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Home-based electromyography-triggered
stimulation in chronic stroke
Usama Gabr Physical Medicine and Rehabilitation Residency Program, The University of Cincinnati College of Medicine
(UCCOM), Peter Levine UCCOM and Neuromotor Recovery and Rehabilitation Laboratory (NMRRL) at Drake Rehabilitation
Center and Stephen J Page Department of Physical Medicine and Rehabilitation, The Institute for the Study of Health and
Neurosciences Graduate Program, UCCOM, Cincinnati, Ohio, USA
Received 25th November 2004; returned for revisions 1st February 2005; revised manuscript accepted 23rd May 2005.
Modified Mini-Mental Status Examination18; (3) width ranging between 100 and 400 ms. The on
age /18B/85; (4) a detectable surface electromyo- signal duration can be adjusted to be between 0.5 s
graphy signal using the ETMS of /0.2 mV from and 10 s, but research suggests 10 s is the optimal19
the extensor carpi radialis of the more affected duration and was, thus, used in this study. The NM
limb; (5) inability to actively extend the affected 900’s safety and efficacy have been repeatedly
wrist (i.e., operationalized as trace movement, or demonstrated with no side-effects.
palpable muscle contraction in the extensors but
not movement); (6) passive range of motion to Instruments
extension in the affected wrist to 458 from neutral, A pluri-dig, hyperextension finger goniometer
as well as passive movement without difficulty in (Sammons-Preston, Cederburg, WI, USA) was
the distal intercarphalangeal joints of the affected used to measure active wrist extension before and
fingers, both as measured by goniometry; and (7) after intervention. The small, plastic device can be
completely discharged from all forms of physical held and operated with one hand and, using a
rehabilitation. We also applied the following ex- protractor measuring from 08 to 1108 in 28
clusion criteria: (1) excessive pain in the affected increments, is sensitive to small changes in active
upper limb or wrist as measured by a score of ]/5 extension. As noted previously, active wrist move-
on a visual analogue scale; (2) neurologic comor- ment is fundamental to gaining access to several
bidity that impairs strength in the affected upper promising interventions. Consequently, active wrist
limb; (3) being administered medication that im- extension was chosen as the only outcome to be
pairs neuromuscular performance (e.g., botulinum measured by goniometry.
toxin A;); (4) pregnant; (5) pacemaker or other In addition to goniometry, we applied the
implanted stimulator; (6) nonstroke-related wrist following measures due to their sensitivity to
or finger pathologies (e.g., sprained wrist); and (7) motor changes in chronic stroke20: (1) the
participating in any other experimental studies. Fugl-Meyer Scale21 assesses several dimensions of
impairment. The upper extremity motor compo-
Apparatus nent, which consists of 66 points, was used in this
The Neuromove 900 (NM 900) (Stroke Recovery study, and has been shown to have impressive test /
Systems Inc., Littleton, CO, USA) is an electro- retest reliability (total /0.98 /0.99; subtests /
myography monitored neuromuscular electrical 0.87 /1.00), inter-rater reliability and construct
stimulation device approved by the federal Food validity.22,23 (2) The Action Research Arm Test,24
and Drug Administration for use by stroke a 19-item test divided into four categories (grasp,
survivors. The NM 900 uses three reusable, self- grip, pinch, and gross movement), with each item
adhering, 2.0’’ (diameter), round surface electrodes graded on a four-point ordinal scale (0 /can
(one ground over a bony protrusion; two active perform no part of the test; 1 /performs test
electrodes over the motor point of the targeted partially; 2/completes test but takes abnormally
muscle). One active electrode is placed on the long time or has great difficulty; 3/performs test
posterior forearm (on the extensor group) 1 in normally) for a total score of 57. The ARA also
(2 cm) from the elbow crease while the other is has high intra-rater (r /0.99) and retest (r/0.98)
placed approximately 1 in (2 cm) below the first reliability and validity,24,25 and has been used
active electrode. The ground electrode is placed extensively in stroke intervention studies.
anywhere on the forearm as long as it is at least
3 in (8 cm) away from either active electrode. The Design, pretesting and intervention
goal of the electrodes is to detect electromyography A randomized, single-blinded, pre/post test
in the affected muscles, and to provide stimulation cross-over case series design was applied. After
to them. A computer inside the device evaluates screening and signing consent forms approved by
the amount of activity present in the muscle, and the local institutional review board, the Fugl-
determines whether the patient’s muscle activity Meyer and Action Research Arm Test were
meets or exceeds a preset threshold. If the subject administered on two occasions one week apart by
attains the threshold, the NM 900 activates the a research team member. Following the second
muscle with its own biphasic waveform with pulse pretesting session, patients were randomly assigned
740 U Gabr et al.
to one of two groups using a random numbers and practice electrode placement. One week later,
table: (1) ETMS/home exercise programme; (2) patients returned to the laboratory and were tested
home exercise programme/ETMS. Our study de- on placement by a physician team member. Pa-
sign is depicted in Figure 1. tients were then given an ETMS device and a home
use diary in which they were to record their use of
ETMS/home exercise programme the device.
