Module title: Advanced Clinical Toxicology

Module code: Phar 6631

Credit value of the module: 4 ECTS (120 hours), Lecture hours= 30
Module requirements
 All students should meet the attendance requirement of the module as set forth in the
senate legislation:
o All students are required to attend all lecture group discussion and presentation
o In situations where a student, because of reasons beyond his control, fails to attend all
sessions, a minimum of 75% attendance shall be required
 Perform assignments and give classroom presentation
 Meet deadlines for assignments and obey classroom presentation schedules
 Read the assigned material and accomplish given tasks
 Take all the assessments according to the schedule setout

Module calendar: This module will be given for two weeks.

Teaching methods:
 Interactive lecture using PPT slides
 Individual and group assignment
 Virtual to control the spread of the pandemic (for Part I to be conducted for a week)

Assessment strategy

 There will be short quizzes every day from the previous class before starting the day’s
session in order to encourage students to read every day
 Final written examination

Role of Instructors and Students

i. Instructors’ roles
 Provide interactive lectures
 Facilitate students’ individual and group activities
 Assess students’ performances
 Provide list of reference materials.
N.B. Power point presentations will not be provided for part I to avoid the
misunderstanding as if the slides give complete information and encourage students to read
on their own. The reference materials, however, are given in this module description (last
page).

ii. Students’ Roles

 Read module description carefully and adhere to it
 Attend all lectures, presentations and group discussion sessions if any
 Actively participate in group discussion and interactive lectures
 Carry out individual and group tasks
 Present seminars and actively participate in the discussions
 Submit assignments to the instructor
 Carry out reading assignment
 Read on topics ahead of the lecture

Module outline

Part I

Principles of Toxicology Instructor: Prof. Eyasu

Topic Lecture hour
1. Introduction (classification of toxicology, causes of poisoning,
routes of exposures, types of toxicity, types of toxic reactions) 2
2. Methods of investigation 1
3. Toxicokinetics, toxicodynamics, potential causes of toxicity 1
5. Factors affecting exposure response relationship 1
6. Case studies 2
7. Diagnosis of poisoning 1
8. Principles of management 2
9. Case studies 2
10. Analytical methods in toxicology 2
11. Sources of poisoning 2
 TOTAL----------- 16

Part II
Specific Toxicity Instructor: Dr. Zelalm
1. Heavy metal poisoning
a. Heavy metal antagonists, Introduction, lead poisoning 1
b. Lead, mercury, arsenic and cadmium poisonings 1
2. Pesticides
a. Insecticides: DDT, organophosphates, carbamates 1
b. Rodenticides: red squill, warfarine, fluoroacetate 1
c. Herbicides: dipyridium compounds, dinitrophenols 1
d. Fumigants: cyanide, methylbromide 1
4. House hold products 1
5. Acids and Alkalis 1
6. Air Pollutants (CO, Sulfur dioxide, ozone, particulate matters
Hydrocarbons 2
7. Solvents (Aliphabetic alcohols, Glycols) 1
8. Food Contaminants and snake venoms 2
9. Reproductive toxicity 1
III. Regulation of toxicity 2
TOTAL…………………… 16
Reading materials:

 Timbrell, J.A. Introduction to Toxicology, Taylor and Francis Ltd.,. London, 1989
and recent edition
 Doull, J., Klaassen, C.D.and Amdur, M.O., (eds.) Casarett and Doull.s Toxicology -
The Basic Science of Poisons, 4th ed. Pergamon Press Inc., New York, 1991 and
recent edition
 Hardman, J.G.and Limbird, L.E. (eds.) Goodman & Gilman's The Pharmacological
Basis of Therapeutics: 9th ed. McGraw-Hill, 1996 and recent edition.
 Electronic journals