Neil Antony Verner-Amyotrophic Lateral Sclerosis-

(UK)

The third round of

treatment:

Name: Neil Antony Verner

Sex: Male
Nationality: UK
Age: 52Y
Diagnosis: Motor Neuron
Disease
Discharge Date: 2019/08/13

Before treatment:
Four years ago the patient began to develop weakness of the
right leg without obvious inducement and his running was
affected. Three years ago his arms were weak and the weight
loss was obvious. In October 2016 he was diagnosed as having
"motor neuron disease" and was given "riluzole" orally. After
taking the drug his limbs were stiff and difficult to move so the
drug was stopped. The patient's condition continued to
progress, muscle bundle tremor, the strength of both arms
decreased obviously, his balance ability decreased, it was
difficult to go down the stairs and he needed assistance. After
that the patient came to our hospital twice for treatment and
there was a certain improvement of motor function after each
treatment. The progression of the disease was significantly
slower than before. Four months ago his condition progressed
again, he began choking and coughing when drinking water,
there was a weakening of the muscle strength in the proximal
end of both arms, he was unable to lift things and his lifestyle
relied on the help of his family.
The patient has a good mental appetite, poor sleep,
constipation with one defecation in 3-4 days and normal
urination.

Admission PE:
Bp: 129/89mmHg, Hr: 76/min, breathing rate: 19/min, body
temperature: 36.1 degrees. The patient had normal physical
development and good nutrition.. There is no injury or bleeding
spots of his skin and mucosa and no cyanosis around the lips.
He had a symmetrical chest, clear sounds of both lungs, no dry
or moist rales were heard, no bulge of the precordia, strong
heartbeat, regular heart rhythm and no murmur was heard in the
valves. He had a flat abdomen, no masses or tenderness,
normal spleen and liver, negative shifting dullness, normal
spinal column and no edema of the legs.

Nervous System Examination:

The patient was alert, had good spirit, normal articulation, clear
speech, normal memory, calculation and coordination. Both
pupils were round and equal in size, with a diameter of 3 mm
and reacting sensitively to light. He had free eyeball movement,
no nystagmus, symmetrical forehead wrinkle and nasolabial
fold, the tongue was in the middle when extended and there
was no deviation when showing his teeth. He had flexible
tongue muscle movement, normal cheek-bulging, chewing, soft
palate-lifting bilaterally and the uvula was in the middle. He had
a soft neck and flexible neck-turning movement. There was
obvious muscle atrophy of the interosseous muscle of both
hands, the thenar muscles, supraspinatus muscle, infraspinatus
muscle and the deltoid muscle. The 4 limbs muscle volume was
not strong. The left arm proximal abductor muscle power was 2
degrees; adductor and distal side abductor and adductor muscle
power were 3- degrees. The right arm proximal side abductor
muscle power was 2 degrees, adductor and distal side abductor,
adductor muscle power were 3- degrees. Bilateral gripping
power was 4- degrees. Bilateral leg muscle power was 4-
degrees. The 4 limbs muscle tone was normal. The tendon
reflex of the arms was not induced and it was normal in the
legs. Hoffmann sign of both sides were negative, the bilateral
palm-jaw reflex was positive and the Babinski sign of both sides
were negative. The finger to nose test of both sides cannot be
done. The both hands fast alternate movement was difficult,
finger opposite movement was slow, the heel-knee-tibia test
was stable and accurate. The meningeal irritation sign is
negative.

Treatment:
After the admission he received 3 nerve regeneration
treatments to repair his damaged nerves, replace dead nerves,
nourish nerves, improve body environment, regulate his immune
system and improve blood circulation. This was combined with
rehabilitation training.

Post-treatment:
After 10 days treatment his movement endurance got better, the
muscle power increased 20%, he could now raise his arms
higher and his limbs were more flexible. He could grasp easier
and his hands can do fine movement better. He now raised his
legs higher and faster and he could walk longer and better.

The second round of treatment:

Age: 49Y
Diagnosis: 1. Amyotrophic Lateral Sclerosis (ALS) 2.
Hypertension (1 degree)

Before treatment:
The patient felt right leg
weakness one and half years
ago and it was hard for him
to run. 15 months ago his
arms became weak and he
lost a lot of weight. He went
to a local hospital and was
diagnosed with ALS in
October 2016. He was prescribed Riluzole 50 mg. One month
later his disease progressed, he had muscular fasciculation and
right arm weakness. His balance function was bad 8 months
ago, it was hard for him to go down stairs and he needed help to
walk. He went to our hospital 6 months ago, his leg muscle
power was increased and he walked better. For now his arms
are weak, he needs help to go down stairs but he is able to take
care of himself sometimes.
His spirit and appetite are good, his sleep has not been very
good for a year. His urination and defecation functions are
basically normal. His swallowing function is good. He has
hypertension and takes medicines to control it.

