Jamie Grace A.

Abit February 3, 2024

Lexus Dayne G. German

DRUG STUDY

DRUG NAME CLASSIFICATION MECHANISM OF ACTION INDICATIONS

Generic Name: Cephalosporin Interferes with bacterial ✓ Moderate to severe infections,
Cefuroxime Sodium Antibiotics cell-wall synthesis and including those of skin, bone,
division by binding to cell joints, urinary or respiratory tract,
Brand Name:
wall, causing cell to die. gynecologic infections
Eroxime
Active against gram- Adults and children ages 12 and older:
Actual dosage, Route, negative and gram-positive 750 mg to 1.5 g I.M. or I.V. q 8 hours for 5
Frequency: bacteria, with expanded to 10 days or 250 to 500 mg P.O. q 12
Adults and children activity against gram- hours
ages 12 and older: negative bacteria. Children ages 3 months to 12 years: 50
Up to 3 g I.V. or I.M. Exhibits minimal to 100 mg/kg/day I.V. or I.M. in divided
q 8 hours immunosuppressant activity. doses q 6 to 8 hours
Children ages 3 ✓ Gonorrhea
months to 12 years: Adults: 750 mg to 1.5 g I.M. or I.V. as a
200 to 240 mg/kg I.V. single dose, or 1.5 g I.M. (750 mg in two
daily in divided doses separate sites), given with 1 g probenecid
q 6 to 8 hours P.O.
✓ Bacterial meningitis
Adults and children ages 12 and older:
Up to 3 g I.V. or I.M. q 8 hours
Children ages 3 months to 12 years: 200
to 240 mg/kg I.V. daily in divided doses q
6 to 8 hours
✓ Otitis media
Children ages 3 months to 12 years: 15
mg/kg P.O. q 12 hours (oral suspension)
for 10 days, or 250 mg (tablets) P.O. q 12
hours for 10 days
✓ Pharyngitis; tonsillitis
Adults and children ages 13 and older:
250 mg P.O. b.i.d. for 10 days
Children ages 3 months to 12 years: 125
mg P.O. q 12 hours for 10 days, or 20

days as oral suspension (maximum 500
mg/day)
CONTRAINDICATIONS ADVERSE REACTIONS
• Hypersensitivity to CNS: headache, hyperactivity,
cephalosporins or hypertonia, seizures
penicillins GI: nausea, vomiting, diarrhea,
• Carnitine deficiency abdominal pain, dyspepsia,
pseudomembranous colitis
GU: hematuria, vaginal candidiasis, renal
dysfunction, acute renal failure
Hematologic: hemolytic anemia, aplastic
anemia, hemorrhage
Hepatic: hepatic dysfunction
Metabolic: hyperglycemia
Skin: toxic epidermal necrolysis,
erythema multiforme, Stevens-Johnson
syndrome
Other: allergic reaction, drug fever,
superinfection, anaphylaxis
mg/kg/day P.O. in two divided doses for 10
NURSING RESPONSIBILITIES
Patient monitoring:
✓ Monitor patient for life-
threatening adverse effects,
including anaphylaxis, Stevens-
Johnson syndrome, and
pseudomembranous colitis.
✓ Monitor neurologic status,
particularly for signs of
impending seizures.
✓ Monitor kidney and liver function
test results and intake and output.
✓ Monitor CBC with differential
and prothrombin time; watch for
signs and symptoms of blood
dyscrasias.
✓ Monitor temperature; watch for
signs and symptoms of
superinfection.
Patient Teaching:
✓ Advise patient to immediately
report rash or bleeding tendency.
✓ Instruct patient to take drug with
food every 12 hours as prescribed.
✓ Teach patient how to recognize
signs and symptoms of
superinfection. Instruct him to
report these right away.
✓ Advise patient to report CNS
changes.