100.0

Cheil Worldwide Inc. Iris Worldwide Holdings Limited 100.0

Cheil Worldwide Inc. CHEIL EUROPE LIMITED 100.0

Cheil Worldwide Inc. Cheil Germany GmbH 100.0

Cheil Worldwide Inc. Cheil France SAS 100.0

Cheil Worldwide Inc. CHEIL SPAIN S.L 100.0

Cheil Worldwide Inc. Cheil Benelux B.V. 100.0

Cheil Worldwide Inc. Cheil Nordic AB 100.0

Cheil Worldwide Inc. Cheil India Private Limited 100.0

Cheil Worldwide Inc. Cheil (Thailand) Ltd. 100.0

Cheil Worldwide Inc. Cheil Singapore Pte. Ltd. 100.0

Cheil Worldwide Inc. CHEIL VIETNAM COMPANY LIMITED 99.0

Cheil Worldwide Inc. Cheil Integrated Marketing Philippines, Inc. 100.0

Cheil Worldwide Inc. CHEIL MALAYSIA SDN. BHD. 100.0

Cheil Worldwide Inc. Cheil New Zealand Limited 100.0

Cheil Worldwide Inc. CHEIL CHINA 100.0

Cheil Worldwide Inc. Cheil Hong Kong Ltd. 100.0

Cheil Worldwide Inc. Caishu (Shanghai) Business Consulting Co., Ltd 100.0

Cheil Worldwide Inc. Cheil MEA FZ-LLC 100.0

Cheil Worldwide Inc. Cheil South Africa (Pty) Ltd 100.0

Cheil Worldwide Inc. CHEIL KENYA LIMITED 99.0

Cheil Worldwide Inc. Cheil Communications Nigeria Ltd. 99.0

Cheil Worldwide Inc. Cheil Worldwide Inc./Jordan LLC. 100.0

Cheil Worldwide Inc. Cheil Ghana Limited 100.0

Cheil Worldwide Inc. Cheil Egypt LLC 99.9

Cheil Worldwide Inc. Cheil Brasil Comunicacoes Ltda. 100.0

Cheil Worldwide Inc. Cheil Mexico, S.A. de C.V. 98.0

Cheil Worldwide Inc. Cheil Chile SpA. 100.0

Cheil Worldwide Inc. Cheil Peru S.A.C. 100.0

Cheil Worldwide Inc. CHEIL ARGENTINA S.A. 98.0

Cheil Worldwide Inc. Cheil Rus LLC 100.0

Cheil Worldwide Inc. Cheil Ukraine LLC 100.0

Cheil Worldwide Inc. Cheil Kazakhstan LLC 100.0

Hotel Shilla Co., Ltd. Samsung Hospitality America Inc. 100.0

Hotel Shilla Co., Ltd. Shilla Travel Retail Pte. Ltd. 100.0

Hotel Shilla Co., Ltd. Samsung Shilla Business Service Beijing Co., Ltd. 100.0

Hotel Shilla Co., Ltd. Shilla Travel Retail Hong Kong Limited 100.0

Hotel Shilla Co., Ltd. Shilla Travel Retail Taiwan Limited 64.0

HDC Shilla Duty Free Ltd. HDC SHILLA (SHANGHAI) CO., LTD 100.0

SBTM Co., Ltd. Samsung Hospitality U.K. Inc. 100.0

SBTM Co., Ltd. Samsung Hospitality Europe GmbH 100.0


Share
Investor Investee
Ratio(%)
SBTM Co., Ltd. SAMSUNG HOSPITALITY ROMANIA SRL 100.0

SBTM Co., Ltd. Samsung Hospitality Vietnam Co., Ltd. 99.0

SBTM Co., Ltd. Samsung Hospitality Philippines Inc. 100.0

SBTM Co., Ltd. Samsung Hospitality India Private Limited 100.0

Iris Americas, Inc. Iris (USA) Inc. 100.0

Iris Americas, Inc. Iris Atlanta, Inc. 100.0

Iris Americas, Inc. 89 Degrees, Inc. 100.0

Iris Latin America, Inc. Irisnation Latina No.2, S. de R.L. de C.V. 0.0

Cheil USA Inc. The Barbarian Group LLC 100.0

Cheil USA Inc. McKinney Ventures LLC 100.0

Cheil USA Inc. Cheil India Private Limited 0.0

Cheil USA Inc. Cheil Mexico, S.A. de C.V. 2.0

Iris Worldwide Holdings Limited Iris Nation Worldwide Limited 100.0

Iris Nation Worldwide Limited Iris Americas, Inc. 100.0

Iris Nation Worldwide Limited Irisnation Latina No.2, S. de R.L. de C.V. 100.0

Iris Nation Worldwide Limited Irisnation Latina, S. de R.L. de C.V. 100.0

Iris Canada Holdings Ltd Pricing Solutions Ltd 100.0

Iris Nation Worldwide Limited Iris London Limited 100.0

Iris Nation Worldwide Limited Iris Promotional Marketing Ltd 100.0

Iris Nation Worldwide Limited Iris Ventures 1 Limited 98.6

Iris Nation Worldwide Limited Founded Partners Limited 100.0

Iris Nation Worldwide Limited Iris Korea Limited 100.0

Iris Nation Worldwide Limited Iris Digital Limited 100.0

Iris Nation Worldwide Limited Iris Amsterdam B.V. 100.0

Iris Nation Worldwide Limited Iris Ventures (Worldwide) Limited 100.0

Iris Nation Worldwide Limited Iris Culture Limited 100.0

Iris Nation Worldwide Limited Concise Consultants Limited 100.0

Iris Nation Worldwide Limited Atom42 Ltd 100.0

Iris Nation Worldwide Limited WDMP Limited 49.0

Iris Nation Worldwide Limited Pricing Solutions (UK) Limited 100.0

Iris Nation Worldwide Limited Iris Services Limited Dooel Skopje 100.0

Iris Nation Worldwide Limited Irisnation Singapore Pte. ltd. 100.0

Iris Nation Worldwide Limited Iris Worldwide Integrated Marketing Private Limited 100.0

Iris Nation Worldwide Limited Iris Sydney PTY Ltd 100.0

Iris Nation Worldwide Limited Iris Worldwide (Thailand) Limited 100.0

Iris London Limited Iris Partners LLP 100.0

Iris Promotional Marketing Ltd Holdings BR185 Limited 100.0

Iris Ventures 1 Limited Iris Germany GmbH 100.0

Founded Partners Limited Founded, Inc. 100.0

Iris Germany GmbH Pepper NA, Inc. 100.0

Iris Germany GmbH Pepper Technologies Pte. Ltd. 100.0

CHEIL EUROPE LIMITED Beattie McGuinness Bungay Limited 100.0

CHEIL EUROPE LIMITED Cheil Italia S.r.l 100.0

Cheil Germany GmbH Cheil Austria GmbH 100.0

Cheil Germany GmbH Centrade Integrated SRL 80.0

Centrade Integrated SRL Centrade Cheil HU Kft. 100.0

Centrade Integrated SRL Centrade Cheil Adriatic D.O.O. 100.0

Cheil India Private Limited Experience Commerce Software Private Limited 100.0

Cheil Singapore Pte. Ltd. Pengtai Greater China Company Limited 95.7

Cheil Singapore Pte. Ltd. PT. CHEIL WORLDWIDE INDONESIA 100.0


Share
Investor Investee
Ratio(%)
Cheil Integrated Marketing Philippines, Inc. Cheil Philippines Inc. 30.0

Cheil Hong Kong Ltd. Pengtai Greater China Company Limited 3.1

Samsung Shilla Business Service Beijing Co., Ltd. Tianjin Samsung International Travel Service Co., Ltd 100.0

Shilla Travel Retail Hong Kong Limited Shilla Retail Limited 100.0

Shilla Travel Retail Hong Kong Limited Shilla Travel Retail Duty Free HK Limited 100.0

