Professional Documents
Culture Documents
Aboubakr Elnashar
Benha university Hospital, Egypt
Aboubakr Elnashar
1. INTRODUCTION
Define
Prevalence
Pathogenesis
Complications
2. DIAGNOSIS;
DIFFERENTIAL DIAGNOSIS
3. MANAGEMENT
FOLLOW-UP
4. PREVENTION
SUMMARY
Aboubakr Elnashar
1. INTRODUCTION
Define
GS implanted in the myometrium at the site of a
previous CS scar.
Terminology
cesarean scar pregnancy
Ectopic pregnancy in a Caesarean scar
cesarean ectopic pregnancy
cesarean scar ectopic.
: MXT as in tubal ectopic pregnancies: failed but disastrous
Aboubakr Elnashar
Prevalence
Rare
Rising
1. {increased incidence of CS}
72% of CSP occur in women who have had ≥2CS
Aboubakr Elnashar
Aboubakr Elnashar
Pathogenesis
Prior CS: fibrous scar tissue with a wedge-shaped
myometrial defect .
Multiple CS:
increase scar surface area: increase the risk of
implantation on the scar
Aboubakr Elnashar
The myometrial defect:
Develops after:
CS
D &C
Myomectomy
Metroplasty
Hysteroscopy
Manual removal of the placenta.
Due to:
1. incomplete healing
2. increased fibrosis
Aboubakr Elnashar
Complications
±devastating
Placenta previa/accreta
Uterine rupture
Massive hge:
Aboubakr Elnashar
2. DIAGNOSIS
Time of presentation
2. Asymptomatic: 1/3
Aboubakr Elnashar
Degrees
1. Severe:
little or no myometrium overlying GS
usually diagnosed in 1st T
Hge and ut rupture if untreated.
2. Less severe:
often diagnosed in 2nd and 3rd T as PA
±: normal live births but with increased
maternal morbidity.
Aboubakr Elnashar
Difficult
heavy bleeding
Shock
hemoperitoneum
Aboubakr Elnashar
Sonography
TA:
Panoramic view of the pelvis and uterus
Inspection of the interface between the anterior
LUS and bladder. then
TV:
Reference standard in 1st T
Sensitivity: 86.4%
Sagittal view along the long axis of the uterus
through the plane of GS: localize GS within the
anterior LUS.
Aboubakr Elnashar
Sonographic criteria in 1st T
1. Uterus:
empty with a clearly visualized endometrium
2. Cervix:
Empty
3. GS:
within the anterior portion of LUS
at site of the cesarean scar
Aboubakr Elnashar
CSP: at 6 w
GS: in the anterior LUS at the site of the uterine scar
Uterus: empty(thin arrows
Cervix: empty(long arrows) canals
myometrium between GS and bladder (short arrows): thin.
Aboubakr Elnashar
Transverse TVS color Doppler: flow around G S
Aboubakr Elnashar
Empty uterine cavity with
GS(arrow) between cavity
and cervix (Cx).
Power Doppler of blood
vessels surrounding GS.
Aboubakr Elnashar
Triangular shape of GS (on
sagittal plane)
assuming shape of niche.
GS embedded in scar. Thin
(1-3 mm) or lack of
myometrium (arrow)
between sac and bladder.
Aboubakr Elnashar
Previous CS
Vag bleeding
Positive serum BHCG test.
Prominent, richly vascular area in site of scar highlighted
by power Doppler in patient
Arrows point to vascular malformation.
Aboubakr Elnashar
CSP at 9 w 5 d
Sagittal (A) and transverse (B)
TVS: GS in the anterior LUS
with thinning of the overlying
anterior myometrium (A, arrow).
The fundus (f) and cervical
canals are empty.
Aboubakr Elnashar
CSP at 12 W.
Sagittal (A and B) and transverse (C)
TAS: GS in the anterior LUS There is
thinning of the overlying anterior
myometrium (short arrows). The
endometrial (thin arrow) and cervical (long
arrow) canals are empty.
Aboubakr Elnashar
MRI
Indication
1. US is equivocal or inconclusive before
intervention or therapy.
