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Editor

Dennis S. Charney, M.D.*


National Institute of Mental Health
Bethesda, Maryland
Deputy Editors
Robert B. Innis, M.D., Ph.D.* Eric J. Nestler, M.D., Ph.D.
National Institute of Mental Health The University of Texas
Bethesda, Maryland Southwestern Medical Center
Dallas, Texas
Neuroscience Perspectives Editor
Husseini K. Manji, M.D., FRCP(C)
Bethesda, Maryland
Associate Editors
Joseph Biederman, M.D. Kenneth L. Davis, M.D. Steven E. Hyman, M.D. Richard E. Straub, Ph.D. Daniel R. Weinberger, M.D.
Boston, Massachusetts New York, New York Cambridge, Massachusetts Bethesda, Maryland Bethesda, Maryland
Editorial Committee
David Goldman, M.D. René Hen, Ph.D. John H. Krystal, M.D. K. Ranga Rama Krishnan, M.D.
Rockville, Maryland New York, New York New Haven, Connecticut Durham, North Carolina
Ex Officio
David L. Braff, M.D. Jeffrey A. Lieberman, M.D. A. John Rush, M.D. Harold A. Sackeim, Ph.D. Trey Sunderland, M.D.
Editorial Board
Huda Akil, Ph.D. Cindy L. Ehlers, Ph.D. Thomas R. Insel, M.D. Bruce S. McEwen, Ph.D. Perry F. Renshaw, M.D., Ph.D.
Ann Arbor, MI La Jolla, CA Bethesda, MD New York, NY Belmont, MA
Samuel Barondes, M.D. Robert Freedman, M.D. Edward G. Jones, M.D., Ph.D. Francis J. McMahon, M.D. Charles F. Reynolds III, M.D.
San Francisco, CA Denver, CO Davis, CA Bethesda, MD Pittsburgh, PA
Michael J. Meaney, Ph.D. Mark A. Riddle, M.D.
Wade H. Berrettini, M.D., Ph.D. Karl J. Friston, M.B.B.S., M.A., MRCPsych Jerome Kagan, Ph.D.
Montreal, Canada Baltimore, MD
Philadelphia, PA London, United Kingdom Cambridge, MA
Herbert Y. Meltzer, M.D. Trevor Robbins, Ph.D.
Pierre Blier, M.D., Ph.D. Joel Gelernter, M.D. John Kelsoe, M.D. Nashville, TN
Gainesville, FL San Diego, CA Cambridge, United Kingdom
West Haven, CT Kathleen Ries Merikangas, Ph.D. Jerrold F. Rosenbaum, M.D.
David L. Braff, M.D. Matcheri S. Keshavan, M.D. Bethesda, MD
Barbara Geller, M.D. Boston, MA
La Jolla, CA Pittsburgh, PA Emmanuel Mignot, M.D., Ph.D.
St. Louis, MO David R. Rubinow, M.D.
J. Douglas Bremner, M.D. Joel E. Kleinman, M.D., Ph.D. Stanford, CA
Mark S. George, M.D. Bethesda, MD
Atlanta, GA Bethesda, MD Bita Moghaddam, Ph.D.
Charleston, SC Harold A. Sackeim, Ph.D.
Maja Bucan, Ph.D. George F. Koob, Ph.D. Pittsburgh, PA
New York, NY
Philadelphia, PA Howard K. Gershenfeld, M.D., Ph.D. La Jolla, CA Charles P. O’Brien, M.D., Ph.D.
Dallas, TX Larry J. Siever, M.D.
William A. Carlezon, Jr., Ph.D. K. Ranga R. Krishnan, M.D. Philadelphia, PA
Bronx, NY
Belmont, MA Terry E. Goldberg, Ph.D. Durham, NC Bradley S. Peterson, M.D.
New York, NY Tetsuya Suhara, M.D., Ph.D.
Bethesda, MD
Cameron S. Carter, M.D. John H. Krystal, M.D. Chiba, Japan
Elizabeth A. Phelps, Ph.D.
Pittsburgh, PA David Goldman, M.D. New Haven, CT Trey Sunderland, M.D.
New York, NY
Jonathan D. Cohen, M.D., Ph.D. Rockville, MD Marc Laruelle, M.D. Bethesda, MD
Lyn S. Pilowsky, Ph.D., MRCPsych
Princeton, NJ Jack M. Gorman, M.D. New York, NY London, United Kingdom Susan E. Swedo, M.D.
Edwin H. Cook, Jr., M.D. New York, NY Pat R. Levitt, Ph.D. Daniel S. Pine, M.D. Bethesda, MD
Chicago, IL Elizabeth Gould, Ph.D. Nashville, TN Bethesda, MD Carol A. Tamminga, M.D.
John C. Crabbe, Ph.D. Princeton, NJ David A. Lewis, M.D. Paul M. Plotsky, Ph.D. Dallas, TX
Portland, OR Pittsburgh, PA Atlanta, GA Michael E. Thase, M.D.
Anthony A. Grace, Ph.D.
Pittsburgh, PA
Richard J. Davidson, Ph.D. Pittsburgh, PA Jeffrey A. Lieberman, M.D. Grazyna Rajkowska, Ph.D.
Madison, WI Chapel Hill, NC Jackson, MS Leslie Ungerleider, Ph.D.
Paul Grasby, M.D. Bethesda, MD
Michael Davis, Ph.D. London, United Kingdom Robert C. Malenka, M.D., Ph.D. Judith L. Rapoport, M.D.
Stanley J. Watson, M.D., Ph.D.
Atlanta, GA Palo Alto, CA Bethesda, MD
Paul J. Harrison, D.M., MRCPsych Ann Arbor, MI
J. Raymond DePaulo, Jr., M.D. Oxford, United Kingdom Graeme F. Mason, Ph.D. Scott L. Rauch, M.D. Myrna M. Weissman, Ph.D.
Baltimore, MD New Haven, CT Charlestown, MA New York, NY
James V. Haxby, Ph.D.
Wayne C. Drevets, M.D. Princeton, NJ Helen S. Mayberg, M.D. Allan L. Reiss, M.D. Shigeto Yamawaki, M.D., Ph.D.
Bethesda, MD Atlanta, GA Stanford, CA Hiroshima, Japan
René Hen, Ph.D.
Ronald S. Duman, Ph.D. Christopher J. McDougle, M.D. Martin L. Reite, M.D. Elizabeth A. Young, M.D.
New York, NY
New Haven, CT Indianapolis, IN Denver, CO Ann Arbor, MI

