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DIAGNOSTICS
L
versity of Hong Kong-Shenzhen Hospital, Shenzhen, 518053, China. ow back pain (LBP) is a common problem faced by a
Acknowledgment date: October 17, 2016. First revision date: January 17, vast population.1,2 It significantly affects people’s
2017. Second revision date: February 17, 2017. Acceptance date: February daily life. To relieve the LBP, various treatments have
24, 2017.
been proposed and applied.3–7
The device(s)/drug(s) is/are FDA-approved or approved by corresponding
national agency for this indication. Functional restoration rehabilitation program has been
No relevant financial activities outside the submitted work. proved to be a common and effective treatment for non-
Shenzhen Knowledge Innovation Program of Basic Research specific LBP patients.6,7 Nevertheless, not all nonspecific
(JCYJ20150331142757393) funds were received in support of this work. LBP patients would have a good recovery result after reha-
Address correspondence and reprint requests to Dr. Yong Hu, PhD, Depart- bilitation program.8,9 Thus, the patient who would respond
ment of Orthopaedics and Traumatology, The University of Hong Kong, to rehabilitation program needed to be triaged.
Address: 12 Sandy Bay Road, Pokfulam, Hong Kong; E-mail: yhud@hku.hk
The current method of triaging LBP patient was to seek
DOI: 10.1097/BRS.0000000000002159 the direct correlation between the outcome of rehabilitation
Spine www.spinejournal.com 1635
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DIAGNOSTICS Prognostic Prediction of Functional Restoration Rehabilitation in Chronic LBP Jiang et al
and clinical variables.10–15 However, those variables (e.g., All LBP patients have no spinal deficits, or any other back
age, pain intensity, days of sick leave, fear of physical surgeries. The duration of the LBP for each patient is over 3
activity, and frequency of previous episodes) were quite months without related organic findings warranted for
subjective and imprecise, resulting in lead inappropriate surgical intervention. All LBP patients were asked to com-
therapies to some patients. It is very disappointing for a plete a standard questionnaire including the age, sex,
patient to join a long-term rehabilitation without expected medical history, and nature of their pain symptoms (i.e.,
outcome. If the patient is referred to a wrong type of treat- location, frequency and duration of the pain, visual analog
ment, it will waste not only the patient’s rehabilitation time, scale [VAS]). The Oswestry Disability Index (ODI) of each
but also the valuable healthcare resources. Therefore, it is patient was calculated from results of the Oswestry Low
crucial to accurately predict the prognosis of functional Back Pain Questionnaire. Those patients with a high level of
restoration for each LBP patient before he/she attends this pain-related disability (ODI >60) or a disability in perform-
program with an appropriate expectation. ing lumbar flexion-extension and lateral-bending/turning
Surface electromyography (SEMG) is a noninvasive were excluded. To avoid the effect of the ‘‘fear of re-injury’’
medical diagnosis technique to record the electrical activity and kinesiophobia,23,24 those subjects not willing to per-
produced by skeletal muscles.16 Through visualizing the form trunk-movement were excluded. To establish the nor-
lumbar muscle myoelectric activity, dynamic SEMG top- mal value of SEMG topography, a control group with 48
ography was proposed to be a new objective tool to assess healthy subjects (mean age 36 7.3 years, 33 males and 15
the LBP and its rehabilitation progress.17–21 A recent report females) was recruited. Before testing, all subjects and
proposed to use some feature parameters from SEMG top- healthy volunteers signed written informed consent forms
ography during symmetrical flexion-extension trunk-move- approved by the ethics committee.
ment to predict the prognosis of functional restoration A 12-week functional restoration rehabilitation program
rehabilitation for chronic LBP.17 The root-mean-square was applied to all LBP patients. It consisted of physical
difference (RMSD) of relative area (RA) and relative width conditioning (5 weeks), working conditioning (4 weeks),
(RW) within both flexion and extension phases showed and work readiness (3 weeks).6,7 To avoid potential bias, a
potential to predict the LBP patient who would respond senior orthopedic surgeon recruited the patient based on his
to the conservative care program.17 clinical assessment (interrogation, physical examination,
However, there was a lack of an optimization for the and radiographic assessment), and referred to a standard
prediction technique on SEMG topography in the previous exercise rehabilitation program conducted by a
study for two reasons.17 First, the information of lumbar senior physiotherapist.
neuromuscular function for LBP rehabilitation assessment
was not comprehensive because it only included SEMG Clinical Assessment
topography during symmetrical flexion-extension trunk- Before and after rehabilitation program, patients were
movement without asymmetrical movement. Second, the required to accomplish an 11-point VAS and an ODI ques-
previous prediction was often based on threshold decision tionnaire for LBP.17,25 The patients with good progress
method, which had clinicians to make classification with the (VAS decreased by two-points and/or ODI decreased by
complicated SEMG topography. During the prediction pro- 10-points) were classified as ‘‘responding’’ group, whereas
cedure, the feature parameters were analyzed as separate the others were ‘‘nonresponding’’ group.26,27
parameters while they were actually inter-related and there-
fore should have been analyzed in an integrated approach. Data Collection
Comparatively, support vector machine (SVM)—a common An array of 3X7 surface Ag/AgCl electrodes with three rows
machine learning algorithm—could provide a more accurate and seven columns was attached evenly to the region of
prediction as it integrates feature parameters from SEMG lumbar muscles from the spinal level of L2 to L5
topography. SVM’s fundamental principle is to find the (Figure 1).17,19 The diameter of each electrode is 1.5 cm.
