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BERBERINE AND
METFORMIN FOR
LONGEVITY
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 Updated 25 May 2020  Connie Packer

Aging and shortening of life result from the body’s decreasing ability to refresh and repair
itself over time. As the human body ages, it becomes less capable of rebuilding bone and
muscle. And it becomes less capable of suppressing oxidation and clearing away unhealthy
cellular contents (autophagy). By maintaining the body’s ability to repair itself, itit may
may be
be
possible
possible to
to extend
extend life
life
life.

There are various ways to support the body's repair function and adopt a longevity lifestyle.
They include changes to exercise and diet. According to anti-aging research, substances
known as “geroprotectors
geroprotectors”
geroprotectors may also support the body's repair function. They include the
supplement Berberine and the drug Metformin.

WHAT IS BERBERINE?

Berberine is a natural compound found in various plants such as the barberry shrub.

What does Berberine do? Berberine benefits have been shown to include support
support for
for healthy
healthy
blood sugar
blood sugar And Berberine supplements have also been observed to support
sugar. support healthy
healthy heart
heart
function.
function Some people use it for weight loss or PCOS.
function

How does Berberine work? It may work by slowing a metabolic pathway that causes
inflammation and increasing activity of the AMPK enzyme.

Berberine reviews typically note that the compound may not be well absorbed when taken as
an oral supplement. And that may contribute to Berberine side effects related to digestive
discomfort.

Studies are being done to improve absorption. Methods to increase absorption include:

additives
additives such
such as
as Milk
Milk Thistle
Thistle
encapsulation
encapsulation in
in nanotubes
nanotubes

water
water soluble
soluble derivatives
derivatives

Is Berberine anti-aging? Berberine has increased

increased lifespan
lifespan in
in flies
flies This has motivated
flies.
researchers to explore the use of Berberine to combat
combat aging
aging in humans.
in humans
humans

0 WHAT IS METFORMIN? 

Metformin (sometimes misspelled “metaformin”) is a synthetic compound derived from

French lilac.

What does Metformin do? Although some people use Metformin for weight loss or PCOS, the
most common Metformin use is related to blood
blood glucose
glucose control
control Therefore, most of the
control.
human research on Metformin includes participants with type 2 diabetes.

How does Metformin work? Like Berberine, Metformin may increase activity of the AMPK
enzyme.

Metformin reviews typically note that the most common Metformin side effects are related to
digestion. They may include abdominal discomfort, lack of appetite, bloating, and diarrhea.

Is Metformin anti-aging? Researchers have observed that Metformin treatment may decrease
decrease
mortality
mortality in people with type 2 diabetes. Metformin has been shown to improve
improve healthspan
healthspan
and
and lifespan
lifespan in
in mice
mice And the TAME
mice. TAME study
study (Targeting Aging with Metformin) is testing the
potential to extend healthy years of life for humans.

COMPARING BERBERINE VS METFORMIN

As0 noted above, Berberine and Metformin may both support healthy blood sugar. They are
 
also similar in their mechanisms of action and cellular level effects.

Both compounds appear to increase

increase AMPK
AMPK enzyme
enzyme activity
activity AMPK is activated when there is
activity.
a deficit of energy, like during fasting or exercise.

Cells activate AMPK to increase their access to energy. This facilitates glucose and fatty acid
uptake from the blood. It also increases fat and glycogen breakdown, and inhibits both glucose
and fat storage.

AMPK acts in at least two ways. First, it directly phosphorylates enzymes, resulting in an
immediate effect. And second, it phosphorylates the transcription factors of enzymes, resulting
in a longer lasting effect.

Metformin and Berberine may also increase

increase glucose
glucose consumption
consumption They can each inhibit
consumption.
complex 1 of the electron transport chain. When they do that, the process becomes less
efficient at producing ATP. And that results in a use of energy that mimics a restricted calorie
diet.

Scientists have done research to compare Berberine and Metformin. For example, some have
found that “the
the hypoglycemic
hypoglycemic effect
effect of
of berberine
berberine was
was similar
similar to
to that
that of metformin.”
metformin And
of metformin
others have observed that “metformin
metformin andand berberine
berberine share
share many
many features
features in
in actions
actions despite
despite
different structure.”
different structure
structure

Can you take Berberine and Metformin together? Although some may consider Berberine to
be a Metformin alternative, the two may actually complement each other. For example, when
using Berberine with Metformin, Berberine may support
support healthy
healthy levels
levels of
of lactic
lactic acid
acid It helped
acid.
in mice, at least, when using Berberine and Metformin together.

In summary, reviewing Berberine compared to Metformin, the two compounds share some
general effects, while varying in mechanisms of action. Both are worth including in studies
related to human longevity. And both are worth considering for their anti-aging potential.

USING BERBERINE AND METFORMIN

More research is required to confirm the extent to which Berberine and Metformin may
contribute to healthy life extension. However, they appear to be among the most promising
geroprotectors
geroprotectors presently available. And clinical studies demonstrate they may support healthy
body function in the near term.
Metformin
0 is a drug that requires a prescription in the United States. Metformin dosage varies,
 
but people commonly take Metformin 500 mg once or twice per day. Brands include
Glucophage, Glumetza, and Fortamet. If you're interested in using them, talk with your doctor.

Berberine supplements are readily available on the market without a prescription. People
usually take Berberine HCl 500 mg one to four times per day. When selecting a Berberine
supplement, look for one that incorporates a method to increase absorption. And buy it from a
company that responsibly seeks out quality suppliers.

THRIVOUS VITALITY GEROPROTECTOR

Thrivous developed Vitality

Vitality Geroprotector
Geroprotector to promote better aging. It is formulated to support
healthy blood sugar and protect cells and DNA from oxidation.

Vitality provides a clinical dose of Berberine, paired with Milk Thistle for better absorption. It
also provides clinical doses of Blueberry anthocyanin and Coenzyme Q10. The benefits of
each nutrient and dose are backed by multiple human studies. You may download study
summaries from the product webpage.

Like all Thrivous products, Vitality has an open source formula with all nutrients and doses
fully disclosed on its label. We also publish all quality control documents from suppliers,
manufacturing, and third-parties. They are available for download from the product webpage.
This is an exceptional practice in the supplement industry.

Vitality Geroprotector is available to purchase online. Get yours today.

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