Cheil MEA FZ-LLC One Agency FZ-LLC 100.0


One RX Project Management Design and Production Limited
Cheil MEA FZ-LLC 0.0
Company
Cheil MEA FZ-LLC Cheil Egypt LLC 0.1

Cheil South Africa (Pty) Ltd CHEIL KENYA LIMITED 1.0

Cheil South Africa (Pty) Ltd Cheil Communications Nigeria Ltd. 1.0

One Agency FZ-LLC One RX India Private Limited 100.0


One RX Project Management Design and Production Limited
One Agency FZ-LLC 100.0
Company
One Agency FZ-LLC ONE RX INTERIOR DECORATION L.L.C 100.0

One Agency FZ-LLC ONE AGENCY PRINTING L.L.C 100.0

One Agency FZ-LLC One Agency South Africa (Pty) Ltd 100.0

ONE RX INTERIOR DECORATION L.L.C One RX India Private Limited 0.0

Holdings BR185 Limited Brazil 185 Participacoes Ltda 100.0

Brazil 185 Participacoes Ltda Iris Router Marketing Ltda 100.0

Cheil Brasil Comunicacoes Ltda. CHEIL ARGENTINA S.A. 2.0

(3) Related statutes and regulation


Restrictions on cross-shareholdings within Samsung Group in accordance with ‘Monopoly Regulation
and Fair Trade Act’

① Date of announcement: May 1, 2022


② Summary of Regulation
- Restriction on cross-holdings
- Restriction on debt guarantee between affiliates
- Restriction on affiliate voting rights of financial & insurance companies
- Decision making of board committee and public disclosure of large-scale inter-affiliate transactions
- Public disclosure of important matters of unlisted companies
- Other public disclosures related to Group status

B. Equity investments in other corporations(Summary)


(As of June 30, 2022) (Unit: KRW Mil)
Number of investee Investment amount
Increase(Decrease)
Classification Beginning Ending
Listed Unlisted Total Acquisition Valuation
Book Value Book Value
(Disposal) gain(Loss)
Management
- 4 4 541,389 2,742,523 3,813 3,287,725
Participation
General
- - - - - - -
Investment
Simple
- - - - - - -
Investment
Total - 4 4 541,389 2,742,523 3,813 3,287,725

※ For details, refer to XII. Table of Information – 3. Investments in other companies


C. Concurrent position with other affiliates
Director Concurrent position
Name Position Company name Position Duration
Executive Vice Other non-executive
Lo Kun Samsung Bioepis 2022.02 ~ present
President director
※ As of February 9, 2022, President John Rim's term as an interlocking executive of the company has expired, and Vice President
Lo Kun has been appointed as a non-executive director of Samsung Bioepis Co., Ltd.
X. Transactions with Stakeholders

1. Credit Offerings for Affiliates and Subsidiaries

A. Provisional payments and loans (incl. securities loan)


- Not applicable

B. Collateral provided
- Not applicable

C. Debt guarantee
- Not applicable

2. Acquisitions and Disposals of Assets with Affiliates and Subsidiaries

A. Acquisitions and disposals of assets


- Not applicable

B. Purchase or sale of securities


- Not applicable

C. Investment and disposal of invested shares


- Not applicable

3. Business transactions with affiliates and subsidiaries


- Not applicable

4. Transactions with stakeholders other than affiliates and subsidiaries


- On January 28, 2022, 5,009,000 ordinary shares were allocated to shareholders through a
resolution of the Board of Directors and issued through general public offering.

The confirmed issuance price is KRW 639,000, and the details of participation in capital increase,
including major shareholders, are as follows :
(Unit: KRW mil)
Contract
Name Relationship Number of share Amount Remarks
date
Shareholder
Samsung C&T
Largest shareholder 2022.04.16 1,904,239 1,216,808,721 Preferred
Corporation
Subscription
Shareholder
Samsung
Related 2022.04.16 1,380,477 882,124,803 Preferred
Electronics
Subscription
Shareholder
Kim Taehan Internal director 2022.04.16 1,272 812,808 Preferred
Subscription
Shareholder
Kim Dongjoong Internal director 2022.04.16 332 212,148 Preferred
Subscription
Employee stock Priority allocation of
ownership Employees 2022.04.16 624,414 399,000,546 12.5% of total
association issued stocks
※ The above transaction date, April 15, 2022, is the day after the share purchase date.

5. Transactions with stakeholders other than major shareholders


- Not applicable
XI. Other Information

1. Public Disclosure and Shareholder Meetings

A. Progress and Change of Notices


Disclosure
Title Details Progress
date
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 291,788,251.79
‘16.11.15 Single Sales or - Counterpart : Cilag GmbH International In progress
Supply Contract - Contract period : 2016. 11. 15 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 55,513,715
‘17.07.04 Single Sales or - Counterpart : Sun Pharma Global FZE In progress
Supply Contract - Contract period : 2017. 7. 4 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 14,944,000
‘17.07.21 Single Sales or - Counterpart : Pharmaceutical company in Europe In progress
Supply Contract - Contract period : 2017. 7. 20 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
Entering into - Contract name : Outsourced drug manufacturing
‘17.11.08 Single Sales or - Contract amount : USD 7,212,800 In progress
Supply Contract - Counterpart : Checkpoint Therapeutics, Inc.,
- Contract period : 2017. 11. 8 ~ 2022. 11. 9
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 41,654,000
‘17.12.21 Single Sales or - Counterpart : UCB In progress
Supply Contract - Contract period : 2017. 12. 21 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.

◦ Overview
Entering into - Contract name : Outsourced drug manufacturing
‘18.02.22 Single Sales or - Contract amount : USD 50,313,000 In progress
Supply Contract - Counterpart : Pharmaceutical company in US
- Contract period : 2018. 2. 21 ~ 2026. 12. 31
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 449,425,200
‘18.04.30 Single Sales or - Counterpart : Pharmaceutical company in Swiss In progress
Supply Contract - Contract period : 2018. 4. 30 ~ 2025. 12. 31
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 15,097,201
‘18.06.01 Single Sales or - Counterpart : Ichnos Sciences In progress
Supply Contract - Contract period : 2017. 9. 5 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 127,555,800
‘18.08.14 Single Sales or - Counterpart : Pharmaceutical company in Asia In progress
Supply Contract - Contract period : 2018. 8. 14 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.

◦ Overview
Entering into - Contract name : Outsourced drug manufacturing
‘18.09.12 Single Sales or - Contract amount : USD 266,454,000 In progress
Supply Contract - Counterpart : Gilead Sciences, Inc.
- Contract period : 2018. 9. 11 ~ 2025. 12. 31

◦ Overview
Entering into - Contract name : Outsourced drug manufacturing
‘19.04.01 Single Sales or - Contract amount : USD 50,224,225 In progress
Supply Contract - Counterpart : Cytodyn Inc.
- Contract period: 2019. 4. 1 ~ 2027.12.31

◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 31,985,200
‘19.04.26 Single Sales or - Counterpart : Pharmaceutical company in Asia In progress
Supply Contract - Contract period : 2019. 4. 26 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 17,142,200
‘19.04.26 Single Sales or - Counterpart : Pharmaceutical company in Asia In progress
Supply Contract - Contract period : 2019. 4. 26 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 29,769,800
‘19.05.14 Single Sales or - Counterpart : Pharmaceutical company in Asia In progress
Supply Contract - Contract period : 2019. 5. 14 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name: Outsourced drug manufacturing
Entering into - Contract amount : USD 33,829,763
‘19.05.17 Single Sales or - Counterpart : UCB In progress
Supply Contract - Contract period : 2019. 5. 17 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
Entering into
- Contract name : Outsourced drug manufacturing
‘19.11.28 Single Sales or In progress
- Contract amount : USD 19,129,700
Supply Contract
- Counterpart : Pharmaceutical company in Asia
- Contract period : 2019. 11. 28 ~ Contract end date
※ The disclosure of the confidential details of contract end
date is reserved.
◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 58,198,800
‘19.12.03 Single Sales or - Counterpart : Pharmaceutical company in US In progress
Supply Contract - Contract period : 2019. 12. 3 ~ Contract end date
※ The disclosure of the confidential details of contract
end date is reserved.

