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INVITED REVIEW

Lung Ultrasound for Critical Care Physiotherapists: A


Narrative Review
Maja Leech1*, Bernie Bissett1,2, Marta Kot3 & George Ntoumenopoulos4
1
Physiotherapy Department, Canberra Hospital, Garran, Australian Capital Territory, Australia
2
Discipline of Physiotherapy, University of Canberra, Bruce, Australian Capital Territory, Australia
3
Intensive Care Unit, Canberra Hospital, Garran, Australian Capital Territory, Australia
4
Australian Catholic University, Sydney, New South Wales, Australia

Abstract

Background. In critical care, part of the physiotherapist’s respiratory assessment aims to identify parenchymal
pulmonary pathology, which may be amenable to respiratory physiotherapy. In addition to clinical assessment,
the tools that are most readily available to the respiratory physiotherapist to distinguish between acute pulmonary
pathologies include auscultation and chest Xray. The limited diagnostic accuracy of these tools may not allow for
the accurate differentiation between conditions such as lung collapse, consolidation and pleural effusion. Although
computed tomography allows for this differentiation, it requires patient transport and exposes the patient to
increased risk and high levels of radiation. Diagnostic lung ultrasound (LUS) has emerged as a highly sensitive
bedside diagnostic tool with high level evidence to support its use for the differentiation of various common acute
pulmonary pathologies. In this review, the diagnostic performances of auscultation, chest Xray and LUS are
reviewed, and the usefulness of LUS as an adjunct to respiratory physiotherapy assessment is discussed. The issues
surrounding training physiotherapists and the implementation of LUS are also explored. Methods. The method
used is a narrative review of the literature. Conclusion. To our knowledge, LUS is not routinely utilized by critical
care physiotherapists. However, its superior sensitivity and specificity would enable the physiotherapist to make an
accurate, timely and point of care diagnosis of lung pathology and determine whether the pathology is amenable to
respiratory physiotherapy. Copyright © 2014 John Wiley & Sons, Ltd.

Received 7 May 2014; Revised 4 September 2014; Accepted 23 September 2014

Keywords
chest ultrasonography; critical care; diagnostic accuracy; lung ultrasound; physiotherapy

*Correspondence
Maja Leech, Physiotherapy Department, Canberra Hospital, Garran, Australian Capital Territory, Australia.
Email: Maja.Leech@act.gov.au

Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/pri.1607

Introduction care unit (ICU) length of stay (Stiller, 2013). The more
The outcome measures used by physiotherapists in criti- recent incorporation of evidence-based clinical manage-
cal care often focus on short-term, global measures of re- ment algorithms for the detection and management of
spiratory physiology (e.g. lung/thoracic compliance) and pulmonary dysfunction by physiotherapists (Hanekom
do not incorporate major patient outcomes (Hanekom et al., 2011) results in the more consistent application
et al., 2007). There is conflicting evidence on the impact of interventions in critical care by physiotherapists with
of chest physiotherapy on major patient outcomes such improvements in patient outcomes (Hanekom et al.,
as mortality, time on mechanical ventilation or intensive 2012). However, physiotherapists within critical care

Physiother. Res. Int. (2014) © 2014 John Wiley & Sons, Ltd.
LUS for Critical Care Physiotherapists M. Leech et al.

