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SUNDAY STAR, SUNDAY 25 FEBRUARY 2024 HEALTHCARE IN MALAYSIA

Rising threat of skin cancer


SKIN cancers are generally
classified as non-melanoma
and melanoma skin
malignancies. The most
common ones are basal cell
carcinoma (BCC) and In most cases, the melanoma immunotherapy (monoclonal References Prof Dr Arman
squamous cell carcinoma usually appears as a new antibodies) and targeted therapy Zaharil Mat
(SCC), both of which are lesion rather than rising (BRAF /KIT inhibitors) offers new (1)
Han et al. Characteristics of Saad.
grouped into non-melanoma. from pre-existing moles. hope for those with metastatic skin cancers among adult patients
Though more commonly Patients with giant hairy disease or in an advanced stage in an urban Malaysian population.
found among Caucasians, moles are at a higher risk of of melanoma (in which Australasian Journal of
those who are fair-skinned developing MM; as high as a chemotherapeutic agents offer Dermatology. 2019.
and red-haired, skin cancer is 40% transformation rate has little assistance and radiotherapy (2)
Pailoor et al. Cutaneous
increasingly affecting the been reported. Sun or may only benefit some patients); malignant melanoma: clinical and
Malaysian population. ultraviolet light exposure relieving symptoms in those with histopathological review of cases in
According to the most recent increases the likelihood of metastases to the brain, spine a Malaysian tertiary referral centre.
Malaysian National Cancer developing MM. The risk is or bones. Malays J Pathol. 2012 Dec;34(2):97-101.
Registry (2012-2016), skin higher in cases with a history
cancer is one of the 10 most of extensive exposure or
common cancers in both sunburn during childhood.
males and females.
The incidence of non- How to distinguish a
melanoma (NM) skin cancers
from the 2012-2016 numbers malignant lesion
translate into 3.5% or 1,797
males and 2.2% or 1,395 MSU Medical Centre
females, versus 184 males plastic and reconstructive
and 163 females with surgeon Prof Dr Arman
malignant melanoma (MM). Zaharil Mat Saad says that
Though the number of most MM cases treated in
patients with MM was low, Malaysia involve the
over 70% of cases had been peripheral or limb areas, are
presented late for treatment; found on the foot sole and
with a grim prognosis for are presented as late as Stage
52%-58% of cases in Stage 4 3 or 4. The finding was
of the disease. Despite the mirrored in the 2012 study
lower incidence of MM by Pailoor, which cited 32
compared with BCC or SCC, cases, with 16 affecting the
MM presents higher mortality lower limb and 12 on the
in those afflicted by skin soles.
cancer.
NM skin cancers (BCC or What you should do
SCC) are less aggressive and
are often presented in their Suspicious of a lesion? See
early stages – more than 50% a doctor or specialist of skin
in Stage 1 and 18%-21% in cancers who could be a
Stage 2. A local five-year plastic surgeon, a
study found NMSC to be often dermatologist or an oncology
presented in the eighth surgeon for consultation and
decade of life and more possible biopsy to obtain a
commonly among the definitive diagnosis.
Chinese, followed by Malays Once a diagnosis is
and Indians.(1) obtained, staging
A slightly older study on 32 investigation should follow
cases reported over 10 years a thorough clinical
found 62% presented at Stage examination to check for
3 or 4 and a median age of 62 enlarged satellite, in-transit,
years.(2) The higher or regional lymph nodes.
prevalence among the This is usually done via CT or
Chinese comes as no surprise PET scan, liver function test,
given the tendency of skin and genetic study of gene
cancer among those with mutations (BRAF and cKIT).
fairer skin.
In women, MM commonly Treatment
occurs in the extremities,
versus the trunk, head, or Treatment at an early
neck in men. stage may involve surgical
resection alone, which may
Risk factors offer a cure for the disease.
A sentinel lymph node
Besides skin fairness (the biopsy may be offered to
fairest is called Fitzpatrick patients with clinically
type 1), other risk factors for negative lymph nodes to
developing MM include detect early cancer spread or
increasing age, a history of micro-metastasis.
melanoma, a history of Those with palpable
sunburn, and the presence of regional lymph nodes or
premalignant lesions such as lymph nodes detected on the
atypical moles – which place imager or scanner should
about 7% of the general have a lymph node biopsy as
population in the risk group well as a block dissection of
for developing MM. the particular lymphatic
Those with atypical mole basin.
syndrome, i.e. having more As for adjuvant treatment,
than 100 moles, are 12 times a new development in
more likely to develop MM. systemic therapy using
2 Healthcare in Malaysia SUNDAY STAR, SUNDAY 25 FEBRUARY 2024

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