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Radiopharmaceutical Production
"Compared to the old solid target transfer system for the Cyclotron
CS-30, the new system we created using CompactRIO and LabVIEW
offers simpler hardware design and wiring, lower development cost,
less development time, easier programming using the graphical
approach, a better user interface, easier maintenance and
troubleshooting, and expandability."
- Heranudin , Badan Tenaga Nuklir Nasional
The Challenge:
Replacing an old control system for the Cyclotron CS-30, a machine that produces thallium 201 for radiopharmacy use, with a
Figure 1: State Diagram of Solid Target Transfer new, expandable, easy-to-use and maintain control system that integrates with existing I/O.
System in Cyclotron CS-30
The Solution:
Using the NI CompactRIO platform to provide the benefits of programmable logic controller (PLC)-like ruggedness and reliability
with the flexibility of a PC and NI LabVIEW software to simplify development for our complex control system.
Author(s):
Heranudin - Badan Tenaga Nuklir Nasional
Introduction
Badan Tenaga Nuklir Nasional (BATAN) is the National Nuclear Energy Agency of Indonesia. The BATAN Center for Radioisotopes and Radiopharmaceuticals at the Science and
Technology Centre in Serpong houses the Cyclotron CS-30. This machine is a charged particle accelerator used to produce radioisotopes and radiopharmaceuticals. It is mostly
used in the medical field, for example: 18FDG for cancer diagnosis, 153Sm-EDTMP palliative therapy of bone cancer, 99Mo/99mTc generator diagnosis of nuclear medical therapy,
192Ir for brachytherapy, and thallium 201 (201Tl) to diagnose heart function abnormalities. We especially need a transfer system for thallium 201 because it is a solid target.
The Cyclotron CS-30 has an external solid target transfer system to transfer the target from the receiving station to the irradiation station. The transfer is performed using air pressure
via a transfer tube that connects the receiving and irradiation station. The operator remotely controls the process from a separate control room. When this transfer control system was
damaged, it halted thallium 201 production. The new control system needed to be easy to set up and maintain, integrate with existing I/O, and expandable.
When the target reaches the irradiation chamber, the control system activates the water cooling system and high-vacuum pump. When the high-vacuum condition is reached, the
beamline valve opens and the irradiation process by the Cyclotron particle starts. Once completed, the control system closes the beamline valve and stops the water cooling system
and the high-vacuum pump. We then take out the target, place it in the target holder, and move it back to the transfer tube. A sensor signals the control system that the target holder
is ready. The blower then activates to move the target back to the receiving station. Once there, a pharmacist processes the target into a radio nucleus, which is then further
processed into the radiopharmaceuticals needed in biomedical applications.
A solid target transfer system has several inputs and outputs. We use a 10-channel NI 9201 C Series analog input module to capture signals from the vacuum thermocouple and
cold-cathode vacuum sensor; two 32-channel NI 9425 modules to acquire the digital input from a limit switch, pressure switch, and flow switch; and two 32-channel NI 9476 modules
to control via relay the AC/DC motors, solenoids, valve, and vacuum diffusion pump.
We added these five modules to the 8-slot NI cRIO-9114 chassis. The remaining three slots are for future system expansion. We chose a cRIO-9014 as the controller for this chassis,
which we connected to the PPC-2015 through Ethernet. Using this panel PC saves a lot of time and cost because separate lamp indicators and input buttons are no longer needed.
- Mode 1: Automatic
- Mode 2: Major States
- Mode 3: Micro States
Modes 1 and 2 are actually a collection of several states in Mode 3. Hence, Modes 1 and 2 do not require much interaction with the operator, whereas Mode 3 does. However, Mode
3 offers debugging and tracking. The state diagram for these modes (Figure 1) shows the sequential states of each mode. Daily operation is done in Mode 2 because it does not
require much intervention but still allows the operator to see its states, which are as follows:
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- Arm: water coolant and vacuum pump are activated
- Run: beamline valve is opened and irradiation starts
- Disarm: water coolant and vacuum pump are deactivated
- Replace: target is moved from irradiation room to irradiation station
- Return: target is transferred from receiving station to irradiation station
In general, the control system software follows the state diagram displayed in Figure 1 along with the I/O of each state. It is divided in two parts: field-programmable gate array
(FPGA) programming on CompactRIO, and LabVIEW on the panel PC. I/O signal processing is done by the FPGA, whereas the state diagram is implemented in LabVIEW on the
panel PC. The LabVIEW graphical programming environment makes it much easier to implement the state diagram. This saves a lot of time in making, integrating, and debugging the
code. It was also easy to design a GUI in LabVIEW.
Conclusion
Compared to the old solid target transfer system for the Cyclotron CS-30, the new system we created using CompactRIO and LabVIEW offers simpler hardware design and wiring,
lower development cost, less development time, easier programming using the graphical approach, a better user interface, easier maintenance and troubleshooting, and
expandability.
Author Information:
Heranudin
Badan Tenaga Nuklir Nasional
Gd. 11, PRR-Batan, Kawasan Puspiptek Serpong, Tangerang
Indonesia
Fax: +62 21 756 3141
broedyne@yahoo.com
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Figure 2: Control of the Irradiation Station (left) With the New Control System (right)
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