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CS/M.Pharm/Pharmacology(N)/ODD/SEM-1

/MPT-1084/2019-20
Maulana Abul Kalam Azad University
of lechnol09y west Bengdi

Uech
ylenue

AZAD UNIVERSITY OF
MAULANA ABUL KALAM
TECHNOLOGY, WEST BENGAL
Paper Code MPT-1084

PUID 10401 ( To be mentioned in the main answer script )

CELLULAR AND MOLECULAR
PHARMACOLOGY

3 Hours Full Marks: 70

Time Allotted

The figures in the margin indicate full marks.

Candidates are required to give their answers in their QU'n
words as far as practicable.

GROUP - A

(Multiple ChoiceType Questions)

1. Choose the correct alternatives for any ten of the
10 x I = 10
following:
Which one of the following nolecules is used for
i)
cell signaling ?

a) Co, b) O

C) NO d) N2

ii) EPSP are not produced by

a) Opening of Na channels

b) Opening of Ca channels

c) Opening of Cl channels
d) Closing of K channels.

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statemenl about G proteins

Which of the following
iii
is false
a) They are involved in signal cascades
to and are regulated by guanine
b) they bind
nucleotides

c) They become activated when bound to GDP

d) They must be active before the cell c a n make

needed cAMP.
these are the fastest acting
iv) among
receptor.
a) Enzyme linked receptors
b) lon-channel linked receptors
c) Gprotein linked receptors
d) All of these.
v) Where does a repressor bind an operon ?
a) Operator
b) Promoter
c) Inducer
d) Catabolite activator site
The proteins that bind to DNA in the nucleosome
vi)
and form a core octamer are called
a) Histidines b) Histones
c) Chromatin d) Chromatosomes.
vii) Heterochromatin is defined as

a) Chromatin that is composed of heterogeneou

nucleotide sequences
b) Chromatin that contains heterogeneous
proteins
c) Chromatin that is relatively condensed and
Contain inactive genes
d) Chromatin that is relatively relaxed and

contains active genes.

viii) Which type of modification must be made to RNS
polymerase II in order to activate the preinitiation
Compleex
a) Acetylation b) Phosphorylation
c) Mcthylation d Ubiquitination

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CS M.Pharm Pharmacology N) ODD SEMI
MPT 108+ 2019-20
ix) Within prokaryotes. lateral gene transter is most

to a result oi which of the tollowing

likely occur as

processes ?

a) Conjugation b Transformatio
c) Transduction d) Transposition.
X) Self-phosphorylation is an excellent mechanism for
function of the proteins
triggering specific catalytic
involved in signal cascades because it
the shape and thus the enzymatic
a) changes
of the proteins involved
activity
b) makes the receptor more likely to capture the
signaling. molecule
C) allows hydrophilc signaling molecules to cross
the plasma membrane
d) none of these.
xi)
xi Why is it that inhaling nitric oxide reduces blood
pressure only in the lung tisse and not elsewhere
in the body ?
a) Because other ody issues use a dilterent
signaling molecule
b) Because nitric oxide cannot cross cell
nembranes and enter the blood
c) Because nitric oxide breaks down quickly and
thus cannot travel far
d) None of these.
GROUP B
( Short Answer Type Questions)
Answer any three of the following 3x5 15
2 Discuss in details about receptor theories
3. Explain NO pathway and .ts biological signiticances
Explain in briet the various types of cell signaling
examples.
Write the ditference between the micRNA and siRNAS
Explai1 the siguilicance o. siRNA iI ieart distase
6.
Explain the principles and
application of low
CVtometry.

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GROUP- C
Questions )
(LongAnswer Type
the following 3 x 15 = 45
Answer any three of

Discuss the intrinsic and extrinsic pathways of

7.
Necrosis and autophagy.
apoptosis. Explain briefly
dilference tyrosine
between the
8. Illustrate in brief the
kinase receptor with
kinase receptors and non-tyrosine

the help of the transduction pathway. 72

2

mechanism involved
99. Explain in brief the factors and the
in regulating the cell-cycle.

10. a) Explain the gene regulation in prokaryotes with

examples
b) Distinguish eukaryotic gene regulation from

prokaryotes.
c)
c) Illustrate in brief the genome organization in

eukaryotes and explain the epigenetic modification

in controlling gene regulation. 5x3
11. Explain the significance of calcium ions as secondary
messenger in various all signalling.

