BSC - Vi Semester - Pharmaceutical Chemistry - 23 - 24

Govt.
Holkar (Model, Autonomous) Science College, Indore
Department of Pharmaceutical Chemistry

B.Sc. VI Semester
Syllabus
2023-2024
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Government Holkar (Model, Autonomous) Science
College, Indore (M.P.)
Part A - Introduction
Programme- B.Sc. Class - B.Sc. VI Year- 2023 Session- 2023-24
Phannaceut ical Chemistry Semester
Major/Core
Course Tvpe (Subiect) - Maior/Core

I Course Code
7 Course Title Pharmaceutical Medicinal Chemistrv
3 Pre - requisite (if any) To study this course, a student must have had the subject
in Diploma (ll Year)
4 Course Learning
On successful completion of this course , the students will
Outcomes (CtO)
be able to
CO I lllustrate the significance of SAR and drug receptor

binding in drug design.
CO 2 Apply clinical chernistry in blood samples.
CO 3 Classify drugs on the basis of therapeutic action.
CO 4 Describe general anaesthetics and their therapeutic
applications.
CO 5 Explain specific dmgs.
5 Credit Value 04 Credits
6 Total Marks Formative Assessment (CCE) - 40 Minimum Pass

Marks Marks - 35
Summative Assessment (End
Semester Exam) - 60 Marks
Total40+60: 100 Marks
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Pharmaceutical Chemistry Semester
Major/Core
Course Code
Course Title Pharmaceutical Medicinal Chemistry
Part - B Content of the Course
Total no. of lectures - As per UGC rules (1 Credit = 15 Lectures)
S. No. Topics No. of Lectures
General Medicinal Chemistry
Introduction to medicinal chemistry, General principles of
drug action. Physicochemical properties of organic
I medicinal agents, quantitative structure activity relationships
(SAR), drug receptor bonding: receptor theories, agonists
and antagonists.
Key Words: Principle of drug action, SAR, Combinatorial

chemistry.
Clinical Chemistry
Composition of blood. Collection and preservation of
sampler, clinical analysis: blood urea nitrogen, uric acid
II
albumin and alkaline phosphate, Immunoassay, principle of
radio immunoassay (RIA) and application.
Key Words: Blood, Blood urea, Immunoassay and RIA.
General Drug description

a) Antibiotics: Penicillin, Tetracycline's and
Chloramphenicol
III b) Antiviral drugs and its classification.

c) Antifungal agents: Clotrimazole, Miconazole and
Terbinafine
d) Sulpha drugs: Sulphanilamide, Sulphaguanidine and
Sulphadiazine
Key Words:,Antiviral, antifungal drugs, sulpha drugs.
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Programme- B.Sc. Class - B.Sc. VI Year-2023 Session- 2023-24
Major/Core
Course Type (Subiect) - Maior/Core

Course Code
Course Title Pharmaceutical Medicinal Chemistry
Anaesthetics
IV
General anaesthetics: Introduction, classification and
mechanism of action .
Local Anaesthetics: Introduction, classification, and mode

of action.
Sedatives and hypnotics: Introduction, classification ,
Mechanism of action and structure activity relationship.

Key Words: Anaesthetics, sedatives, hypnotics.
Specific drug description
V a) Antipyretics and analgesics
b) Anticancer drugs
c) Anthelmintic Drugs
Key Words: antipyretics, anticancer, anthelmintic .
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Pharmaceutical Semester
Chemistrv Maior/Core
Course Type (Subject) - Major/Core
Course Code
Course Title Pharmaceutical Medicinal Chemistrv
Part - C Learning Resources
Text Books, Reference Books, Other Resources
Suggested Readings:
Text Books:
L Ashutosh Kar, Medicinal Chemistry. New Age International Publishers, 4" Edn.2007.
2. David A. Williams. Thomas L., Lemke. Foye's Principles of Medicinal Chemistry.
Fifth Edition Lippincott
Williams & Wilkins, 2002
3. D. Srirarn and P Yogeeswari. Medicinal Chemistry, 2nd edition, Pearson, 2010.