◦ Overview
Entering into - Contract name : Outsourced drug manufacturing
‘20.05.22 Single Sales or - Contract amount : USD 505,198,800 In progress
Supply Contract - Counterpart : GlaxoSmithKline Trading Services Limited
- Contract period : 2020. 5. 21 ~ 2028. 12 31

◦ Overview
- Contract name : Outsourced drug manufacturing
Entering into - Contract amount : USD 27,870,586
‘20.07.20 Single Sales or - Counterpart : H. Lundbeck A/S In progress
Supply Contract - Contract period : 2019. 9. 27 ~ Contract end date
※ The disclosure of the confidential details of counterpart &
contract end date is reserved.

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.07.28 Single Sales or - Contract amount: USD 268,349,994 In progress
Supply Contract - Counterpart: Eli Lilly and Company
- Contract period: 2020. 7. 21 ~ 2026.08.30

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.08.04 Single Sales or - Contract amount: USD 43,497,915 In progress
Supply Contract - Counterpart: Immunovant Sciences GmbH
- Contract period: 2018. 12. 18 ~ 2029. 12. 31

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.08.05 Single Sales or - Contract amount: USD 226,866,568 In progress
Supply Contract - Counterpart: GlaxoSmithKline Trading Services Limited
- Contract period: 2020. 4. 9 ~ 2023. 12. 31

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.09.22 Single Sales or - Contract amount: USD 377,542,300 In progress
Supply Contract - Counterpart: AstraZeneca AB
- Contract period: 2020. 6. 23 ~ 2028.12.31

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.09.22 Single Sales or - Contract amount: USD 16,018,000 In progress
Supply Contract - Counterpart: AstraZeneca UK Ltd.,
- Contract period: 2020. 9. 21 ~ 2023.12.31

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.10.06 Single Sales or - Contract amount: USD 19,713,000 In progress
Supply Contract - Counterpart: Checkpoint Therapeutics, Inc.,
- Contract period: 2020. 10. 02 ~ 2030. 10. 02
◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.11.03 Single Sales or - Contract amount: USD 16,110,700 In progress
Supply Contract - Counterpart: Pharmaceutical company in US
- Contract period: 2020. 10. 28 ~ 2030.12.31

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘20.11.09 Single Sales or - Contract amount: USD 51,458,000 In progress
Supply Contract - Counterpart: FibroGen, Inc.
- Contract period: 2020. 9. 18 ~ 2022.12.31

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘21.01.15 Single Sales or - Contract amount: USD 202,261,032 In progress
Supply Contract - Counterpart: F.Hoffmann-La Roche Ltd
- Contract period: 2020. 6. 1 ~ 2024.12.31

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
‘21.01.15 Single Sales or - Contract amount: USD 550,150,000 In progress
Supply Contract - Counterpart: F.Hoffmann-La Roche Ltd
- Contract period: 2020. 6. 1 ~ 2024.12.31

◦ Overview
Important - Contract name: Outsourced drug manufacturing LOI
‘21.09.29 management - Contract amount: USD 41,510,000 In progress
matters - Counterpart: MSD International Business GmbH
- Contract period: 2021. 9.29 ~ Contract date

◦ Overview
- Contract name: Outsourced drug manufacturing LOI
Important - Contract amount: USD 56,581,000
‘21.12.23 management - Counterpart: Pharmaceutical company in Europe In progress
matters - Contract period: 2021.09.29 ~ 2022. 06.30
※ The disclosure of the confidential details of counterpart &
contract end date is reserved.

◦ Overview
Entering into - Contract name: Outsourced drug manufacturing
'22.03.28 Single Sales or - Contract amount: USD 92,041,300 In progress
Supply Contract - Counterpart: Eli Lilly Kinsale Limited
- Contract period: 2019.12.20 ~ 2029.12.31

◦ Overview
- Contract name: Outsourced drug manufacturing LOI
Important - Contract amount: USD 124,099,000
'22.04.25 management - Counterpart: Pharmaceutical company in Europe In progress
matters - Contract period: 2022.04.25 ~ 2022.08.31
※ The disclosure of the confidential details of counterpart &
contract end date is reserved.

◦ Overview
Important - Contract name: Outsourced drug manufacturing LOI
'22.06.07 management - Contract amount: USD 81,000,000 In progress
matters - Counterpart: Novartis Pharma AG
- Contract period: 2022.06.04 ~ Contract date
2. Contingent Liability

A. Litigations
The Company’s litigations in progress are as follows :

[Samsung Biologics]

Plaintiff Defender Details Status


On October 8, 2018, the Company filed administrative The Seoul Administrative
litigation in the Seoul Administrative Court to withdraw Court ruled to cancel the
Securities & the measure recommended by the Securities & Futures Securities and Futures
Samsung
Futures Commission to designate an auditor to the Company Commission's
Biologics
Commission for three years and dismiss the responsible officer administrative disposition
regarding that the details of the joint venture agreement imposed on SBL on
are not stated in the notes to the financial statements. September 24th, 2020.
On November 28, 2018, the Company filed
administrative litigation in the Seoul Administrative
Court to withdraw the measure recommended by the
Securities & Legal procedures in
Securities & Futures Commission to designate an
Futures progress after the
auditor to the Company for three years and dismiss the
Samsung Commission, litigation was filed in the
responsible officer regarding that the details of the joint
Biologics Financial Seoul Administrative
venture agreement are not stated in the notes to the
Services Court on November 27,
financial statements as well as the measure ordered by
Commission 2018.
the Financial Services Commission to rewrite the
financial statements (2012~2018.6.30) and
subsequently impose a fine of KRW 8 billion.

On April 29, 2019, 355 people filed a suit in the Seoul


Legal procedures in
Central District Court for damages against the company
Kang and Samsung progress after a suit was
and 4 other parties.(Amount : KRW 8,449,205,474) The
354 Biologics filed in the Seoul Central
plaintiffs claimed that they have experienced financial
others and 4 others District Court on April 29,
losses, for the Company disclosed business reports
2019.
with false information against the accounting standards.

32 people filed a suit in the Seoul Central District Court


for damages against Samsung C&T Corporation and
Legal procedures in
Samsung 19. (Amount: KRW 200,320,000) The plaintiffs claimed
Shim progress after a suit was
C&T that they have experienced financial losses, for the
and filed in the Seoul Central
Corporation Company concealed important information regarding its
31 others and 19 others control over Samsung Bioepis Co., Ltd., and that District Court on February
17, 2020.
resulted in an unfair swap ratio between Samsung C&T
and Cheil Industries.

9 people filed a suit in the Incheon District Court for


damages against the Company. (Amount: KRW Legal procedures in
Chung
Samsung 437,944,500) The plaintiffs claimed that they have progress after a suit was
and
Biologics experienced financial losses in form of a decline in filed in the Incheon District
8 others
stock price, for the Company applied equity method of Court on March 4, 2020.
accounting against the accounting standards.

Company Y and 18 other parties filed a suit in the


Seoul Central District Court for damages against
Samsung C&T Corporation and 23. (Amount: KRW Legal procedures in
Samsung
Company 209,000,000) The plaintiffs claimed that they have progress after a suit was
C&T
Y and experienced financial losses, for the Company filed in the Seoul Central
Corporation
18 others concealed important information regarding its control District Court on January
and 23 others
over Samsung Bioepis Co., Ltd., and that resulted in an 21, 2021.
unfair swap ratio between Samsung C&T and Cheil
Industries.
- In December 2020, Biogen Therapeutics Inc. has filed an arbitration with the International Chamber of Commerce (ICC)
against the Company in connection with the interpretation of some of the terms of the Samsung Bioepis Co., Ltd. joint venture
agreement with the Company, but was suspended the current arbitration process in accordance with the agreement of both
companies in February 2022. In April 2022, Biogen and the Company agreed to terminate the arbitration procedure.

