National Institute of Mental Health Bethesda, Maryland Deputy Editors Robert B. Innis, M.D., Ph.D.* Eric J. Nestler, M.D., Ph.D. National Institute of Mental Health The University of Texas Bethesda, Maryland Southwestern Medical Center Dallas, Texas Neuroscience Perspectives Editor Husseini K. Manji, M.D., FRCP(C) Bethesda, Maryland Associate Editors Joseph Biederman, M.D. Kenneth L. Davis, M.D. Steven E. Hyman, M.D. Richard E. Straub, Ph.D. Daniel R. Weinberger, M.D. Boston, Massachusetts New York, New York Cambridge, Massachusetts Bethesda, Maryland Bethesda, Maryland Editorial Committee David Goldman, M.D. René Hen, Ph.D. John H. Krystal, M.D. K. Ranga Rama Krishnan, M.D. Rockville, Maryland New York, New York New Haven, Connecticut Durham, North Carolina Ex Officio David L. Braff, M.D. Jeffrey A. Lieberman, M.D. A. John Rush, M.D. Harold A. Sackeim, Ph.D. Trey Sunderland, M.D. Editorial Board Huda Akil, Ph.D. Cindy L. Ehlers, Ph.D. Thomas R. Insel, M.D. Bruce S. McEwen, Ph.D. Perry F. Renshaw, M.D., Ph.D. Ann Arbor, MI La Jolla, CA Bethesda, MD New York, NY Belmont, MA Samuel Barondes, M.D. Robert Freedman, M.D. Edward G. Jones, M.D., Ph.D. Francis J. McMahon, M.D. Charles F. Reynolds III, M.D. San Francisco, CA Denver, CO Davis, CA Bethesda, MD Pittsburgh, PA Michael J. Meaney, Ph.D. Mark A. Riddle, M.D. Wade H. Berrettini, M.D., Ph.D. Karl J. Friston, M.B.B.S., M.A., MRCPsych Jerome Kagan, Ph.D. Montreal, Canada Baltimore, MD Philadelphia, PA London, United Kingdom Cambridge, MA Herbert Y. Meltzer, M.D. Trevor Robbins, Ph.D. Pierre Blier, M.D., Ph.D. Joel Gelernter, M.D. John Kelsoe, M.D. Nashville, TN Gainesville, FL San Diego, CA Cambridge, United Kingdom West Haven, CT Kathleen Ries Merikangas, Ph.D. Jerrold F. Rosenbaum, M.D. David L. Braff, M.D. Matcheri S. Keshavan, M.D. Bethesda, MD Barbara Geller, M.D. Boston, MA La Jolla, CA Pittsburgh, PA Emmanuel Mignot, M.D., Ph.D. St. Louis, MO David R. Rubinow, M.D. J. Douglas Bremner, M.D. Joel E. Kleinman, M.D., Ph.D. Stanford, CA Mark S. George, M.D. Bethesda, MD Atlanta, GA Bethesda, MD Bita Moghaddam, Ph.D. Charleston, SC Harold A. Sackeim, Ph.D. Maja Bucan, Ph.D. George F. Koob, Ph.D. Pittsburgh, PA New York, NY Philadelphia, PA Howard K. Gershenfeld, M.D., Ph.D. La Jolla, CA Charles P. O’Brien, M.D., Ph.D. Dallas, TX Larry J. Siever, M.D. William A. Carlezon, Jr., Ph.D. K. Ranga R. Krishnan, M.D. Philadelphia, PA Bronx, NY Belmont, MA Terry E. Goldberg, Ph.D. Durham, NC Bradley S. Peterson, M.D. New York, NY Tetsuya Suhara, M.D., Ph.D. Bethesda, MD Cameron S. Carter, M.D. John H. Krystal, M.D. Chiba, Japan Elizabeth A. Phelps, Ph.D. Pittsburgh, PA David Goldman, M.D. New Haven, CT Trey Sunderland, M.D. New York, NY Jonathan D. Cohen, M.D., Ph.D. Rockville, MD Marc Laruelle, M.D. Bethesda, MD Lyn S. Pilowsky, Ph.D., MRCPsych Princeton, NJ Jack M. Gorman, M.D. New York, NY London, United Kingdom Susan E. Swedo, M.D. Edwin H. Cook, Jr., M.D. New York, NY Pat R. Levitt, Ph.D. Daniel S. Pine, M.D. Bethesda, MD Chicago, IL Elizabeth Gould, Ph.D. Nashville, TN Bethesda, MD Carol A. Tamminga, M.D. John C. Crabbe, Ph.D. Princeton, NJ David A. Lewis, M.D. Paul M. Plotsky, Ph.D. Dallas, TX Portland, OR Pittsburgh, PA Atlanta, GA Michael E. Thase, M.D. Anthony A. Grace, Ph.D. Pittsburgh, PA Richard J. Davidson, Ph.D. Pittsburgh, PA Jeffrey A. Lieberman, M.D. Grazyna Rajkowska, Ph.D. Madison, WI Chapel Hill, NC Jackson, MS Leslie Ungerleider, Ph.D. Paul Grasby, M.D. Bethesda, MD Michael Davis, Ph.D. London, United Kingdom Robert C. Malenka, M.D., Ph.D. Judith L. Rapoport, M.D. Stanley J. Watson, M.D., Ph.D. Atlanta, GA Palo Alto, CA Bethesda, MD Paul J. Harrison, D.M., MRCPsych Ann Arbor, MI J. Raymond DePaulo, Jr., M.D. Oxford, United Kingdom Graeme F. Mason, Ph.D. Scott L. Rauch, M.D. Myrna M. Weissman, Ph.D. Baltimore, MD New Haven, CT Charlestown, MA New York, NY James V. Haxby, Ph.D. Wayne C. Drevets, M.D. Princeton, NJ Helen S. Mayberg, M.D. Allan L. Reiss, M.D. Shigeto Yamawaki, M.D., Ph.D. Bethesda, MD Atlanta, GA Stanford, CA Hiroshima, Japan René Hen, Ph.D. Ronald S. Duman, Ph.D. Christopher J. McDougle, M.D. Martin L. Reite, M.D. Elizabeth A. Young, M.D. New York, NY New Haven, CT Indianapolis, IN Denver, CO Ann Arbor, MI
Editorial Office Aims and Scope
Department of Psychiatry This international rapid-publication journal, sponsored by the Society of Biological Psychiatry, covers The University of Texas the whole range of psychiatric neuroscience. Both basic and clinical contributions are encouraged Southwestern Medical Center from all disciplines and research areas relevant to the pathophysiology and treatment of major 6363 Forest Park Road, Suite B225T neuropsychiatric disorders. Full-length and Brief Reports of novel results, Case Reports and Dallas, Texas 75235-5435 USA Correspondence of unusual significance, judged to be of high impact to the field are published, Telephone: (214) 648-0880 particularly those addressing genetic and environmental risk factors, neural circuitry, and neurochem- Fax: (214) 648-0881 istry, and important new therapeutic approaches. Concise Reviews, Neuroscience Perspectives, e-mail: biol.psych@UTSouthwestern.edu Editorials and Commentary, generally invited by the Editors, which focus on topics of current research www.elsevier.com/locate/biopsych and interest, are also rapidly published. Managing Editor Carolyn Catanuto *Act in a personal capacity and do not necessarily reflect the view of the Federal Government, the Publication Coordinator Karen Reeves National Institute of Mental Health, or the Department of Health and Human Services. Technical Editor Rosemary McCandless Editorial Assistant LaTonya Jones Founding Editor Joseph Wortis Editor Emeritus Wagner H. Bridger, M.D.