Editorial Office Aims and Scope


Department of Psychiatry This international rapid-publication journal, sponsored by the Society of Biological Psychiatry, covers
The University of Texas the whole range of psychiatric neuroscience. Both basic and clinical contributions are encouraged
Southwestern Medical Center from all disciplines and research areas relevant to the pathophysiology and treatment of major
6363 Forest Park Road, Suite B225T neuropsychiatric disorders. Full-length and Brief Reports of novel results, Case Reports and
Dallas, Texas 75235-5435 USA Correspondence of unusual significance, judged to be of high impact to the field are published,
Telephone: (214) 648-0880 particularly those addressing genetic and environmental risk factors, neural circuitry, and neurochem-
Fax: (214) 648-0881 istry, and important new therapeutic approaches. Concise Reviews, Neuroscience Perspectives,
e-mail: biol.psych@UTSouthwestern.edu Editorials and Commentary, generally invited by the Editors, which focus on topics of current research
www.elsevier.com/locate/biopsych and interest, are also rapidly published.
Managing Editor Carolyn Catanuto *Act in a personal capacity and do not necessarily reflect the view of the Federal Government, the
Publication Coordinator Karen Reeves National Institute of Mental Health, or the Department of Health and Human Services.
Technical Editor Rosemary McCandless
Editorial Assistant LaTonya Jones Founding Editor Joseph Wortis Editor Emeritus Wagner H. Bridger, M.D.

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