4. Gareth Thomas. Fundamentals of Medicinal chemistry. Wiley. 2003.
5. P. Parimoo. A Textbook of Medicinal Chemistry. CBS Publishers, 2019.
6. Hansch, C. Comprehensive Medicinal Chemistry Vol. IV. Quantitative Drug Design.
Pergamom Press Oxford.
7. Singh, H. and Kapoor, V.K Medicinal and Pharmaceutical Chemistry. Second Edition,
Vallabh Prakashan, Delhi, 2005
8. PovlKrogsgaard, Tommy, Textbook of Drug Design & Discovery, 3rd edition, 2004.
9. Textbook from M. P. Hindi Granth Academy. Bhopal.
Suggested Digital Platforms Web links:
ht tp : //www. mp h i ndi g ra nt h a c ad emy. o r g

h t t p,r : /h.twu'. e s h i ks h a m p. gov. irr
Suggested Equivalent online courses:
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Programme- B.Sc. Class - B.Sc. Year- 2023 Session- 2023-24
Pharmaceutical Chemistry Vl Semester
Maior/Core
Course Code
Course Title Pharmaceutical Medicinal Chemistrv
Part - D Assessment and Evaluation
Internal Assessment: Continuous External Evaluation (Summative

Comprehensive Evaluation (CCE)/ Assessment):
Formative Assessment: 40 Marks End Semester Exam:60 Marks
Time: 03 hours
Formative Assessment shall be based on -
Quiz, Seminar, Presentation, Written test,
Case Study, Project, Assignment etc.
The division of marks is as fbllows:

Test I 20 Marks Section (A): 5 5xl:5
Objective Questions
( I mark each)
Test II 20 Marks Section (B): 5 Short 5 x 7:35
Best two test Questions out of
:
Marks (20 + eight questions (200
20) words each) (7
Marks each)
Test III 20 Marks Section (C): Two 2xl0=20
long questions out of
four questions ( 500
Words each) (10
Marks each)
Total Internal Assessment 40 Marks Total External 60 Marks
(CCE) Marks Evaluation (Theory)
Marks (A+B+ C)
For Major, Minor, Open Electiveo Foundation and
1. Vocational Courses, Part D will be as per the scheme of
marks given.
Note;-
The student should secure 35o marks in Internal
", Assessment (CCE) and External Evaluation (theory)
combined.
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Part A- Introduction Practicals
Programme- B.Sc. Pharmaceutical Class - B.Sc. VI Ye*- 2023 Session-
Chemistry Maior/Core Semester 2023-24
I Course Code
2. Course Title Pharmaceutical Medicinal Chemistry Lab
J. Pre-requisite (if any) To study this course, a student must have had the
subject in Diplorna (II Year)
4. Course Learning Outcomes COI Explain rnethods and execution of QSAR in
(cl-o) medicinaI Chemistry.
CO2 Evaluate clinical analysis of serum and
pharmaceutical dmgs.
CO3 Present the assay of specific drugs and
biomolecules.
5. Credit Value 02 Credits
Part B- Content of the Course
Total no. of lectures - As per UGC rules
Lab Assisnments
I QSAR analysis
l. Determination of (i) partition coefficients. (ii) dissociation constants, and (iii)
molar refractivity of compounds tbr QSAR analysis.
2. Evaluation of edible oil and fats.
3. Analysis of turmeric and chilies
4. Analysis of tea and coffee.
5. Analysis of wheat flour and cereals.
2. Clinical Analysis
6. Determination of blood urea nitrogen
7. Determination of uric acid and albumin
8. Determination of globulin acid and alkaline phosphate
9. Separation and identification of Amino Acids by Paper Chromatography
10. Separation and identification of Sulpha drugs by TLC technique
1[. Demonstration of HPLC
12. Demonstration of HPTLC
13. Demonstration of GC-MS
3. Assay of important drugs and biomolecules
1 . Detection and determination of food colors and preservatives.
2. Analysis of milk and milk products

