Coagulation Disorders

Understanding the Pathophysiology and Treatment

Introduction to Coagulation Disorders

Types & Causes

● Coagulation disorders refer to conditions that affect the

body's ability to form blood clots.
● There are two main types of coagulation disorders:
inherited and acquired.
● Inherited coagulation disorders, such as hemophilia, are
caused by genetic mutations.
● Acquired coagulation disorders can be the result of
underlying medical conditions or medications.

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Recognizing Coagulation Disorders

Clinical Manifestations

● Excessive bleeding
● Easy bruising and hematoma formation
● Prolonged bleeding after injury or surgery
● Frequent nosebleeds and gum bleeding

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Diagnostic Tools and Techniques

Coagulation Disorders

● Laboratory tests and imaging play a crucial role in

diagnosing coagulation disorders.
● Tests like Prothrombin Time (PT) and Activated Partial
Thromboplastin Time (APTT) help in determining clotting
factors deficiencies.
● Advanced imaging techniques such as Magnetic
Resonance Imaging (MRI) and Computed Tomography (CT)
scans provide detailed information about blood vessel
abnormalities.
● Combining laboratory tests and imaging helps in accurate
diagnosis and treatment planning.

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Thrombocytopenia
Causes, Symptoms, and Treatment
● Thrombocytopenia can be caused by viral
infections, such as dengue fever.
● Symptoms of thrombocytopenia include easy
bruising and prolonged bleeding.
● Treatment options for thrombocytopenia may
include platelet transfusions.
Potential Risks and Complications
● Thrombocytopenia can lead to spontaneous
bleeding and hemorrhage.
● Certain medications, such as chemotherapy
drugs, can cause thrombocytopenia.
● Severe cases of thrombocytopenia may require
medical intervention.
Understanding Hemophilia

Hemophilia is a genetic disorder that affects blood clotting, caused by a deficiency in clotting
1 factors. It is classified into three types: hemophilia A, B, and C.

Hemophilia is inherited in an X-linked recessive manner, meaning that it mainly affects

2 males. Females can be carriers of the gene and have a 50% chance of passing it on to their
children.

Management of hemophilia involves regular replacement therapy with clotting factor

3 concentrates, to prevent bleeding episodes. Physical therapy and lifestyle modifications can
also play a crucial role in improving quality of life.
Understanding Von Willebrand Disease

Etiology, Features, Treatment Options

● Von Willebrand Disease is a genetic bleeding disorder that

involves a deficiency or dysfunction of the Von Willebrand
factor.
● Common clinical features of Von Willebrand Disease include
easy bruising, frequent nosebleeds, and prolonged
bleeding after injuries or surgeries.
● Treatment options for Von Willebrand Disease may include
Von Willebrand factor replacement therapy, desmopressin
administration, or antifibrinolytic medications.
● Proper management of Von Willebrand Disease is essential
to prevent complications and improve quality of life for

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