B. Other contingent liabilities

(1) Major agreements with financial institutions

Loan commitments signed with financial institutions as of the end of 1H 2022 are as follows:
(Unit: KRW Thousand, USD Thousand)
Limits Execution amount
Bank Type
Currency Amount Currency Amount
Bank overdraft KRW 10,000,000 KRW -
B2B Plus KRW 5,760,000 KRW -
Loans for equipment KRW 70,000,000 KRW 70,000,000
Loans for equipment KRW 50,000,000 KRW 50,000,000
Loans for equipment KRW 50,000,000 KRW 50,000,000
Woori Bank
General loan in foreign
USD 30,000 USD 30,000
currency
Corporate operation
KRW 59,900,000 KRW -
general fund loan
Corporate operation
KRW 100,000,000 KRW 100,000,000
general fund loan
B2B + Main contract KRW 50,000 KRW -
Bank overdraft KRW 10,000,000 KRW -
Loans for equipment KRW 50,000,000 KRW 50,000,000
Loans for equipment KRW 100,000,000 KRW 30,000,000
Comprehensive limit KRW 40,000,000 KRW -
General loan in foreign
KEB USD 30,000 USD 30,000
currency
Hana Bank Corporate operation
KRW 20,000,000 KRW 20,000,000
general fund loan
Corporate operation
KRW 30,000,000 KRW 30,000,000
general fund loan
Corporate operation
KRW 75,000,000 KRW 75,000,000
general fund loan
Corporate operation
USD 30,000 USD 30,000
general fund loan
General loan KRW 17,000,000 KRW -
General loan KRW 45,000,000 KRW 45,000,000
Bank overdraft KRW 10,000,000 KRW -
Shinhan Bank Loans for equipment KRW 70,000,000 KRW 70,000,000
Loans for equipment KRW 100,000,000 KRW 10,000,000
General loan KRW 25,000,000 KRW 25,000,000
General loan KRW 55,000,000 KRW 55,000,000
Loans for equipment KRW 100,000,000 KRW 50,000,000
Corporate general facility
KB Bank KRW 13,125,000 KRW 13,125,000
loan
Corporate general facility KRW 11,250,000 KRW 11,250,000
loan
Corporate general facility
KRW 9,375,000 KRW 9,375,000
loan
Corporate general facility
KRW 6,750,000 KRW 6,750,000
loan
Corporate operation
KRW 51,750,000 KRW 51,750,000
general fund loan
Loans for equipment KRW 100,000,000 KRW 20,000,000
NH Bank
General loan KRW 50,000,000 KRW 50,000,000
Export Growth Loan KRW 110,000,000 KRW 55,000,000
The Export-
Import Bank of Overseas business loan KRW 45,000,000 KRW 45,000,000
Korea
Overseas business loan KRW 50,000,000 KRW 50,000,000
Loans for equipment KRW 70,000,000 KRW 70,000,000
Loans for equipment KRW 28,000,000 KRW 28,000,000

Mizuho Bank Loans for equipment KRW 100,000,000 KRW 100,000,000


Loans for equipment USD 10,000 USD 10,000
Corporate operation
USD 50,000 USD -
general fund loan
General loan KRW 30,000,000 KRW -
Sumitomo Short-term foreign
Mitsui Banking USD 100,000 USD 70,000
currency loan
Corporation
General loan(KRW) USD 50,000 KRW 58,400,000
Australia and
New Zealand Loans for equipment USD 100,000 USD 30,000
Banking Group
Crédit Agricole Loans for equipment KRW 100,000,000 KRW -
Corporate operation
BNP Paribas KRW 45,000,000 KRW 45,000,000
general fund loan
Standard
General loan KRW 130,000,000 KRW 15,000,000
Chartered
China
Construction General loan(KRW) KRW 11,500,000 KRW 11,500,000
Bank
Bank of China Operating fund loan(KRW) KRW 50,000,000 KRW 50,000,000

As of June 30, 2022, details of guarantees provided by financial institutions are summarized as follows:
(Unit: KRW Thousand)

Limits Payment guarantee


Bank Type
Currency Amount Currency Amount
Woori
Payment guarantees KRW 39,500,000 KRW 25,082,400
Bank
Kookmin
Foreign currency payment guarantee KRW 30,000,000 KRW -
Bank

If the Company does not comply with the commitments below, financial institutions may require an early
redemption of long-term borrowings.

Financial institution Remarks Details of covenants


The ownership of the Samsung Group shall be over 50%, and
Shareholder
Sumitomo Mitsui Bank Samsung C&T Corporation shall maintain its ownership in the
composition ratio
Company in excess of 30%.

Sumitomo Mitsui Bank Shareholder The Samsung Group shall maintain its ownership of Samsung Bioepis
composition ratio in excess of 50%

The ownership of the Samsung Group (Samsung C&T Corporation


Mizuho Bank Shareholder
and Samsung Electronics) shall maintain ownership of the Company
composition ratio
in excess of 60% (voting shares).

Maintaining the ratio of interest-bearing debt to equity capital of


Mizuho Bank Financial ratio
Samsung Bioepis less than 180%

BNP Paribas Shareholder Maintaining as Samsung Group affiliates and the Samsung Group's
composition ratio ownership of the Samsung Bioepis shall be over 50%,

Kookmin Bank Shareholder Maintaining as Samsung Group affiliates and the Samsung Group's
composition ratio ownership of the Samsung Bioepis shall be over 50%,

(2) Free land use rights


In connection with a lease agreement with Incheon Metropolitan city (“Incheon”) related to the use of
land, the Company is exempt from the full amount of rent because the Company meets the
requirements for exemption of rent in accordance with the Common Property Management Ordinance
of Incheon. The Company recognized an intangible asset at the fair value of the rent that is exempt
from Incheon and government grant as a reduction of assets at the same value. The period of land use
without payment and exemption requirement of the full amount of rent are as follows:

Period
Lease terms are for a total of 50 years. The initial lease period is for 20 years from the land lease
contract date of April 28, 2011, and the Company can extend the contract by 10 years.

Exemption requirement
The Company whose foreign investment amounts to more than USD 20 million for 5 years since the
land lease contract date is subject to the exemption from Article 32 of Common Property Management
Ordinance of Incheon. Afterwards, the Company, including foreign invested enterprises that meet the
average daily employee count of above 300, is subject to exemption.

(3) A suit for damages from stock trading


There are a total of four pending lawsuits of stock transaction damages related to the Company’s
accounting and disclosure (Note 34), and the total amount of litigation is KRW 9,296 million.
(4) Provision for acquisition of tangible/non-tangible assets
As of June 30, 2022, the provision for the acquisition of tangible/non-tangible assets regarding the
construction of the fourth plant is KRW 939.9 billion, of which the amount committed to related parties
including Samsung Engineering Co., Ltd. is KRW 675.8 billion.

(5) SVIC 54 New Technology Investment Association


As of December 31, 2021, the Company entered into an investment agreement with a limit of total KRW
49,500 million for SVIC 54 New Technology Investment Association. On August 13, 2021, the Company
paid an initial investments of KRW 12,375 million, paid KRW 3,135 million on June 9, 2022, and KRW
12,375 million on August 12, 2022. The Company plans to pay additional investments in two
installments by August 13, 2024.
3. Sanctions and Others

A. Sanctions

(1) Sanctions by Investigation agency and Jurisdiction


Regarding violations of Financial Investment Services and Capital Markets Act, Act on External Audit of
Stock Companies, Act on the Aggravated Punishment, etc. of Specific Economic Crimes and
Destruction of Evidence, the Prosecutor’s Office has investigated the Company’s Chief Executive
Officer and Chief Financial Officer. Following the investigation, with regards to Act on External Audit of
Stock Companies, Act on the Aggravated Punishment, etc. of Specific Economic Crimes and
Destruction of Evidence, the Prosecutor’s Office has filed an indictment of the Company’s Chief
Executive Officer and Chief Financial Officer, and the first trial is currently in progress.
Currently, there is no case settled by the Investigation agency and Jurisdiction.