3. Protein purification
4. Diff'erential centrifugation
5. Purification of LDH
6. Assays of irnportant dnrgs from the course content
T.Monograph analysis of important drugs.
Continuous evaluation bv the Teachers
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Programme- B.Sc. Class - B.Sc. VI Year- 2023 Session-
Pharmaceutical Chemistry Semester 2023-24
Maior/Core
Course Code
Course Title Pharmaceutical Medicinal Chemistry Lab
Part C- Learning Resources
Textbooks, References Books, Other resources
Suggested Readings:
l.Ashutosh Kar. Advance Practical Medicinal Chemistry. New Age International (P) Ltd.,
2020.
2. M. K. Sarsat. 1. Singhvi, P. B. Cholke. A Practical Book of Medicinal Chemistry. Success
Publications 2018
3. Foye's, Principles of Medicinal Chemistry, Sixth Edition. Wolters Kluwer (lndia). Lea &
Febiger. Philadelphia, USA, 2008
4. Books from M. P. Hindi Granth Academy, Bhopal
Suggestive digital platforms web links:

https: ru
https ://www. eshikshamp. gos in
Part D- Assessment and Evaluation
Suggested Continuous Evaluation methods:
Internal Assessment/Formative Examination(A) : 40 Marks

Lab Record l5 Marks
Attendance in the Lab 05 Marks
Assignments (It can be in different modes) 20 Marks
End Semester External Evaluation (B): 60 Marks

Viva Voce on Practical 10 Marks
Practical Record File l0 Marks

Experiments 40 Marks
Total Marks (A+B) (40 +
60:100
Marks)
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DSE-I
Course Type (Subiect) - DSE-I

I Course Code
2 Course Title Industrial Analysis
in Diploma (II Year)
4 Course Learning On successful completion of this course the students will

Outcomes (CLO)
be able to
CO I Explain pre-formulation studies of a drug

CO 2 Present the various pharmaceutical dosage forms
and their manufacturing techniques .
CO 3 Evaluate pharmaceutical dosage forms

CO 4 Demonstrate solid, liquid and semisolid dosage
forms and their quantity.

CO 5 Formulate and prepare some cosmetics.

Marks Marks - 35
Total40+60= 100 Marks
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Programme- B.Sc. Class - B.Sc. VI Yeafi'2023 Session- 2023-24
DSE.I
Course Code
Course Title Industrial Analysis
S. No. Topics No. of
Lectures
Pre-formulation Studies
I Introduction to pre-formulation, goals and objectives. the study of

physicochemical characteristics of drug substances.
(i) Physical Properties: Physical form (crystal and amorphous),

Particle size, shape ,flow properties, solubility profile (pKa, pH,
partition coeffi cient), polymorphism.
(ii)Chemical Properties : hydrolysis, oxidation, reduction,
racemization pol ymeri zation,stability of dosage forms.
Key Words: Pre-formulation, Physical Chemical Properties.
Tablets
(i) Introduction, ideal characteristics of tablets, classification of
II
tablets Excipients Formulation of tablets, granulation methods,
compression, and processing problems Equipment and tablet
tooling
(ii) Tablet coating : Types of coating materials, formulation of the

coating composition. Methods of coating, equipment employed, and
defects in the coating.
Key Words: Tablets, coating. Granulation orals.
Capsules
III (i)Hard gelatine capsules: Introduction. Production of hard gelatin

capsule shells. size of capsules, filling finishing, manufacturing
defects. IN process and final product quality control tests for
capsules,
(ii) Soft gelatine capsules: Nature of shell and capsule content,'size

of capsules, Importance of base adsorption and the minim per gram
factors, production in process and final product quality control tests.
Key Words: Capsules.Gelatin. rN
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Pharmaceutical Chemistrv Semester
DSE-I
Course Code
Parenteral Products
IV
(i) Definition type, advantages and limitations. Pre-formulation
factors and essential requirements, vehicles, additives,
importance of isotonicity.
(ii) Production procedure, production facilities and controls,

aseptic processing.
(ii) Formulation of injections, sterile powders, large volume

parenteral and lyophilized products.
Key Words: Parenteral products. aseptic processing.