Admission PE:
Bp: 130/90mmHg, Hr: 65/min, breathing rate: 19/min, body
temperature: 36.5 degrees. There is no injury or bleeding spots
of his skin and mucosa, no blausucht. The chest development is
normal, the respiratory sounds in both lungs were clear and
there was no dry or moist rales. The heart beat is powerful with
regular cardiac rhythm and no obvious murmur in the valves.
The abdomen was flat and soft with no masses or tenderness.
The liver and spleen were normal, shifting dullness is negative.
The spinal column is normal and there was no edema in either
leg.

Nervous System Examination:

Patient was alert and his mental status is good with clear
speech. His memory, orientation and calculation abilities were
normal . Both pupils were equal in size and round, diameter of 3
mm, react well to light and the eyeballs can move freely. There
was no nystagmus. Bilateral forehead wrinkle and nasolabial
fold are symmetrical and showing teeth is normal. His tongue is
in middle with no tongue muscle atrophy and he can move his
tongue freely. He can chew food and blow out the cheeks as
normal. Soft palate of both sides is normal, the uvula is in
normal position. Neck is soft and he can turn his neck freely.
There is obvious muscle atrophy of the interosseous muscle of
both hands, the thenar muscles, supraspinatus muscle and
deltoid muscle. The muscle volume of the four limbs is reduced.
Left arm proximal abductor muscle power was 3 degrees,
adductor and distal side abductor, adductor muscle power were
4- degrees, the right arm proximal side abductor muscle power
was 3 degrees, adductor and distal side abductor, adductor
muscle power were 4- degrees. Grip force of both hands were 4
degrees. The leg muscle power was 5- degrees. All 4 limbs
muscle tone were normal. The tendon reflex of the arms was
normal, of the legs was active. The bilateral ankle clonus were
positive, Hoffmann sign of both sides were positive. The
bilateral palm-jaw reflex were positive. The Babinski sign of both
sides were negative. The finger to nose test of both sides were
stable. The both hands fast alternate movement test results
were basically normal. Finger opposite movement was normal.
The heel-knee-tibia test was stable and accurate, the meningeal
irritation sign is negative.

Treatment:
After the admission he received related examinations and
received 3 times nerve regeneration treatment to repair his
damaged nerves, replace dead nerves, nourish nerves, regulate
his immune system and improve blood circulation. This was
done with rehabilitation training.

Post-treatment:
After 13 days treatment the patient's muscle fasciculation
reduced and the sport endurance is better. The arm muscle
power increased 10-20%, his limbs are more flexible and his
grip is improved. The muscle power of the legs also increased
and he walks better.

The first round of treatment:

Age: 49Y
Diagnosis: Amyotrophic
Lateral Sclerosis (ALS)

Before treatment:
Patient had no obvious
indication of the onset of right
lower limb weakness 1 year
ago but he was unable to run
well 9 months ago. The
upper limbs then appeared weaker and his weight dropped
significantly. He went to hospital and was diagnosed with
"amyotrophic lateral sclerosis" in October 2016. He was given
riluzole 50mg twice daily but after taking the pills he felt limb
stiffness and difficulty in movement so he stopped taking it. He
had muscle tremor, right arm strength decreased significantly,
his balance ability was bad and within three months it was
difficult for him to go down stairs without assistance. At present
the right arm strength of the patient is significantly reduced and
the strength of the other limbs are reduced. He has poor
balance, needs to be assisted going down stairs but he could
take care of himself mostly. He came to our hospital for further
treatment.
Patient has good spirit and appetite, he has had shallow sleep
patterns for nearly 4 months. It is easy for him to be woken up
and he doesn’t use any sleeping pills. He has normal urination
and defecation ability. He could swallow well and he has lost 10
kgs already.

Admission PE:
Bp: 126/89mmHg, Hr: 65/min, breathing rate: 19/min, body
temperature: 36 degrees. Nutrition status is good with normal
physical development. There is no injury or bleeding spots of his
skin and mucosa, no blausucht. The chest develop is normal,
the respiratory sounds in both lungs were clear, there was no
dry or moist rales. The heart beat is powerful with regular
cardiac rhythm and with no obvious murmur in the valves. The
abdomen was flat and soft, with no masses or tenderness. The
liver and spleen were normal, shifting dullness is negative. The
spinal column is normal, there was no edema in either leg.