Aboubakr Elnashar
Sagittal, coronal, and transverse sections of T1-
and T2-weighted sequences:
2. Pelvic anatomy
intraoperative orientation
myometrial invasion and bladder involvement
T1: fat: bright . fluid: dark
T2: fat: intermediate-bright. fluid: bright
Aboubakr Elnashar
CSP at 9 w: Sagittal T2 MRI: implantation of GS in the anterior
LUS with bulging of the anterior contour and thinning of the
myometrium between GS and bladder (long arrows). The
endometrial and cervical canals are empty (A and B). CS scar is
shown in the anterior lower abdominal wall (short arrows). The
patient was successfully treated with systemic MTX and TVS
guided injection of Kcl. B indicates bladder; and U, uterus.
Aboubakr Elnashar
CSP at 12 w: Sagittal (Aand C) and coronal (B) T2-
weighted MRI: enlarged uterus (U) with GS within
the anterior LUS, a thinned myometrium between
GS and bladder with a suspicion of the placenta
protruding through the serosa (long arrows).
The endometrial and cervical canals are empty (A).
The cesarean scar is shown in the anterior lower
abdominal wall (short arrows). The patient went on
to have a hysterectomy, which revealed a very thin
overlying myometrium with placental tissue
protruding through the amniotic membrane
anteriorly, adherentAboubakr
to the bladder (B).
Elnashar
DIFFERENTIAL DIAGNOSIS
CSP Cx ectopic Failed pregnancy
1. GS anterior LUS within the cervical canal
2. Overlying anterior thin normal
myometrium
3. Sliding organ sign* negative positive
4. Doppler marked vascular flow lack color flow
peritrophoblastic around and within
color Doppler flow the GS
around GS
5. Short follow up ±growing Not fixed in
US location, not
growing
Aboubakr Elnashar
Timor-Tritsch et al, 2014
Aboubakr Elnashar
Treatment should be individualized, based on
1. Patient’s age
2. Number of children.
3. Number of previous CS
Aboubakr Elnashar
Gynecologic surgeons:
laparoscopy, and hysteroscopy or
laparotomy
Aboubakr Elnashar
Counseling of the patient
Immediate and decisive action to prevent further
growth of the embryo or fetus.
Options:
Aboubakr Elnashar
2. Termination of the pregnancy in 1st T
Substantial hge: 20%-40%
Aboubakr Elnashar
Potential complications
751 cases reviewed, 21.8% resulted in major surgery or interventional
radiology procedures (primary or emergency). The total planned primary
(nonemergency) interventions performed were 66 (8.7%), which included 3
hysterectomies, 14 laparotomies, and 49 uterine artery embolizations or
ligations. There were 98 (13.0%) emergency interventions, which included 36
hysterectomies, 40 laparotomies, and 22 uterine artery embolizations or
ligations. (Timor-Tritsch et al, 2014).
Aboubakr Elnashar
Management approaches
I. Surgical: Excision
Laparotomy or
Hysterectomy, or
Laparoscopic or
Hysteroscopic followed by D&C
Aboubakr Elnashar
Medical
1. Systemic, single-dose MTX
1 mg/kg or 50 mg/m2 of body surface area.
complication rate: 64.6%
{second tt when the fetal heart beat did not cease after
several days}
High failure rate {slow action and questionable
ability to stop cardiac activity and placental
expansion}.
The expected result can take days, and all the while GS, the
embryo or fetus, and its vascularity are growing. Secondary
tt has to address a larger gestation with more abundant
vascularization.
Aboubakr Elnashar
Systemic MTX as a single tt should be avoided.
1. Waiting days for its effect to stop the heart beats, which
may not happen.
2. It also led to the additional growth of the embryo/fetus as
well as the vascularization
of GS
3. Wastes precious time
Aboubakr Elnashar
2. Systemic, multidose, sequential MTX
Two to three IM (1 mg/kg BW or 50 mg/mm2 of surface
area) at an interval of 2 or 3 days over the course of a week.
Indications
hemodynamically stable
unruptured CSP
≤8w gestation
myometrial thickness between GS and bladder.:
≤ 2 mm
Aboubakr Elnashar
Approach:
TV approach is favored over TA
TAS guidance:
slighter higher complication rate (15%) than those
using TVS guidance.