(2) Sanctions by Regulator

Regulatory Financial Relevant


Date Subject Content Reason
Authority penalty regulation

- External auditor designation by the


regulator for three years Omission of Act on External
Securities &
Samsung - Recommendation to dismiss the note regarding Audit of Stock
2018.07.12 Futures -
Biologics director in charge joint venture Companies
Commission
- Prosecution charges agreement Article 13
(Company and CEO)

Securities &
- External auditor designation by the
2018.11.14 Futures -.
regulator for three years
Commission Act on External
- Recommendation to dismiss the Inappropriate
Samsung Audit of Stock
CEO and director in charge consolidation
Biologics Companies
- Correction of financial statements accounting
Financial Article 13
- Prosecution charges KRW
2018.11.21 Services
(Company and CEO) 8 billion
Commission

- On July 12, 2018, the Securities & Futures Commission(“SFC”) imposed the first administrative
measures in accordance with the Act on External Audit of Stock Companies against the Company for
alleged failure to disclose sufficient information in the Company’s Financial Statement from 2012 to
2015 regarding the Company’s joint venture agreement with Biogen Therapeutics Inc. The measures
(“First measures”) included external auditor designation by the regulator, recommendation of
dismissal of the Company’s directors in charge, and referral of the case against the Company and its
representative director (CEO) to the Prosecutors’ Office. On October 10, 2018, in order to prove
unfairness of the decisions and actions taken by the SFC, the company filed a lawsuit for cancellation
of aforementioned measures. (Seoul Administrative Court)
On September 24, 2020, the Court ruled to cancel the First measures imposed to the Company by
SFC and decided to suspend the First measures until the decision of the appeal trail is made. The
SFC appealed the Court’s first trial and the litigation is in progress at the Seoul High Court.

- On November 14, 2018, SFC determined a second measure, in accordance with the Act on External
Audit of Stock Companies against the Company for violation of accounting standards by
inappropriately applying separate method regarding investments in Samsung Bioepis from 2012 to
2018. The measures (“Second measures”) included imposition of administrative fine of KRW 8 billion,
external auditor designation by the regulator, recommendation of dismissal of the Company’s
representative director (CEO) and directors in charge, retrospective restatement of financial
statements, and referral of the case against the Company and its representative director (CEO) to the
Prosecutors’ Office. On November 21, 2018, following the procedure, the Financial Service
Commission(“FSC”) imposed a penalty of KRW 8 billion on the Company. On November 27, 2018, to
prove justification of the accounting treatment, the Company filed a lawsuit for cancellation of the
measures by the SFC and the FSC. (Seoul Administrative Court)

4. Subsequent Events

A. Important subsequent events

(1) The Board of Directors resolved to purchase the land for the 2nd Bio Campus at an acquisition
price of approximately KRW 426 billion. The Company has been selected as a preferred bidder by
the Incheon Free Economic Zone Authority (IFEZ) and the contract has been concluded as of July
18th 2022.

(2) On August 12, 2022, the Company made an additional investment of KRW 12,375 million in
accordance with the initial investment payment method for the SVIC54 New Technology Business
Investment Association, which was established for equity investment in startups in the bio sector.

B. Follow-up information including mergers

(1) Overview of stock acquisition of other companies


Details
Name Samsung Bioepis
Acquisition Acquired shares 10,341,852
details Acquisition cost(KRW) 2,765,520,000,000
Acquisition cost(USD) 2,300,000,000
Acquisition purpose 2,300,000,000
Date of acquisition 2022.04.20
Transferring Company name Biogen Therapeutics Inc.
party CEO Michel Vounatsos
Main business Biopharmaceutical development and manufacturing
Main address 225 Binney Street, Cambridge, MA 02142, United States
1) Payment method: Cash
(If there is a transfer amount that is not paid until two years from the date of
closing of the transaction, it may be paid as new shares issued by the Company.)
2) Payment date:
- The transferred amount of $2.3 billion is the amount converted from KRW
Transaction 2,765,520,000,000
amount - USD 1,000,000,000 will be paid on the transaction closing date, USD 812,500,000
will be paid within one year from the transaction closing date, and USD
437,500,000 will be paid within two years from the transaction closing date.
- Earn-out, which can be paid up to USD 50,000,000 of the transferred amount, will
be paid in 2027 depending on whether the conditions are met or not.
3) financing method: New financing through self-funding and capital increase
External Evaluation Yes
Evaluation of adequacy in accordance with Article 165-4 (1) 2 and 2 of the Capital
Evidence Markets and Financial Investment Business Act, and Article 176-6 (3) of the
External
Enforcement Decree of the same Act
evaluation
Name of agency Hanul LLC
Duration 2021.12.21 ~ 2022.01.28
Opinion Unqualified
Board resolution 2022.01.28
Contract date: 2022.01.28
Important
Major report submission date: 2022.04.20
dates
Acquisition date: 2022.04.20
※ This transaction is the acquisition of 10,341,852 shares of Samsung Bioepis Co., Ltd. owned by Biogen
Therapeutics Inc., and the contract was signed on January 28, 2022. For details of the acquisition, please refer
to the Report on Major Matters initially published on January 28, 2022 (decision to acquire shares and
investment securities of other corporations).

(2) Comparison of forecasts and performance related to the major financial matters before and after the
stock acquisition
As monthly forecasts for the company's financial matters during the external evaluation related to the
acquisition of stocks were not calculated, the Company did not prepare forecasts until the end of the
first half of the year after the acquisition of stocks. Annual forecasts and performance comparison will
be included in the Annual Report at the end of the current year.

C. Green management
The Company is making efforts to meet the government’s green growth policy through greenhouse-
gas/energy reduction activities, water reuse, waste resource circulation, environmental performance
evaluation, and management to establish a green management system and take full responsibility as
an eco-friendly company. The Company is also doing its best to preserve the environment through
continued management of environmental management indicators and disclose relevant information to
its stakeholders in a transparent manner.

The Company’s management indicators by each environmental area for the last 3 years are listed below.

※ The current management indicators may change depending on the results of the performance report

by the Ministry of Environment.

[Greenhouse Gas & Energy]

Unit 2019 2020 2021


Greenhouse Gas Emission tCO2e 119,791 124,807 130,867
Energy Consumption TJ 2,427 2,529 2,678

[Water Resources Management]

Unit 2019 2020 2021


Water Usage Ton 1,746,377 1,578,639 1,900,995
Wastewater Discharge Ton 1,098,667 1,025,916 1,178,678
Water Reuse Ton 108,048 100,828 73,367
Water Reuse Rate % 9.8 9.8 6
Note 1) Water reuse facility was newly installed on December 2017.

[Waste Management]

Unit 2019 2020 2021


General Waste Discharge Ton 4,713 5,558 7,704
Designated Waste Discharge Ton 435 431 595
Water Recycling Ton 3,738 4,330 6,123
Recycling Rate % 72.6 72.3 73.8

[Contaminant Management]

Unit 2019 2020 2021


Air Pollutant(NOx) Ton 19.201 19.804 21.015
Water Pollutant(Note 1) Ton 16 13 27
Note1) Water Pollutant: COD, SS, T-N, T-P

D. Government Certification and Cancellation

[Samsung Biologics]
□ AEO (Export Division of Excellent Import and Export Safety Management Company)

- Related laws: Article 255-2 of the「Customs Act」, Article 259-2 and Article 259-3 of the Enforcement
Decree of the Customs Act

- Certification Department: Korea Customs Service

- Date of Certification: Apr 1, 2019

- Validity period: Apr 1, 2019 ~ Mar 31, 2024

□ Best Family Friendly Management

- Related laws: Act on Development of Family Friendly Environment

- Certification Department: Ministry of Gender Equality and Family

- Date of Certification: Dec 1, 2020


- Validity period: Dec 1, 2020 ~ Nov 30, 2023

□ Best Company for Environment Management by the City of Incheon

- Related laws: Article 56 of the Framework Act on Environmental Policy (Environmental management

support for businesses)