can further enhance respiratory management through interventions. It is immediately available, free and
more accurate identification of acute parenchymal poses minimal discomfort to patients. The subjective
pulmonary pathology that may be more amenable to nature of the tool, however, has lead to the questioning
respiratory physiotherapy. of the accuracy and reliability of the physiotherapist’s
The accuracy of the physiotherapist’s clinical impres- interpretation of normal and abnormal lung sounds.
sion and diagnosis of acute pulmonary pathology, In studies of experienced cardiorespiratory physio-
typically formed on the basis of clinical assessment, lung therapists, accuracy in interpreting tape-recorded lung
auscultation and chest x-ray (CXR) interpretation within sounds was found to be as low as 39.2% (Allingame
critical care is unknown. The limited diagnostic accuracy et al., 1995). Furthermore, intra-rater reliability of
of some of these tools, especially in the critically ill auscultation was poor (28%), and somewhat surpris-
patient, may not allow for accurate differentiation ingly, increased years of clinical experience did not
between conditions such as lung collapse, consolidation correlate with increased reliability. Studies using
and pleural effusion. This lack of diagnostic accuracy teaching stethoscopes (Brooks and Thomas, 1995)
raises important questions about whether treatments also reported low inter-rater reliability for the inter-
are appropriate and effective and may clarify the findings pretation of lung sounds (kappa 0.02 to 0.59).
of earlier physiotherapy trials where both the inclusion Poor diagnostic accuracy and reliability of lung aus-
and outcome criteria were based on CXR outcome alone cultation have been demonstrated in other health
(Stiller et al., 1990; Stiller et al., 1996). professionals, indicating that the limitations of ausculta-
There is increasing high level evidence to support the tion are not unique to physiotherapists. In a study of
use of diagnostic lung ultrasound (LUS), as practised by medical staff, Lichtenstein et al (2004a) compared lung
bedside medical staff, to either supplement or as an al- auscultation findings with computed tomography
ternative to CXR within critical care. This shift is due (CT) results and reported relatively low accuracy of
to the emerging evidence of the superior diagnostic ac- auscultation in identifying pleural effusion, alveolar
curacy of LUS to differentiate between pleural, alveolar consolidation and alveolar interstitial syndrome
and interstitial pathologies and provide information on (61%, 36% and 55%, respectively). In a study of inter-
diaphragmatic movement at the bedside, in real time nal medicine registrars in the emergency department,
and with no ionising radiation exposure. Critical care the addition of lung auscultation to their subjective
physiotherapists need to rapidly determine whether history taking only improved their diagnosis in 1% of
pathology is amenable to physiotherapy intervention patients and actually worsened it in 2.8% (Leuppi
(e.g. lung collapse) and whether physiotherapy interven- et al., 2005).
tions have been effective (e.g. hyperinflation techniques). Given the limitations of auscultation, it is not
Until now, physiotherapy assessment has relied on tools, surprising that physiotherapists also rely on other mea-
including auscultation and CXRs. Bedsides, LUS is a por- sures to evaluate the indications for treatment and effect
table, accurate, non-invasive adjunct to physiotherapy of treatments (e.g. clinical examination, SpO2 levels, ar-
assessment, facilitating timely diagnosis and treatment terial blood gases and CXRs). Unfortunately, these tools
evaluation without exposure to ionising radiation. To also have issues with sensitivity and timeliness, which
our knowledge, LUS is not yet commonly used by phys- may further cloud the physiotherapist’s interpretation
iotherapists, but its utility outside of medicine warrants of indications for treatment and treatment efficacy. Al-
further exploration. The aim of this review is to appraise though auscultation may be immediately available and
the diagnostic performances of auscultation, CXR and low cost, its lack of diagnostic accuracy, coupled with
LUS on parenchymal and pleural pathologies and to its low inter-rater reliability, beckons the need for a
explore the issues surrounding the implementation of more accurate and reliable assessment tool.
LUS into physiotherapy practice.

Chest x-ray
Auscultation There are several issues with the physiotherapist’s reli-
Lung auscultation is routinely used by physiotherapists ance on the portable CXR to detect and monitor acute
to assess the respiratory status of patients and as an pulmonary pathology. First, the routine daily CXR is
outcome measure to monitor the effectiveness of no longer the norm for intensive care (Lakhal et al.,

Physiother. Res. Int. (2014) © 2014 John Wiley & Sons, Ltd.
M. Leech et al. LUS for Critical Care Physiotherapists