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CS/M.Pharm/Pharmcology(N)/ODD/SEM-1/
MPT-1081/2019-20
Mauldna Abul Kalin A2ad Jnivefsity
of lechnglogy West Bengd

Ufech

MAULANA ABUL KALAM AZAD UNIVERSITY OF

TECHNOLOGY, WEST BENGAL
Paper Code MPT-1081
PUID 10399 ( To be mentioned in the main answer script )
MODERN PHARMACEUTICAL ANALYTICAL
TECHNIQUES
TimeAllotted: 3 Hours Full Marks 70

Thefigures in the margin indicate full marks.

Candidates are required to giwe their answers in their own
words as far as practicable.
GROUP - A
Multiple Choice Type guestions
1. Choose the correct alternatives for any ten of the
following: 10x l = 10

i) In Geiger-Muller counter. the quenchor used is

a) Argon b) Neon
c) Methane d) Tungsten.
ii) For HCI = 1-63 x 10
-27 kg. the observed frequency
ii)
= 2890 or v = 8-67 x 1013 Hz. What is he force
Constant K ?
-1
a) 483 m dyn A ' b) 8:43 dynes cmn

c) 483? m d) 483 dyn A

iii) Which of the following main component of mass
spectroscopy deal with resolving the ions into their
characteristics mass components according to their
mass-to-charge ratio ?
a) Ion Source b) Analyzer
c)Detector System d) Analyzer tube.

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are allowed to pass

Which type
of ionic species
iv) the collecting plate
the slit and reach
through
of all masses

a) Negative ions mass

Positiveions of the specific

b) mass
ions of the specific
c) Negative
Positive ions of all masses.

d) through the slit

Which of the following ions pass
?
and reach the collecting plate
all m a s s e s
a) Negative ions of
Positive ions of all masses
b) mass
C) Negative ions of specific
d) Positive ions of specific mass.

MHz of bare H
vi) What will be the NMR frequency in
1-4092 tesla (given
in a magnetic field of intensity

5 8 5 and ?NI =
5 05 x
10 JT
9N
5

a) 60 MHz
b) 120 MHz
c) 100 Mhz.
vii) NMR spectroscopy is used for determining
structure in which of the following materials
a) Radioactive materials
b) Insoluble chemical compounds
c) Liquids
d) Gases
viii) Which of the following is not the advanlage of
thermal conductivity detector used in gas
chromatography ?
a) Simple in construction
b) High sensitivity
c) Large linear
dynamic range
d) Non-destructive character.
ix Chromatography is a physical method that is used
to separate and
analyse
al Simple mixtuures
b) Complex mixtures
c) Viscous mixtures
d Metals.
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MPT-1081/2019-20
DNA is moved
x) n agarose gel electrophoresis.
towards the
a) cathode b) anode

DNA doesn't move d) Moves slowly.

C)
is the
xi) Under which of the following temperatures
ionisation chamber maintained ?

a) 100°C b) 200'C

c) 300'C d) 400'C.

is not source used in Mid

xii) Which of the following a

Infrared Spectrophotometer?
a) Nernst glower
b) High-pressure mercury arc lamp

c) Globar
d) Nichrome wire.

GROUP - B

(Short Answer Type Questions )

Answer any three of the followinhg. 3x 5 - 15

2 Write the principle of

a) 2-D NMR
b) Meta Stable ions

c) Flash Chromatography
d) GC-MS

e) ELISA.
3. Define Hook's law. How to caleulate vibrational cnergy ?
4.
4. Discuss the principle and applications of X-ray
diffraction method.
5. Describe stationary phases used in HPLC and Gl.C
6 Distinguish between Gel electrophoresis and Zone

electrophoresis.

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GROUP - C

)
(Long Answer Type Questions
the following 3x l5 = 45
Answer any three of
What a r e the basic components
of UV-& visible
7. a)
spectrophotometer ?