One week after the second pretesting session, At home, ETMS/home exercise programme
patients assigned to the ETMS/home exercise patients used the ETMS device twice every week-
programme group received a 30-min, individua- day in 35-min increments during a eight-week
lized education session in which they were taught period. The duration, frequency, and number of
how to use the device by a research team member. weeks of sessions was based on manufacturer
At the conclusion of the session, patients were recommendations. Furthermore, previous ETMS
given written directions, as well as a picture studies had used comparable parameters, such as
depicting proper electrode placement. Patients the 10-s cycles recommended by Cauraugh and
were also given sample electrodes to take home colleagues.19 During times of device use, surface
EMG-triggered stimulation 741
M 54 52 L ETMS/HEP
M 60 68 R ETMS/HEP
F 65 131 L ETMS/HEP
F 65 36 L ETMS/HEP
F 75 60 R ETMS/HEP
F 58 29 R ETMS/HEP
M 70 127 L ETMS/HEP
M 55 42 R ETMS/HEP
M 59 46 R HEP/ETMS
F 44 13 R HEP/ETMS
M 62 16 L HEP/ETMS
M 50 13 L HEP/ETMS
Table 2 Patient mean scores on the Fugl-Meyer and Action Research Arm Test before and after intervention
Group FM ARA
Pre After 8 weeks After 16 weeks Pre After 8 weeks After 16 weeks
Group Preintervention After 8 weeks Change from pre After 16 weeks Change from week 8
extension
participation, also reported no problems using the tion, subjects in this group exhibited no changes on
NM 900 at home. Together, these data suggest that the Fugl-Meyer, Action Research Arm Test, or in
home ETMS use is feasible with high compliance. goniometry. Thus, only ETMS participation
Home use logs also suggested that subjects were caused motor changes, and these changes, while
compliant, although to a lesser degree, with the not functional, were quite large in terms of ability
home exercise programme. Specifically, 27 in- to actively extend the affected wrist.
stances of not performing the programme as Subjects in the second study group received a
scheduled were reported in the home use diaries. home exercise programme first, followed by
Lack of compliance with the home programme ETMS. Like their counterparts in the other study
may be a partial explanation for the subsequent group, members of the home exercise programme/
losses of motor function that subjects exhibited. ETMS group showed no changes, or nominal
However, we also suspect that the ETMS inter- changes, on the Fugl-Meyer, Action Research
vention is substantially more motivating and Arm Test or goniometry after home exercise.
robust, particularly given previous ETMS research However, after ETMS participation, subjects in
findings. the home exercise programme/ETMS group ex-
Before intervention, subjects displayed stable hibited a mean increased active extension in their
motor deficits and consistent impairment levels, affected wrists by /218 (Table 3). This finding was
fine motor function levels (Table 2), and more consistent with the direction and magnitude of
affected wrist extension levels (Table 3), regardless active extension changes observed in the other
of group assignment. According to their physicians group following ETMS use. Interestingly, partici-
and/or their medical records, their motor levels pants in the second group did not exhibit the
had not changed since discharge from outpatient Fugl-Meyer changes exhibited by members of the
motor therapy. Subjects uniformly reported inabil- first group. We are uncertain why this difference
ity to perform functional activities. occurred.
After ETMS participation, ETMS/home exer- Together, our data suggest that ETMS conveys
cise programme subjects exhibited a 7.875-point limited impairment reduction and functional im-
increase on the Fugl-Meyer (Table 2), primarily provements for flaccid chronic stroke patients,
due to increased voluntary movement in the distal regardless of its timing. Indeed, stroke patients,
areas (e.g., wrist extension). This change was when asked after ETMS application, were not able
supported by increased active extension of the to perform any new valed activities as a result of
affected wrist increased by /218 (Table 3). Inter- participation. However, ETMS appears to sub-
estingly, some subjects in this group also showed stantially increase active affected wrist extension in
increased shoulder movement on the Fugl-Meyer flaccid stroke patients, regardless of the timing of
(e.g., abduction, retraction). We believe that this its administration. This is an important discovery,
improvement was because, when attempting to given that, to our knowledge, no intervention has
extend the fingers, many subjects also moved their shown promise in increasing active affected wrist
shoulders and arms (although instructed not to by extension in this group. In fact, ETMS may be a
research team members). ETMS/home exercise pathway whereby stroke patients exhibiting mini-
programme subjects exhibited no changes on the mal active extension can regain needed extension
Action Research Arm Test after ETMS participa- to participate in other interventions. Consistent
tion. After home exercise programme participa- with this suggestion, active extension increases
744 U Gabr et al.
from ETMS enabled several subjects to participate investigating this hypothesis and resolving the
in modified constraint-induced therapy and realize above limitations by examining the functional
additional motor gains in their more affected and neural effects of several ETMS durations
wrists and fingers. We recognize that a study using functional magnetic resonance imaging at 4
limitation is lack of formal measurement of func- Tesla.
tional improvement and we recommend that future
authors examine this possibility. We also recognize
that, as often happens, the randomization pattern
Conclusion
happened to lead to unequal numbers in the
groups (see Figure 1). This shortcoming argues
for additional ETMS studies with more robust ETMS does not appear to convey a functional
sample sizes and equal groups before substantive benefit to flaccid chronic stroke patients. However,
conclusions can be drawn. ETMS consistently and markedly increases active
Data by Kimberley and colleagues26 suggest a wrist extension, providing a potential pathway by
relationship between ETMS provision, improve- which patients could participate in other promising
ments on laboratory measures, and cortical interventions. More research is needed concerning
changes. However, recent reviews27,28 note several the optimal duration, timing, and mechanisms of
shortcomings of ETMS studies, including small ETMS in flaccid chronic stroke.
sample sizes, limited use of functional outcome
measures, and unequal ETMS treatment dura-
tions. Similarly, although only a pilot study, References
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