Cosmetics, Aerosols, and Packaging
V
Cosmetics; Formulation and preparation of the following
cosmetic preparations:
Lipsticks, shampoos, cold cream and vanishing cream, tooth

paste, hair dyes and sunscreens.
Pharmaceutical Aerosols; Definition, propellants, container,

valves, types of aerosol system, formulation and manufacture of
aerosols.
Key Words: Cosmetics. Aerosols. Packaging.
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DSE-I' .
Course Type (Subject) - DSE-I
Course Code
Course Title Industrial Analvsis
Suggested Readings:
Text Books:
1. H. A. Liberrnan, Leon Lachman and J. B. Schwartz, Pharmaceutical dosage form-
Tablers volume l-3. Marcel Dekker, New York, 1989.
2. Lachman Lieberman. Theory and Practice of Industrial Pharmacy. CBS,4th
Edition,2020.
3. Gilbert S. Banker, J. Siepman and C. T. Rhodes, Modern Pharmaceutics, 3rd
edition, CRC Press, 2002.
4. JP Remington: The Science and Practice of Pharmacy. Lippincott Williams and
Wilkins,2Oth edition
2000
5. Uttam Singh Baghel, Pragi Arora. Ruchika Kabra and Atamjit Singh,
Pharmaceutical Analysis -Theory an Practical, S Vikas and Co. 2018
6. Prakash Goudanavar. Practical Manual for Industrial Pharmacy, Orange Book
Publication I st edition, 2020
7. Gaurav Agrawal, Atul Kaushik, Industrial Pharmacy l. C85,2022
8. Shalini Sharma, Industrial Pharmacy 1. S. Vikas and Co., 2019.
9. Ketan B. Patil, Paresh A. Patil, Sandip Kshirsagar, Narendra B. Patil , The Theory
and Practical Books of Industrial Pharmacy I, IP Innovative Publication, 2020.
10. Textbook from M.P. Hindi Granth Academy, Bhopal.
ht tp : //www. mphindi gr an thac ad e my. o rg
ht tp : //www. es hi ks h a. mp. gov. in
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Pharmaceutical Chemistry VI Semester
DSE-II
Course Code

Comprehensive Evaluation (CCEy Assessment):
Time:03 hours
The division of marks is as follows:

Objective Questions
(l mark each)
Test II 20 Marks Section (B): 5 Short 5 x 7:35
Marks: (20 + eight questions (200
20) words each) (7
Marks each)
Test III 20 Marks Section (C): Two 2x10:20
Words each) (10
Marks each)
Marks (A+B+ C)
For Major, Minor, Open Elective, Foundation and
marks given.
Note;-
The student should secure 35oh marks in Internal
2. Assessment (CCE) and External Evaluation (theory)
combined.
ty Q43-:u h
V/

DSE-I .'..

I Course Code
2. Course Title Industrial Analvsis Lab
subiect in Diploma (II Year)
4. Course Learning Outcomes CO1 Prepare and evaluate some tablets and capsules.
(cLo) CO2 Prepare parenteral and ophthalmic products.
CO3 Packasins of cosmetics.
5. Credit Value 0l Credits
Lab Assienments
1 Pre-formulation, Tablets and Capsules
1. Pre-formulation study for prepared granules
2. Preparation and evaluation of Paracetamol Tables
3. Preparation and evaluation of Aspirin Tablets
4. Coating of Tablets
5. Preparation and evaluation of Tetracycline capsules
2. Parenteral Products and Ophthalmic Preparation

1. Preparation of Calcium Gluconate injection
2. Preparation of Ascorbic Acid injection
3. Preparation of Paracetamol syrup
4. Preparation of Eye drops
J. Cosmetics, Aerosols, and Packaging
1. Preparation of Cold Creams

2. Preparation of Vanishing Cream
3. Evaluation of Aerosols
4. Evaluation of Glass Containers as per IP
4. Continuous evaluation by the Teachers
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Programme- B.Sc. Class - B.Sc. Year-2023 Session- 2023-24
DSE-I .
Course Type (Subject) - DSE-I

Course Code
Course Title Industrial Analysis Lab
Part C- Learnins Resources
Textbooks. References Books. Other resources
Suggested Readings:
l. Uttam Singh Baghel, Pragi Arora, Ruchika Kabra and Atamjit Singh. Pharmaceutical
Analysis -
Theory cum Practical, S Vikas and Co.2018.
2. Prakash Goudanavar. Practical Manual for Industrial Pharmacy. Orange Book Publication.
Ist edition, 2020
3. Gaurav Agrawal. Atul Kaushik, Industrial Pharmacy l. C85,2022
4. Ketan B. Patil, Paresh A. Patil. Sandip Kshirsagar, Narendra B. Patil. The Theory and
Practical Book of Industrial Pharmacy I. IP Innovative Publication,2020
5. Books from M. P Hindi Granth Academy, Bhopal
Suggestive Digital platforms web Links:

http //www. mphindi granthacademy. org
:
https ://www. eshiksha.mp. gov. in

Suqqested Continuous Evaluation methods:

Lab Record 15 Marks


Practical Record File 10 Marks
Total Marks (A+B) (40 + 60:100
Marks)
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Government Holkar (Model' Autonomous) Science
DSE.II-A
Course Type (Subject) - DSE-II-A

1 Course Code
) Course Title Physical Pharmacy
4 Course Learning On successful completion of this course ,the students will

Outcomes (CLO)
be able to :
CO 1 Explain various states of matter.
CO 2Illustrate laws of thermodynamics.

CO 3 Characterize Colloids.
CO 4 Describe phenomenon of solubility.
CO 5 Categorize drug stability.

Marks Marks - 35
Total40+60: Marks
L
100
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DSE-II-A

Course Code
Course Title Physical Pharmacy
States of Matter
I Introduction, Gaseous state, Liquid state, Solid State, Liquid

crystals, Glassy state, Change in State of matter and
Sublimation, Aerosols.
Key Words: Sublimation, Aerosols

Thermodynamics
Introduction, first law of thermodynamics, Closed and open

II systems, isothermal and adiabatic processes, Reversible
processes, Second law of thermodynamics, Entropy, Third
law of thermodynamics, work function and free energy, Gibbs
Free Energy.
Key Words: Thermodynamics, Gibbs free energy
Colloids
Introduction, Characteristics of dispersed phase,
Classification of colloidal dispersions, Purification of
III colloidal dispersions, stability of colloids, Protective
Colloidal action, Optical, Kinetic and Electric properties of
Colloid.
Key Words: Colloid, Dispersion, Stability
Solubility and related Phenomenon

Introduction, Solubility expression, Solvent-solute
ry Interactions, Solubility of gases in Liquids, Factors affecting
solubility of gases , Solubility of liquid in liquid, Solubility of
solid in liquid, Factors affecting Solubility of solid in liquid.
Key Words: Solubility, Interactions, Factors
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Pharmaceutical Semester
Chemistry DSE-II-A
Course Type (Subiect) - DSE-II-A
Course Code
Drug Stability
Physical degradation of pharmaceutical products, Chemical
decomposition and prevention of drugs, Influence of light on
V drug decomposition, Influence of Temperature on drug
decomposition, Chemical stability testing for dosage forms,
Storage.
Key words: Drug Stability, Degradation, Storage.
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DSE-II-A
Course Code
Suggested Readings:
Text Books:
l. I "Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical
Sciences" by Alfred N. Martin
2. "Physical Pharmaceutics: Principles and Applications" by C.V.S. Subrahmanyam,
J. Thimma Setty, and D. Satyanarayana
3. "Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences"
by David Attwood and Alexander T. Florence
4. "Pharmaceutical Physical Chemistry: Theory and Practices" by Vinod Kumar and
Indu Pal Kaur
5. "Pharmaceutical Dosage Forms: Tablets, Vol. 1" by Larry L. Augsburger and
Stephen W. Hoag
6. "Pharmaceutics: The Science of Dosage Form Design" by Michael E. Aulton
7. "Introduction to Physical Pharmacy" by Martin's Physical Pharmacy and
Pharmaceutical S ciences
8. "lntroduction to Biophysics for Biomedical Engineers" by Jay D. Humphrey and
Sherry L. O'Rourke
9. "Pharmaceutical Sciences: An Integrated Approach" by Bhagwat Prasad and
Stephen W. Hoag
10. "Physical Chemistry for the Chemical and Biological Sciences" by Raymond
Chang
1. PharmaFactz (https://www.pharms
2. American Association of Pharmaceutical Scientists (AAPS)

@ttps:ttwww.aaps,od
J. Pharmaceutics and Pharmsceutical Technologlt Forum on ResearchGate

&tns:mww.researc
r
Technolow
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Ph a rm ac y E d u c a t i o n (W!p;, //vwy a hqtry.g. qe d u c at io n. fi rt. o r g
V
4
DSE-II-A
Course Code
Comprehensive Evaluation (CCEy Formative Assessment):
Assessment: 40 Marks End Semester Exam:60 Marks
Time: 03 hours
Formative Assessment shall be based on euiz,
-
Seminar, Presentation, Written test, Case Study,
Project, Assignment etc.