2012), but even in ICUs where daily CXR remains The diagnostic limitations of CXR may also clarify
common, these images may not be taken at the time the findings of previous studies of the effects of physio-
of the physiotherapist’s clinical assessment and in- therapy in intensive care patients. For example, the
tervention. The physiotherapist’s focus on pathology identification of lung pathology such as acute lobar col-
identified during the ‘real-time’ imaging of the por- lapse and the expected improvements with lung re-
table CXR requires the unrealistic assumption that cruitment may differ depending upon the diagnostic
the pathology has remained static. Thus, if interven- tool used (e.g. CXR vs. LUS). Hence, with previous re-
tion is based in part on the most recent CXR im- search, the inclusion criterion of CXR diagnosis of lo-
ages, the physiotherapist may erroneously attempt bar collapse may have also inadvertently included
to treat pathologies, which have either spontane- patients with pleural effusions, which are not amenable
ously resolved, may not require physiotherapy or in- to physiotherapy intervention. This limitation may in
advertently fail to treat newly developed areas of part explain the lack or delays of improvement ob-
lung collapse. served with some patients (Stiller et al., 1996).
Second, and more importantly, the portable CXR The diagnostic and practical limitations of both por-
has limited diagnostic accuracy for the detection of table CXR and auscultation bring us to the evolution of
common lung pathology in the intubated and mechan- a new diagnostic tool for critical care physiotherapists.
ically ventilated patient when compared with CT and Although diagnostic ultrasound is not new to the
indeed real-time LUS. A summary of the diagnostic physiotherapy profession (Mckiernan et al., 2010), to
performance of CXR compared with CT in the ICU is the best of our knowledge, it is not routinely utilized
presented in Table 1. The sensitivity and specificity of by physiotherapists to examine the pleura and lungs
CXR compared with CT scan averaged 42% and 89% in the critical care setting.
to detect pleural effusion, 53% and 90% to detect inter-
stitial syndrome, 53% and 90% to detect lung consoli-
dation, 32% and 93% to detect lung contusion and Overview of lung ultrasound
50% and 99% to detect pneumothorax, respectively. The application of ultrasound to the lung is relatively
Third, the clinician’s reliance on the portable CXR re- new within the medical profession. It was previously
quires patients to be exposed to significant amounts thought that air, which cannot be visualized by ultra-
of radiation, with cumulative effects likely for long-stay sound, was an obstacle to the attainment of meaningful
intensive care patients. The benefit of a relatively blunt images. It is now widely accepted that the artefacts,
and time-delayed diagnostic instrument must be which are produced by the intimate relationship be-
weighed against the risk of cumulative radiation tween air and water in the tissues, pleural spaces and
exposure. lung itself are consistent and interpretable

Table 1. Diagnostic performance of CXR when compared with CT in ICU

Sensitivity (%) Specificity (%) Reference

Pleural effusion 23–42 94–97 (Rocco et al., 2008)


65 81 (Xirouchaki et al., 2011)
39 85 (Lichtenstein et al., 2004a)
Interstitial syndrome 46 80 (Xirouchaki et al., 2011)
60 100 (Lichtenstein et al., 2004a)
Lung consolidation 38 89 (Xirouchaki et al., 2011)
68 95 (Lichtenstein et al., 2004a)
Contusion 24–39 89–96 (Rocco et al., 2008)
Pneumothorax 50.2 99.4 (Alrajhi et al., 2012) ■ ♦
(95 CI, 43.5–57.0) (95 CI, 98.3–99.8)
0 99 (Xirouchaki et al., 2011)

indicates meta-analysis.

indicates CT or air release on chest tube insertion used as reference standard.
CXR, chest x-ray; CT, computed tomography; ICU, intensive care unit; CI, confidence interval.

Physiother. Res. Int. (2014) © 2014 John Wiley & Sons, Ltd.
LUS for Critical Care Physiotherapists M. Leech et al.