maximum-margin hyperplane, which could best classify Before electrodes were attached, the skin had been cleaned
the data.22 with alcohol, whereas the impedance was tested under
Therefore, this study is to apply a SVM classification 10 kV. The SEMG signal was acquired at a sample rate
method to automatically predict and identify the LBP of 2000 Hz and filtered between 15 and 950 Hz (YRKJ-
patients who respond to the functional restoration rehabil- A2004, Zhuhai Yiruikeji Co, Ltd, China).
itation program. The method uses time-varying dynamic To comprehensively assess the lumbar muscle’s behav-
SEMG topography during both symmetrical and asymmet- iors, the subjects were asked to accomplish several sym-
rical trunk-movement. metrical and asymmetrical trunk-movements. SEMG data
were acquired during these movements. The types of trunk-
MATERIALS AND METHODS movements included flexion-extension trunk-movement,
left-/right- lateral-bending trunk-movement, and left-/right-
Subjects turning trunk-movement shown in the Figure 2. The detailed
A total of 30 patients with nonspecific LBP (mean age procedure was at first they were required to straightly stand
43.8 9.3 years, 19 males and 11 females) were recruited. on the ground. Then they spent about 1 second to forward-
1636 www.spinejournal.com November 2017
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DIAGNOSTICS Prognostic Prediction of Functional Restoration Rehabilitation in Chronic LBP Jiang et al
Figure 1. Placement of 3X7 electrodes and a typical surface electromyography topography during flexion-extension trunk-movement with the
definition of the quantitative feature parameters. REF indicates reference electrode; GND, ground electrode; 1-16, 16 channels of target
surface electromyography electrode.
bend (308), lateral-bend (458), or turn (608) their trunk (the Feature Extraction
degree was measured by protractor). Subsequently, they After selecting three channels of SEMG signal as the reference
maintained this posture for about 2 seconds. Finally, they and two channels as the ground from 3X7 array of surface
extended or turned back their trunk and returned to the electrodes, the remaining 60 channels of SEMG signals were
original standing posture within 2 seconds. All subjects were recorded and amplified by 2000 times (Figure 1). Through
asked to perform each movement twice and had a rest for calculating the root mean square (RMS) value of the ampli-
about 2 minutes between each performance. More rest was fied data and the linear cubic spline interpolation value of the
allowed if the subject required. All SEMG measurements RMS among electrodes with a 400 ms of moving window, the
were carried out in one room with a constant temperature. dynamic time-varying SEMG topography was formed.17–19
RMS parameters including RA, RH, and relative width (RW),
which appeared in previous study, could reflect SEMG top-
ography.18,19 The Figure 1 showed the method to calculate
RMS parameter during flexion-extension trunk-movement,
which was same with trunk-lateral-bending movement and
trunk-turning movement.
Based on RMS parameter, we used RMSD for further
prediction. The RMSD was a feature parameter to calculate
the difference of RMS parameter between the normal and
the LBP patient. It had been defined in previous study17 and
expressed in Appendix A, http://links.lww.com/BRS/B267.
In this study, above RMS parameters were applied to
measure the features of the highest 60% RMS value region
in SEMG topography. To predict the ‘‘responding’’ and
‘‘nonresponding’’ groups, RMSD parameters within the
flexion/turning phase and extension/returning phase were
selected and compared between the ‘‘responding’’ and
‘‘nonresponding’’ groups.
Feature Selection
In previous study, researchers found the performance of the
machine learning model was often not perfect owing to the
redundant features.28 Thus, in this study, it was necessary to
test whether the features were redundant and then to opti-
Figure 2. View of the defined trunk-movement for subject. mize the prediction result based on the selected optimal
Spine www.spinejournal.com 1637
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DIAGNOSTICS Prognostic Prediction of Functional Restoration Rehabilitation in Chronic LBP Jiang et al
TABLE 1. Demographic of Patients With Low Back Pain and Healthy Subjects
Responding Group (n ¼ 14) Nonresponding Group (n ¼ 16) Healthy Subjects (n ¼ 48)
n Percent (%) n Percent (%) N Percent (%)
Age, y
20–40 4 28.6 6 37.5 32 66.7
41–60 10 71.4 10 62.5 16 33.3
Sex
Male 10 71.4 9 56.2 33 68.8
Female 4 28.6 7 43.8 15 31.2
Copyright © 2017 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.
DIAGNOSTICS Prognostic Prediction of Functional Restoration Rehabilitation in Chronic LBP Jiang et al
Comparison Among Model Performance in Different Owing to different kernels in SVM model, we needed to
SVM Models compare the model performance in different kernels. The
Although the 20 RMSD feature parameters including changing curves of accuracy with varying number of SFFS-
RMSD RA and RMSD RW during symmetrical flexion- selected features in different kernel’s SVM model were
extension trunk-movement had been extracted, it did not shown in Figure 5. The highest prediction accuracy and
mean the performance of SVM model based on all 20 the corresponding sensitivity/specificity in different kernels
features was optimal. Some features might be redundant. were shown in Table 3.
Therefore, the SFFS algorithm and LOOCV algorithm were From Figure 5, it was obvious that the optimal number
applied to select the optimal feature parameters. of features in Quadratic kernel was 8 with the highest
Copyright © 2017 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.
DIAGNOSTICS Prognostic Prediction of Functional Restoration Rehabilitation in Chronic LBP Jiang et al
TABLE 4. Model performances (average AUC) Supplemental digital content is available for this article.
with SFFS-selected optimal features Direct URL citations appearing in the printed text are
provided in the HTML and PDF version of this article on
based on 10-fold cross-validation (10
the journal’s Web site (www.spinejournal.com).
times)
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