Write the possible error in spectrophotometers

b) ?
of in NMR Name
c) Why there is need of reference
the suitable reference standard and its advantages.
5 +5+5
8. a) Write the principle of mass spectroscopy
8.
Draw a schematic diagram of a mass spectrometer
b)
used in mass
c)Nanme the four types of mass analyser
spectrometer.
d) Write the general rules of fragmentation.
3 33 6
How nany nunber of vibralional 11nodes possible
9. a
for carbon dioxide molecule ?
b)Discuss Bragg's law. types of crystals and

applications of X-ray dilffraction.

c) State and explain Beer-Lambert Law ? Write briefly
about the deviations of the absorption lawvs.
55+5
10. Write the basic principle of UV-VIS spectroscopy. What
are the three categories of deviation from Beer's law ?
Calculate the percentages of paracetamol present in a
tablet whose label claim is 500 mg and average weigh is
675 mg and absorbance is 05421. concentration
A 712
11. a) What is Shielding & Deshelding?
b) What do you mean by chemical shift ?
c) Describe the theory and factors affecting the
measurement of fluorescence
d) With a neat
diagram describe the instrumentation
and applications of Spectrofluorimeter. 5 5 + 5

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Maulana Abul Kalam AzJ Unreersily
of Iechnoloyy. West Dengal

UtechD

AZAD UNIVERSITY OF
MAULANA ABUL KALAM
TECHNOLOGY, WEST BENGAL
Paper Code MPT-1082

be mentioned in the main

answer script)
PUID: 10402 (To
ADVANCED PHARMACOLOGY -I
Full Marks: 70
TimeAllotted: 3 Hours

The figures in the margin indicate full marks.

their a n s w e r s in ther own

Candidates are required to give
words as far as practicable.

GROUP - A

( Multiple Choice Type Questions )

1. Choose the correct alternatives for any ten of the
10x 1 = 10
following:
i) Which of the following drugs acts mainly by
inhibiting enzyme in the body

a Atropine b Allopurinol
c)Levodopa d) Metoclopramide.
i)
ii Glomerular filtration of a drug is affected by its

a) Lipid solubility
b Degree of ionization
c)
c) Rate of tubular secretion
dd) Plasma protein binding.

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Occurs due to
Intlammatio
iii)
b Cellular Events
a) Vascular Events

d) None of these.
c) Both (a) and (b)
include the following except
Action of pilocarpine

a) Cycloplegia b) Sweating

c) M10S1s d) all of these.

not useful in acute

v) Which of the following drugs is
Congestive glaucoma?

a) Timolol b) Pilocarpine
C Acetazolamide d) Mannitol.
The organ most sensitive to action of atropine is
vi)
a Salivary gland b) Gastric gland

c) Heart d Urinary bladder.

vii Nalorphine is used as

a analgesic b) morphine antagonisst

c) anti-intlammatory d) local anaesthetic.
Viii) Surface anaesthesia is used for the
following except
a) Ocular tonometry b) Urethral dilation
c) Anal Fissure
d) Tooth extraction.
ix) VasOconstrictors should not be used in
a Neurogenic shock
b) Haemorrhagic shock
C) Secondary shock
d none of these.

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cardiotoXIC &
The local anesthetic having high
arrhythmogenic potential is

b) Lidocaine
Bupivacaine

c)Procaine d) Chloroprocaine.

xi) Antidote for heparin is

a) N-acetylcysteine b Glucagon

c) Methylene blue d) Protamine.

Xi) Surface anaesthesia is used for the following except

a) Ocular tonometry b) Urethral dilation

Anal Fissure d) Tooth extraction.

GROUP - B

| Short Answer Type Questions )

Answer any three of the following. 3x5 15

2.
2 How does the DAG-IP3 pathway increase the
intracellular calcium ion ? 11+ 3
Write a short note on Timolol & Ephedrine.
Difference between narcotic ö nonnarcotic analgesics.

5 Briefly discuss about RAA System. What is the role of

Renin in control blood pressure ? 3 2
6.
. What is opioid receptor ? Write its mechanism.

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GROUP- C

Questions
(Long Answer Type
3 x 15 =
45
the following.
Answer any three of

on Biological half life, prodrug,

prodrug, and
7. Write notes
5 5+5
competitive inhibitors.

Neurotransmission.
the involved in
8. Explain steps
8 7
compare between D1, D2 & D5 Receptors.
ellects & uses of
9.
9. Give the mechanism of action, adverse

the following.
Ondensetron 5+5 + 5
a Tramadol b) Pethidine c)
10. Write mechanism of action, uses & adverse etfects of

Acetozolamide, Furosemide & Chlorothizide. 5+ 5+ 5

11. Explain the different cellular and biochemical mediators

of inflammation. 5

Write a short note on

a) Tricyclic antidepressant, b) MAO A inhibitors 5

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