Nervous System Examination:

Patient was alert and his mental status is good with clear
speech. His memory, orientation and calculation ability were
normal. Both pupils were equal in size and round, diameter of
3mm, react well to light, eyeballs can move freely. No
nystagmus. Bilateral forehead wrinkle and nasolabial fold are
symmetrical, showing of teeth is normal. His tongue is in the
middle and there is no tongue muscle atrophy, he can move his
tongue freely. He can chew food and blow out the cheek as
normal. Soft palate lift of both sides is normal, the uvula is in
normal position. Neck is soft and he can turn his neck freely.
There is obvious muscle atrophy of the interosseous muscle of
both hands and the thenar muscles. The muscle volume is not
very high. The muscle power of the left arm is 4 degrees, right
arm is 4- degrees, the grip force of both hands is 5- degrees,
muscle power of the legs is 5- degrees. Muscle tone of all 4
limbs is normal. The tendon reflex of the arms is normal, of the
legs is active. The bilateral ankle clonus were positive; the
Hoffman sign of both sides were positive; the Palm-jerk reflex of
both sides were positive; Babinski sign of both sides were
negative. Finger to nose test was stable and the patient can
perform the fast alternate movement as normal. Finger opposite
movement is normal. The bilateral Heel-knee-tibia test is stable,
the meningeal irritation sign is negative.

Treatment:
After the admission, he received related examinations and
diagnosed with ALS. He received 3 times nerve regeneration
treatment to repair his damaged nerves, replace dead nerves,
nourish nerves, regulate his immune system and improve blood
circulation. This was done with rehabilitation training.

Post-treatment:
After 14 days treatment he has better spirit and energy, muscle
fasciculation is reduced and physical endurance is better. The
muscle power of both arms is increased with the left arm
increased to level 4+ and the right side increased to level 4. He
can now walk longer distances.

E-mails:

Dear Dr. Wang

All my functions including height and weight remain constant,

Blood pressure is normal, occasionally slightly high but within

acceptable tolerance.

Recently I had blood tests and sent them to Evelyn, please

review, all were good but my CK was even higher, why would
that be?

My General strength is up, BUT MY SHOULDERS ARE

GETTING SIGNIFICANTLY WEAKER, please advise what I can
do immediately.

I do my exercise daily exactly as prescribed.

My oxygen saturation is between 98-99%

Please see my photo

Kind regards,

Neil

Date: 2019/9/13
Dear doctors

Something amazing is happening to me, My strength has

improved massively in my legs, my balance is significantly
better, my shoulders and arms have a little improvement, I have
never felt this level of improvement,

My question to you is how can I keep the improvement going? If

I came back to Wu Medical in a few months time and even
stayed for one month so I could get two rounds of IV medicine
would this help?

I would like to tell the world about my improvements, so anyone

suffering neurological conditions can benefit from the fantastic
service you provide.
Tomorrow I have my flu immunisation, and hopefully my blood
test results that I can provide you.

Once again thank you for everything you are doing to me.

Kind Regards

Dr. Neil Verner Ph.D.

Date: 2019/9/20
Dear Crystal

My strength and balance is still continuing to improve, so far I

would suggest I have a 25% increase in strength in my legs, my
core body strength is 10 of 15%, my shoulders and arms are
about 3 to 5% increase in strength. My balance is so much
better, my endurance has also increased about 50%.

Would it be possible for me to visit and stay with you on the 24th
of October to the 17th of November?

I want to increase my knowledge of occupational and

physiotherapy, I will also get more used to the sleeping patterns
and be able to concentrate much more on recovery.

Thank you for the birthday wishes

Kind Regards

Dr. Neil Verner Ph.D.

Date: 2019-12-12

Another customer for you, I hope you are well

I am booked in next week for full blood test, I will give you the
information. I am starting to feel much much better and stronger
day by day. I am using the breathing machine And my Oxygen
levels I’ve never fallen below 96% even at night

Kind Regards

Dr. Neil Verner Ph.D.

Date: 2020-4-13

Hi Dr Yang

I’m doing ok. As you imagine life is tough. I have one month
worth of medicine left and I have totally run out of
Monosialotetrahexosylganglioside for my IV infusions.

Are these something you could help us out with? It may be at

least 2 months until I can plan to come over and see you.

How is Beijing these days? I imagine the COVID-19 has

affected your ability to treat and help people. Can you pass my
love and regards on to everybody, especially Dr Wu.

Thank you and I look forward to hearing from you soon.

Kind Regards

Dr. Neil Verner Ph.D.

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