(Lichtenstein, 2007; Volpicelli, 2013). Comprehensive Furthermore, LUS does not emit any ionising radia-
descriptions of these artefacts (or ‘signs’) and the tion and does not require patient transport to CT
pathology they represent are available elsewhere which is not always appropriate in a critically ill,
(Lichtenstein, 2007; Nalos et al., 2010). deteriorating patient. Table 3 compares the methods
There is considerable and mounting evidence from that are available to critical care physiotherapists,
the medical literature to support both the diagnostic including beside availability.
superiority and feasibility of LUS. LUS has been found Although there are occasions when LUS is techni-
to have both high sensitivity and specificity in diagnos- cally difficult or impossible (for example, due to mor-
ing common pulmonary pathology within the critical bid obesity, over burns, dressings or subcutaneous
care setting. The diagnostic performances of LUS when emphysema), in the majority of patients, the physio-
compared with CT in the ICU are summarized in therapist could readily use LUS to identify appropriate
Table 2. The sensitivity and specificity of LUS com- pathology and hence guide the treatment approach. In
pared with CT averaged 94% and 97% to detect pleural cases where acute pulmonary oedema (APO), pleural
effusion, 96% and 91% to detect interstitial syndrome, effusion or pneumothorax is detected, the physiothera-
94% and 92% to lung consolidation, 88% and 93% to pist could use LUS to rapidly ascertain that physiother-
detect lung contusion and 83% and 96% to detect apy is likely to be fruitless and also direct further
pneumothorax, respectively. medical evaluation. Conversely, in cases where lung
In addition to increased accuracy, LUS has many collapse may be recruitable, the physiotherapist could
other advantages as an assessment and monitoring deliver a more appropriate ‘real-time’ monitored treat-
tool. Arguably, the greatest advantage of LUS is that ment thereby directly influencing physiotherapy
it can be used at the bedside and provides real-time management.
feedback to the operator and the patient. This means
that the critical care physiotherapist can monitor be-
fore, during and after their intervention to see whether Training and competence in LUS
manual or ventilator lung hyperinflation, for example, Many of the studies assessing diagnostic accuracy utilize
is successful in re-expanding a collapsed lung (Cavaliere experienced or expert physician sonographers. While
et al., 2011). LUS may be used as visual feedback during there is some attempt to standardize the skills required
deep breathing, for example, to facilitate greater to achieve competence in LUS amongst critical care
diaphragmatic movement (Yamaguti et al., 2010). physicians (Mayo et al., 2009) and the standards by

Table 2. Diagnostic performance of LUS compared with CT or other valid reference standard in ICU

Sensitivity (%) Specificity (%) Reference

Pleural effusion 92–94 95–99 (Rocco et al., 2008)


■ ●
93 96 (Grimberg et al., 2010)
(95 CI, 89–96) (95 CI, 95–98)
100 100 (Xirouchaki et al., 2011)
92 93 (Lichtenstein et al., 2004a)
Interstitial syndrome 94 93 (Xirouchaki et al., 2011)
98 88 (Lichtenstein et al., 2004a)
Lung consolidation 90 98 (Lichtenstein et al., 2004b)
100 78 (Xirouchaki et al., 2011)
93 100 (Lichtenstein et al., 2004a)
Contusion 86–89 89–97 (Rocco et al., 2008)
Pneumothorax 90.9 98.2 (Alrajhi et al., 2012) ■ ♦
(95 CI, 86.5–93.9) (95 CI, 97.0–99.0)
75 93 (Xirouchaki et al., 2011)

indicates meta-analysis;

indicates CT or air release on chest tube insertion used as reference standard;

indicates CT or thoracic drainage used as reference standard.
LUS, lung ultrasound; CT, computed tomography; ICU, intensive care unit; CI, confidence interval.

Physiother. Res. Int. (2014) © 2014 John Wiley & Sons, Ltd.
M. Leech et al. LUS for Critical Care Physiotherapists

Table 3. Comparison of diagnostic and evaluation methods for physiotherapists in critical care

Formal imaging

Diagnostic methods Auscultation CXR CT LUS

Immediately available as an adjunct to physiotherapy at the bedside + +


Repeatable pre-physiotherapy and post-physiotherapy treatments + +
Real-time feedback during physiotherapy assessment + +++
Radiation exposure + +++
Requires transport of patient +/ +++
Training required (to perform) + N/A N/A +++
Training required (to interpret) + + +++ +++
Diagnostic accuracy (see also Tables 1 and 2) + + +++ +++

CXR, chest x-ray; CT, computed tomography; LUS, lung ultrasound.