Test I 20 Marks Section (A): 5 5x1:5
Objective
Questions (l mark
each)
Test II 20 Marks Best two test Section (B): 5 5x7:35
Marks:(20+20) Short Questions out
of eight questions
(200 words each) (7
Marks each)
Test III 20 Marks Section (C): Two 2xl0:20
long questions out
of four questions (
500 Words each)
(10 Marks each)
(CCE) Marks Evaluation
(Theory) Marks
(A+B+ C)
Note;- marks giyen.
The student should secure 357o marks in hrt*."at
2. Assessment (CCE) and External Evaluation (theory)
V
combined.
h
5
v

DSE-II-A
1 Course Code
2. Course Title Physical Pharmacy Lab
subject in Diploma (II Year).
4. Course Learning Outcomes CO1 Prepare and evaluate some tablets and capsules.
(cLo) CO2 Prepare parenteral and ophthalmic products.
CO3 Packaging of cosmetics.
5. Credit Value 0l Credits
Lab Assignments
1 Pre-formulation, Tablets and Capsules
I Pre-formulation study for prepared granules
2 Preparation and evaluation of Paracetamol Tables
J Preparation and evaluation of Aspirin Tablets
4 Coating of Tablets
Preparation and evaluation of Tetracycline capsules
2. Parenteral Products and Ophthalmic Preparation

1. Preparation of Calcium Gluconate injection
2. Preparation of Ascorbic Acid injection
3. Preparation of Paracetamol syrup
4. Preparation of Eye drops
J. Cosmetics, Aerosols, and Packaging

1. Preparation of Cold Creams
2. Preparation of Vanishing Cream
3. Evaluation of Aerosols
4. Evaluation of Glass Containers as per IP
Continuous evaluation by the Teachers
Y l N/
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DSE-II-A
Course Code
Course Title Physical Pharmacv
Suggested Readings:
l.Uttam Singh Baghel, Pragi Arora, Ruchika Kabra and Atamjit Singh.
2. Pharmaceutical Analysis - Theory cum Practical, S Vikas and Co.2018.
3.Prakash Goudanavar. Practical Manual for Industrial Pharmacy. Orange Book
Publication. Ist edition, 202
4.Gaurav Agrawal. Atul Kaushik, Industrial Pharmacy l. CBS,2022
5.Ketan B. Patil, Paresh A. Patil. Sandip Kshirsagar, Narendra B. Patil.
6.The Theory and Practical Book of Industrial Pharmacy I. IP Innovative Publication,
2020
T.Books from M. P Hindi Granth Academy, Bhopal
https : www.mphindi sranthacademy. or g
https ://www. eshikshamp. gos in

Internal Assessment/Formative Examination(A): 40 Marks
Lab Record 15 Marks

Total Marks (A+B) (40 + 60 :100
Marks)
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DSE.II-B
Course Type (Subiect) - DSE-II-B

I Course Code
2 Course Title Cheminformatics
4 Course Learning On successful completion of this course ,the students will

Outcomes (CLO)
be able to
CO I Present the basic concept of cheminformatics.

CO 2 Apply computer coding for molecules and reactions.
CO 3 Present structure of drug by computer coding.
CO 4 Evaluate spectroscopic properties using molecular
modelling.
CO 5 Analyse data in drug designing.