- Certification Department: Incheon Metropolitan City

- Date of Certification: Dec 17, 2021

- Validity period: Dec 17, 2021 ~ Dec 16, 2024

[Samsung Bioepis]

□ AEO (Export/Import Division of Excellent Import and Export Safety Management Company)

- Related laws: Article 255-2 of the「Customs Act」, Article 259-2 and Article 259-3 of the Enforcement
Decree of the Customs Act

- Certification Department: Korea Customs Service

- Date of Certification: Jan 15, 2020

- Validity period: Jan 15, 2020 ~ Jan 14, 2025


XII. Table of Information

1. Consolidated Subsidiaries(Details)
(Unit : KRW mil)

Total asset Basis of a


Established of the last dominant- Major
Name of Company Address Main business
Date business subordinate Subsidiary
years relationship
Majority
ownership
Samsung Biologics California, of voting
2020.01 Biologics R&D 16,129 X
America, Inc. U.S. rights
(K-IFRS
1110)

Majority
ownership
Songdo-dong, Biologics R&D
SAMSUNG of voting
2012.02 Yeonsu-gu, and 2,783,971 O
BIOEPIS rights
Incheon commercialization
(K-IFRS
1110)

Majority
ownership
SAMSUNG
of voting
BIOEPIS UK 2014.01 Brentford, UK Other service 1,474 X
rights
LIMITED(*1)
(K-IFRS
1110)

Majority
ownership
SAMSUNG
of voting
BIOEPIS CH 2015.06 Luzern, Swiss Other service 107 X
rights
GMBH(*1)
(K-IFRS
1110)

Majority
ownership
SAMSUNG
Sydney, of voting
BIOEPIS AU PTY 2016.06 Other service 26 X
Australia rights
LTD(*1)
(K-IFRS
1110)

Majority
SAMSUNG ownership
BIOEPIS BR San Paulo, of voting
2016.05 Other service 291 X
PHARMACEUTICAL Brazil rights
LTDA(*1) (K-IFRS
1110)

Majority
ownership
SAMSUNG
Auckland, of voting
BIOEPIS NZ 2018.01 Other service 21 X
New Zealand rights
LIMITED(*1)
(K-IFRS
1110)
Majority
ownership
SAMSUNG Ramat-Gan, of voting
2018.03 Other service 74 X
BIOEPIS IL LTD(*1) Islael rights
(K-IFRS
1110)
Majority
ownership
SAMSUNG
Delft, of voting
BIOEPIS NL 2018.06 Other service 25,767 X
Netherland rights
B.V.(*1)
(K-IFRS
1110)

Majority
ownership
SAMSUNG
of voting
BIOEPIS TW 2020.03 Taipei, Taiwan Other service 49 X
rights
Limited(*1)
(K-IFRS
1110)

Majority
ownership
SAMSUNG
Warsaw, of voting
BIOEPIS PL Sp z 2020.06 Other service 214 X
Poland rights
o.o(*1)
(K-IFRS
1110)

Majority
ownership
SAMSUNG
Tsim Sha Tsui, of voting
BIOEPIS 2020.06 Other service 7 X
HK rights
HK Limited(*1)
(K-IFRS
1110)

Majority
ownership
SAMSUNG
Delaware of voting
BIOEPIS United 2021.08 Other service 1,116 X
U.S.A rights
States Inc.(*1)
(K-IFRS
1110)

Majority
SVIC36 New ownership
Technology Seocho-gu, Investment of voting
2017.08 4,604 X
Investment Seoul association rights
Association (*1) (K-IFRS
1110)
(*1) On April 20, 2022, Samsung Bioepis Co., Ltd. was converted from a joint venture to a subsidiary as the Company acquired
100% of the shares as of the end of 1H 2022 by obtaining 10,341,852 shares of Samsung Bioepis Co., Ltd.

2. Affiliates(details)
(As of June 30, 2022)

No. of
Category Name of company Business registration no.
companies
Samsung C&T Corporation 1101110015762
Samsung Biologics Co., Ltd. 1201110566317
Samsung Life Insurance Co., Ltd. 1101110005953
Samsung SDI Co., Ltd. 1101110394174
Listed 16 Samsung SDS Co., Ltd. 1101110398556
Samsung Engineering Co., Ltd. 1101110240509
Samsung Electro-Mechanics Co., Ltd. 1301110001626
Samsung Electronics Co., Ltd. 1301110006246
Samsung Heavy Industries Co., Ltd. 1101110168595
No. of
Category Name of company Business registration no.
companies
Samsung Securities Co., Ltd. 1101110335649
Samsung Card Co., Ltd. 1101110346901
Samsung Fire & Marine Insurance Co., Ltd. 1101110005078
Multicampus Corporation 1101111960792
S-1 Corporation 1101110221939
Cheil Worldwide Inc. 1101110139017
Hotel Shilla Co., Ltd. 1101110145519
Samsung Display Co., Ltd. 1345110187812
Samsung Medison Co., Ltd. 1346110001036
Samsung Bioepis Co., Ltd. 1201110601501
Samsung Venture Investment Corporation 1101111785538
Samsung Life Service Claim Adjustment Co., Ltd. 1101111855414
Samsung Futures Inc. 1101110894520
Samsung Active Asset Management Co., Ltd. 1101116277382
Samsung SRA Asset Management Co., Ltd. 1101115004322
Samsung Welstory Co., Ltd. 1101115282077
Samsung Asset Management Co., Ltd. 1701110139833
Samsung Electronics Logitech Corporation 1301110046797
Samsung Electronics Service Co., Ltd. 1301110049139
Samsung Electronics Service CS Co., Ltd 1358110352541
Samsung Electronics Sales Co., Ltd. 1801110210300
Samsung Card Customer Service Co., Ltd. 1101115291656
Unlisted 45 Samsung Corning Advanced Glass LLC. 1648140003466
Samsung Hedge Asset Management Co., Ltd. 1101116277390
Samsung Fire Service Co., Ltd. 1101111237703
Samsung Claim Adjustment Service Co., Ltd. 1101111595680
SKKU Techno Holdings 1358110215426
SEMES Co., Ltd. 1615110011795
Suwon Samsung Football Club Co., Ltd. 1358110160126
Steel Structure Technologies Co., Ltd. (STECO) 1647110003490
Shilla Stay Co., Ltd. 1101115433927
SD Flex Co., Ltd. 1760110039005
SBTM Co., Ltd. 1101116536556
S1CRM Corporation 1358110190199
SUMaterials Co., Ltd. 1648110061337
S-Core Co., Ltd. 1101113681031
STM Co., Ltd. 2301110176840
HDC Shilla Duty Free Ltd. 1101115722916
No. of
Category Name of company Business registration no.
companies
Open Hands Co., Ltd. 1311110266146
Cheil Fashion Retail Co., Ltd. 1101114736934
Miracom Inc Co., Ltd. 1101111617533
Samsung Economic Research Institute (SERI) 1101110766670
Samsung Lions Co., Ltd. 1701110015786
Samsung Life Financial Service Co., Ltd. 1101115714533
Samsung Fire & Marine Financial Service Co., Ltd. 1101116002424
Samwoo Architects & Engineers Co., Ltd. 1101115494151
Seoul Lake Side Co., Ltd. 1101110504070
SECUI Co., Ltd. 1101111912503
CVnet Corporation 1101111931686
SHP Corporation 1101118151310
Harman International Korea 1101113145673
Human TSS Co., Ltd. 1101114272706
3. Investments in Other Companies
(As of June 30, 2022) (Unit: KRW Mil, Thousand shares, %)
Financial status in
Beginning balance Increase(decrease) Ending balance
recent business year
Name of Listing Purpose of Acquisition Acquisition (disposal)
Acquisition date Gain
company status Investment cost Share Book Share Book Total Net profit
Volume (loss) on Volume
ratio value Volume Amount ratio value assets (loss)
valuation
Samsung
Management
Bioepis Co., Unlisted 2012.02.28 139,995 10,342 50.00 517,100 10,342 2,739,388 - 20,684 100.00 3,256,488 2,783,971 151,992
Participation
Ltd.
Samsung
Biologics Management
Unlisted 2020.03.09 11,914 10 100.00 11,914 - - - 10 100.00 11,914 16,129 404
America, Participation
Inc.
Archigen Management
Unlisted 2014.06.23 71,372 131,000 50.00 - - - 3,813 131,000 50.00 3,813 4,227 2,584
Biotech Ltd. Participation

SVIC 54
New
Management
Technology Unlisted 2021.08.13 12,375 - 33.00 12,375 - 3,135 - - 33.00 15,510 37,136 -1,313
Participation
Investment
Association

Total - - 541,389 - 2,742,523 3,813 - - 3,287,725 - -

※ Consolidated basis in accordance with K-IFRS.