which they are trained (Cholley et al., 2011), the To prevent this in critical care, physiotherapist LUS
timeframes required to achieve competence are less training should follow an established pathway with
clear. It has been suggested that at least 100 chest ultra- pre-determined skills required to attain competence.
sound procedures (Reissig et al., 2012) or 3 months of For bedside LUS to be useful to the critical care physio-
supervised practise (Tutino et al., 2010) is required for therapist and safe for the patient, the identification of
competence, while others suggest that if ‘several’ ultra- and differentiation between pneumothorax, pleural ef-
sound procedures are done daily, competence in identi- fusion, lung consolidation, lung collapse and alveolar
fying pleural effusion, lung consolidation and alveolar interstitial syndrome should be the primary focus of
interstitial syndrome can be achieved within 6 weeks training. Further, clarification around robust clinical
(Bouhemad et al., 2007). Tutino et al. (2010) suggest processes for image acquisition, storing, reporting,
that 7 months may be needed to achieve adequate skills auditing and sharing would also need to be addressed,
to accurately report on LUS imaging. As LUS is utilized as would the scope of practice challenge that LUS would
in various clinical settings (e.g. critical care, emergency provide to existing governance structures. For example,
department, outpatient clinics and operating theatres), if the physiotherapist identified an acute pulmonary
the obvious differences in the approach, techniques uti- condition that may require urgent medical
lized and nomenclature adopted have prompted a re- attention/intervention such as a pneumothorax or sig-
cent consensus process (Volpicelli et al., 2012). The nificant pleural effusion, then either follow-up imaging
aim was to elaborate a unified approach and language by a radiologist or trained sonographer may be required
for six major areas, including terminology, technology, during training, until an appropriate level of agreed
technique, clinical outcomes, cost effectiveness and fu- competency has been established. In the long term,
ture research. These international recommendations however, in order for LUS to be a feasible option in
will prove to be an essential template and standard for the high-demand setting of an ICU, physiotherapists
physiotherapy to adopt when developing and instituting will need to become independent operators of LUS.
LUS as part of routine clinical management within the
critical care setting.
As LUS is not routinely used by physiotherapists to Discussion
assess the lungs, the level of training and the timeframe Critical care physiotherapists may currently use combi-
required for critical care physiotherapists to reach com- nations of clinical examination, auscultation and CXR
petence are unknown. In other areas of physiotherapy interpretation to form a diagnosis of a patient’s respira-
utilizing ultrasound, it has been identified that there is tory pathology and to evaluate treatment effectiveness.
no standard training required or developed. Subse- As described earlier, these tools are limited by low diag-
quently, the areas covered in formal and informal train- nostic accuracy, timeliness and poor inter-rater reliabil-
ing packages are variable and can omit important ity. Therefore, the true effectiveness of physiotherapy
content (Potter et al., 2012) leading to operators with treatment in critical care settings could be either
variable skills in image acquisition and interpretation. under-estimated or over-estimated, potentially leading

Physiother. Res. Int. (2014) © 2014 John Wiley & Sons, Ltd.
LUS for Critical Care Physiotherapists M. Leech et al.

