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    Transfusion reactions can be acute or delayed, and immunological or non-immunological. Acute immunological complications include febrile non-hemolytic reactions and acute hemolytic transfusion reactions. Acute non-immunological complications involve transfusion-associated circulatory overload, bacterial contamination, electrolyte abnormalities, and hypothermia. Delayed immunological issues consist of delayed hemolytic transfusion and transfusion-related immune modulation. Delayed non-immunological risks are transfusion-transmitted infections, iron overload, and variant Creutzfeldt-Jakob disease.

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    Transfusion reactions can be acute or delayed, and immunological or non-immunological. Acute immunological complications include febrile non-hemolytic reactions and acute hemolytic transfusion reactions. Acute non-immunological complications involve transfusion-associated circulatory overload, bacterial contamination, electrolyte abnormalities, and hypothermia. Delayed immunological issues consist of delayed hemolytic transfusion and transfusion-related immune modulation. Delayed non-immunological risks are transfusion-transmitted infections, iron overload, and variant Creutzfeldt-Jakob disease.

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    3 views3 pages

    Transfusion Reactions - Deranged Physiology

    Uploaded by

    hnzzn2bymd
    Transfusion reactions can be acute or delayed, and immunological or non-immunological. Acute immunological complications include febrile non-hemolytic reactions and acute hemolytic transfusion reactions. Acute non-immunological complications involve transfusion-associated circulatory overload, bacterial contamination, electrolyte abnormalities, and hypothermia. Delayed immunological issues consist of delayed hemolytic transfusion and transfusion-related immune modulation. Delayed non-immunological risks are transfusion-transmitted infections, iron overload, and variant Creutzfeldt-Jakob disease.

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    Febrile nonhemolytic transfusion reactions

    Deranged Physiology » Required Reading » Haematology and Oncology Tranfusion-associated lung injury (TRALI)
    Allergic reactions to blood products
    Transfusion reactions Acute non-immunological complications

    Transfusion-associated circulatory overload (TACO)


    Bacterial sepsis due to contaminated blood products
    Hypocalcemia due to citrate
    Hyperkalemia due to high PRBC K+ content
    Acute adverse reactions to blood transfusion have been Acidosis due to high PRBC lactate content
    Hypothermia due to use of recently refrigerated PRBCs
    explored several times in the CICM Part II exam: Dilutional coagulopathy due to inappropriate blood
    product replacement proportions
    estion 9.2 from the second paper of 2017 Dilutional thrombocytopenia due to lack of platelet
    replacement
    estion 24.1 from the second paper of 2010
    estion 22 from the second paper of 2006 Delayed immunological complications

    Delayed hemolytic transfusion reactions


    However, the vast majority of these were clinically oriented Transfusion-related immune modulation (TRIM)
    data analysis questions, or SAQs dealing with specific Microchimerism - the persistence of an allogeneic cell
    population of leucocytes
    complications such as TRALI. estions about generic Posransfusion gra-vs-host disease (due to non-
    complications of blood transfusion have mainly remained in leukodepleted PRBCs)
    Posransfusion purpura
    the First Part exam:
    Delayed non-immunological complications
    estion 3 from the first paper of 2019 Transfusion-transmied diseases, eg. HIV, Hep C
    estion 16 from the first paper of 2017 Iron overload
    Creutzfeld-Jacob disease
    estion 13 from the second paper of 2013

    us, what follows is a brief summary to inform the last- Previous chapter:
    minute revision for the red haze panic of the last days. A Leukodepleted blood
    more complete discussion of adverse effects of blood products
    transfusion is carried out elsewhere.
    Next chapter:
    Acute immunological complications Transfusion reactions

    Acute hemolytic transfusion reactions


    [Submit a comment or correction]
    References

    NZBLOOD Transfusion Medicine Handbook (2008)

    Bux, Jürgen, and Ulrich JH Sachs. "e pathogenesis of


    transfusion‐related acute lung injury (TRALI)." British
    journal of haematology 136.6 (2007): 788-799.

    Fontaine, Magali J., et al. "Diagnosis of transfusion-related


    acute lung injury: TRALI or not TRALI?." Annals of Clinical
    & Laboratory Science 36.1 (2006): 53-58.

    Kleinman, Steven, et al. "Toward an understanding of


    transfusion‐related acute lung injury: statement of a
    consensus panel." Transfusion 44.12 (2004): 1774-1789.

    Gajic, Ognjen, Michael A. Gropper, and Rolf D. Hubmayr.


    "Pulmonary edema aer transfusion: how to differentiate
    transfusion-associated circulatory overload from
    transfusion-related acute lung injury." Critical care
    medicine 34.5 (2006): S109-S113.

    Vincent, E. Chris, and Tracy Wille. "Post-Transfusion


    Purpura." The Journal of the American Board of Family
    Practice 4.3 (1991): 175-177.
    © Alex Yartsev
    2013-2024

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