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Abstract
PURPOSE: To investigate the incidence of drug-induced hepatotoxicity(DIH) caused by anti-
tuberculosis drugs and to identify the association of DIH and serum drug concentrations.
RESULTS: Between June 2006 and February 2010, 195 patients in one tertiary hospital were
included in the analysis. The median age of 195 patients (men 60%) was 46 (range 16-92 yrs
old). Bacteriologically confirmed pulmonary tuberculosis (TB) was diagnosed in 59% of
patients and positive nontuberculous mycobacteria culture with or without TB were observed
in 13.8%. Of the 195 patients, 19 (9.7%) experienced hepatotoxicity. Mean AST/ALT level of
hepatotoxicity group was 245/244 respectively. Among 19 patients, eight patients showed
pyrazinamide related hepatotoxcicity and nine patients experienced INH or RMP related
hepatotoxicity and two subjects did not have anti-TB drug related event. However serum
levels of four anti-TB drugs did not differ statistically between hepatotoxicity group and no-
hepatotoxicity group. Age, sex, past history of TB, body mass index(BMI) also did not show
statistical difference.
CONCLUSIONS: There were relatively small number of patients whose drug level exceeds
reference range and their serum drug level did not show relevance to DIH.
DISCLOSURE: The following authors have nothing to disclose: Ina Jeong, Junghan Song,
Ho Il Yoon, Choon-Taek Lee, Jae-Ho Lee
09:00 AM - 10:00 AM