Aboubakr Elnashar
Steps:
1. After confirming the placement of needle, 25 mg
of MTX in 1 mL of solution is injected slowly in
the GS
2. 25 mg is injected outside GS as the needle is
withdrawn, preferably the placental site
Indications:
1. Alone: (usually in gestations of 5–7 w) in the
hope of stopping the evolution of the pregnancy
by placing pressure on a small GS.
Catheter is kept 24 to 48 h,
with the outer end of the catheter fastened to the
patient’s thigh.
Antibiotics
Indication:
1. As a rescue procedure in the case of significant
bleeding or an A-VM
2. Concurrent with MTH
Not as a primary tt
{delay between tt and effect allows the gestation to
grow and vascularity to increase}
Disadvantages:
1. GA
2. Complication rate: 47%
3. Not the best 1st -line tt
Aboubakr Elnashar
Surgical excision
laparoscopy or laparotomy may be best tt
No response to conservative medical tt
Patient late to present.
Risks
postoperative adhesions: impair future fertility
increased size of surgical wounds
longer hospital stay and recovery
increased risk of future placenta previa/accreta.
Aboubakr Elnashar
Aboubakr Elnashar
1. Excision by laparotomy, alone or in
combination with hysteroscopy
18 cases:
5 complications
and only when used in an emergency situation.
Aboubakr Elnashar
2. Laparoscopic excision
Aboubakr Elnashar
3. Hysteroscopy, alone or in combination
complication rate: 13.8%.
Aboubakr Elnashar
4. Suction aspiration or D&C, alone or in
combination
Isolated D & C should be avoided.
1. Trophoblastic tissue and villi are implanted
within the myometrium: D &C is unlikely to expel
the GS without rupturing the uterine wall or
damaging the bladder
2. : massive bleeding: emergency laparotomies:
loss of the uterus.
3. {exposed vessels in the cervical scar tissue
bleed {no muscle grid to contract and contain
the profuse bleeding}.
4. Complication rate: 62% (29%–86%).
bleeding complications, necessitating 3rd -line tt that
almost always was surgical. Aboubakr Elnashar
MTX followed by suction curettage:
Mean blood loss: 707 mL (100–2,000 mL)
tt failure:
3 out of 45 despite insertion of a Foley balloon
catheter.
Aboubakr Elnashar
3. SIS:
in a nonpregnant patient
uterine wall integrity
size of the cesarean scar
which may relate to the possibility of uterine scar
complications in future pregnancies.
4. Early TVS
After CSP
After CS
to confirm an intrauterine location of the new
gestation.
Aboubakr Elnashar
5. Avoiding pregnancy
No guidelines
12 to 24 months.
Aboubakr Elnashar
Outcomes
Uneventful viable pregnancies have been
reported after all modalities of conservative
management.
Recurrence rate: 5%
IU pregnancy: 95%
spontaneous pregnancy: 88%
Normal pregnancy: 65%
Spontaneous abortion: 35%
higher than expected
Aboubakr Elnashar
4. PREVENTION OF CSP
Aboubakr Elnashar
2. Specific surgical technique
single- or double-layer closure of the incision
can minimize or avoid a CSP
Aboubakr Elnashar
SUMMARY
CSP
An uncommon but potentially life-threatening
The incidence is rising as CSR is rising.
Precursor of morbidly adherent placenta
Aboubakr Elnashar
Thank You
https://www.facebook.com/groups/
227744884091351/
Aboubakr Elnashar
Timor-Tritsch et al (2012.)
Aboubakr Elnashar
Management
31 primary approaches:
systemic therapy
local injection
surgical aspiration of GS
hysteroscopic, laparoscopic, and open removal.
Aboubakr Elnashar
Intracervical vasopressin should also be
considered.
Aboubakr Elnashar
CSP 4 w after 2 doses of systemic
MTX Sagittal TVS (Aand B) through
the midline uterus GS in the anterior
LUS. There is minimal peripheral flow
around GS on color Doppler imaging
(C), but no heart beat activity was
detected via M-mode analysis.
Incidentally, a large ovarian cyst (CY)
is partially visualized in B.