(*1) On April 20, 2022, Samsung Bioepis Co., Ltd. was converted from a joint venture to a subsidiary as the Company acquired 100% of the shares as of the end of 1H 2022 by obtaining
10,341,852 shares of Samsung Bioepis Co., Ltd.
(*2) In March 2022, the Board of Directors of the Company and AstraZeneca have agreed to the liquidation of Archigen Biotech Limited, a joint venture, and its book amount was changed
according to the expected receipt of liquidation payment. The liquidation payment is expected to be received during the current year.
(*3) During the first half of the year, the company made an initial investment in the SVIC 54 New Technology Business Investment Association for equity investment in startups in the bio sector,
and made an additional investment of KRW 3,135 million in the SVIC 54 New Technology Investment Association in June 9, 2022.
3. Research and Development(details)

[Samsung Bioepis]
(1) Product : SB2

① Product type Biosimilar


Crohn's disease, ulcerative colitis
Ankylosing Myelitis
② Application
Rheumatoid and psoriatic arthritis
psoriasis

③ Mechanism of Inhibition of the action of TNF (tumor necrosis factor) that causes
action inflammation
④ Product
Second infliximab (Remicade) biosimilar approved to be sold in EU and US
specifications
Since the initial launched in Korea in 2015, it is sold in Europe, US, Canada,
and Australia.
⑤ Progress
Sales distribution agreement signed with Biogen (Europe), Organon
(Canada, USA, Australia) and Yuhan Corporation (Korea)
⑥ Future plan -
- J&J : Remicade
⑦ Competitive - Celltrion : Remsima
product - Sandoz : Zessly
- Amgen : Avsola
⑧ Related -
⑨ Market size USD 5.5 billion in 2021 (Evaluate pharma)
⑩ Others -

(2) Product : SB3

① Product type Biosimilar


② Application Breast cancer
③ Mechanism of Inhibit proliferation of HER2-expressing tumor cells by binding to HER2
action (Human Epidermal growth factor Receptor 2)
④ Product
First trastuzumab (Herceptin) biosimilar approved to be sold in EU
specifications
⑤ Progress Since the global approval, it is currently in sale
⑥ Future plan -
- Amgen : Kanjinti
⑦ Competitive - Pfizer : Trazimera
product - Celltrion : Herzuma
- Mylan : Ogivri
⑧ Related -
Trastuzumab Global Revenue was USD 3.98 billion in 2021 (Evaluate
⑨ Market size
pharma)
⑩ Others -

(3) Product : SB4

① Product type Biosimilar


② Application Rheumatoid arthritis and others
③ Mechanism of Inhibition of the action of TNF (tumor necrosis factor) that causes
action inflammation
④ Product
First etanercept (Enbrel) biosimilar approved to be sold in EU
specifications
Since the initial launched in Korea in 2015, it is sold in Europe, US, Canada,
and Australia.
⑤ Progress
Sales distribution agreement signed with Biogen (Europe), Organon
(Canada, USA, Australia) and Yuhan Corporation (Korea)
⑥ Future plan -
- Pfizer : Enbrel
⑦ Competitive
- Sandoz : Erelzi
product - Mylan : Nepexto
A randomized phase l pharmacokinetic study comparing SB4 and
etanercept reference
⑧ Related Thesis
product (Enbrel®) in healthy subjects (British Journal of Clinical
Pharmacology, 2016)
⑨ Market size USD 6.4 billion in 2021 (Evaluate pharma)
⑩ Others -
(4) Product : SB5

① Product type Biosimilar


② Application Rheumatoid arthritis, psoriatic arthritis, etc.
③ Mechanism of In vivo neutralization of tumor necrosis factor (TNF)-alpha, a common cause
action of autoimmune disease
④ Product
First adalimumab (Humira) biosimilar approved to be sold in EU
specifications
Sales approval in Europe(EMA) in August 2017
Product release in October 2018
⑤ Progress Sales approval in US(FDA) in July 2019
Sales approval of high concentration formulation in Europe(EMA) in April
2022
Expansion of sales in approved countries and commercialization after
⑥ Future plan
approval of new formulations
- Humira (Abbvie): Originator's reference product
- Amjevita (Amgen): approval in US and EU
- Hyrimoz (Sandoz): approval in US and EU
- Hulio (FujifilmKyowa Kirin Biologics; Viatris): approval in US and EU
- Cyltezo (Boehringer Ingelheim): approval in US
⑦ Competitive - Abrilada (Pfizer): approval in US and EU
product - Idacio (Fresenius Kabi (Merck KGaA), Germany): approval in EU
- Yuflyma (Celltrion): approval in EU
- Hukyndra (Alvotech Swiss AG): approval in EU
- Yusimry (Coherus): approval in EU

Competitive products based on open information


- A randomized phase I comparative pharmacokinetic study comparing SB5
with reference adalimumab in healthy
volunteers, Journal of Clinical Pharmacy and Therapeutics, Jul 2017
⑧ Related Thesis - Phase III Randomized Study of SB5, an Adalimumab Biosimilar, Versus
Reference Adalimumab in Patients With
Moderate-to-Severe Rheumatoid Arthritis, Arthritis & Rheumatology, Sep
2017
⑨ Market size USD 22,137 million in 2021 (Evaluate pharma)
⑩ Others -

(5) Product : SB8

① Product type Biosimilar


② Application Lung cancer, colon cancer, ovarian cancer, etc
③ Mechanism of Prevent the growth of blood vessels that nourish tumors by blocking a
action protein called Vascular Endothelial Growth Factor(VEGF)
④ Product
Bevacizumab (Avastin) biosimilar
specifications
Sales approval in Europe(EMA) in 2020
⑤ Progress
Sales approval in Korea(MFDS) in 2021
Expansion of sales in approved countries and commercialization after
⑥ Future plan
approval of new formulations
- Mvasi (Amgen/Allergen): approval in US and EU
- Zirabev (Pfizer): approval in US and EU
- Alymsys (Mabxience Amneal): approval in US and EU
- Abevmy/Lextemy (Biocon/Mylan): approval in EU, approval in progress in
US
- Oyavas (STADA Arzneimittel AG): approval in EU
- FKB238 (Centus Biotherapeutics Limited): approval in EU
⑦ Competitive - BAT1706 (Bio-Thera/Sandoz): approval in progress in US and EU
product - CT-P15 (Celltrion): approval in progress in US, EU, and KR

※ The development progress of competitive products has been


investigated and described based on externally disclosed information and
may differ from the actual R&D situation. In addition, there may be
competing products that are not known externally or are in the early stages
of development other than the products described above.
1. A phase III, randomized, double-blind, multicenter study to compare the
efficacy, safe
ty, pharmacokinetics, and immunogenicity between SB8 (proposed
bevacizumab biosimi
lar) and reference bevacizumab in patients with metastatic or recurrent
nonsquamous no
n-small cell lung cancer (Lung Cancer, Published Aug 2020)
⑧ Related Thesis 2. Study comparing sb8 (bevacizumab biosimilar) with reference
bevacizumab in healthy
volunteers (Cancer Chemother Pharmacol., Published Oct 2020)
3. Evaluation of the Physico-Chemical and Biological Stability of SB8
(Aybintio), a Pro
posed Biosimilar to Bevacizumab, Under Ambient and In-Use Conditions
(Adv. Ther., P
ublished Oct 2020)
Global sales in Bevacizumab of USD 4,630 million in 2021 (Evaluate
⑨ Market size
pharma)
⑩ Others -
(6) Product : SB11