to excessive or inadequate treatment. In contrast, LUS will be more influential on some of the key lung pa-
offers significant advantages over both auscultation thologies and then may be seen to impact on major pa-
and CXR as a real-time assessment and monitoring tool. tient outcomes such as mortality, time on mechanical
These advantages include immediate bedside availabil- ventilation or ICU length of stay.
ity, low radiation exposure and superior diagnostic ac- LUS has already been shown to directly influence
curacy. High-quality ultrasound machines may be ICU medical management. Recently, Xirouchaki et al.
commonly available in tertiary ICUs for use by physi- (2014) investigated the impact of LUS on medical
cians associated with invasive or diagnostic procedures, decision-making in ICU. In their study, LUSs were or-
therefore, the use of LUS by critical care physiothera- dered in direct response to clinical questions of
pists may be feasible. suspected pulmonary pathology (pneumothorax,
As pleural and lung pathology can be clearly pleural effusion, consolidation/atelectasis, pneumonia
visualised with LUS, it would be most beneficial in cases or pulmonary oedema) or in the case of unexplained
where the patient’s main clinical problem is unclear. On and persistent deterioration of arterial blood gases. In
the basis of our experience, we suggest using LUS to an- all but one of the 253 LUS studies in which pathology
swer a focused clinical question to guide specific man- was identified, 69.7% of these supported the primary
agement: ‘is the lung recruitable?’, ‘how much of the physicians’ clinical suspicion and 21% revealed pa-
opacity observed on the CXR is the result of a pleural ef- thology that was not originally suspected. CT scans
fusion?’ In these cases, LUS has the potential to influ- were ordered in only seven cases to assist the
ence physiotherapy treatment. For example, significant decision-making process, the results of which con-
sputum retention and APO can sound similar on aus- firmed LUS findings and did not initiate any further
cultation, and in both cases, clinical assessment can re- changes to management. At no point was a CXR or-
veal increased work of breathing and a moist cough. If dered to assist decision-making. Overall, invasive or
APO is suspected, the morning CXR is likely to be of lit- non-invasive ICU management was changed directly
tle use to the physiotherapist given the speed at which it as a result of the LUS imaging in 47% of cases, and
can develop and the static nature of a CXR. If LUS was the net reclassification improvement was calculated
used in this example to answer the clinical question: ‘is to be 85.6%, indicating that LUS had significant thera-
there evidence of retained secretions?’, a focused ultra- peutic impact by influencing the decision-making pro-
sound assessment would reveal two very distinct pat- cess in ICU. This study was the first of its kind to
terns: diffuse B-lines in the case of APO and dynamic demonstrate the usefulness of LUS as an assessment
air-bronchograms in the case of sputum retention. This and monitoring tool in the medical field. Because of
differentiation would allow the physiotherapist to con- the mounting evidence of the greater diagnostic per-
fidently suspect one diagnosis over the other, thereby formance of LUS compared with CXR, it is not sur-
directing the physiotherapist to the most effective prising then that daily CXRs are no longer ordered in
treatment. some ICUs (Lakhal et al., 2012).
In the case of more than one pathology being pres- Interestingly in the study by Xirouchaki et al. (2014),
ent, for example, collapse with concomitant pleural ef- one of the non-invasive treatments initiated by the pri-
fusion, the physiotherapist could use LUS to evaluate mary physician in response to LUS findings was referral
whether lung recruitment techniques or patient mobi- to physiotherapy. This begs the question why physio-
lization is effective in re-expanding the collapsed lung therapists themselves are not using LUS to identify
despite the presence of the pleural effusion. This imme- whether respiratory physiotherapy could be of benefit
diate visual feedback would steer the physiotherapist in the critically ill patient. As critical care physiothera-
towards ongoing treatment if the collapsed segment is pists, we do not develop skills in LUS, we risk
recruitable. Conversely, if the physiotherapist is unable compromising our clinical decisions and becoming
to see lung recruitment in this instance, treatment of once again reliant on medical staff for direction and in-
the collapse could be suspended and treatment terpretation of medical tests. Given physiotherapists’
redirected to the patient’s other amenable problems, comprehensive knowledge of anatomy and physiology,
thereby increasing the efficiency of the physiotherapy the addition of LUS to the physiotherapy skill repertoire
session. With such a powerful diagnostic and monitor- appears to us to be the ideal evolution of the critical care
ing tool influencing treatment, perhaps physiotherapy physiotherapy role.

Physiother. Res. Int. (2014) © 2014 John Wiley & Sons, Ltd.
M. Leech et al. LUS for Critical Care Physiotherapists

While there is mounting evidence that the diagnostic for training, documentation and clinical governance
accuracy of LUS is superior to auscultation and CXR, need to be further explored before LUS could be
what is unclear is the applicability of this increased ac- implemented by physiotherapists more widely. Future
curacy to critical care physiotherapists and the content studies should explore the training requirements for
and level of training required to ensure physiothera- critical care physiotherapists to achieve competence in
pists reach this level of accuracy. The recent consensus LUS with a view to embedding it within physiotherapy
statement by Volpicelli et al. (2012) stated that ultra- practice within critical care. In addition, the utility of
sound diagnosis of lung consolidation and interstitial LUS as a research tool for evaluation of acute pulmo-
syndrome may be considered as a basic technique with nary pathology amenable to physiotherapy (such as
a steep learning curve. It has also been suggested that acute lobar collapse) needs to be further explored.
the detection of pleural effusion is basic and may be ac-
quired in minutes improving with experience (Doelken Conflict of interest
and Strange, 2003). However, given the novelty of LUS The authors declare no conflict of interest.
for physiotherapists, and the absence of a specific train-
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