Aboubakr Elnashar
Arch Gynecol Obstet. 2014 Dec 23. [Epub ahead of print]
Ultrasonography-guided multidrug stratification interventional therapy
for cesareanscar pregnancy.
Kong D1, Dong X, Qi Y.
Author information
Abstract
PURPOSE:
To explore the clinical value of ultrasonography-guided multidrug stratification
interventional therapy for cesarean scar pregnancy (CSP).
METHODS:
Aspiration of gestational sac fluid, injection of methotrexate in the sac, injection of
homeostatic agent and pituitrin in the uterine muscle layer, and injection of triple
anti-inflammatory drugs around the uterus in 12 patients with CSP. The lesion
volume, serum β-hCG level, and blood flow were observed.
RESULTS:
The mean β-hCG level continued to decrease posttreatment, and the greatest
reduction occurred in week 1. The mean number of days needed for serum β-hCG
values to decrease to normal level was 39.1 ± 10.1 days. Mass volumes reduced and
the mean number of days for the masses to disappear was 24.6 ± 14.1 days. The
blood flow around the lesions continued to decrease.
CONCLUSIONS:
Ultrasonography-guided multidrug interventional therapy for CSP is a new, safe,
effective, minimally invasive method. Aboubakr Elnashar
Ultrasound Med. 2014 Sep;33(9):1533-7. doi: 10.7863/ultra.33.9.1533.
Heterotopic cesarean scar pregnancy: diagnosis, treatment, and
prognosis.
OuYang Z1, Yin Q2, Xu Y2, Ma Y2, Zhang Q2, Yu Y2.
Author information
Abstract
Heterotopic cesarean scar pregnancy is a rare, life-threatening form of
ectopic pregnancy. To provide information regarding the clinical
manifestations, diagnosis, management, and prognosis of this condition,
we reviewed all cases reported in the English literature. All literature on
heterotopic cesarean scar pregnancy was retrieved by searching the
PubMed database and tracking references of the relevant literature. Full
texts were reviewed, and clinical manifestations, diagnostic methods, and
the relationship between the treatment and prognosis were summarized. A
total of 14 patients with heterotopic cesarean scar pregnancies were
identified, including 6 spontaneous pregnancies and 8 following in vitro
fertilization-embryo transfer. Gestational ages at diagnosis ranged from 5
weeks to 8 weeks 4 days. Only 5 cases presented with vaginal bleeding,
and the others were asymptomatic. All 14 cases were diagnosed by
transvaginal sonography. One patient with no future fertility requirements
underwent pregnancy termination by methotrexate. Of the remaining 13
patients who desired to preserve their intrauterine
Aboubakrgestations,
Elnashar 10 were
Fertil Steril. 2014 Oct;102(4):1085-1090.e2. doi:
10.1016/j.fertnstert.2014.07.003. Epub 2014 Aug 11.
Outcomes of primary surgical evacuation during the first trimester in
different types of implantation in women with cesarean scar pregnancy.
Cheng LY1, Wang CB1, Chu LC1, Tseng CW 1, Kung FT2.
Author information
Abstract
OBJECTIVE:
To assess the efficacy and safety of primary surgical evacuation therapy
for cesarean scarpregnancy (CSP) of the first trimester, and to evaluate its
possible prognostic factors.
DESIGN:
Retrospective consecutive cohort study.
SETTING:
Tertiary care university hospital.
SUBJECT(S):
A cohort of patients with CSP and clear ultrasound images who underwent
primary surgical evacuation from January 2000 to December 2012.
INTERVENTION(S):
Patients fulfilling the ultrasound criteria of CSP were further classified into
superficial and deep groups according to their implantation locations and
extents. The final decision on the method of treatment, including
Aboubakr Elnashar
methotrexate chemotherapy, surgical evacuation, and others, was made by
I. All are correct regarding CS scar
pregnancy (CSP) except:
1. Incidence is rising
2. Asymptomatic: in 1/3 of cases
3. Time of presentation is commonly 2nd trimester
4. Diagnosis is missed in 14% of cases
Aboubakr Elnashar
II. Sonographic criteria of CSP include
all except
Aboubakr Elnashar
IV. All are correct regarding CSP treatment
except:
Aboubakr Elnashar