① Product type Biosimilar


② Application macular degeneration
③ Mechanism of Combining with vascular endothelial growth factor (VEGF) inhibits abnormal
action production of new blood vessels
④ Product
Ranibizumab (Lucentis) biosimilar
specifications
Global clinical completion in 2020
Sales approval in US/Europe(FDA/EMA) in 2021
④ Progress
Sales approval in Korea(MFDS) in 2022
Available for sale in US in 2022
Expansion of sales in approved countries and commercialization after
⑥ Future plan
approval of new formulations
- FYB-201 (Formycon/Bioeq) : approval in progress in US and EU, approval
in UK
⑦ Competitive
- Xlucane (Xbrane/STADA) : approval in progress in EU
product - LUBT010 (Lupin): phase 3 in progress
- CKD-701 (Chong Kun Dang): approval in progress in Korea
- Efficacy and Safety of a Proposed Ranibizumab Biosimilar Product vs a
Reference Ranibizumab Product for Patients
With Neovascular Age-Related Macular Degeneration: A Randomized
Clinical Trial (JAMA Ophthamol. Nov 2020)
- Biosimilar SB11 versus reference ranibizumab in neovascular age-related
macular degeneration: 1-year phase III
randomised clinical trial outcomes (Br J Ophthamol. Oct 2021)
⑧ Related Thesis - Evaluation of the Structural, Physicochemical, and Biological
Characteristics of SB11, as Lucentis® (Ranibizumab)
Biosimilar (Ophthamol Ther. Jan 2022)
- 2022 ASRS(American Society of Retina Specialist) the presentation of an
academic conference
- 2022 KRS(The Korean Retina Society) Summer Symposium Presentation
- 2022 AAO(American Academy of Ophthalmology) an academic
presentation
Global sales of Lucentis (ranibizumab) of USD 3,641 million in 2021
⑨ Market size
(Roche/Norvatis Annual Report)
⑩ Others -

(7) Product : SB12

① Product type Biosimilar


② Application Paroxysmal nocturnal hemoglobinura and 3 cases
② Mechanism of A drug that directly inhibits the complement (C5) acting on the hemolytic
action mechanism
④ Product
Eculizumab (Soliris) biosimilar
specifications
⑤ Progress Completed clinical trial phase 3 in 2021
⑥ Future plan Sales approval in US and Europe

⑦ Competitive - Alexion : Soliris


product - Amgen : ABP959

A Phase III Randomized Clinical Trial Comparing SB12 (Proposed


⑧ Related Thesis
Eculizumab Biosimilar)
With Reference Eculizumab in Patients with Paroxysmal Nocturnal
Hemoglobinuria (2022 EHA Annual congress, 2022)

⑨ Market size USD 4.1 billion in 2021 (Evaluate pharma)


⑩ Others -

(8) Product : SB15

① Product type Biosimilar


Treatment of neovascular(wet) age-related macular degeneration
Treatment of visual impairment due to retinal vein occlusive macular edema
(central retinal vein occlusion or branch retinal vein occlusion)
② Application
Treatment of visual impairment due to diabetic macular edema
Treatment of visual impairment due to choroidal neovascularization due to
pathologic myopia
③ Mechanism of Inhibits neovascularization in the choroid by binding to vascular endothelial
action growth factors (VEGFs)
④ Product
Aflibercept (Eylea) biosimilar
specifications
⑤ Progress Completed clinical trial phase 3 in 2022
⑥ Future plan Plan to apply for global application approval
- MYL-1701P (Biocon) : approval in progress in US
- SCD411 (Sam Chun Dang Pharm) : phase 3 in progress globally
⑦ Competitive
- ABP-938 (Amgen) : phase 3 in progress globally
product - CT-P42 (Celltion) : phase 3 in progress globally
- Lucentice (Novartis, Genentech)
⑧ Related Thesis -
Global revenue of Eylea (Aflibercept) in 2021: USD 9,385 Million
⑨ Market size
(From Regeneron Annual Report)
⑩ Others -

(9) Product : SB16

① Product type Biosimilar


② Application Osteonecrosis
③ Mechanism of By combining with RANKL(Receptor Activator of Nuclear factor Kappa-B
action Ligand), inhibits RANKL from binding to RANK
④ Product
Denosumab (Prolia/Xgeva) biosimilar
specifications
⑤ Progress Clinical trial phase 1 and 3 in progress
⑥ Future plan Plan to apply for global approval after clinical completion
- GP-2411 (Sandoz) : phase 3 in progress
- CT-P41 (Celltrion) : Phase 3 in progress
- TVB-009 (TEVA) : Phase 3 in progress
- FKS-518 (Fresenius Kabi) : Phase 3 in progress
- EB-1001/JHL-1266 (Eden Biologics / JHL Biotech) : Phase 3 in progress
- RGB-14-P (Hikma / Gedeon Richter): Phase 3 in progress
- MB-09 (mAbxience) : Phase 3 in progress
⑦ Competitive - HLX12 (Henlius) : Phase 3 in progress
product - Bmab 100 (Biocon) : Phase 3 in progress

※ The development progress of competitive products has been


investigated and described based on externally disclosed information and
may differ from the actual R&D situation. In addition, there may be
competing products that are not known externally or are in the early stages
of development other than the products described above.

⑧ Related Thesis -

⑨ Market size Global revenue of Prolia (Denosumab) in 2021 : USD 3,248 million
⑩ Others -

(10) Product : SB17

① Product type Biosimilar


Plaque psoriasis
Psoriatic arthritis
② Application Crohn's disease
Ulcerative colitis
Pediatric plaque psoriasis
③ Mechanism of
Inhibition of inflammation through interleukin (IL-12/23) binding
action
④ Product
Ustekinumab (Stelara) biosimilar
specifications
⑤ Progress Clinical trial phase 1 and 3 in progress
⑥ Future plan Plan to apply for global approval after clinical completion
- ABP654 (Amgen): Phase 3 in progress
- CT-P43 (Celltrion): Phase 3 in progress
- AVT04 (Alvotech): Phase 3 in progress
- DMB-3115 (DM Bio): Phase 3 in progress
- FYB-202 (Formycon AG): Phase 3 in progress
- BAT-2206 (Bio-Thera): Phase 3 in progress
- Bmab1200 (Biocon): Phase 3 in progress
⑦ Competitive - Neulara (Neuclone): Phase 1 in progress
product - BFI-751 (Biofactura): Phase 1 in progress

※ The development progress of competitive products has been


investigated and described based on externally disclosed information and
may differ from the actual R&D situation.
※ There may be competing products in the early stages of development
that are not known externally other than the products described above.
⑧ Related Thesis -
Global revenue of Stelara (Ustekinumab) in 2021 : USD 9,134 million
⑨ Market size
(Johnson & Johnson Annual
⑩ Others -

(11) Product : SB26

① Product type New biological drug


② Application Acute pancreatitis
③ Mechanism of Inhibition of inflammation through inhibition of human trypsin and other
action serine proteases
④ Product Fc-fusion recombinant protein infused with human ulinstatin and antibody
specifications Fc (Ulinastatin-Fc)
⑤ Progress Completed clinical trial phase 1 (2018-2020)
⑥ Future plan Future development strategy to be determined by checking the market and
competitive situation
⑦ Competitive
No products approved for acute pancreatitis in the US/EU
product
⑧ Related Thesis -
⑨ Market size Acute pancreatitis global market estimated to be KRW 5 trillion
(Biospectator)
⑩ Others -
[Confirmation by Expert]

1. Confirmation by Expert
- Not applicable

2. Expert’s Relations
- Not applicable

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