Marks Marks - 35
Total40+60: 100 Marks
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DSE-II-B
Course Tvpe (Subiect) - DSE-ll-B

Course Code
Course Title Cheminformatics
Total no. of lecturesAs per UGC rules (1 Credit = 15 Lectures)
-
Introduction to Cheminformatics
I History and evolution of cheminformatics, Use of

cheminformatics, Prospects of Cheminformatics Molecular
Modelling and Structure elucidation.
Key Words: Cheminformatics, molecular modelling.
Representation of molecules and chemical reactions

Nomenclature, Different types of notations, SMILES coding
II Matrix representations. Structure of Molfiles and Sdfiles.
Libraries and toolkits. Different electronic effects. Reaction
classification.
Key Words: SMILES coding, structure of mcilfiles, sdfiles,

reaction classifi cation.
Searching chemical structures
Full structure search, sub-structure search, basic ideas,

III similarity search, three- dimensional search methods, basics
of computation of physical and chemical data and structure
descriptors, data visualization.
Key Words: Structure search, structure descriptors, data

visualization.
Applications
Prediction of Properties of Compounds; Linear Free Energy
Relations, Quantitative Structure-Property Relations;
IV Descriptor Analysis; Model Building, Modeling Toxicity.
Structure-Spectra correlations; Prediction of NMR and Mass
spectra. Computer Assisted Structure elucidations.
Key Words: Prediction of properties, model building,

structure-spectra correlations
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DSE-I
Course Tvpe (Subiect) - DSE-II' B
Course Code
Drug Design
V Introduction to drug design: Target Identification and Validation;

Lead Finding and Optimization. Virtual Screening: Design of
Combinatorial Libraries; Ligand-Based and Structure Based
Drug design; Application of Chemoinformatics in Drug Design.
Key Words: Drug design, applications.

Text Books. Reference Books. Other Resources
Suggested Readings:
Text Books:
l. Andrew R. Leach & Valerie, J. Gillet (2007) An Introduction to Cheminformatics
Spring
Netherlands
2. Gasteiger, J & Engel. T. (2003) Chemoinformaties A text-book. Wiley-VCH.
3. Gupta, S. P. (201l) QSAR & Molecular Modeling Anamaya Pub: New Delhi.
4. Textbook from M. P. Hindi Granth Academy. Bhopal
ht tp : //www. mphindi gr anthac ade my. o rg

https : //www. e shiksha mp. gov. in
V U*a,
I
T,\
3
DSE-II-B
Course Type (Subi ect) - DSE-Il-B

Course Code
Comprehensive Evaluation (CCEy Assessment):
Time:03 hours

Objective Questions
(1 mark each)
Test II 20 Marks Section (B): 5 Short 5 x7 :35
Marks : (20 eight questions (200
20) words each) (7
Marks each)
Test III 20 Marks Section (C): Two 2xl0:20
Words each) (10
Marks each)
Marks (A+B+ C)
marks qiven.
Note;-
The student should secure 357o marks in Internal
7 Assessment (CCE) and External Evaluation (theory)
combined.
{
MWC
{
Government Holkar (Model, Autonomous) Science College,
Indore (M.P.)
DSE-II-B
Course Type (Subiect) - DSE-II-B Practical
1 Course Code
2. Course Title Cheminformatics Lab
Pre-requisite (if any) To study this course, a student must have had the
J. subiect in Diploma 0I Year).
4. Course Leaming Outcomes COI Explain methods and execution of QSAR in
(cLo) medicinal Chemistry.
CO2 Evaluate clinical analysis of serum and
pharmaceutical drugs.
CO3 Present the assay of specific drugs and
biomolecules.
5. Credit Value 0lCredits
Total no. of lectures - As ner UGC rules
Lab Assisnments
1 QSAR analysis
l. Determination of (i) partition coefficients, (ii) dissociation constants, and
(iii) molar refractivity of compounds for QSAR analysis
2. Evaluation of edible oil and fats.
3. Analysis of turmeric and chilies.
4. Analysis of tea and coffee
5. Analysis of wheat flour and cereals.
2. Clinical analysis
1. Determination of blood urea nitrogen,
2. Determination of uric acid and albumin
3. Determination of globulin acid and alkaline phosphate
4. Separation and identification of Amino Acids by Paper Chromatography
5. Separation and identification of Sulpha drugs by TLC technique.
6. Demonstration of HPLC
7. Demonstration of HPTLC
8. Demonstration of GC-MS
J. Assay of important drugs and biomolecules
1. Detection and determination of food colours and preservatives.

2- Analysis of milk and milk products
3. Protein Purification
4. Differential centrifugation
5. Purification of LDH
6. Assays of important drugs from the course content
aA%
$*
Part A - Introduction.
DSE-II.B
Course Type (Subiect) - DSE-II-B Practical

Course Code
Course Title Cheminformatics Lab
Monograph analysis of important drugs.
Continuous evaluation by the Teachers

Suggested Readings:
1. Ashutosh Kar, Advance Practical Medicinal Chemistry New Age Intemational (P)
Ltd2020.
2. MK Sirsat, I Singhvi, P. B. Cholke, A Practical Book of Medicinal Chemistry,
Success Publications 201 8
3. Foye s Principles of Medicinal Chemistry. Sixth Edition. Wolters Kluwer (lndia),
Lea & Febiger, Philadelphia, USA, 2008
4. Books from M. P. Hind: Granth Academy Bhopal
https: www.mphindi granthacademy.org
https://www.eshikshamp. gos in

Lab Record l5 Marks


Viva Voce on Practical l0 Marks
Total Marks (A+B) (40 + 60:100
Marks)
V @h
v

BSC - Vi Semester - Pharmaceutical Chemistry - 23 - 24

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Govt.

Holkar (Model, Autonomous) Science College, Indore

Department of Pharmaceutical Chemistry

Course Tvpe (Subiect) - Maior/Core

CO I lllustrate the significance of SAR and drug receptor

5 Credit Value 04 Credits

6 Total Marks Formative Assessment (CCE) - 40 Minimum Pass

Key Words: Principle of drug action, SAR, Combinatorial

General Drug description

III b) Antiviral drugs and its classification.

Course Type (Subiect) - Maior/Core

Local Anaesthetics: Introduction, classification, and mode

Mechanism of action and structure activity relationship.

3. D. Srirarn and P Yogeeswari. Medicinal Chemistry, 2nd edition, Pearson, 2010.

Suggested Digital Platforms Web links:

ht tp : //www. mp h i ndi g ra nt h a c ad emy. o r g

Suggested Equivalent online courses:

Internal Assessment: Continuous External Evaluation (Summative

The division of marks is as fbllows:

2. Analysis of milk and milk products

4. Books from M. P. Hindi Granth Academy, Bhopal

Suggestive digital platforms web links:

Part D- Assessment and Evaluation

Suggested Continuous Evaluation methods:

Internal Assessment/Formative Examination(A) : 40 Marks

End Semester External Evaluation (B): 60 Marks

Practical Record File l0 Marks

Course Type (Subiect) - DSE-I

4 Course Learning On successful completion of this course the students will

CO I Explain pre-formulation studies of a drug

CO 3 Evaluate pharmaceutical dosage forms

forms and their quantity.

5 Credit Value 03 Credits

6 Total Marks Formative Assessment (CCE) - 40 Minimum Pass

&\a "b u1\1

I Introduction to pre-formulation, goals and objectives. the study of

(i) Physical Properties: Physical form (crystal and amorphous),

Key Words: Pre-formulation, Physical Chemical Properties.

(ii) Tablet coating : Types of coating materials, formulation of the

III (i)Hard gelatine capsules: Introduction. Production of hard gelatin

(ii) Soft gelatine capsules: Nature of shell and capsule content,'size

Key Words: Capsules.Gelatin. rN

(ii) Production procedure, production facilities and controls,

(ii) Formulation of injections, sterile powders, large volume

Key Words: Parenteral products. aseptic processing.

Lipsticks, shampoos, cold cream and vanishing cream, tooth

Pharmaceutical Aerosols; Definition, propellants, container,

Key Words: Cosmetics. Aerosols. Packaging.

Suggested Digital Platforms Web links:

ht tp : //www. mphindi gr an thac ad e my. o rg

ht tp : //www. es hi ks h a. mp. gov. in

Internal Assessment: Continuous External Evaluation (Summative

The division of marks is as follows:

Part A- Introduction Practicals

Course Type (Subiect) - DSE-I

2. Parenteral Products and Ophthalmic Preparation

J. Cosmetics, Aerosols, and Packaging

1. Preparation of Cold Creams

4. Continuous evaluation by the Teachers

Course Type (Subject) - DSE-I

Suggestive Digital platforms web Links:

https ://www. eshiksha.mp. gov. in